Exhibit 99.1

20 21 Complete financial statements in PRUDENTIAL December 31, 2021

ITAÚ UNIBANCO HOLDING S.A. To our stockholders: We present the Executive Board Report and the financial statements of ITAÚ UNIBANCO HOLDING S.A. and its subsidiaries (ITAÚ UNIBANCO HOLDING PRUDENTIAL), for the periods from December 31, 2021 and December 31, 2020 for balance sheet accounts and January 1 to December 31, 2021 and 2020 for income statement accounts, which were prepared in accordance with Brazilian Central Bank (BACEN), Resolution No. 4,280 of October 31,2013 and Circular No. 3,701 of March 13, 2014, and fit for the specific purposes of this resolution. Net income and Stockholder’ equity ITAÚ UNIBANCO HOLDING PRUDENTIAL Net income totaled R$ 26,515 million for the period and Net earnings per share – basic were R$ 2.71 and Net earnings per share—diluted were R$ 2.70. Stockholders’ equity totaled R$ 144,657 million. Assets and funds raised Assets totaled R$ 1,954,548 and were substantially composed of R$ 727,273 million of Interbank investments, Securities and Derivative financial instruments, and R$ 909,597 million of Operations with credit granting characteristics and Foreign exchange portfolio. Circular No. 3,068/01—BACEN ITAÚ UNIBANCO HOLDING PRUDENTIAL hereby represents that it has the financial capacity and the intention to hold to maturity securities classified under the line “Held to maturity”, amounting to R$ 140,956 million, corresponding to only 29.0% of the total Securities and Derivative financial instruments. Acknowledgements We thank our stockholders and clients for their support and trust, and our employees for their determination and commitment, which have been essential to reaching these positive results. São Paulo, February 25, 2022. Executive Board Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 1.1

ITAÚ UNIBANCO HOLDING S.A. BOARD OF DIRECTORS BOARD OF EXECUTIVE OFFICERS Co-Chairmen Chief Executive Officer and Member of the Executive Committee Pedro Moreira Salles Milton Maluhy Filho Roberto Egydio Setubal Vice President Officers and Members of the Executive Committee Ricardo Villela Marino Alexandre Grossmann Zancani Alexsandro Broedel Lopes Members André Luís Teixeira Rodrigues Alfredo Egydio Setubal André Sapoznik Ana Lúcia de Mattos Barretto Villela Carlos Fernando Rossi Constantini Candido Botelho Bracher Flávio Augusto Aguiar de Souza Fábio Colletti Barbosa Leila Cristiane Barboza Braga de Melo Frederico Trajano Inácio Rodrigues Matias Granata João Moreira Salles Pedro Paulo Giubbina Lorenzini Marco Ambrogio Crespi Bonomi Ricardo Ribeiro Mandacaru Guerra Maria Helena dos Santos Fernandes de Santana Sergio Guillinet Fajerman Pedro Luiz Bodin de Moraes AUDIT COMMITTEE Officers Chairman Adriano Cabral Volpini Gustavo Jorge Laboissière Loyola Álvaro Felipe Rizzi Rodrigues Andre Balestrin Cestare Members Daniel Sposito Pastore Alexandre de Barros Emerson Macedo Bortoloto Luciana Pires Dias José Geraldo Franco Ortiz Júnior Otavio Yazbek José Virgilio Vita Neto Ricardo Baldin Paulo Sergio Miron Rogério Carvalho Braga Renato Barbosa do Nascimento Renato da Silva Carvalho Renato Lulia Jacob (1) FISCAL COUNCIL Tatiana Grecco Teresa Cristina Athayde Marcondes Fontes Chairman José Caruso Cruz Henriques Members Alkimar Ribeiro Moura Artemio Bertholini Accountant Arnaldo Alves dos Santos CRC 1SP210058/O-3 (1) Group Head of Investor Relations and Market Intelligence. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 2.1

ITAÚ UNIBANCO HOLDING S.A. Prudential Consolidated Balance Sheet (In millions of Reais) Assets Note 12/31/2021 12/31/2020 Current and Non-current assets 1,907,804 1,846,421 Cash 44,373 46,099 Interbank investments 3b and 4 241,601 293,221 Money market 166,140 237,668 Interbank deposits 69,661 55,553 Voluntary investments with the Central Bank of Brazil 5,800—Securities and derivative financial instruments 3c, 3d and 5 485,672 484,185 Own portfolio 242,796 293,206 Subject to repurchase commitments 104,941 54,216 Pledged in guarantee 29,097 14,251 Deposited with the Central Bank of Brazil 5 6,019 Securities under resale agreements with free movement 39,941 40,378 Derivative financial instruments 68,881 76,104 Guarantee Assets 11 11 Interbank accounts 160,354 134,260 Pending settlement 55,727 44,171 Central Bank of Brazil deposits 104,592 90,059 National Housing System (SFH) 21 13 Correspondents 14 17 Interbranch accounts 369 381 Loan, lease and other credit operations 6 775,795 663,474 Operations with credit granting characteristics 3e 819,993 711,441 (Provision for loan losses) 3f (44,198) (47,967) Other receivables 196,374 221,927 Current tax assets 7,557 9,180 Deferred tax assets 10b I 56,065 61,960 Sundry 9a 132,752 150,787 Other assets 3g 3,266 2,874 Assets held for sale 702 844 (Valuation allowance) (345) (529) Prepaid expenses 9c 2,909 2,559 Permanent assets 46,744 58,809 Investments 3h 25,018 39,896 Investments in associates and joint ventures 24,700 39,596 Other investments 467 449 (Allowance for losses) (149) (149) Real estate 3i and 11 5,937 5,993 Fixed assets 3,722 3,482 Other fixed assets 16,061 15,162 (Accumulated depreciation) (13,846) (12,651) Goodwill and Intangible assets 3j, 3k and 12 15,789 12,920 Goodwill 192 237 Intangible assets 46,971 41,451 (Accumulated amortization) (31,374) (28,768) Total assets 1,954,548 1,905,230 The accompanying notes are an integral part of these financial statements. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 3.1

ITAÚ UNIBANCO HOLDING S.A. Prudential Consolidated Balance Sheet (In millions of Reais) Liabilities and stockholders’ equity Note 12/31/2021 12/31/2020 Current and Non-current liabilities 1,795,858 1,754,381 Deposits 3b and 7b 860,024 814,689 Demand deposits—158,572 135,309 Savings deposits—190,619 179,476 Interbank deposits—3,776 3,430 Time deposits—506,229 496,403 Other deposits 828 71 Deposits received under securities repurchase agreements 3b and 7c 271,104 285,680 Own portfolio—102,719 53,609 Third-party portfolio—115,511 156,602 Free portfolio—52,874 75,469 Funds from acceptances and issuance of securities 3b and 7d 143,138 136,638 Real estate, mortgage, credit and similar notes—79,421 73,108 Foreign loans through securities—62,960 62,571 Funding from strutured operations certificates 757 959 Interbank accounts—64,307 51,202 Pending settlement—64,011 50,862 Correspondents—296 340 Interbranch accounts—8,995 7,947 Third-party funds in transit—8,994 7,898 Internal transfer of funds—1 49 Borrowing and onlending 3b and 7e 97,005 83,200 Borrowing—86,229 71,744 Onlending—10,776 11,456 Derivative financial instruments 3d and 5f 63,974 79,620 Allowance for financial guarantees provided and loan commitments 6c 4,784 4,250 Provisions 8b 15,869 15,832 Other liabilities—266,658 275,323 Current tax liabilities 10c 8,388 6,551 Deferred tax liabilities 10b II 2,511 3,051 Subordinated debt 7f 75,036 74,916 Sundry 9d 180,723 190,805 Deferred income 3p 3,178 3,184 Total stockholders’ equity of controlling shareholders 13 144,657 136,702 Capital—90,729 97,148 Capital reserves—2,247 2,323 Revenue reserves—56,752 40,434 Other comprehensive income 3c and 3d (4,543) (2,296) (Treasury shares)—(528) (907) Non-controlling interests 12e 10,855 10,963 Total stockholders’ equity 155,512 147,665 Total liabilities and stockholders’ equity 1,954,548 1,905,230 The accompanying notes are an integral part of these financial statements. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 3.2

ITAÚ UNIBANCO HOLDING S.A. Prudential Consolidated Statement of Income (In millions of Reais, except for number of shares and earnings per share information) 2nd Half of 01/01 to 01/01 to Note 2021 12/31/2021 12/31/2020 Income from financial operations 90,270 146,204 123,773 Loan, lease and other credit operations—54,206 93,735 79,879 Securities and Derivative financial instruments—32,396 46,325 40,948 Foreign exchange operations—1,121 2,531 704 Compulsory deposits—2,547 3,613 2,242 Expenses of financial operations—(55,372) (76,149) (82,392) Money market—(35,758) (51,803) (55,450) Borrowing and onlending 7e (19,614) (24,346) (26,942) Income from financial operations before loan losses—34,898 70,055 41,381 Result of allowance for loan losses 6 (10,457) (15,276) (26,774) Expenses for allowance for loan losses—(12,170) (18,477) (30,154) Income from recovery of credits written off as loss—1,713 3,201 3,380 Gross income from financial operations—24,441 54,779 14,607 Other operating revenues / (expenses)—(5,661) (16,337) (11,463) Commissions and Banking Fees 9e 21,351 41,308 38,383 Personnel expenses 9g (11,209) (22,033) (20,250) Other administrative expenses 9h (11,787) (22,200) (22,205) Provision expenses 8 (1,159) (3,435) (3,543) Provision for lawsuits civil (415) (795) (874) Provison for labor claims (792) (2,620) (2,098) Provison for tax and social security obligations 79 65 (24) Other risks (31) (85) (547) Tax expenses 3o and 10a II (3,724) (7,560) (5,671) Equity in earnings of affiliates, jointly ventures and other investments 2d 3,905 5,022 10,849 Other operating revenues 1,334 2,296 2,000 Other operating expenses 9i (4,372) (9,735) (11,026) Operating income—18,780 38,442 3,144 Non-operating income 574 798 598 Income before taxes on income and profit sharing—19,354 39,240 3,742 Income tax and social contribution 3o and 10a I (5,305) (11,347) 12,431 Due on operations for the period—(1,763) (5,574) (6,939) Related to temporary differences—(3,542) (5,773) 19,370 Profit sharing – Management Members—Statutory 13b (108) (205) (109) Non-controlling interests 13e (386) (1,173) 2,626 Net income 13,555 26,515 18,690 Earnings per share—Basic 16 Common 1.38 2.71 1.92 Preferred 1.38 2.71 1.92 Earnings per share—Diluted 16 Common 1.38 2.70 1.91 Preferred 1.38 2.70 1.91 Weighted average number of shares outstanding—Basic 16 Common 4,958,290,359 4,958,290,359 4,958,290,359 Preferred 4,818,741,579 4,818,741,579 4,801,324,161 Weighted average number of shares outstanding—Diluted 16 Common 4,958,290,359 4,958,290,359 4,958,290,359 Preferred 4,883,534,958 4,873,042,114 4,843,233,835 The accompanying notes are an integral part of these financial statements. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 3.3

ITAÚ UNIBANCO HOLDING S.A. Prudential Consolidated Statement of Comprehensive Income (In millions of Reais) 2nd Half of 01/01 to 01/01 to Note 2021 12/31/2021 12/31/2020 Consolidated Net income 13,941 27,688 16,064 Financial assets at available for sale (1,898) (2,735) (790) Change in fair value (3,547) (5,398) (288) Tax effect 1,274 1,953 (356) (Gains) / losses transferred to income statement 811 1,420 (265) Tax effect (436) (710) 119 Hedge (596) 705 (3,616) Cash flow hedge 5f V (80) 550 505 Change in fair value (203) 982 974 Tax effect 123 (432) (469) Hedge of net investment in foreign operation 5f V (516) 155 (4,121) Change in fair value (1,067) 168 (7,723) Tax effect 551 (13) 3,602 Remeasurements of liabilities for post-employment benefits (*) 41 45 (191) Remeasurements 17 61 64 (355) Tax effect (20) (19) 164 Foreign exchange variation in foreign investments 782 (262) 4,322 Total other comprehensive income (1,671) (2,247) (275) Total comprehensive income 12,270 25,441 15,789 Comprehensive income attributable to the owners of the parent company 11,884 24,268 18,415 Comprehensive income attributable to non-controlling interests 386 1,173 (2,626) (*) Amounts that will not be subsequently reclassified to income. The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 3.4

ITAÚ UNIBANCO HOLDING S.A. Prudential Consolidated Statement of Changes in Stockholders’ Equity (Note 13) (In millions of Reais) Attributed to owners of the parent company Total Total Other comprehensive income stockholders’ stockholders’ Treasury Capital Revenue Cumulative Retained equity – owners equity – non- Total Capital Available for sale Remeasurements of Gains and shares reserves reserves translation earnings of the parent controlling securities liabilities of post- losses – (1) adjustments (2) company interests Adjustments employment benefits Hedge abroad Balance at 07/01/2021 90,729 (528) 1,987 46,813 (365) (1,526) 4,360 (5,341)—136,129 10,501 146,630 Transactions with owners — 260 — — — 260 52 312 Recognition of share-based payment plans — 260 — — — 260—260 (Increase) / Decrease to the owners of the parent company (Note 13) — — — — — 52 52 Other ——10 — ——10—10 Unclaimed dividends and Interest on capital — — — — 28 28—28 Total comprehensive income — — (1,898) 41 782 (596) 13,555 11,884 386 12,270 Consolidated net income — — — — 13,555 13,555 386 13,941 Other comprehensive income — — (1,898) 41 782 (596)—(1,671)—(1,671) Appropriations: Legal reserve ——672 — — (672) — -Statutory reserve ——9,257 — — (9,257) — -Dividends — — — — (586) (586) (84) (670) Interest on capital — — — — (3,068) (3,068)—(3,068) Balance at 12/31/2021 90,729 (528) 2,247 56,752 (2,263) (1,485) 5,142 (5,937)—144,657 10,855 155,512 Change in the period — 260 9,939 (1,898) 41 782 (596)—8,528 354 8,882 Balance at 01/01/2020 97,148 (1,274) 1,979 36,414 1,262 (1,339) 1,082 (3,026)—132,246 11,110 143,356 Transactions with owners—367 344 — — — 711 2,988 3,699 Result of delivery of treasury shares—367 200 — — — 567—567 Recognition of share-based payment plans — 144 — — — 144—144 (Increase) / Decrease to the owners of the parent company (Note 13) — — — — — 2,988 2,988 Other ——11 — ——11—11 Dividends—declared after previous period ——(4,709) — ——(4,709)—(4,709) Interest on capital—declared after previous period ——(5,102) — ——(5,102)—(5,102) Unclaimed dividends and Interest on capital — — — — 118 118—118 Total comprehensive income — — (790) (191) 4,322 (3,616) 18,690 18,415 (2,626) 15,789 Consolidated net income — — — — 18,690 18,690 (2,626) 16,064 Other comprehensive income — — (790) (191) 4,322 (3,616)—(275)—(275) Appropriations: Legal reserve ——935 — — (935) — -Statutory reserves ——12,885 — — (12,885) — -Dividends — — — — (1,756) (1,756) (509) (2,265) Interest on capital — — — — (3,232) (3,232)—(3,232) Balance at 12/31/2020 97,148 (907) 2,323 40,434 472 (1,530) 5,404 (6,642)—136,702 10,963 147,665 Change in the period—367 344 4,020 (790) (191) 4,322 (3,616)—4,456 (147) 4,309 Balance at 01/01/2021 97,148 (907) 2,323 40,434 472 (1,530) 5,404 (6,642)—136,702 10,963 147,665 Transactions with owners—379 111 — — — 490 (1,197) (707) Result of delivery of treasury shares—379 193 — — — 572—572 Recognition of share-based payment plans — (82) — — — (82)—(82) (Increase) / Decrease to the owners of the parent company (Note 13) — — — — — (1,197) (1,197) Partial spin-off (Note 2d) (6,419)—(187) (3,392) 77—(23) 24—(9,920)—(9,920) Reversal of Dividends or Interest on capital—declared after previous period ——166 — ——166—166 Unclaimed dividends and Interest on capital — — — — 102 102—102 Total comprehensive income — — (2,812) 45 (239) 681 26,515 24,190 1,173 25,363 Consolidated net income — — — — 26,515 26,515 1,173 27,688 Other comprehensive income — — (2,812) 45 (239) 681—(2,325)—(2,325) Appropriations: Legal reserve ——1,312 — — (1,312) — -Statutory reserves ——18,232 — — (18,232) — -Dividends — — — — (1,466) (1,466) (84) (1,550) Interest on capital — — — — (5,607) (5,607)—(5,607) Balance at 12/31/2021 90,729 (528) 2,247 56,752 (2,263) (1,485) 5,142 (5,937)—144,657 10,855 155,512 Change in the period (6,419) 379 (76) 16,318 (2,735) 45 (262) 705—7,955 (108) 7,847 (1) Includes the share in Other Comprehensive Income of Investments in Associates and Joint Ventures related to Available for sale securities. (2) Includes Cash flow hedge and hedge of net investment in foreign operation. The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 3.5

