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Note 19 - Related Party Transactions (Details Textual) - USD ($)
$ in Thousands
12 Months Ended
Aug. 16, 2017
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Mar. 10, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number   17,919,954      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number   13,455,439      
Share-based Payment Arrangement, Accelerated Cost   $ 0 $ 66    
The 2016 Purchase Agreement [Member]          
Common Stock Purchase Agreement, Number of Shares Authorized to Issue and Sell to Investors         405,000,000
Common Stock Purchase Agreement, Value of Shares Authorized to Issue and Sell to Investors         $ 63,400
Former CFO [Member] | Former CFO Separation Agreement [Member]          
Separation Agreement, Base Annual Salary $ 240        
Separation Agreement, Period for Base Annual Salary 1 year        
Separation Agreement, Period for COBRA Healthcare Coverage 1 year        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number 247,650        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number 2,889,749        
Share-based Payment Arrangement, Accelerated Cost     48 $ 89  
Accrued Liabilities, Total   $ 0 0    
Chairman of Eontec [Member] | Minimum [Member]          
Beneficial Ownership Percentage   5.00%      
Eontec [Member] | License Agreement [Member]          
Related Party Transaction, Amounts of Transaction   $ 31 $ 213