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Income Taxes - Effective Income Tax Rate (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Effective income tax rate reconciliation      
Tax benefit at U.S. federal statutory rate $ (62,023) $ (50,788) $ (17,629)
Stock based compensation (7,844)   (47)
162M limitation 7,996 22  
Other nondeductible expenses 16 5 14
State income taxes benefit before valuation allowance, net of federal benefit 13,090 (19,622) (6,613)
Increase in domestic valuation allowance 59,466 79,258 26,843
Research and development credit (10,712) (9,002) (2,636)
Other adjustments 11 127 68
Income tax expense (benefit) $ 0 $ 0