ITAÚ UNIBANCO HOLDING S.A. Prudential Consolidated Statement of Cash Flows (In millions of Reais) 2nd Half of 01/01 to 01/01 to Note 2021 12/31/2021 12/31/2020 Adjusted net income 74,716 106,989 47,079 Net income 13,555 26,515 18,690 Adjustments to net income: 61,161 80,474 28,389 Share-based payment 260 (20) 217 Effects of changes in exchange rates on cash and cash equivalents 36,855 40,703 7,481 Allowance for loan losses 6c 12,170 18,477 30,154 Interest and foreign exchange income related to operations with subordinated debt 18,768 24,279 20,775 Depreciation and amortization 2,707 5,131 4,827 Expense from update / charges on the provisions for lawsuits civil, labor claims, tax and social security 133 559 879 lawsuits and other risks 8b Provisions for lawsuits civil, labor claims, tax and social security lawsuits and other risks 8b 1,188 3,483 3,588 Interest income from escrow deposits (217) (357) (327) Deferred taxes (excluding hedge tax effects) 6,522 8,611 (1,669) Equity in earnings of associates, joint ventures and other investments (3,905) (5,022) (10,849) Income from foreign exchange income related to available-for-sale securities (11,239) (15,167) (20,756) Income from foreign exchange income related to held-to-maturity securities (5,706) (5,501) (7,083) Income from sale of available-for-sale financial assets 811 1,420 (265) Income from sale of investments, assets held for sale and fixed assets (3) (97) (110) Non-controlling interests 13e 386 1,173 (2,626) Other 2,431 2,802 4,153 Change in assets and liabilities (2,538) (71) 19,836 (Increase) / Decrease in assets Interbank investments (14,303) 50,925 (43,773) Securities and derivative financial instruments (assets / liabilities) 29,596 33,421 (79,937) Compulsory deposits with the Central Bank of Brazil (6,375) (14,533) 1,189 Interbank and interbranch accounts (assets / liabilities) (2,904) 2,604 4,635 Loan, lease and other credit operations (107,034) (131,056) (145,441) Other receivables and other assets (673) 11,309 (21,170) (Decrease) / Increase in liabilities Deposits 63,352 45,335 296,007 Deposits received under securities repurchase agreements 20,856 (14,576) 15,432 Funds for issuance of securities 15,513 6,500 (6,931) Borrowing and onlending 11,228 13,805 6,807 Provisions and Other liabilities (10,198) (577) (3,096) Deferred income (71) (6) 476 Payment of income tax and social contribution (1,525) (3,222) (4,362) Net cash Provided by / (Used in) operating activities 72,178 106,918 66,915 Dividends / Interest on capital received from associates and joint ventures 1,033 7,019 2,290 Funds received from sale of available-for-sale securities 27,724 39,997 14,599 Funds received from redemption of held-to-maturity securities 968 9,456 11,729 (Purchase) / Disposal of Assets held for sale 184 376 635 Disposal of investments 8 90 50 Cash and Cash equivalents, net of assets and liabilities arising from the spin-off of XP Inc. (10) (10) -Sale of fixed assets 35 161 240 Termination of intangible asset agreements 8 40 307 (Purchase) of available-for-sale securities (18,602) (57,891) (45,594) (Purchase) of held-to-maturity securities (7,970) (27,589) (4,318) (Purchase) of investments (27) (58) 13,712 (Purchase) of fixed assets 11 (782) (1,382) (1,659) (Purchase) of intangible assets 12 (5,362) (7,648) (3,283) Net cash Provided by / (Used in) investing activities (2,793) (37,439) (11,292) Subordinated debt obligations raisings 5,500 8,229 5,260 Subordinated debt obligations redemptions (18,231) (32,388) (10,581) Change in non-controlling interests (32) (1,281) 2,480 Income from delivery of treasury shares—510 494 Dividends and interest on capital paid to non-controlling interests — (1) Dividends and interest on capital paid (3,065) (6,267) (11,552) Net cash Provided by / (Used in) financing activities (15,828) (31,197) (13,900) Net Increase / (Decrease) in cash and cash equivalents 53,557 38,282 41,723 Cash and cash equivalents at the beginning of the period 79,967 99,090 64,848 Effects of changes in exchange rates on cash and cash equivalents (36,855) (40,703) (7,481) Cash and cash equivalents at the end of the period 3a 96,669 96,669 99,090 Cash 44,373 46,099 Interbank deposits 12,441 3,833 Securities purchased under agreements to resell—Collateral held 34,055 49,158 Voluntary investments with the Central Bank of Brazil 5,800—Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 3.6

ITAÚ UNIBANCO HOLDING S.A. Notes to the Prudential Consolidated Financial Statements At 12/31/2021 and 12/31/2020 for balance sheet accounts and from 01/01 to 12/31 of 2021 and 2020 for income statement (In millions of Reais, except information per share) Note 1—Operations Itaú Unibanco Holding S.A. (ITAÚ UNIBANCO HOLDING) is a publicly-held company, organized and existing under the laws of Brazil. The head office is located at Praça Alfredo Egydio de Souza Aranha, n° 100, in the city of São Paulo, state of São Paulo, Brazil. ITAÚ UNIBANCO HOLDING has a presence in 18 countries and territories and offers a wide variety of financial products and services to personal and corporate customers in Brazil and abroad, not necessarily related to Brazil, through its branches, subsidiaries and international affiliates. It offers a full range of banking services, through its different portfolios: commercial banking; investment banking; real estate lending; loans, financing and investment; leasing and foreign exchange business. ITAÚ UNIBANCO HOLDING is a financial holding company controlled by Itaú Unibanco Participações S.A. (“IUPAR”), a holding company which owns 51.71% of our common shares, and which is jointly controlled by (i) Itaúsa S.A. (“ITAÚSA”), a holding company controlled by members of the Egydio de Souza Aranha family, and (ii) Companhia E. Johnston de Participações (“E. JOHNSTON”), a holding company controlled by the Moreira Salles family. Itaúsa also directly holds 39.21% of ITAÚ UNIBANCO HOLDING’s common shares. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.1

Note 2 – Presentation of the Consolidated Financial Statements a) Presentation The financial statements of ITAÚ UNIBANCO HOLDING PRUDENTIAL have been prepared in accordance with the National Monetary Council (CMN), Resolution No. 4,280 of October 31, 2013 and BACEN Circular 3,701 of March 13, 2014, and they fit for the specific purposes of this resolution. The definitions and criteria for the valuation and recognition of assets, liabilities, income and expenses set forth in the regulation embodied in the Accounting Plan for National Financial System Institutions (COSIF) were applied. For entities not subject to the rules of COSIF, necessary adjustments were made to ensure that the valuation and recognition of assets, liabilities, income and expenses could properly reflect the required regulation. The information in the financial statements and accompanying notes evidence all relevant information inherent in the financial statements, and only them, which are consistent with information used by management in its administration. With the entry into force of the BCB Resolution nº 2/2020, as from January 2021, the Balance Sheet accounts are presented in order of liquidity and enforceability. Leases are shown at present value in the Prudential Consolidated Balance Sheet. The related income and expenses, representing the financial results of these operations, are grouped together under Loan, Lease and Other Credit Operations in the Prudential Consolidated Statement of Income. Advances on exchange contracts have been reclassified from Other Liabilities – Foreign Exchange Portfolio to Loan Operations. Foreign exchange income consists of exchange rate differences on balance sheet accounts denominated in foreign currencies. The expected credit loss for loan commitments is presented in liabilities under Allowance for Financial Guarantees Provided and Loan Commitments, but it is detailed in the notes with the Supplementary Allowance for Loan Losses. b) Consolidation The consolidated financial statements of ITAÚ UNIBANCO HOLDING PRUDENTIAL relate to the consolidation of subsidiaries located in Brazil and abroad, over which it has direct or indirect control, except for the insurance group which is not governed by item 6, article 1 of CMN, Resolution No. 4,280 of October 31, 2013. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.2

The consolidated financial statements cover ITAÚ UNIBANCO HOLDING PRUDENTIAL and its direct and indirect subsidiaries. We present below the main subsidiaries which together represent over 95% of total consolidated assets: Interest in voting Interest in total Functional Country of Activity capital % capital % currency (1) Incorporation 12/31/2021 12/31/2020 12/31/2021 12/31/2020 In Brazil Banco Itaú BBA S.A. Real Brazil Financial Institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Consignado S.A. Real Brazil Financial Institution 100.00% 100.00% 100.00% 100.00% Banco Itaucard S.A. Real Brazil Financial Institution 100.00% 100.00% 100.00% 100.00% Banco Itauleasing S.A. Real Brazil Financial Institution 100.00% 100.00% 100.00% 100.00% Dibens Leasing S.A.—Arrendamento Mercantil Real Brazil Leasing 100.00% 100.00% 100.00% 100.00% Financeira Itaú CBD S.A. Crédito, Financiamento e Investimento Real Brazil Consumer Finance Credit 50.00% 50.00% 50.00% 50.00% Hipercard Banco Múltiplo S.A. Real Brazil Financial Institution 100.00% 100.00% 100.00% 100.00% Itaú Corretora de Valores S.A. Real Brazil Securities Broker 100.00% 100.00% 100.00% 100.00% Itaú Unibanco S.A. Real Brazil Financial Institution 100.00% 100.00% 100.00% 100.00% Luizacred S.A. Sociedade de Crédito, Financiamento e Investimento Real Brazil Consumer Finance Credit 50.00% 50.00% 50.00% 50.00% Redecard Instituição de Pagamento S.A. (2) Real Brazil Acquier 100.00% 100.00% 100.00% 100.00% Foreign Itaú Corpbanca Colombia S.A. Colombian Peso Colombia Financial Institution 49.30% 34.16% 49.30% 34.16% Banco Itaú (Suisse) S.A. Swiss Franc Switzerland Financial Institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Argentina S.A. Argentine Peso Argentina Financial Institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Paraguay S.A. Guarani Paraguay Financial Institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Uruguay S.A. Uruguayan Peso Uruguay Financial Institution 100.00% 100.00% 100.00% 100.00% Itau Bank, Ltd. Real Cayman Islands Financial Institution 100.00% 100.00% 100.00% 100.00% Itau BBA International plc US Dollar United Kingdom Financial Institution 100.00% 100.00% 100.00% 100.00% Itau BBA USA Securities Inc. Real United States Securities Broker 100.00% 100.00% 100.00% 100.00% Itaú CorpBanca (3) Chilean Peso Chile Financial Institution 56.60% 39.22% 56.60% 39.22% (1) All overseas offices of ITAÚ UNIBANCO HOLDING PRUDENTIAL have the same functional currency as the parent company, except for CorpBanca New York Branch, which uses the US Dollar. (2) New company name of Redecard S.A (3) ITAÚ UNIBANCO HOLDING PRUDENTIAL controls ITAÚ CORPBANCA due to the shareholders’ agreement. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.3

c) Critical accounting estimates and judgments The preparation of Consolidated Financial Statements requires Management to make estimates and assumptions that affect the reported amounts of assets, liabilities, and contingent assets and liabilities at the date of the Financial Statements, due to uncertainties and the high level of subjectivity involved in the recognition and measurement of certain items. Estimates and judgments that present a significant risk and may have a material impact on the values of assets and liabilities are disclosed below. Actual results may differ from those established by these estimates and judgments. Topic Notes Consolidation 2c (I) and 2b Fair value of financial instruments 2c (II) and 15 Provision for loan losses 2c (III) and 6 Goodwill impairment 2c (IV) and 12 Deferred income tax and social contribution 2c (V) and 10 Defined benefit pension plans 2c (VI) and 17 Provisions, contingencies and legal obligations 2c (VII) and 8 (I) Consolidation—subsidiaries are all those in which ITAÚ UNIBANCO HOLDING PRUDENTIAL, either directly or through other subsidiaries, is the holder of partner rights that permanently ensure preponderance in corporate resolutions and the power to elect the majority of managers. The existence of control is assessed continuously. Subsidiaries are consolidated from the date control is established to the date on which it ceases to exist. The consolidated financial statements are prepared using consistent accounting policies. Intercompany asset and liability account balances, income accounts and transaction values have been eliminated. (II) Fair value of financial instruments—the fair value of financial instruments, including derivatives that are not traded in active markets, is calculated by using valuation techniques based on assumptions that consider market information and conditions. The main assumptions are: historical data, information on similar transactions and pricing techniques. For more complex or illiquid instruments, significant judgment is necessary to determine the model used with the selection of specific inputs and, in certain cases, evaluation adjustments are applied to the model amount our price quoted for financial instruments that are not actively traded. The methodologies used to estimate the fair value of certain financial instruments are described in Note 15. (III) Provision for loan losses – The analysis of the provision for loan losses from the operations granted by ITAÚ UNIBANCO HOLDING PRUDENTIAL is conducted based on the assessment of the default classification (Ratings AA-H), on an individual or collective basis, established in CMN Resolution No. 2,682, of December 21, 1999. Management exercises its judgment in the assessment of the adequacy of the expected loss amounts resulting from models and, according to its experience, makes adjustments that may result from certain clients’ credit condition or from temporary adjustments resulting from new situations or circumstances that have not yet been reflected in modeling. In addition to the default classification the following aspects are also considered: • 12-month horizon, using base macroeconomic scenarios, i.e., with no weighting; and • Highest risk classification according to the operation, client, default, renegotiation, among others. The criteria for the provision for loan losses are detailed in Note 19. (IV) Goodwill impairment – The review of goodwill due to impairment reflects the Management’s best estimate for future cash flows of Cash Generating Units (CGU), with the identification of the CGU and estimate of their fair value less costs to sell and/or value in use. To determine this estimate, ITAÚ UNIBANCO HOLDING PRUDENTIAL adopts the discounted cash flow methodology for a period of 5 years, macroeconomic assumptions, growth rate and discount rate. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.4

