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Stock-Based Compensation Expense Related to Common Stock Options, Restricted Common Stock and Common Stock Warrants (Detail) (USD $)
12 Months Ended 162 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2013
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense $ 3,789,000 $ 2,792,000 $ 16,163,000
Research and development
     
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense 991,000 922,000  
General and administrative
     
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense $ 2,798,000 $ 1,870,000