Exhibit 31.1

CERTIFICATION

I, Duane DeSisto, certify that:

     (1) I have reviewed this Quarterly Report on Form 10-Q/A of Insulet Corporation;

     (2) Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

/s/ Duane DeSisto  

Duane DeSisto 

President and Chief Executive Officer 

November 19, 2010