The discount rate generally reflects financial and economic variables, such as the risk-free interest rate and a risk premium. Cash-Generating Units or CGU groups are identified at the lowest level at which goodwill is monitored for internal management purposes. (V) Deferred income tax and social contribution—deferred tax assets are recognized only in relation to deductible temporary differences, tax losses and social contribution loss carryforwards for offset to the extent that i) it is considered probable that ITAÚ UNIBANCO HOLDING PRUDENTIAL will generate future taxable income for its use; and ii) it presents a history of taxable income or income in at least three of the last five fiscal years. The expected realization of deferred tax assets is based on the projection of future taxable profits and technical studies, as disclosed in Note 10. (VI) Defined benefit pension plans—the current amount of pension plans is obtained from actuarial calculations, which use assumptions such as discount rate, which is appropriated at the end of each year and used to determine the present value of estimated future cash outflows. To determine the appropriate discount rate, ITAÚ UNIBANCO HOLDING PRUDENTIAL considers the interest rates of National Treasury Notes that have maturity terms similar to the terms of the respective liabilities. The main assumptions for Pension plan obligations are partly based on current market conditions. Additional information is disclosed in Note 17. (VII) Provisions, Contingencies and Legal Obligations—ITAÚ UNIBANCO HOLDING PRUDENTIAL periodically reviews its contingencies. These contingencies are evaluated based on management´s best estimates, taking into account the opinion of legal counsel when there is a likelihood that financial resources will be required to settle the obligations and the amounts may be reasonably estimated. Contingencies classified as probable losses are recognized in the Consolidated Balance Sheet under Provisions. Contingent amounts are measured using appropriate models and criteria, despite the uncertainty surrounding the ultimate timing and amounts. Provisions, contingencies and other commitments are detailed in Note 8. d) Business development Reduction of non-controlling interest in XP Inc. On November 26, 2020, ITAÚ UNIBANCO HOLDING disclosed that the Board of Directors approved the partial spin-off of the investment held in XP Inc. (XP INC) to a new company (XPart S.A.). On December 2 and 17, 2020, ITAÚ UNIBANCO HOLDING sold 4.44% and 0.07%, respectively, of its investments in XP INC, through the public offering on the Nasdaq, giving a result before taxes of R$ 4,001. Concurrently with the sales, XP INC completed a public offering (follow-on) which resulted in the dilution of the interest held by ITAÚ UNIBANCO HOLDING to 41.00% of capital, giving a result in XP INC primary subscription of R$ 546. Additionally, on May 14, 2021, ITAÚ UNIBANCO HOLDING sold 0.48% of its interest in XP INC, generating income before taxes of R$ 486. After a favorable opinion of the US Federal Reserve Board, XPart S.A. was constituted on May 31, 2021 by the portion of investment in XP INC plus a cash amount corresponding to R$ 10, as approved in the Extraordinary Stockholders’ Meeting held on January 31, 2021. The percentage of XP INC’s capital spun-off to XPart S.A. was 40.52%, which corresponded to XPart S.A. stockholders’ equity value of R$ 9,985 on the base date May 31, 2021. In General Meetings on October 1, 2021, the merger of XPart S.A. into XP INC. was approved. In view of the merger and subsequent extinction of XPart S.A. into XP INC, ITAÚ UNIBANCO HOLDING’s stockholders that hold an ownership interest in XPart S.A., received in replacement, an ownership interest of XP INC. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.5

After all the events described above, ITAÚ UNIBANCO HOLDING no longer holds an equity interest in XP INC. However, the original agreement establishes an additional acquisition of interest of XP INC in 2022 by ITAÚ UNIBANCO HOLDING, approved by BACEN and subject to future approval by foreign regulatory bodies, as disclosed in Announcement to the Market of November 08, 2021. Itaú CorpBanca The Itaú CorpBanca (ITAÚ CORPBANCA) is controlled as of April 1st, 2016 by ITAÚ UNIBANCO HOLDING. On the same date, ITAU UNIBANCO HOLDING entered into a shareholders’ agreement with Corp Group, which sets forth, among others, the right of ITAÚ UNIBANCO HOLDING and Corp Group to appoint members for the Board of Directors of ITAÚ CORPBANCA in accordance to their interests in capital stock, and this group of shareholders have the right to appoint the majority of members of the Board of Directors of ITAÚ CORPBANCA and ITAÚ UNIBANCO HOLDING are be entitled to appoint the majority of members elected by this block. On September 10, 2020, ITAÚ UNIBANCO HOLDING, through its subsidiary ITB Holding Brasil Participações Ltda, indirectly acquired additional ownership interest of 1.08% (5,558,780,153 shares) in the ITAÚ CORPBANCA’s capital for the amount of R$ 229, and now it holds 39.22%. The effective acquisition and financial settlement occurred on September 14, 2020, after obtaining the regulatory authorizations. At the Extraordinary Stockholders’ Meeting of Itaú CorpBanca held on July 13, 2021, the capital increase of Itaú CorpBanca in the total amount of CLP 830 billion was approved, through the issuance of 461,111,111,111 shares, which were fully subscribed, paid in and settled in October and November 2021, after regulatory approvals. ITAÚ UNIBANCO HOLDING subscribed the total of 350,048,242,004 shares for the amount of CLP 630 billion (approximately R$ 4,296), then holding 56.60% of the capital of ITAÚ CORPBANCA. Recovery do Brasil Consultoria S.A. On December 31, 2015, ITAÚ UNIBANCO HOLDING, through its subsidiary Itaú Unibanco S.A. (ITAÚ UNIBANCO), entered into an agreement for purchase and sale and other covenants with Banco BTG Pactual S.A. (BTG) and with Misben S.A. for acquisition of 89.08% of interest in capital of Recovery do Brasil Consultoria S.A. (RECOVERY), corresponding to total interest of RECOVERY’s parties, for the amount of R$ 735. On July 7, 2016 an additional interest of 6.92% was acquired from International Finance Corporation, for the amount of R$ 59, then holding 96% of its capital. On May 26, 2020, ITAÚ UNIBANCO HOLDING, through its subsidiary ITAÚ UNIBANCO, acquired from International Finance Corporation an additional interest of 4% for the amount of R$ 20.7, then holding 100% of capital of RECOVERY. The effective acquisition and financial settlement occurred on May 28, 2020. Acquisition of Zup I.T. Serviços em Tecnologia e Inovação S.A. On October 31, 2019, ITAÚ UNIBANCO HOLDING, through its subsidiary Redecard Instituição de Pagamento S.A. (REDE), entered into a purchase and sale agreement of 100% of the capital of Zup I.T. Serviços em Tecnologia e Inovação S.A. (ZUP). The purchase will be carried out in three phases over four years. In the first phase, ITAÚ UNIBANCO HOLDING acquired 52.96% of ZUP’s total voting capital for approximately R$ 293, then holding the company’s control. In the third year, after the operation is closed, ITAÚ UNIBANCO HOLDING will acquire an additional 19.6% interest; in the fourth year, the remaining interest, so as to achieve 100% of ZUP’s capital. Effective acquisitions and financial settlements occurred on March 31, 2020, after obtaining the regulatory authorizations required. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.6

Note 3 – Significant accounting policies a) Cash and cash equivalents—Defined as cash and current accounts with banks, shown in the Consolidated Balance Sheet under the heading Cash, Interbank Deposits, Money Market (Collateral Held) and Voluntary investments with the Central Bank of Brazil with original maturities not exceeding 90 days. b) Interbank investments, Remunerated restricted Credits held at the Central Bank of Brazil (BACEN), Remunerated deposits, deposits received under securities repurchase agreements, funds from acceptances and issuance of securities, borrowing and onlending, subordinated debt and other receivables and payables – Operations with fixed interest and charges are booked at present value. Operations with floating interest and charges are booked at the adjusted principal amount. Operations subject to foreign exchange variation are booked at the corresponding amount in local currency. Liabilities are presented net of the transaction costs incurred, if significant, calculated pro rata on a daily basis. c) Securities—Recorded at the cost of acquisition restated by the index and/or effective interest rate and presented in the Balance Sheet as required by BACEN Circular 3,068, of November 08, 2001. Securities are classified into the following categories: · Trading securities – Securities acquired to be actively and frequently traded. They are measured at fair value, with a counterparty to the results for the period; · Available for sale securities – Securities that can be negotiated but are not acquired for the purposes of active and frequent trading. They are measured at fair value, with a counterparty to a specific account in stockholders’ equity; · Held to maturity securities –Securities, other than non-redeemable shares, which the bank has the financial capacity and intends, or is required, to hold in the portfolio to maturity. They are recorded at the cost of acquisition, or at fair value, whenever these are transferred from another category. Securities are adjusted up to maturity date, but are not measured at fair value. Gains and losses on available for sale securities, when realized, are recognized on the trade date in the statement of income, with a counterparty to a specific account in stockholders’ equity. Decreases in the fair value of available for sale and held to maturity securities below to cost, resulting from causes not considered to be temporary, are recorded in the results as realized losses. d) Derivative financial instruments—These are classified on the date of their acquisition, according to whether or not management intends to use them for hedging, according to BACEN Circular 3,082, of January 30, 2002. Transactions involving financial instruments, carried out at a customer’s request, for the bank’s own account, or which do not comply with the hedging criteria (mainly derivatives used to manage overall risk exposure), are stated at fair value, including realized and unrealized gains and losses, which are recorded directly in the statement of income. Derivatives that are used for protection against risk exposure or to modify the characteristics of financial assets and liabilities, where changes in fair value are closely related to those of the items being protected at the beginning and throughout the duration of the contract, and which are considered to be effective in reducing the risk exposure in question, are classified as hedges of the following types: · Market Risk Hedge – Financial assets and liabilities, as well as their related financial instruments, are booked at fair value, plus realized and unrealized gains and losses, which are recorded directly in the statement of income; · Cash Flow Hedge—The effective portion of a hedge of financial assets and liabilities, and the related financial instruments, are booked at fair value plus realized and unrealized gains and losses, net of tax effects, when applicable, and recorded in a specific account in stockholders’ equity. The ineffective portion is recorded directly in the statement of income; Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.7

· Hedge of Net Investments in Foreign Operations—Accounted for similarly to a cash flow hedge, i.e. the portion of gains or losses on a hedging instrument that is determined to be an effective hedge is recognized in stockholders’ equity, and reclassified to income for the period in the event of the disposal of the foreign operation. The ineffective portion is recognized in income for the period. e) Loans, leases and other credit operations (operations with lending characteristics) – These transactions are recorded at present value and calculated pro rata on a daily basis in line with variations in a defined indexer and interest rate, and are adjusted up to the 60th day of arrears, according to the expectation of payment. After the 60th day, income is recognized only on actual receipt of payments. Credit card operations include receivables arising from purchases made by cardholders. Funds corresponding to these amounts to be paid to the credit card companies are shown as liabilities, under the heading Interbank Accounts – Receipts and Payments Pending Settlement. f) Provision for loan losses—The balance of the provision for loan losses is recorded based on a credit risk analysis, at an amount considered sufficient to cover loan losses in accordance with the rules determined by CMN Resolution Nº. 2,682 of December 21, 1999, which include the following: · Provisions are recorded from the date on which loans are granted, based on the customer’s risk rating and on a periodic quality assessment of customers and business sectors, and not only in the event of default; · Exclusively in the case of default, losses are written off 360 days after the credits have matured, or after 540 days for operations with maturities longer than 36 months. g) Other assets—They are comprised of Assets Held for Sale, relating to real estate, vehicles and other assets available for sale (owned but deactivated, received as payment in kind or resulting from execution of guarantees). These assets are adjusted to fair value by setting up a provision in accordance with current regulations and prepaid expenses, corresponding to disbursements which will produce benefits in future years. h) Investments—Include goodwill identified in the acquisition of associates and joint ventures, net of any accumulated impairment loss. They are initially recognized at acquisition cost and are subsequently accounted for under the equity method. · Associates: are companies over which ITAÚ UNIBANCO HOLDING PRUDENTIAL has significant influence, but which it does not control. · Joint Ventures: ITAÚ UNIBANCO HOLDING PRUDENTIAL has joint venture whereby the parties that have joint control of the arrangement have rights to the net assets. i) Fixed assets—Are booked at their acquisition cost less accumulated depreciation and adjusted for impairment, if applicable. Depreciation is calculated on the straight-line method using rates based on the estimated useful lives of these assets. Such rates and other details are presented in Note 11. The residual values and useful lives of assets are reviewed and adjusted, if appropriate, at the end of each period. ITAÚ UNIBANCO HOLDING PRUDENTIAL reviews its assets in order to identify indications of impairment in their recoverable amounts. The recoverable amount of an asset is defined as the higher of its fair value less the cost to sell and its value in use. For the purposes of assessing impairment, assets are grouped at the lowest level for which independent cash flows can be identified (cash-generating units). The assessment may be made at an individual asset level when the fair value less the cost to sell can be reliably determined. j) Goodwill – Corresponds to the amount paid in excess in the acquisition of investments and it is amortized based on the expected future profitability or on its realization. It is semiannually submitted to the asset impairment test with the adoption of an approach that involves the identification of cash-generating units (CGU) and the estimate of its fair value less the cost to sell and/or its value in use. The breakdown of intangible assets is described in Note 12. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.8

k) Intangible assets – Composed of: (i) Goodwill paid upon acquisition of a company, transferred to intangible assets due to merger of the acquired company’s equity into the acquirer company; (ii) Rights on the acquisition of payrolls and association agreements, amortized according to agreement terms or as economic benefits flow to the company; and (iii) Software, amortized over five years, and customer portfolios, amortized within ten years. Intangible assets with definite useful lives are amortized using the straight-line method over their estimated useful lives and those with indefinite useful lives are tested on a semiannually basis to identify possible impairment losses. l) Capital Transactions with Non-Controlling Stockholders—Changes in an ownership interest in a subsidiary, which do not result in a loss of control, are accounted for as capital transactions and any difference between the amount paid and the carrying amount of non-controlling stockholders is recognized directly in consolidated stockholders’ equity. m) Provisions, Contingent Assets and Contingent Liabilities – these are possible rights and potential obligations arising from past events for which realization depends on uncertain future events. Contingent assets are not recognized in the Consolidated Balance Sheet, except when Management of ITAÚ UNIBANCO HOLDING PRUDENTIAL considers that realization is practically certain. In general they correspond to lawsuits with favorable outcomes in final and unappealable judgments and to the withdrawal of lawsuits as a result of a settlement payment received or an agreement for set-off against an existing liability. These contingencies are evaluated based on Management’s best estimates, and are classified as: · Probable: in which liabilities are recognized in the Consolidated Balance Sheet under Provisions; · Possible: which are disclosed in the Consolidated Financial Statements, but no provision is recorded; · Remote: which require neither a provision nor disclosure. The amount of deposits in guarantee is adjusted in compliance with current legislation. Contingencies guaranteed by indemnity clauses in privatization processes and others, and with liquidity are recognized upon judicial notification with simultaneous recognition of receivables, without any effect on results. Legal Obligations and Tax and Social Security Obligations Represented by amounts payable for tax liabilities, the legality or constitutionality of which are subject to judicial challenge, recognized for the full amount under discussion. n) Allowance for Financial Guarantees Provided – Recognized based on the expected loss model, in an amount sufficient to cover any probable losses over the whole guarantee period. o) Income Tax and Social Contribution – There are two components of the provision for income tax and social contribution: current and deferred. The current component is approximately the total of taxes to be paid or recovered during the reporting period. Deferred income tax and social contribution, represented by deferred tax assets and liabilities, is obtained based on the differences between the tax bases of assets and liabilities and the amounts reported in the financial statements at each period. The income tax and social contribution expense is recognized in the Consolidated statement of income under Income Tax and Social Contribution, except when it refers to items directly recognized in Stockholders’ Equity, such as tax on marking available for sale financial assets to fair value, post-employment benefits and tax on cash flow hedges and hedge of net investment in foreign operations. Subsequently, these items are recognized in income upon realization of the gain/loss on the instruments. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.9

Changes in tax legislation and rates are recognized in the Consolidated statement of income under Income tax and social contribution in the period in which they are enacted. Interest and fines are recognized in the Consolidated statement of income under Other administrative expenses. Tax rates, as well as their calculation bases, are detailed in Note 10. p) Deferred income – this refers to: (i) interest received in advance on which there is no prospect of demand for payment and which depends only on the passage of time to be appropriated to effective income, and (ii) the negative goodwill on acquisition of investments, which has not been absorbed in the consolidation process. q) Post-employments benefits Pension plans—defined benefit plans The liability (or asset, as the case may be) is recognized in the consolidated balance sheet with respect to a defined benefit plan corresponds to the present value of the defined benefit obligations at the balance sheet date less the fair value of the plan assets. The defined benefit obligations are calculated annually using the projected unit credit method. The present value of the defined benefit obligation is determined by discounting the estimated amount of future cash flows of benefit payments at the rate for Brazilian treasury long term securities denominated in Reais and with maturity periods similar to the term of the pension plan liabilities. Pension plans—defined contribution For defined contribution plans, contributions to plans made by ITAÚ UNIBANCO HOLDING PRUDENTIAL, through pension plan funds, are recognized as expenses, when due. Other post-employment benefit obligations Like defined benefit pension plans, these obligations are assessed annually by independent, qualified actuaries, and the costs expected from these benefits are accrued over the period of employment. Gains and losses arising from changes in practices and variations in actuarial assumptions are recognized in Stockholders’ equity, in the period in which they occur. r) Foreign currency translation I—Functional and presentation currency The Financial Statements of ITAÚ UNIBANCO HOLDING PRUDENTIAL are presented in Brazilian Reais, its functional and presentation currency. For each subsidiary, joint venture or investment in associates, ITAÚ UNIBANCO HOLDING PRUDENTIAL defines the functional currency as the currency of the primary economic environment in which the entity operates. II—Foreign Currency Operations Foreign currency operations are translated into the functional currency using the exchange rates prevailing on the dates of the transactions. Foreign exchange gains and losses are recognized in the Consolidated Statement of Income, unless they are related to cash flow hedges and hedge of net investments in foreign operations, which are recognized in Stockholders’ Equity. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.10

