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                 September 14, 2022

       Robert Mattacchione
       Chief Executive Officer
       Novo Integrated Sciences, Inc.
       11120 NE 2nd Street, Suite 100
       Bellevue, WA 98004

                                                        Re: Novo Integrated
Sciences, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed September 13,
2022
                                                            File No. 333-267401

       Dear Mr. Mattacchione:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

              Please refer to Rule 461 regarding requests for acceleration. We
remind you that the
       company and its management are responsible for the accuracy and adequacy
of their disclosures,
       notwithstanding any review, comments, action or absence of action by the
staff.

               Please contact Jeff Kauten, Staff Attorney, at (202) 551-3447,
or in his absence, Josh
       Shainess, Legal Branch Chief, at (202) 551-7951, with any questions. If
you require further
       assistance, please contact Larry Spirgel, Office Chief, at (202)
551-3815.




                 Sincerely,


                 Division of Corporation Finance

                 Office of Technology
       cc:                                              Craig D. Linder, Esq.