Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Ontrak, Inc. (“Ontrak") for the quarter ended June 30, 2021, as filed with the Securities and Exchange Commission on the date hereof (the “Report), I, Jonathan Mayhew, Chief Executive Officer of Ontrak certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m(a) or 78o(d)); and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Ontrak.

/s/ JONATHAN MAYHEW	August 5, 2021
Jonathan Mayhew	Date
Chief Executive Officer
(Principal Executive Officer)