Income Taxes Schedule of Income Tax Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
Federal income tax expense (benefit) at 21%	$ 52,188	$ 27,153	$ (15,173)
State income tax expense (benefit), net of federal income tax impact	6,690	(1,942)	(1,509)
(Decrease) increase in valuation allowance	(211,039)	44,727	8,147
Worthless stock deduction of international subsidiary	0	(67,322)	0
Foreign income subject to tax at other than federal statutory rate	(94)	237	318
Share-based compensation	(2,690)	(4,117)	315
Executive compensation limitation	3,051	1,434	858
Non-deductible expenses and other	634	47	66
Effective Income Tax Rate Reconciliation, FDII, Amount	(2,932)	0	0
Research and development credits, net	0	0	(1,091)
Orphan drug credits, net of federal add back	0	0	(5,718)
Convertible note discount in APIC	0	0	13,776
Income Tax Expense (Benefit), Continuing Operations, Discontinued Operations	$ (154,192)	$ 217	$ (11)