Note 4—Interbank investments 12/31/2021 12/31/2020 0—30 31—180 181—365 Over 365 days Total % Total % Money market 138,828 26,537—775 166,140 68.8 237,668 81.1 Collateral held (1) 32,886 7,183—775 40,844 16.9 55,672 19.0 Collateral repledge 101,879 12,634 — 114,513 47.4 155,825 53.1 Assets received as collateral with right to sell or repledge 14,218 12,634 — 26,852 11.1 24,157 8.2 Assets received as collateral without right to sell or repledge 87,661 ——87,661 36.3 131,668 44.9 Short position 4,063 6,720 — 10,783 4.5 26,171 9.0 Interbank deposits 50,913 7,031 5,840 5,877 69,661 28.8 55,553 18.9 Voluntary investments with the Central Bank of Brazil 5,800 ——5,800 2.4—0.0 Total (2) 195,541 33,568 5,840 6,652 241,601 100.0 293,221 100.0 % per maturity date 80.9 13.9 2.4 2.8 100.0 Total at 12/31/2020 228,653 49,038 8,353 7,177 293,221 % per maturity date 78.1 16.7 2.8 2.4 100.0 (1) Includes R$ 9,266 (R$ 11,119 at 12/31/2020) related to Money market—Assets received as collateral with right to sell or repladge, in which securities are restricted to guarantee transactions at the B3 S.A.—Brasil, Bolsa, Balcão (B3) and BACEN. (2) Includes a securities valuation allowance in the amount of R$ (57) (R$ (6) at 12/31/2020). Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.11

Note 5 – Securities and derivative financial instruments (assets and liabilities) See below the composition by Securities and Derivatives financial instruments type, maturity and portfolio already adjusted to their respective fair values. a) Summary per maturity 12/31/2021 12/31/2020 Adjustment to fair value reflected in: Cost Fair value % 0—30 31—90 91—180 181—365 366—720 Over 720 days Fair value Stockholders’ Income equity Government securities—Brazil 218,785 (1,609) (1,375) 215,801 44.3 2,020 1,423 2,430 28,796 51,173 129,959 252,215 Financial treasury bills 23,179 2—23,181 4.8—1,356—14,061 4,660 3,104 27,872 National treasury bills 66,057 (945) (136) 64,976 13.3 2,009—2,369 2,765 20,272 37,561 97,105 National treasury notes 78,048 (652) (1,209) 76,187 15.6 10 67 61 11,970 20,813 43,266 74,672 National treasury / Securitization 110—30 140 0.0 — ——140 184 Brazilian external debt bonds 51,391 (14) (60) 51,317 10.6 1 ——5,428 45,888 52,382 Government securities—abroad 60,917 (20) (330) 60,567 12.7 12,088 10,157 8,989 15,080 3,215 11,038 61,680 Argentina 1,308 29 (4) 1,333 0.3 563 227 259 244 23 17 1,477 Chile 21,543 (2) (160) 21,381 4.4 8,801 3,978—2 652 7,948 23,216 Colombia 3,938 (12) (95) 3,831 0.8 41 184 698 272 57 2,579 8,089 Korea 5,604 — 5,604 1.2 — 1,113 4,121 370—3,936 Spain 6,132 — 6,132 1.3—210—3,932 1,990—4,870 United States 7,227 (35) (2) 7,190 1.5 654 841 2,298 3,205—192 5,835 Italy — — 0.0 — — — 130 Mexico 12,424—(16) 12,408 2.6 1,769 3,752 4,255 2,613—19 10,232 Paraguay 1,512—(55) 1,457 0.3 49 339 58 658 123 230 2,950 Peru 7 — 7 0.0 — ——7 4 Uruguay 1,222—2 1,224 0.3 211 626 308 33—46 941 Corporate securities 140,723 (1) (299) 140,423 28.8 12,611 2,479 5,096 7,740 15,165 97,332 94,186 Shares 6,617 48 85 6,750 1.4 6,750 — ——6,309 Rural product note 12,639—114 12,753 2.6 284 705 2,197 2,581 1,171 5,815 5,834 Bank deposit certificates 173 — 173 0.0 45—2 126 — 368 Real estate receivables certificates 4,732 (2) (42) 4,688 1.0—3 4 4 7 4,670 5,324 Fund quotas 9,107 9—9,116 1.8 2,614—161—3,461 2,880 4,218 Credit rights 6,502 — 6,502 1.3 — 161—3,461 2,880 2,353 Fixed income 1,671 — 1,671 0.3 1,671 — ——1,245 Variable income 934 9—943 0.2 943 — ——620 Debentures 86,928 2 (501) 86,429 17.8 2,487 387 1,080 2,170 6,194 74,111 55,549 Eurobonds and other 10,241 (39) 1 10,203 2.1 373 45 108 2,152 2,036 5,489 7,607 Financial bills 1,141 (1) (1) 1,139 0.2 — 3 216 732 188 639 Promissory notes 7,227—30 7,257 1.5 58 1,201 1,382 426 1,380 2,810 7,222 Other 1,918 (18) 15 1,915 0.4—138 159 65 184 1,369 1,116 Subtotal—securities 420,425 (1,630) (2,004) 416,791 85.8 26,719 14,059 16,515 51,616 69,553 238,329 408,081 Trading securities 123,090 (1,630)—121,460 25.0 8,002 1,878 3,365 23,218 41,338 43,659 167,625 Available for sale securities 156,379—(2,004) 154,375 31.8 18,676 11,968 11,421 20,069 12,811 79,430 197,779 Held to maturity securities (*) 140,956 — 140,956 29.0 41 213 1,729 8,329 15,404 115,240 42,677 Derivative financial instruments 41,869 27,012—68,881 14.2 15,337 6,161 6,030 5,630 8,839 26,884 76,104 Total securities and derivative financial instruments (assets) 462,294 25,382 (2,004) 485,672 100.0 42,056 20,220 22,545 57,246 78,392 265,213 484,185 Derivative financial instruments (liabilities) (41,658) (22,316)—(63,974) 100.0 (7,109) (7,066) (9,109) (7,643) (8,679) (24,368) (79,620) (*) Unrecorded adjustment to fair value in the amount of R$ 1,072 (R$ 2,530 at 12/31/2020) according to Note 5e. During the period, ITAÚ UNIBANCO HOLDING PRUDENTIAL recognized impairment of R$ (170) (R$ (1,453) from 01/01 to 12/31/2020) of Financial Assets Available for Sale. The income related to Securities and Derivative financial instruments totaled R$ 2,029 (R$ (741) from 01/01 to 12/31/2020). In the period from 01/01 to 12/31/2020, the result of Derivative Financial Instruments as well as Adjustment to Fair Value of Securities (particularly private securities) had their amounts affected by oscillations of rates and other market variables arising from the impact of the COVID-19 pandemic on the macroeconomic scenario in the period (Note 20d). Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.12

b) Summary by portfolio 12/31/2021 Restricted to Assets Derivative guaranteeing Own portfolio Repurchase Pledged financial Total Free portfolio (*) Central Bank technical agreements guarantees instruments provisions Government securities—Brazil 99,143 75,046 38,909 2,693 5—5 215,801 Financial treasury bills 21,792 255—1,124 5—5 23,181 National treasury bills 45,451 18,223—1,302 ——64,976 National treasury notes 17,778 56,568 1,574 267 ——76,187 National treasury / Securitization 140 — — — 140 Brazilian external debt bonds 13,982—37,335 — — 51,317 Government securities—abroad 49,548 2,382 173 8,464 ——60,567 Argentina 1,153 — 180 ——1,333 Chile 19,922 1,429—30 ——21,381 Colombia 3,584—75 172 ——3,831 Korea 3,284 — 2,320 ——5,604 Spain 3,951 — 2,181 ——6,132 United States 6,513 — 677 ——7,190 Italy — — — — Mexico 9,514 — 2,894 ——12,408 Paraguay 496 953—8 ——1,457 Peru 7 — — — 7 Uruguay 1,124—98 2 ——1,224 Corporate securities 94,105 27,513 859 17,940 — 6 140,423 Shares 6,749 — 1 ——6,750 Rural product note 12,753 — — — 12,753 Bank deposit certificates 167 — ——6 173 Real estate receivables certificates 4,688 — — — 4,688 Fund quotas 9,114 — 2 ——9,116 Credit rights 6,502 — — — 6,502 Fixed income 1,671 — — — 1,671 Variable income 941 — 2 ——943 Debentures 44,138 27,513—14,778 ——86,429 Eurobonds and other 9,344—859 — — 10,203 Financial bills 1,139 — — — 1,139 Promissory notes 4,098 — 3,159 ——7,257 Other 1,915 — — — 1,915 Subtotal—securities 242,796 104,941 39,941 29,097 5—11 416,791 Trading securities 64,118 52,822 1,845 2,659 5—11 121,460 Available for sale securities 96,639 45,871 3,138 8,727 ——154,375 Held to maturity securities 82,039 6,248 34,958 17,711 ——140,956 Derivative financial instruments — ——68,881—68,881 Total securities and derivative financial instruments (assets) 242,796 104,941 39,941 29,097 5 68,881 11 485,672 Total securities and derivative financial instruments (assets) –12/31/2020 293,206 54,216 40,378 14,251 6,019 76,104 11 484,185 (*) Represent securities deposited with Contingent Liabilities (Note 8d), Stock Exchanges and the Clearing Houses. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.13

c) Trading securities See below the composition of the portfolio of trading securities by type, stated at cost and fair value and by maturity term. 12/31/2021 12/31/2020 Adjustment to fair Over 720 Cost value Fair value % 0—30 31—90 91—180 181—365 366—720 Fair value days (in income) Government securities—Brazil 99,028 (1,609) 97,419 80.1 2,006 1,423 2,327 20,283 36,515 34,865 148,801 Financial treasury bills 19,300 2 19,302 15.9—1,356—10,183 4,659 3,104 27,871 National treasury bills 30,379 (945) 29,434 24.2 1,995—2,266 971 12,442 11,760 72,843 National treasury notes 46,954 (652) 46,302 38.0 10 67 61 9,129 19,407 17,628 45,035 Brazilian external debt bonds 2,395 (14) 2,381 2.0 1 ——7 2,373 3,052 Government securities—abroad 5,037 (20) 5,017 4.1 720 294 701 1,775 245 1,282 8,174 Argentina 899 29 928 0.8 563 222 16 87 23 17 1,475 Chile 370 (2) 368 0.3 153 10—2 178 25 828 Colombia 1,071 (12) 1,059 0.9 — 5—43 1,011 3,603 United States 2,634 (35) 2,599 2.1—49 677 1,681—192 2,085 Italy ——0.0 — — — 130 Mexico 19—19 0.0 — ——19 5 Paraguay 10—10 0.0—6 — 1 3 3 Peru 7—7 0.0 — ——7 4 Uruguay 27—27 0.0 4 7 3 5—8 41 Corporate securities 19,025 (1) 19,024 15.8 5,276 161 337 1,160 4,578 7,512 10,650 Shares 2,414 48 2,462 2.0 2,462 — ——3,196 Bank deposit certificates 74—74 0.1 3 — 71 — 65 Real estate receivables certificates 123 (2) 121 0.1 — — 7 114 45 Fund quotas 9,107 9 9,116 7.6 2,614—161—3,461 2,880 3,954 Credit rights 6,502—6,502 5.4 — 161—3,461 2,880 2,353 Fixed income 1,671—1,671 1.4 1,671 — ——981 Variable income 934 9 943 0.8 943 — ——620 Debentures 1,308 2 1,310 1.1 ——2 45 1,263 1,120 Eurobonds and other 5,480 (39) 5,441 4.5 197 35 14 1,039 1,024 3,132 2,202 Financial bills 43 (1) 42 0.0 — 3 3 36—3 Other 476 (18) 458 0.4—126 159 45 5 123 65 Total 123,090 (1,630) 121,460 100.0 8,002 1,878 3,365 23,218 41,338 43,659 167,625 % per maturity date 6.6 1.5 2.8 19.1 34.0 36.0 Total – 12/31/2020 166,592 1,033 167,625 100.0 13,626 9,265 41,920 20,958 34,822 47,034 % per maturity date 8.1 5.5 25.0 12.5 20.8 28.1 Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.14

d) Available for sale securities See below the composition of the portfolio of available for sale securities by type, stated at cost and fair value and by maturity term. 12/31/2021 12/31/2020 Adjustments to fair value (in Over 720 Cost Fair value % 0—30 31—90 91—180 181—365 366—720 Fair value stockholders’ days equity) Government securities—Brazil 39,538 (1,375) 38,163 24.6 14—103 8,513 1,822 27,711 65,581 Financial treasury bills 3,879—3,879 2.5 ——3,878 1—1 National treasury bills 3,020 (136) 2,884 1.8 14—103 1,794—973 24,262 National treasury notes 27,929 (1,209) 26,720 17.3 ——2,841 1,406 22,473 27,594 National treasury / Securitization 110 30 140 0.1 — ——140 184 Brazilian external debt bonds 4,600 (60) 4,540 2.9 — — 415 4,125 13,540 Government securities—abroad 37,453 (330) 37,123 24.1 11,327 9,653 6,563 4,980 610 3,990 52,986 Argentina 409 (4) 405 0.3—5 243 157 — 2 Chile 15,429 (160) 15,269 9.9 8,648 3,968 — 474 2,179 22,388 Colombia 1,942 (95) 1,847 1.2—184 81—14 1,568 3,986 Korea ——0.0 — — — 3,936 Spain ——0.0 — — — 4,870 United States 4,593 (2) 4,591 3.0 654 792 1,621 1,524 — 3,750 Mexico 12,405 (16) 12,389 8.0 1,769 3,752 4,255 2,613 — 10,227 Paraguay 1,502 (55) 1,447 0.9 49 333 58 658 122 227 2,947 Uruguay 1,173 2 1,175 0.8 207 619 305 28—16 880 Corporate securities 79,388 (299) 79,089 51.3 7,335 2,315 4,755 6,576 10,379 47,729 79,212 Shares 4,203 85 4,288 2.8 4,288 — ——3,113 Rural product note 12,639 114 12,753 8.3 284 705 2,197 2,581 1,171 5,815 5,834 Bank deposit certificate 99—99 0.1 42—2 55 — 303 Real estate receivables certificates 1,074 (42) 1,032 0.7 — ——1,032 1,010 Fund quotas of fixed income ——0.0 — — — 264 Debentures 46,845 (501) 46,344 30.0 2,487 387 1,080 2,168 5,941 34,281 54,429 Eurobonds and other 4,761 1 4,762 3.1 176 10 94 1,113 1,012 2,357 5,403 Financial bills 1,098 (1) 1,097 0.7 ——213 696 188 636 Promissory and commercial notes 7,227 30 7,257 4.7 58 1,201 1,382 426 1,380 2,810 7,222 Other 1,442 15 1,457 0.9—12—20 179 1,246 998 Total (*) 156,379 (2,004) 154,375 100.0 18,676 11,968 11,421 20,069 12,811 79,430 197,779 % per maturity date 12.1 7.8 7.4 13.0 8.3 51.4 Total – 12/31/2020 195,108 2,671 197,779 100.0 18,132 10,048 16,564 19,108 29,197 104,730 % per maturity date 9.2 5.1 8.3 9.7 14.7 53.0 (*) In order to reflect the current risk management strategy, in the period ended at 12/31/2021, ITAÚ UNIBANCO HOLDING PRUDENTIAL changed the classification of Trading securities, being R$ 4,415 of Government Securities – Brazil and R$ 162 of Government securities—abroad. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.15

