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Stock-Based Compensation - Additional Information (Detail) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Stock Based Compensation Plans [Line Items]          
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options $ 900,000   $ 900,000    
Stock-based compensation expense 200,000 $ 200,000 $ 400,000 $ 700,000  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term     2 years 1 month 6 days    
Research and Development Expense          
Stock Based Compensation Plans [Line Items]          
Stock-based compensation expense 22,000 49,000 $ 100,000 300,000  
General and Administrative Expense          
Stock Based Compensation Plans [Line Items]          
Stock-based compensation expense $ 100,000 $ 100,000 $ 400,000 $ 400,000  
2007 Stock Incentive Plan          
Stock Based Compensation Plans [Line Items]          
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant         1,200,000