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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating activities:      
Net loss $ (32,231) $ (68,375) $ (83,479)
Adjustments to reconcile net loss to net cash used in operating activities:      
Share-based compensation 20,838 15,274 9,538
Depreciation and amortization 1,677 1,762 1,227
Non-cash interest expense 1,243 2,025 156
Amortization of premiums marketable securities, net 879 1,457 1,116
Loss on disposal of equipment 8 233 0
Changes in operating assets and liabilities:      
Accounts receivable, net (23,261) (52) 6,606
Inventories (3,083) (236) (3,499)
Prepaid expenses and other assets (15,774) (265) 1,959
Restricted cash 0 0 (100)
Accounts payable and accrued expenses 13,866 (816) 7,888
Deferred revenue (1,411) 1,490 9,297
Other liabilities 166 (15) (48)
Net cash used in operating activities (37,083) (47,518) (49,339)
Investing activities:      
Purchases of marketable securities (71,482) (88,884) (48,947)
Proceeds from maturities of marketable securities 79,730 57,301 3,375
Purchases of property and equipment (2,360) (1,368) (2,297)
Net cash provided by (used in) investing activities 5,888 (32,951) (47,869)
Financing activities:      
Proceeds from issuance of common stock under equity incentive plans, net 13,098 6,788 5,079
Proceeds from issuance of common stock, net 0 107,713 0
Proceeds from issuance of long-term debt, net 0 0 19,985
Net cash provided by financing activities 13,098 114,501 25,064
Net (decrease) increase in cash and cash equivalents (18,097) 34,032 (72,144)
Cash and cash equivalents at beginning of period 61,389 27,357 99,501
Cash and cash equivalents at end of period 43,292 61,389 27,357
Supplemental disclosure of cash flow information:      
Interest Paid 3,775 3,460 3,099
Supplemental disclosure of noncash investing and financing activities:      
Amounts accrued for purchases of property and equipment 473 156 100
Capitalized property and liability associated with a build-to-suit lease arrangement $ 0 $ 0 $ (1,450)