e) Held to maturity securities See below the composition of the portfolio of held to maturity securities by type, stated at cost and by maturity term. The cost includes an added/(reduced) value of R$ (786) (R$ 116 at 12/31/2020) referring to the adjustment to fair value of securities reclassified from Available for Sale to Held to Maturity. 12/31/2021 12/31/2020 Cost % 0—30 31—90 91—180 181—365 366—720 Over 720 days Fair value Cost Fair value Government securities—Brazil 80,219 56.8 — — 12,836 67,383 79,843 37,833 40,458 National treasury bills 32,658 23.2 — — 7,830 24,828 31,548 —National treasury notes 3,165 2.2 — ——3,165 3,173 2,043 2,410 Brazilian external debt bonds 44,396 31.4 — — 5,006 39,390 45,122 35,790 38,048 Government securities—abroad 18,427 13.2 41 210 1,725 8,325 2,360 5,766 18,423 520 527 Chile 5,744 4.1 — ——5,744 5,744 —Colombia 925 0.7 41—612 272 — 913 500 493 Korea 5,604 4.0 — 1,113 4,121 370—5,604 —Spain 6,132 4.4—210—3,932 1,990—6,128 —Uruguay 22 0.0 — ——22 34 20 34 Corporate securities 42,310 30.0—3 4 4 208 42,091 41,618 4,324 4,222 Real estate receivables certificates 3,535 2.5—3 4 4—3,524 3,368 4,269 4,167 Debentures 38,775 27.5 — — 208 38,567 38,250 — Eurobonds and other — — — ——2 2 Other — — — ——53 53 Total (*) 140,956 100.0 41 213 1,729 8,329 15,404 115,240 139,884 42,677 45,207 % per maturity date—0.2 1.2 5.9 10.9 81.8 Total – 12/31/2020 42,677 100.0 6,568—153 543 37 35,376 45,207 % per maturity date 15.4—0.4 1.3 0.1 82.9 (*) In order to reflect the current risk management strategy, in the period ended at 12/31/2021, ITAÚ UNIBANCO HOLDING PRUDENTIAL changed the classification of Available for sale securities, being R$ 19,138 of Government Securities—Brazil, R$ 38,338 of Debentures and R$ 17,139 of Sovereign Bonds. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.16

f) Derivative financial instruments ITAÚ UNIBANCO HOLDING PRUDENTIAL trades in derivative financial instruments with various counterparties to manage its overall exposure and to assist its customers in managing their own exposure. Futures – Interest rate and foreign currency futures contracts are commitments to buy or sell a financial instrument at a future date, at an agreed price or yield, and may be settled in cash or through delivery. The notional amount represents the face value of the underlying instrument. Commodity futures contracts or financial instruments are commitments to buy or sell commodities (mainly gold, coffee and orange juice) at a future date, at an agreed price, which are settled in cash. The notional amount represents the quantity of such commodities multiplied by the future price on the contract date. Daily cash settlements of price movements are made for all instruments. Forwards – Interest rate forward contracts are agreements to exchange payments on a specified future date, based on the variation in market interest rates from trade date to contract settlement date. Foreign exchange forward contracts represent agreements to exchange the currency of one country for the currency of another at an agreed price, on an agreed settlement date. Financial instrument forward contracts are commitments to buy or sell a financial instrument on a future date at an agreed price and are settled in cash. Swaps – Interest rate and foreign exchange swap contracts are commitments to settle in cash on a future date or dates the differentials between specific financial indices (either two different interest rates in a single currency or two different rates each in a different currency), as applied to a notional principal amount. Swap contracts shown under Other in the table below correspond substantially to inflation rate swap contracts. Options – Option contracts give the purchaser, for a fee, the right, but not the obligation, to buy or sell a financial instrument within a limited time, including a flow of interest, foreign currencies, commodities, or financial instruments at an agreed price that may also be settled in cash, based on the differential between specific indices. Credit Derivatives – Credit derivatives are financial instruments with value deriving from the credit risk on debt issued by a third party (the reference entity), which permits one party (the buyer of the hedge) to transfer the risk to the counterparty (the seller of the hedge). The seller of the hedge must pay out as provided for in the contract if the reference entity undergoes a credit event, such as bankruptcy, default or debt restructuring. The seller of the hedge receives a premium for the hedge but, on the other hand, assumes the risk that the underlying instrument referenced in the contract undergoes a credit event, and the seller may have to make payment to the purchaser of the hedge for up to the notional amount of the credit derivative. ITAÚ UNIBANCO HOLDING PRUDENTIAL buys and sells credit protection in order to meet the needs of its customers, management and mitigation of its portfolios’ risk. CDS (Credit Default Swap) is a credit derivative in which, upon a default related to the reference entity, the protection buyer is entitled to receive the amount equivalent to the difference between the face value of the CDS contract and the fair value of the liability on the date the contract was settled, also known as the recovered amount. The protection buyer does not need to hold the debt instrument of the reference entity for it to receive the amounts due pursuant to the CDS contract terms when a credit event occurs. TRS (Total Return Swap) is a transaction in which a party swaps the total return of an asset or of a basket of assets for regular cash flows, usually interest and a guarantee against capital loss. In a TRS contract, the parties do not transfer the ownership of the assets. The total value of margins pledged in guarantee by ITAÚ UNIBANCO HOLDING PRUDENTIAL was R$ 4,043 (R$ 14,860 at 12/31/2020) and was basically comprised of government securities. Further information on internal controls and parameters used to manage risks may be found in Note 19—Risk, Capital Management and Fixed Asset Limits. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.17

I—Derivatives Summary See below the composition of the Derivative Financial Instruments portfolio (assets and liabilities) by type of instrument, stated at cost, fair value, and maturity term. 12/31/2021 12/31/2020 Adjustments to fair Cost value (in income / Fair value % 0—30 31—90 91—180 181—365 366—720 Over 720 days Fair value stockholders’ equity) Asset Swaps—adjustment receivable 13,434 24,604 38,038 55.2 1,819 370 838 2,598 7,349 25,064 46,019 Option agreements 20,327 903 21,230 30.8 10,525 3,504 3,787 1,908 688 818 20,141 Forwards (onshore) 2,954 (13) 2,941 4.3 1,515 1,078 289 56 3—1,959 Credit derivatives (271) 513 242 0.4 — 7 8 22 205 156 NDF—Non Deliverable Forward 5,256 687 5,943 8.6 1,193 1,207 1,109 1,053 752 629 7,596 Other Derivative Financial Instruments 169 318 487 0.7 285 2—7 25 168 233 Total 41,869 27,012 68,881 100.0 15,337 6,161 6,030 5,630 8,839 26,884 76,104 % per maturity date 22.3 8.9 8.8 8.2 12.8 39.0 Total – 12/31/2020 43,351 32,753 76,104 100.0 17,295 5,504 2,827 9,071 6,468 34,939 % per maturity date 22.7 7.2 3.7 11.9 8.5 46.0 12/31/2021 12/31/2020 Adjustments to fair Cost value (in income / Fair value % 0—30 31—90 91—180 181—365 366—720 Over 720 days Fair value stockholders’ equity) Liabilities Swaps—difference payable (15,276) (19,375) (34,651) 54.2 (1,563) (639) (1,058) (2,276) (6,944) (22,171) (51,825) Option agreements (20,202) (3,110) (23,312) 36.4 (4,040) (5,170) (7,479) (4,264) (869) (1,490) (20,332) Forwards (onshore) (762)—(762) 1.2 (762) — ——(905) Credit derivatives (261) 63 (198) 0.3 — (1) (1) (8) (188) (76) NDF—Non Deliverable Forward (5,017) 121 (4,896) 7.7 (739) (1,256) (565) (1,097) (822) (417) (6,426) Other derivative financial instruments (140) (15) (155) 0.2 (4) (2) (6) (5) (36) (102) (56) Total (41,658) (22,316) (63,974) 100.0 (7,108) (7,067) (9,109) (7,643) (8,679) (24,368) (79,620) % per maturity date 11.1 11.0 14.2 11.9 13.6 38.2 Total – 12/31/2020 (47,500) (32,120) (79,620) 100.0 (16,623) (4,269) (2,716) (12,677) (6,898) (36,437) % per maturity date 20.9 5.4 3.4 15.9 8.7 45.7 The result of derivative financial instruments in the period totaled R$ 8,468 (R$ (8,726) from 01/01 to 12/31/2020). Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.18

II—Derivatives by index and Risk Fator Balance sheet account Adjustment to fair value Off-balance sheet / receivable / (received) (in income / stockholders’ Fair value Notional amount (payable) / paid equity) 12/31/2021 12/31/2020 12/31/2021 12/31/2021 12/31/2021 12/31/2020 Future contracts 855,947 775,492 — —Purchase commitments 470,539 335,435 — — Shares 14,627 8,150 — — Commodities 703 1,170 — — Interest 429,510 301,889 — — Foreign currency 25,699 24,226 — — Commitments to sell 385,408 440,057 — — Shares 14,165 7,535 — — Commodities 3,308 2,201 — — Interest 341,248 394,027 — — Foreign currency 26,687 36,294 — — Swap contracts (1,842) 5,229 3,387 (5,806) Asset position 1,339,163 1,443,199 13,434 24,604 38,038 46,019 Commodities 2 278 ——1 Interest 1,318,788 1,423,884 10,363 23,835 34,198 41,983 Foreign currency 20,373 19,037 3,071 769 3,840 4,035 Liability position 1,339,163 1,443,199 (15,276) (19,375) (34,651) (51,825) Shares 497 108 (37) (3) (40) (10) Commodities 130 341—(1) (1) (9) Interest 1,310,484 1,426,654 (13,336) (19,377) (32,713) (47,732) Foreign currency 28,052 16,096 (1,903) 6 (1,897) (4,074) Option contracts 1,510,350 1,600,615 125 (2,207) (2,082) (191) Purchase commitments—long position 147,470 133,399 17,907 1,548 19,455 16,108 Shares 11,902 12,375 521 1,135 1,656 1,338 Commodities 471 356 20 20 40 27 Interest 65,782 53,061 53 155 208 57 Foreign currency 69,315 67,607 17,313 238 17,551 14,686 Commitments to sell—long position 609,854 672,115 2,420 (645) 1,775 4,033 Shares 18,928 14,659 878 339 1,217 790 Commodities 306 75 9 (3) 6 1 Interest 523,560 588,368 141 (135) 6 2,441 Foreign currency 67,060 69,013 1,392 (846) 546 801 Purchase commitments—short position 83,332 131,546 (17,548) (3,593) (21,141) (15,816) Shares 14,043 13,075 (348) (1,186) (1,534) (1,467) Commodities 274 899 (8) (1) (9) (46) Interest 6,884 57,770 (21) (859) (880) (299) Foreign currency 62,131 59,802 (17,171) (1,547) (18,718) (14,004) Commitments to sell—short position 669,694 663,555 (2,654) 483 (2,171) (4,516) Shares 16,535 13,196 (648) (368) (1,016) (680) Commodities 266 246 (19) 11 (8) (4) Interest 583,969 581,943 (216) 200 (16) (2,280) Foreign currency 68,924 68,170 (1,771) 640 (1,131) (1,552) Forward operations 26,129 23,989 2,192 (13) 2,179 1,054 Purchases receivable 1,016 18,666 1,016 (27) 989 885 Shares 948 304 948 (27) 921 301 Interest 68 584 68—68 584 Foreign currency—17,778 — — Purchases payable obligations — (68)—(68) (584) Interest — (68)—(68) (584) Sales deliverable 20,765 1,132 1,938 14 1,952 1,074 Shares 1,258 770 1,244 (1) 1,243 766 Interest — 694—694 308 Foreign currency 19,507 362—15 15—Sales receivable obligations 4,348 4,191 (694)—(694) (321) Interest 694 308 (694)—(694) (308) Foreign currency 3,654 3,883 ——(13) Credit derivatives 21,556 20,060 (532) 576 44 80 Asset position 13,414 15,877 (271) 513 242 156 Shares 1,784 2,796 (37) 101 64 88 Commodities 18 19 ——1 Interest 11,612 13,062 (234) 412 178 67 Liability position 8,142 4,183 (261) 63 (198) (76) Shares 1,865 1,154 (63) 17 (46) (34) Commodities—3 — — Interest 6,277 3,026 (198) 46 (152) (42) NDF—Non Deliverable Forward 278,531 313,463 239 808 1,047 1,170 Asset position 144,123 156,542 5,256 687 5,943 7,596 Shares 5 — ——Commodities 2,489 1,715 478 (1) 477 262 Foreign currency 141,629 154,827 4,778 688 5,466 7,334 Liability position 134,408 156,921 (5,017) 121 (4,896) (6,426) Commodities 1,104 975 (50) 3 (47) (38) Foreign currency 133,304 155,946 (4,967) 118 (4,849) (6,388) Other derivative financial instruments 6,217 6,585 29 303 332 177 Asset position 5,256 5,352 169 318 487 233 Shares 202 126—8 8 2 Interest 4,993 5,224 166 28 194 174 Foreign currency 61 2 3 282 285 57 Liability position 961 1,233 (140) (15) (155) (56) Shares 576 799 (9) (11) (20) (37) Interest 376 434 (131) (3) (134) (19) Foreign currency 9 — (1) (1)—Assets 41,869 27,012 68,881 76,104 Liabilities (41,658) (22,316) (63,974) (79,620) Total 211 4,696 4,907 (3,516) Derivative contracts mature as follows (in days): Off-balance sheet / notional amount 0—30 31—180 181—365 Over 365 days 12/31/2021 12/31/2020 Future contracts 368,410 248,922 74,456 164,159 855,947 775,492 Swap contracts 131,709 155,157 121,179 931,118 1,339,163 1,443,199 Option contracts 1,113,431 268,244 46,117 82,558 1,510,350 1,600,615 Forwards 3,173 13,402 9,551 3 26,129 23,989 Credit derivatives—6,602 826 14,128 21,556 20,060 NDF—Non Deliverable Forward 77,962 113,359 48,091 39,119 278,531 313,463 Other derivative financial instruments 199 739 648 4,631 6,217 6,585 Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.19

III—Derivatives by notional amount See below the composition of the Derivative Financial Instruments portfolio by type of instrument, stated at their notional amounts, per trading location (organized or over-the-counter market) and counterparties. 12/31/2021 NDF—Non Other derivative Future Swap Option Credit Forwards Deliverable financial contracts contracts contracts derivatives Forward instruments Stock exchange 855,947 818,335 1,413,681 25,368 7,535 65,035 -Over-the-counter market—520,828 96,669 761 14,021 213,496 6,217 Financial institutions—413,651 57,540 761 14,021 76,415 4,861 Companies—103,758 38,078 — 136,270 1,353 Individuals—3,419 1,051 — 811 3 Total 855,947 1,339,163 1,510,350 26,129 21,556 278,531 6,217 Total – 12/31/2020 775,492 1,443,199 1,600,615 23,989 20,060 313,463 6,585 IV—Credit derivatives See below the composition of the Credit Derivatives portfolio stated at their notional amounts, and their effect on the calculation of Required Reference Equity. 12/31/2021 12/31/2020 Notional amount of credit Notional amount of credit Notional amount of Notional amount of protection purchased with Net position protection purchased with Net position credit protection sold credit protection sold identical underlying amount identical underlying amount CDS (9,837) 6,109 (3,728) (8,501) 3,705 (4,796) TRS (5,610)—(5,610) (7,854)—(7,854) Total (15,447) 6,109 (9,338) (16,355) 3,705 (12,650) The effect of the risk received on the reference equity (Note 19c) was R$ 135 (R$ 86 at 12/31/2020). During the period, there were no credit events relating to the taxable events provided for in the agreements. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.20

