ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Textual) - USD ($)	1 Months Ended	12 Months Ended
	Mar. 28, 2019	Dec. 31, 2018	Dec. 31, 2017	Oct. 19, 2017
Accounting Policies [Line Items]
Common Stock, Par or Stated Value Per Share		$ 0.001	$ 0.001
Research and Development Expense		$ 12,066,800	$ 10,766,095
Cash, Cash Equivalents, and Marketable Securities		7,300,000	14,100,000
Comprehensive Income (Loss), Net of Tax, Attributable to Parent		(15,190,322)	2,439,519
Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax		773	8,096
Amortization of Intangible Assets		43,276	49,206
Depreciation		114,376	94,968
Restricted Cash and Cash Equivalents		300,000	700,000
Proceeds from Issuance of Common Stock		6,714,324	$ 11,073,152
Amount Available Under Grant Awards		700,000
Tax Credit Carryforward, Amount		76,100,000
Research Tax Credit Carryforward [Member]
Accounting Policies [Line Items]
Tax Credit Carryforward, Amount		$ 1,400,000
Tax Credit Carry forwards Expiration Year		2027
General Business Tax Credit Carryforward [Member]
Accounting Policies [Line Items]
Operating Loss Carry forwards Expiration Year		2035
Tax Credit Carryforward, Amount		$ 2,300,000
Domestic Tax Authority [Member]
Accounting Policies [Line Items]
Operting Loss Carry forwards Indefinetly		$ 13,300,000
Tax Credit Carryforward, Limitations on Use		The 2018 net operating loss generated of $13.3 million will carryforward indefinitely, but may be subject to an 80% limitation upon utilization
Operating Loss Carryforwards		$ 89,400,000
Operating Loss Carry forwards Expiration Year		2026
State and Local Jurisdiction [Member]
Accounting Policies [Line Items]
Operating Loss Carryforwards		$ 84,600,000
Operating Loss Carry forwards Expiration Year		2028
October 2017 ATM Program [Member]
Accounting Policies [Line Items]
Common Stock, Par or Stated Value Per Share				$ 0.001
Stock Issued During Period, Shares, New Issues		4,687,021
Shares Issued, Price Per Share		$ 1.48
Common Stock Sales Agreement, Maximum Amount To Be Issued				$ 14,000,000
Proceeds from Issuance of Common Stock	$ 10,800,000
Subsequent Event [Member] | October 2017 ATM Program [Member]
Accounting Policies [Line Items]
Stock Issued During Period, Shares, New Issues	7,986,741
Shares Issued, Price Per Share	$ 1.40
Proceeds from Issuance of Common Stock	$ 10,800,000
Common Stock Sales Agreement available for further issuance	$ 2,800,000