Certain Balance Sheet Items - Accrued Expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Summary of Accrued Expenses
Accrued compensation and payroll taxes	$ 9,858	$ 8,078
Accrued outsourced manufacturing expenses	6,514	4,535
Other accrued expenses	5,793	6,468
Lease liability	2,820	4,868
Total accrued expenses	24,985	23,949
Less long-term portion	(544)	(3,466)
Total accrued expenses, current	24,441	20,483
Operating Lease, Accretion Of Liability	$ 300	$ 500	$ 800
Operating Lease, Liability, Statement of Financial Position [Extensible List]	Total accrued expenses, current	Total accrued expenses, current
Operating Lease, Cost	$ 1,900	$ 2,200	2,600
Operating Lease, Payments	$ 2,700	$ 3,200	$ 3,100