V—Hedge accounting I) Cash flow—the purpose of this hedge of ITAÚ UNIBANCO HOLDING PRUDENTIAL is to hedge cash flows of interest receipt and payment (CDB / Syndicated Loans / Assets Transactions / Funding and agreements to resell) and exposures to future exchange rate (anticipated transactions and unrecognized firm commitments) related to its variable interest rate risk (CDI / LIBOR / UF* / TPM* /Selic), and foreign exchange rate risk, making the cash flow constant (fixed rate) and regardless of the variations of DI CETIP Over, LIBOR / UF*/ TPM* / Selic and foreign exchange rate. *UF (Chilean Unit of Account) / TPM (Monetary Policy Rate). 12/31/2021 Hedge Item Hedge Instruments Book value Strategies Variation in the amounts Cash flow hedge Variation in the amounts recognized in Nominal amount used to calculate hedge (*) reserve Assets Liabilities Stockholders’ Equity ineffectiveness Interest rate risk Hedge of deposits and securities purchased under agreements to resell—38,445 1,064 1,064 38,080 1,072 Hedge of assets transactions 8,621—(409) (409) 8,213 (409) Hedge of asset-backed securities under repurchase agreements 40,526—(1,686) (1,686) 39,962 (1,698) Hedge of assets denominated in UF 14,558—(127) (127) 14,683 (127) Hedge of funding—5,749 30 30 5,779 30 Hedge of loan operations 131 ——131 1 Foreign exchange risk Hedge of highly probable forecast transactions 3,508—188 656 3,508 188 Total 67,344 44,194 (940) (472) 110,356 (943) 12/31/2020 Hedge Item Hedge Instruments Strategies Book value Variation in the amounts Cash flow hedge Variation in the amounts recognized in Nominal amount used to calculate hedge (*) reserve Assets Liabilities Stockholders’ Equity ineffectiveness Interest rate risk Hedge of deposits and securities purchased under agreements to resell—101,929 (2,423) (2,464) 103,417 (2,433) Hedge of assets transactions 5,673—66 66 5,743 66 Hedge of asset-backed securities under repurchase agreements 29,533—697 697 31,417 699 Hedge of assets denominated in UF 16,674—(4) (4) 16,677 (1) Hedge of funding—2,007 (10) (10) 1,996 (11) Hedge of loan operations 327—12 12 316 15 Variable costs risks Hedge of highly probable forecast transactions 31,594—(3) (3) 15,803 (3) Foreign exchange risk Hedge of highly probable forecast transactions 1,271—(101) 56 1,271 (101) Total 85,072 103,936 (1,766) (1,650) 176,640 (1,769) (*) Recorded under heading Other Comprehensive Income. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.21

12/31/2021 Variation in the Book value (1) amounts Variation in value Hedge Amount reclassified Hedge Instruments Notional recognized in ineffectiveness from Cash flow used to calculate amount Stockholders’ recognized in hedge reserve into hedge (2) Assets Liabilities Equity income income ineffectiveness Interest rate risk (3) Futures 86,255 144—(1,035) (1,031) (4) (16) Swap 20,593 5,749 14,688 (96) (97) 1—Foreign exchange risk (4) Futures 3,508—3,665 188 188—Total 110,356 5,893 18,353 (943) (940) (3) (16) 12/31/2020 Variation in the Hedge Book value (1) amounts Variation in value ineffectiveness Amount reclassified Hedge Instruments Notional recognized in from Cash flow used to calculate recognized in amount Stockholders’ hedge reserve into hedge (2) income Assets Liabilities Equity income ineffectiveness Interest rate risk (3) Futures 140,577 146—(1,668) (1,660) (8) (657) Swap 18,989 2,007 17,006 3 (2) 5—Foreign exchange risk (4) Futures 17,074 5 298 (104) (104) — Total 176,640 2,158 17,304 (1,769) (1,766) (3) (657) (1) Recorded under heading Derivative financial instruments. (2) Recorded under heading Other comprehensive income. (3) DI Future negotiated on B3 and interest rate swap negotiated on Chicago Mercantile Exchange. (4) DDI Futures contracts and Dollar Purchase Options negotiated on B3. The gains or losses related to the accounting hedge of cash flows that ITAÚ UNIBANCO HOLDING PRUDENTIAL expect to recognize in results in the following 12 months, totaling R$ 378 (R$ (1,728) at 12/31/2020). Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.22

II) Market risk – The hedging strategies against market risk of ITAÚ UNIBANCO HOLDING PRUDENTIAL consist of hedge of exposure to variation in market risk, in interest receipts, which are attributable to changes in interest rates relating to recognized assets and liabilities. 12/31/2021 Hedge Item Hedge Instruments Variation in the Strategies Book value Fair value Variation in value amounts recognized in Notional amount used to calculate Assets Liabilities Assets Liabilities income (*) hedge ineffectiveness Interest rate risk Hedge of loan operations 8,890—8,917—27 8,890 (28) Hedge of funding—11,051—10,661 390 11,051 (388) Hedge of available for sale securities 11,765—10,328—(1,437) 11,359 1,432 Hedge of other financial assets 19,551—19,121—(430) 19,289 422 Total 40,206 11,051 38,366 10,661 (1,450) 50,589 1,438 12/31/2020 Hedge Item Hedge Instruments Book value Fair value Variation in the Strategies Variation in value amounts recognized in Notional amount used to calculate Assets Liabilities Assets Liabilities income (*) hedge ineffectiveness Interest rate risk Hedge of loan operations 9,205—9,616—411 9,205 (423) Hedge of funding—10,200—11,591 (1,391) 10,200 1,390 Hedge of available for sale securities 24,677—25,857—1,180 26,866 (1,186) Total 33,882 10,200 35,473 11,591 200 46,271 (219) (*) Recorded under heading Results from Securities and Derivative Financial Instruments. In the period, the amount of R$ 24,447 was reversed from the hedge relationship, which effective portion is R$ 587, with no effect on the result because it is a market risk hedge of Available for sale securities. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.23

12/31/2021 (1) Variation in the Hedge Book value Hedge Instruments amounts used to ineffectiveness Notional amount calculate hedge recognized in Assets Liabilities ineffectiveness income Interest rate risk Swap 24,689 2 10,130 15 (4) Other Derivatives 2,491—7,164 1,700—Futures 23,409—13,347 (277) (8) Total 50,589 2 30,641 1,438 (12) 12/31/2020 (1) Variation in the Hedge Book value Hedge Instruments amounts used to ineffectiveness Notional amount calculate hedge recognized in Assets Liabilities ineffectiveness income Interest rate risk Swap 23,985 2,871—750 (19) Other Derivatives 22,286—21,336 (969)—Total 46,271 2,871 21,336 (219) (19) (1) Recorded under heading Securities and Derivative financial instruments. To protect against market risk variation upon receipt and payment of interest, ITAÚ UNIBANCO HOLDING PRUDENTIAL uses interest rate swap contracts. Hedge items refer to prefixed assets and liabilities denominated in Chilean Unit of Account – UF, fixed rate and denominated in Euros and US dollars, issued by subsidiaries in Chile, London and Colombia, respectively. Receipts (payments) of interest flows are expected to occur and will affect the statement of income in monthly periods. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.24

III) Hedge of net investment in foreign operations – ITAÚ UNIBANCO HOLDING PRUDENTIAL’s strategy of net investments in foreign operations consist of a hedge of the exposure in foreign currency arising from the functional currency of foreign operations, compared to the functional currency of the head office. 12/31/2021 Hedged item Hedge Instruments Book value Variation in value Variation in the Strategies recognized in Foreign currency amounts used to Notional amount Stockholders’ convertion reserve calculate hedge Assets Liabilities Equity (*) ineffectiveness Foreign exchange risk Hedge of net investment in foreign operations 9,646—(10,453) (10,453) 13,888 (10,560) Total 9,646—(10,453) (10,453) 13,888 (10,560) 12/31/2020 Hedged item Hedge Instruments Book value Variation in value Variation in the Strategies recognized in Foreign currency amounts used to Notional amount Stockholders’ convertion reserve calculate hedge Assets Liabilities Equity (*) ineffectiveness Foreign exchange risk Hedge of net investment in foreign operations 15,277—(10,353) (10,353) 24,619 (10,475) Total 15,277—(10,353) (10,353) 24,619 (10,475) (*) Recorded under heading Other comprehensive income. In the period, the amount of R$ 11,752 was reversed from the hedge relationship, which remaining balance in the Foreign currency convertion reserve (Stockholders’ equity) is R$ (6,196), with no effect on the result as foreign investments were maintained. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.25

12/31/2021 Variation in the Book value (1) Variation in the Hedge Amount reclassified amount Hedge Instruments amounts used to ineffectiveness from foreign Notional amount recognized in calculate hedge recognized in currency Stockholders’ Assets Liabilities ineffectiveness (2) income convertion reserve Equity Foreign exchange risk (3) Futures 2,126 286—(2,150) (2,131) (19)—Futures / NDF—Non Deliverable Forward 6,000 208—(2,846) (2,815) (31)—Futures / Financial Assets 5,762 6,566 3,653 (5,564) (5,507) (57)—Total 13,888 7,060 3,653 (10,560) (10,453) (107)—12/31/2020 Variation in the Book value (1) Variation in the Hedge Amount reclassified amount Hedge Instruments amounts used to ineffectiveness from foreign Notional amount recognized in calculate hedge recognized in currency Stockholders’ Assets Liabilities ineffectiveness (2) income convertion reserve Equity Foreign exchange risk (3) Futures 5,052—31 (2,468) (2,450) (18)—Futures / NDF—Non Deliverable Forward 15,196 445—(6,318) (6,237) (81)—Futures / Financial Assets 4,371 4,556 2,762 (1,689) (1,666) (23)—Total 24,619 5,001 2,793 (10,475) (10,353) (122)—(1) Recorded under heading Securities and Derivative financial instruments. (2) Recorded under heading Other comprehensive income. (3) Futures negotiated on B3 and Financial Assets or NDF contracts entered into by our subsidiaries abroad. Receipts (payments) of interest flows are expected to occur and will affect the statement of income upon the total or partial disposal of investments. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.26

IV) We present below the maturity terms of cash flow hedge, market risk hedge strategies and Hedge of net investiment in foreign operations: 12/31/2021 0-1 year 1-2 years 2-3 years 3-4 years 4-5 years 5-10 years Over 10 years Total Hedge of deposits and securities purchased under agreements to resell 10,680 13,838 6,771 5,257—1,534—38,080 Hedge of highly probable forecast transactions 3,508 — — — 3,508 Hedge of assets transactions 2,198—6,015 — — 8,213 Hedge of assets denominated in UF 10,148 4,535 — ——14,683 Hedge of funding (Cash flow) 2,147 3,632 — ——5,779 Hedge of loan operations (Cash flow) 131 — — — 131 Hedge of loan operations (Market risk) 3,377 1,522 797 838 809 1,547—8,890 Hedge of funding (Market risk) 1,206 1,072 302 273 2,920 3,916 1,362 11,051 Hedge of available for sale securities 326 2,108 1,153 2,487 680 3,670 935 11,359 Hedge of asset-backed securities under repurchase agreements 2,322 14,963 8,976 13,098—603—39,962 Hedge of net investment in foreign operations (*) 13,888 — — — 13,888 Hedge of other financial assets (Market risk) 13,602 485 456 779 1,106 2,078 783 19,289 Total 63,533 42,155 24,470 22,732 5,515 13,348 3,080 174,833 12/31/2020 0-1 year 1-2 years 2-3 years 3-4 years 4-5 years 5-10 years Over 10 years Total Hedge of deposits and securities purchased under agreements to resell 70,202 9,077 13,059 5,504 4,856 719—103,417 Hedge of highly probable forecast transactions 17,074 — — — 17,074 Hedge of assets transactions 3,604 2,139 — ——5,743 Hedge of assets denominated in UF 15,400 1,277 — ——16,677 Hedge of funding (Cash flow) 1,765 27 204 — — 1,996 Hedge of loan operations (Cash flow) 212 104 — ——316 Hedge of loan operations (Market risk) 2,999 1,793 1,297 447 898 1,771—9,205 Hedge of funding (Market risk) 213 657 549 176 581 5,448 2,576 10,200 Hedge of available for sale securities 5,897 1,668 2,589 2,318 2,105 10,931 1,358 26,866 Hedge of asset-backed securities under repurchase agreements 22,186 2,297 6,130—804 — 31,417 Hedge of net investment in foreign operations (*) 24,619 — — — 24,619 Total 164,171 19,039 23,828 8,445 9,244 18,869 3,934 247,530 (*) Classified as current, since instruments are frequently renewed. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.27

g) Sensitivity analysis (trading and banking portfolios) ITAÚ UNIBANCO HOLDING PRUDENTIAL carried out a sensitivity analysis for each market risk factor considered significant. The biggest losses arising, by risk factor, in each scenario, were stated together with their impact on the results, net of tax effects, providing an overview of ITAÚ UNIBANCO HOLDING PRUDENTIAL’s exposure under exceptional scenarios. The sensitivity analyses of the banking and the trading portfolio shown in this report are a static evaluation of the portfolio exposure and, therefore, do not take into account management’s quick response capacity (treasury and control areas), which triggers risk mitigating measures whenever a situation of loss or high risk is identified, thus minimizing the possibility of significant losses. In addition, the study’s sole purpose is to show the exposure to risk and the respective protective actions, taking into account the fair value of financial instruments, irrespective of the accounting practices adopted by ITAÚ UNIBANCO HOLDING PRUDENTIAL. Trading portfolio Exposures 12/31/2021 (*) Scenarios Risk factors Risk of variation in: I II III Fixed Interest Rate Fixed Interest Rates in Reais (0.3) (86.5) (167.4) Currency Coupon Foreign Exchange Coupon Rates (0.1) (42.7) (78.2) Foreign Currency Foreign Exchange Rates (3.1) (13.1) (38.5) Price Indices Inflation Coupon Rates—(37.3) (80.5) TR TR Coupon Rates ——Equities Prices of Equities 0.2 56.5 169.7 Other Exposures that do not fall under the definitions above (0.1) 5.4 15.4 TOTAL (3.4) (117.7) (179.5) (*) Amounts net of tax effects. Trading and Banking portfolios Exposures 12/31/2021 (*) Scenarios Risk factors Risk of variation in: I II III Fixed Interest Rate Fixed Interest Rates in Reais (12.7) (3,397.4) (6,573.2) Currency Coupon Foreign Exchange Coupon Rates (3.3) (309.9) (585.9) Foreign Currency Foreign Exchange Rates 2.3 (124.3) (263.7) Price Indices Inflation Coupon Rates (2.3) (210.6) (376.5) TR TR Coupon Rates 0.9 (175.3) (360.9) Equities Prices of Equities 4.0 (39.1) (21.6) Other Exposures that do not fall under the definitions above—1.8 0.8 TOTAL (11.1) (4,254.8) (8,181.0) (*) Amounts net of tax effects. The following scenarios are used to measure these sensitivities: · Scenario I: Addition of 1 base point in fixed interest rates, currency coupon, inflation, and interest rate index, and 1 percentage point in currency and share prices; · Scenario II: Shocks of 25 percent in fixed interest rates, currency coupon, inflation, interest rate indexes and currency and share prices, both up and down, taking the highest resulting losses per risk factor; · Scenario III: Shocks of 50 percent in fixed interest rates, currency coupon, inflation, interest rate indexes and currency and share prices, both up and down, taking the highest resulting losses per risk factor. Derivative financial instruments contracted by ITAÚ UNIBANCO HOLDING PRUDENTIAL are shown in the item Derivative financial instruments in this note. Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.28

