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Summary of Significant Accounting Policies Research and Development (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Research and Development Arrangement, Contract to Perform for Others [Line Items]      
Research and development $ 93,236 $ 79,696 $ 96,640
In-license technologies [Member]      
Research and Development Arrangement, Contract to Perform for Others [Line Items]      
Research and development $ 0