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.29 12/31/2020 AA A B C D E F G H Total Total Loan operations 411,530 110,316 67,378 45,744 14,162 5,570 5,653 6,880 11,011 678,244 599,804 Loans and discounted trade receivables 200,890 85,805 50,875 34,911 10,188 4,405 4,531 5,919 9,656 407,180 363,851 Financing 81,925 12,166 12,403 8,474 3,355 816 507 731 870 121,247 119,702 Farming financing 9,905 1,072 267 23 9 27 9 2 7 11,321 10,598 Real estate financing 118,810 11,273 3,833 2,336 610 322 606 228 478 138,496 105,653 3,151 3,913 680 541 82 46 47 82 75 8,617 9,278 1,045 102,477 6,853 4,592 1,533 1,051 1,019 843 3,614 123,027 95,008 7,748 343 281 62 36 9 30 41 1 8,551 5,250 115 524 133 10—4 93 6 669 1,554 2,101 423,589 217,573 75,325 50,949 15,813 6,680 6,842 7,852 15,370 819,993 711,441 83,156 69,166 423,589 217,573 75,325 50,949 15,813 6,680 6,842 7,852 15,370 903,149 780,607 340,268 197,751 70,955 45,063 13,665 7,810 12,544 8,672 14,713 711,441 Total with Financial guarantees provided (1) Includes Advances on exchange contracts and Income receivable from advances granted, reclassified from Liabilities – Foreign exchange portfolio / Other receivables (Note 2a). (2) Includes Securities and credits receivable, Debtors for purchase of assets and Endorsements and sureties honored. (3) Recorded in Offsetting accounts. Financial guarantees provided (3) Total operations with credit granting characteristics at 12/31/2020 Other sundry receivables (2) Total operations with credit granting characteristics Lease operations Credit card operations Advance on exchange contracts (1) 12/31/2021 Risk levels a) Composition of the portfolio with credit granting characteristics Note 6—Loan, lease and other credit operations I – By type of operations and risk level

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.30 12/31/2020 AA A B C D E F G H Total Total Falling due installments — 1,991 2,538 2,067 1,623 1,639 1,679 4,548 16,085 14,060 01 to 30 — 94 110 89 76 78 72 217 736 596 31 to 60 — 79 115 86 73 74 71 210 708 627 61 to 90 — 72 107 89 76 78 76 219 717 516 91 to 180 — 194 272 221 180 191 188 533 1,779 1,453 181 to 365 — 322 453 372 294 341 316 881 2,979 2,430 Over 365 days — 1,230 1,481 1,210 924 877 956 2,488 9,166 8,438 Overdue installments — 681 975 1,263 1,296 1,520 3,017 7,384 16,136 13,543 01 to 14 — 10 44 34 31 32 29 103 283 222 15 to 30 — 644 145 120 113 107 74 192 1,395 1,008 31 to 60 — 27 751 277 224 172 125 349 1,925 1,839 61 to 90 ——24 770 131 289 130 312 1,656 1,438 91 to 180 ——11 62 747 846 2,543 1,123 5,332 3,205 181 to 365 — ——50 74 116 5,023 5,263 5,542 Over 365 days — — — — 282 282 289 — 2,672 3,513 3,330 2,919 3,159 4,696 11,932 32,221 27,603 Subtotal—12/31/2020 — 2,023 2,808 3,706 2,383 2,850 2,761 11,072 27,603 Falling due installments 422,724 216,516 72,499 47,256 12,379 3,710 3,609 3,125 3,382 785,200 680,997 01 to 30 31,189 48,152 9,153 7,971 2,514 329 381 189 649 100,527 78,909 31 to 60 34,123 23,047 4,543 2,698 544 133 129 115 251 65,583 52,350 61 to 90 21,302 14,648 4,070 2,392 435 165 329 114 179 43,634 40,074 91 to 180 44,120 29,858 8,927 5,361 1,010 324 275 145 335 90,355 83,716 181 to 365 57,951 30,042 10,772 7,383 1,553 712 641 394 435 109,883 93,282 Over 365 days 234,039 70,769 35,034 21,451 6,323 2,047 1,854 2,168 1,533 375,218 332,666 Overdue up to 14 days 865 1,057 154 180 104 51 74 31 56 2,572 2,841 423,589 217,573 72,653 47,436 12,483 3,761 3,683 3,156 3,438 787,772 683,838 Subtotal—12/31/2020 340,268 197,751 68,932 42,255 9,959 5,427 9,694 5,911 3,641 683,838 423,589 217,573 75,325 50,949 15,813 6,680 6,842 7,852 15,370 819,993 711,441 (2,494) (1,918) (2,980) (5,091) (4,465) (3,339) (4,657) (7,850) (15,370) (48,982) (52,217) Minimum—(1,087) (751) (1,514) (1,551) (1,997) (3,270) (5,469) (15,370) (31,009) (33,721) Financial Guarantees — — — ——(818) (754) Additional (3) (2,494) (831) (2,229) (3,577) (2,914) (1,342) (1,387) (2,381)—(17,155) (17,742) (20,814) (21,353) (28,168) (30,864) 340,268 197,751 70,955 45,063 13,665 7,810 12,544 8,672 14,713 711,441 (2,042) (1,867) (1,286) (5,308) (6,095) (3,299) (8,186) (8,667) (14,713) (52,217) Minimum—(987) (705) (1,329) (1,325) (2,339) (6,258) (6,065) (14,713) (33,721) Financial Guarantees — — — ——(754) Additional (3) (2,042) (880) (581) (3,979) (4,770) (960) (1,928) (2,602)—(17,742) (1) (2) (3) Existing non-current provision 12/31/2021 Portfolio total (a + b) Related to expected and potential loss. II – By maturity and risk level Overdue Operations (1) (2) Portfolio total at 12/31/2020 Operations with overdue installments for more than 14 days or under control of administrators or in companies in the process of declaring bankruptcy. The balance of non-accrual operations amounts to R$ 23,938 (R$ 19,925 at 12/31/2020). Non-overdue operations Subtotal (a) Subtotal (b) Existing allowance Existing allowance at 12/31/2020 Existing current provision

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.31 III – BByy bbuussiinneessss sseeccttoorr 3,488 0.4% 3,787 0.5% 816,505 99.6% 707,654 99.5% 395,593 48.2% 367,228 51.6% 420,912 51.4% 340,426 47.9% 819,993 100.0% 711,441 100.0% 12/31/2020 % Total 12/31/2021 % Public Sector Private sector Companies Individuals IV—Financial guarantees provided by type Type of guarantees Portfolio Provision Portfolio Provision Endorsements or sureties pleged in legal and administrative tax proceedings 26,346 (189) 27,190 (188) Sundry bank guarantees 34,282 (351) 26,681 (357) Other financial guarantees provided 10,112 (193) 8,248 (153) Tied to the distribution of marketable securities by Public Offering 5,698 (6) 1,445 (1) Restricted to bids, auctions, service provision or execution of works 3,422 (44) 3,543 (27) Restricted to international trade of goods 2,120 (33) 1,295 (26) Restricted to supply of goods 1,176 (2) 764 (2) Total 83,156 (818) 69,166 (754) 12/31/2021 12/31/2020 b) Credit concentration Risk % of total Risk % of total Largest debtor 6,414 0.7 7,243 0.9 10 largest debtors 33,694 3.7 37,863 4.9 20 largest debtors 49,541 5.5 54,812 7.0 50 largest debtors 79,402 8.8 83,438 10.7 100 largest debtors 111,115 12.3 112,334 14.4 Risk % of total Risk % of total Largest debtor 15,941 1.4 13,145 1.4 10 largest debtors 64,570 5.8 73,609 7.7 20 largest debtors 97,046 8.8 107,100 11.3 50 largest debtors 158,886 14.3 164,323 17.3 100 largest debtors 216,880 19.6 214,907 22.6 12/31/2020 12/31/2020 (*) The amounts include financial guarantees provided. 12/31/2021 Loan, lease and other credit operations and securities of companies and financial institutions (*) Loan, lease and other credit operations (*) 12/31/2021 (*) The amounts include financial guarantees provided.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.32 (52,217) (39,792) (18,477) (30,154) Minimum (19,000) (22,540) Financial Guarantees Provided (64) 105 Additional (1) 587 (7,719) 18,214 20,083 3,498 (2,354) (48,982) (52,217) Minimum (31,009) (33,721) Financial Guarantees Provided (818) (754) Additional (3) (17,155) (17,742) (1) (2) (3) c) Changes in allowance for loan losses and Allowance for Financial Guarantees Provided 12/31/2021 Opening balance—01/01 12/31/2020 Net increase for the period In the period from 01/01 to 12/31/2020, the impact in the Provision for Expected Loan Loss – Supplementary is related to the change in the macroeconomic scenario as from the second half of March 2020 and that impacted our provisioning model for expected loss (Note 20d); Other, mainly foreign exchange Write-Off The provision for loan losses regarding the lease portfolio amounts to: R$ (220) (R$ (367) at 12/31/2020); At 12/31/2021, the balance of the provision regarding the loan portfolio is equivalent to 6.0% (7.3% at 12/31/2020). Closing balance (2) Includes Provision for Loan Commitments. Portfolio (1) Provision for Loan Losses % Portfolio (1) Provision for Loan Losses % Total renegotiated loans 33,981 (12,845) 37.8% 35,919 (12,490) 34.8% (-) Renegotiated loans overdue up to 30 days (2) (12,246) 2,944 24.0% (12,684) 2,249 17.7% Renegotiated loans overdue over 30 days (2) 21,735 (9,901) 45.6% 23,235 (10,241) 44.1% (2) Delays determined upon renegotiation. d) Renegotiation of credits 12/31/2021 12/31/2020 (1) The amounts related to renegotiated loans up to 30 days of the Lease Portfolio are: R$ 106 (R$ 146 at 12/31/2020). 0—30 31—180 181—365 Over 365 days Total Total Income (expenses) Income (expenses) Loan operations 108 13—5,710 5,831 6,784 782 1,965 Foreign borrowing through securities 108 13—5,709 5,830 6,784 (783) (1,963) (1) 2 e) Restricted operations on assets Restricted operations on assets Liabilities—restricted operations on assets 12/31/2021 Net revenue from restricted operations At 12/31/2021 and 12/31/2020 there were no balances in default. See below the information related to the restricted operations on assets, in accordance with CMN Resolution No. 2,921, of January 17, 2002. 12/31/2020 01/01 to 12/31/2020 01/01 to 12/31/2021

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.33 f) Operations of sale or transfers and acquisition of financial assets ITAÚ UNIBANCO HOLDING PRUDENTIAL carried out operations of sale or transfer of financial assets in which there was retention of credit risks of financial assets transferred under co-obligation covenants. Thus these credits are still recorded in the Consolidated Balance Sheet and are represented as follows: Book value Fair value Book value Fair value Book value Fair value Book value Fair value Mortgage Loan 2 09 209 2 09 209 3 15 326 3 13 324 Working capital 8 00 800 7 95 795 1 ,297 1,299 1 ,310 1,312 Total 1 ,009 1,009 1 ,004 1,004 1 ,612 1 ,625 1 ,623 1,636 From 01/01 to 12/31/2021 operations of transfers of financial assets with no retention of risks and benefits generated impact on the result of R$ 810, net of the Provision for Loan Losses (R$ 309 from 01/01 to 12/31/2020). (1) Under Other sundry liabilities. 12/31/2020 Assets Liabilities (1) Nature of operation 12/31/2021 Assets Liabilities (1)

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.34 AA A B C D E F G H Total Total 278 196 329 561 355 27 46 45 155 1,992 2,938 — (1) (3) (5) (1) (3) (5) (23) (41) (17) 4,054 939 87 61 38 7 17 17 16 5,236 3,917—(5) (1) (2) (4) (2) (8) (12) (16) (50) (35) 10,447 1,026 1,121 237 161 122 109 63 65 13,351 15,984—(5) (11) (7) (16) (37) (55) (44) (65) (240) (54) (2) Allowance considers the double counting of delay periods for risk level classification purposes. Existing Allowance (1) (1) Provision recognized on the loan portion which risk is of ITAÚ UNIBANCO HOLDING PRUDENTIAL, i.e., 15% of the loan portfolio. 12/31/2020 g) Government Programs for Granting Credit Risk levels 12/31/2021 Emergency Employment Support Program (PESE) National Support Program for Micro and Small Companies (PRONAMPE) Existing Allowance (2) Emergency Program for Access to Credit (PEAC-FGI) Existing Allowance (2)

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.35 0-30 31-180 181-365 Over 365 days Total Total Deposits 403,950 52,260 38,628 365,186 860,024 814,689 Deposits received under securities repurchase agreements 258,004 2,627 725 9,748 271,104 285,680 Funds from acceptances and issuance of securities 2,310 18,077 16,235 106,516 143,138 136,638 Borrowing and onlending 7,386 30,470 29,627 29,522 97,005 83,200 Subordinated debt—7,105 14,098 53,833 75,036 74,916 Total 671,650 110,539 99,313 564,805 1,446,307 1,395,123 % per maturity date 46.4 7.6 6.9 39.1 100.0 Total – 12/31/2020 615,391 134,785 114,012 530,935 1,395,123 % per maturity date 44.1 9.7 8.2 38.0 100.0 Note 7 – Funding, borrowing and onlending a) Summary 12/31/2021 12/31/2020 0-30 31-180 181-365 Over 365 days Total Total Interest-bearing deposits 244,550 52,260 38,628 365,186 700,624 679,309 Time deposits 53,109 50,926 37,294 364,900 506,229 496,403 Savings deposits 190,619 ——190,619 179,476 Interbank deposits 822 1,334 1,334 286 3,776 3,430 Non-interest bearing deposits 159,400 ——159,400 135,380 Demand deposits 158,572 ——158,572 135,309 Other deposits 828 ——828 71 Total 403,950 52,260 38,628 365,186 860,024 814,689 % per maturity date 47.0 6.1 4.5 42.4 100.0 Total – 12/31/2020 371,219 81,052 60,018 302,400 814,689 % per maturity date 45.6 9.9 7.4 37.1 100.0 b) Deposits 12/31/2021 12/31/2020

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.36 0—30 31—180 181—365 Over 365 days Total Total 100,786 1,151 648 134 102,719 53,609 Government securities 74,728 1 17—74,746 28,947 Corporate securities 24,862 815 — 25,677 20,773 Own issue—1—73 74 2,208 Foreign 1,196 334 631 61 2,222 1,681 115,511 ——115,511 156,602 41,707 1,476 77 9,614 52,874 75,469 258,004 2,627 725 9,748 271,104 285,680 95.1 1.0 0.3 3.6 100.0 250,037 3,080 6,877 25,686 285,680 87.5 1.1 2.4 9.0 100.0 Total – 12/31/2020 % per maturity date 12/31/2020 c) Deposits received under securities repurchase agreements % per maturity date 12/31/2021 Own portfolio Third-party portfolio Total Free portfolio

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.37 0-30 31-180 181-365 Over 365 days Total Total 1,871 16,139 11,893 49,518 79,421 73,108 1,093 12,313 6,904 3,749 24,059 43,589 555 1,503 1,570 7,035 10,663 4,205 214 2,242 1,886 9,359 13,701 14,285 9 81 1,533 29,375 30,998 11,029 422 1,895 4,259 56,384 62,960 62,571 Brazil risk note programme 37 574 412 11,985 13,008 13,048 Structure note issued 216 614 1,079 4,867 6,776 6,220 Bonds—408 2,319 30,378 33,105 31,939 Fixed rate notes 86 — 5,581 5,667 6,685 Eurobonds 2 — 60 62 53 Mortgage notes — 6 152 158 222 Other 81 299 443 3,361 4,184 4,404 17 43 83 614 757 959 2,310 18,077 16,235 106,516 143,138 136,638 1.6 12.7 11.3 74.4 100.0 1,978 20,477 19,872 94,311 136,638 1.5 15.0 14.5 69.0 100.0 12/31/2021 12/31/2020 Real state loans 42,362 12,286 Government securities—Brazil 1,147 2 Total asset portfolio 43,509 12,288 Total adjusted asset portfolio 43,509 12,287 Liabilities for issue of LIGs 30,998 11,029 Remuneration of the Fiduciary Agent 2 1 12/31/2021 12/31/2020 Breakdown 97.4% 100.0% Sufficiency Notional amount 140.4% 111.4% Present value under stress 117.4% 111.5% Weighted average term Of the asset portfolio 149,0 monthly 138,8 monthly Of outstandings LIGs 45,6 monthly 47,1 monthly Liquidity Net assets 1,147 2 12/31/2020 d) Funds from acceptances and issuance of securities 12/31/2021 Real estate, mortgage, credit and similar notes Total – 12/31/2020 % per maturity date (*) The fair value of the funding from structured operations certificates issued is R$ 790 (R$ 1,018 at 12/31/2020). Financial bills % per maturity date Total Foreign loans through securities Guaranteed real estate bills Real estate credit bills Rural credit bills Funding from structured operations certificates (*) II—Requirements of asset portfolio Guaranteed Real Estate Notes Guaranteed Real Estate Bills (LIGs) are registered, transferrable and free trade credit securities, that are guaranteed by asset portfolio of the issuer itself, submitted to the fiduciary system. The “Instrument of LIG Issue”, which details the conditions of LIG transactions, is available on the website www.itau.com.br/relacoes-cominvestidores, section resultados e relatórios / documentos regulatórios / letra imobiliária garantida. I – Breakdown of Asset Portfolio The credit portfolio linked to LIGs corresponds to 2.23% of ITAÚ UNIBANCO HOLDING PRUDENTIAL’s total assets. Its composition is presented in the table below. Further details are available in the Statement of Asset Portfolio – SAP, in section resultados e relatórios / documentos regulatórios / letra imobiliária garantida.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.38 e) 0-30 31-180 181-365 Over 365 days Total Total 7,095 28,829 27,630 22,675 86,229 71,744 1,770 ——1,770 1,809 5,325 28,829 27,630 22,675 84,459 69,935 291 1,641 1,997 6,847 10,776 11,456 BNDES 151 766 982 3,745 5,644 6,779 FINAME 134 642 772 2,640 4,188 3,947 Other 6 233 243 462 944 730 7,386 30,470 29,627 29,522 97,005 83,200 7.6 31.4 30.6 30.4 100.0 8,140 30,176 21,777 23,107 83,200 9.8 36.3 26.2 27.7 100.0 Borrowing and onlending Borrowing In Brazil Onlending—In Brazil—official institutions Foreign (*) 12/31/2021 12/31/2020 % per maturity date Total (*) Foreign borrowing are basically represented by foreign exchange transactions relating to export pre-financing and import financing. Total – 12/31/2020 % per maturity date

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.39 0-30 31-180 181-365 Over 365 days Total Total—110 6,316 13,639 20,065 13,196—6,996 7,748 32,674 47,418 53,818—(1) (2) (6) (9) (19) — 36 7,526 7,562 7,921—7,105 14,098 53,833 75,036 74,916 0.0 9.5 18.8 71.7 100.0 6,657—5,468 62,791 74,916 8.9 0.0 7.3 83.8 100.0 Grand total % per maturity date Total – 12/31/2020 % per maturity date f) Subordinated debt, including perpetual debts 12/31/2021 12/31/2020 Financial bills Euronotes Bonds (-) Transaction costs incurred (Note 3b) Subordinated financial bills—BRL 6 2011 2021 109.25% to 110.5% of CDI—14 2,313 2012 2022 IPCA + 5.15% to 5.83% 6,380 5,484 20 2012 2022 IGPM + 4.63% 44 38 2,146 2019 Perpetual 114% of SELIC 2,187 2,143 935 2019 Perpetual SELIC + 1.17% to 1.19% 976 963 50 2019 2028 CDI + 0.72% 55 52 2,281 2019 2029 CDI + 0.75% 2,502 2,379 450 2020 2029 CDI + 2% 481 452 106 2020 2030 IPCA + 4.64% 125 109 1,556 2020 2030 CDI + 2% 1,664 1,562 5,488 2021 2031 CDI + 2% 5,651—Total 20,065 13,196 Subordinated euronotes—USD 1,000 2010 2021 5.75%—5,361 1,042 2011 2021 5.75% to 6.2%—3,891 550 2012 2021 6.2%—2,858 2,592 2012 2022 5.5% to 5.65% 14,742 13,839 1,858 2012 2023 5.13% 10,432 9,762 1,250 2017 Perpetual 6.13% 6,997 6,510 750 2018 Perpetual 6.5% 4,262 3,967 750 2019 2029 4.5% 4,205 3,915 700 2020 Perpetual 4.6% 3,967 3,696 500 2021 2031 3.9% 2,804—Total 47,409 53,799 Subordinated bonds—CLP 27,776 1997 2022 7.45% to 8.30% 36 74 180,351 2008 2033 3.50% to 4.92% 1,423 1,515 97,962 2009 2035 4.75% 1,079 1,135 1,060,250 2010 2032 4.35% 106 111 1,060,250 2010 2035 3.90% to 3.96% 244 255 1,060,250 2010 2036 4.48% 1,160 885 1,060,250 2010 2038 3.9% 845 1,215 1,060,250 2010 2040 4.15% to 4.29% 651 682 1,060,250 2010 2042 4.45% 317 332 57,168 2014 2034 3.8% 414 434 Total 6,275 6,638 Subordinated bonds—COP 104,000 2013 2023 IPC + 2% 145 160 146,000 2013 2028 IPC + 2% 203 224 648,171 2014 2024 LIB 939 899 Total 1,287 1,283 Total 75,036 74,916 Name of security / currency Principal amount (original currency) Issue Maturity Return p.a. 12/31/2021 12/31/2020

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.40 Note 8 – Provisions, Contingent Assets and Contingent Liabilities In the ordinary course of its business, ITAÚ UNIBANCO HOLDING PRUDENTIAL may be a party to legal proceedings to labor, civil and tax nature. The contingencies related to these lawsuits are classified as follows: a) Contingent Assets: There are no contingent assets recorded. b) Provisions and contingencies: ITAÚ UNIBANCO HOLDING PRUDENTIAL’s provisions for judicial and administrative challenges are long-term, considering the time required for their questioning, and this prevents the disclosure of a deadline for their conclusion. The legal advisors believe that ITAÚ UNIBANCO HOLDING PRUDENTIAL is not a party to this or any other administrative proceedings or lawsuits, in addition to those highlighted troughout this note, that could significantly affect the results of its operations. Civil lawsuits: In general, provisions and contingencies arise from claims related to the revision of contracts and compensation for material and moral damages. The lawsuits are classified as follows: Collective lawsuits: Related to claims of a similar nature and with individual amounts that are not considered significant. Provisions are calculated on a monthly basis and the expected amount of losses is accrued according to statistical references that take into account the nature of the lawsuit and the characteristics of the court (Small Claims Court or Regular Court). Contingencies and provisions are adjusted to reflect the amounts deposited into court as guarantee for their execution when realized. Individual lawsuits: Related to claims with unusual characteristics or involving significant amounts. The probability of loss is ascertained periodically, based on the amount claimed and the special nature of each case. The amounts considered as probable losses are recorded as provisions. ITAÚ UNIBANCO HOLDING PRUDENTIAL, despite having complied with the rules in force at the time, is a defendant in lawsuits filed by individuals referring to payment of inflation adjustments to savings accounts resulting from economic plants implemented in the 1980s and the 1990s, as well as in collective lawsuits filed by: (i) consumer protection associations; and (ii) the Public Attorney’s Office, on behalf of the savings accounts holders. ITAÚ UNIBANCO HOLDING PRUDENTIAL recognizes provisions upon receipt of summons, and when individuals demand the enforcement of a ruling handed down by the courts, using the same criteria as for provisions for individual lawsuits. The Federal Supreme Court (STF) has issued some decisions favorable to savings account holders, but it has not established its understanding with respect to the constitutionality of the economic plans and their applicability to savings accounts. Currently, the appeals involving these matters are suspended, by order of the STF, until it pronounces its final decision. In December 2017, through mediation of the Federal Attorney’s Office (AGU) and supervision of the BACEN, savers (represented by two civil associations, FEBRAPO and IDEC) and FEBRABAN entered into an instrument of agreement aiming at resolving lawsuits related the economic plans, and ITAÚ UNIBANCO HOLDING PRUDENTIAL has already accepted its terms. Said agreement was approved on March 1, 2018, by the Plenary Session of the Federal Supreme Court (STF) and savers could adhere to its terms for a 24- month period. Due to the end of this term, the parties signed an amendment to the instrument of agreement to extend this period in order to contemplate a higher number of holders of savings accounts and, consequently, to increase the end of lawsuits. In May, 2020 the Federal Supreme Court (STF) approved this amendment and granted a 30-month term for new adhesions, and this term may be extended for another 30 months, subject to the reporting of the number of adhesions over the first period.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.41 Labor claims Provisions and contingencies arise from lawsuits in which labor rights provided for in labor legislation specific to the related profession are discussed, such as: overtime, salary equalization, reinstatement, transfer allowance and, pension plan supplement. These lawsuits are classified as follows: Collective lawsuits: related to claims considered similar and with individual amounts that are not considered significant. The expected amount of loss is determined and accrued on a monthly basis in accordance with a statistical model which calculates the amount of the claims and it is reassessed taking into account court rulings. Provisions and contingencies are adjusted to reflect the amounts deposited into court as security for execution. Individual lawsuits: related to claims with unusual characteristics or involving significant amounts. These are periodically calculated based on the amounts claimed. The probability of loss is estimated in accordance with the actual and legal characteristics of each lawsuit. Other Risks These are quantified and accrued on the basis of the value of rural credit transactions with joint liability and FCVS (salary variations compensation fund) credits assigned to Banco Nacional. I—Civil, labor and other risks provisions 12/31/2020 Civil Labor Other Risks Total Total 3,453 7,951 1,483 12,887 13,033 (216) (943)—(1,159) (1,193) 3,237 7,008 1,483 11,728 11,840 217 153—370 671 795 2,601 85 3,481 3,519 Increase (*) 1,151 2,830 119 4,100 3,990 Reversal (356) (229) (34) (619) (471) (1,221) (2,472) (10) (3,703) (4,302) 3,028 7,290 1,558 11,876 11,728 226 877—1,103 1,159 3,254 8,167 1,558 12,979 12,887 1,243 2,512 1,558 5,313 2,598 2,011 5,655—7,666 10,289 3,453 7,951 1,483 12,887 (*) Includes, in the labor provision, the effects of the provision for restructuring (Note 20e). Below are the changes in civil, labor and other Risks provisions: 12/31/2021 (-) Provisions guaranteed by indemnity clauses (Note 3m) Opening balance—01/01 Subtotal Closing balance Closing balance at 12/31/2020 Payment Changes in the period reflected in results Monetary restatement/charges (+) Provisions guaranteed by indemnity clauses (Note 3m) Subtotal Current Non-current

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.42 II—Tax and social security provisions Tax and social security provisions correspond to the principal amount of taxes involved in administrative or judicial tax arguments, subject to tax assessment notices, plus interest and, when applicable, fines and charges. The table below shows the changes in the provisions: The main discussions related to Tax and Social Security Obligations are described below: • INSS – Non-compensatory Amounts – R$ 1,781: the non-levy of social security contribution on amounts paid as profit sharing is defended. The balance of the deposits in guarantee is R$ 1,015; • PIS and COFINS – Calculation basis – R$ 622: defending the levy of PIS and COFINS on revenue, a tax on revenue from the sales of assets and services. The balance of the deposits in guarantee is R$ 628; 12/31/2020 Legal obligation (Note 10c) Tax and Social Security Obligations Total Total Opening balance—01/01 3,076 2,945 6,021 7,459 (-) Provisions guaranteed by indemnity clauses (Note 3m)—(71) (71) (68) Subtotal 3,076 2,874 5,950 7,391 Monetary restatement / charges 52 137 189 208 Changes in the period reflected in results 87 (85) 2 69 Increase 94 77 171 133 Reversal (7) (162) (169) (64) Payment (195) (108) (303) (1,718) Subtotal 3,020 2,818 5,838 5,950 (+) Provisions guaranteed by indemnity clauses (Note 3m)—72 72 71 Closing balance 3,020 2,890 5,910 6,021 Current—10 10 56 Non-current 3,020 2,880 5,900 5,965 Closing balance at 12/31/2020 3,076 2,945 6,021 12/31/2021

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.43 III—Contingencies not provided for in the Balance Sheet Amounts involved in administrative and judicial arguments with the risk of loss estimated as possible are not provided for and they are basically composed of: Civil and Labor Claims In Civil Lawsuits with possible loss, total estimated risk is R$ 4,635 (R$ 4,172 at 12/31/2020), and in this total there are no amounts arising from interests in Joint Ventures. For Labor Claims with possible loss, estimated risk is R$ 448 (R$ 388 at 12/31/2020). Tax and Social Security Obligations: The tax and social security obligations of possible loss totaled R$ 33,446 (R$ 28,993 at 12/31/2020), and the main cases are described below: • INSS – Non-compensatory Amounts – R$ 8,033: defends the non-levy of this contribution on these amounts, among which are profit sharing and stock options; • IRPJ, CSLL, PIS and COFINS – Funding Expenses – R$ 4,923: the deductibility of raising costs (Interbank deposits rates) for funds that were capitalized between Group companies; • ISS – Banking Activities – R$ 4,601: the levy and/or payment place of ISS for certain banking revenues are discussed; • IRPJ and CSLL – Goodwill – Deduction – R$ 3,479: the deductibility of goodwill for future expected profitability on the acquisition of investments; • PIS and COFINS—Reversal of Revenues from Depreciation in Excess – R$ 2,428: discussing the accounting and tax treatment of PIS and COFINS upon settlement of leasing operations; • IRPJ, CSLL, PIS and COFINS – Requests for Offsetting Dismissed – R$ 1,245: cases in which the liquidity and the certainty of credits offset are discussed; • IRPJ and CSLL – Disallowance of Losses – R$ 1,208: discussion on the amount of tax loss (IRPJ) and/or social contribution (CSLL) tax loss carryforwards used by the Federal Revenue Service when drawing up tax assessment notes that are still pending a final decision;

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.44 c) Accounts receivables – Reimbursement of provisions The receivables balance arising from reimbursements of contingencies totals R$ 888 (R$ 907 at 12/31/2020) (Note 9a), arising basically from the collateral established in Banco Banerj S.A. privatization process occurred in 1997, when the State of Rio de Janeiro created a fund to guarantee the equity recomposition in provisions for Civil, Labor and Tax and Social Security Claims. d) Guarantees of contingencies, provisions and legal obligations The guarantees related to legal proceedings involving ITAÚ UNIBANCO HOLDING PRUDENTIAL and basically consist of: 12/31/2020 Civil Labor Tax Total Total Deposits in guarantee (Note 9a) 1,394 1,955 8,273 11,622 11,801 Investment fund quotas 405 200 78 683 928 Surety 63 48 3,457 3,568 3,494 Insurance bond 1,666 1,321 14,639 17,626 17,271 Guarantee by government securities 7—235 242 245 Total 3,535 3,524 26,682 33,741 33,739 12/31/2021 a) 12/31/2021 12/31/2020 89,604 98,674 17,231 28,200 11,622 11,801 2,738 2,310 3,245 2,748 4,545 3,490 493 585 888 907 618 712 1,768 1,360 132,752 150,787 114,620 122,739 18,132 28,048 Note 9—Breakdown of accounts Other receivables—Sundry Foreign exchange portfolio (Note 9b) Deposits in guarantee of contingencies, provisions and legal obligations (Note 8d) Trading and intermediation of securities Current Non-current Operations without credit granting characteristics, net of provisions Income receivable Sundry domestic Total Other Sundry foreign Net amount receivables from reimbursement of provisions (Note 8c) Post-employment benefits plan assets (Note 17e) 12/31/2021 12/31/2020 89,604 98,674 Exchange purchase pending settlement – foreign currency 49,597 50,639 Bills of exchange and term documents – foreign currency 36 18 Exchange sale rights – local currency 40,615 48,334 (Advances received) – local currency (644) (317) 90,876 99,499 Exchange sales pending settlement – foreign currency 40,864 49,522 Liabilities from purchase of foreign currency – local currency 49,722 49,713 Other 290 264 3,949 3,624 Outstanding import credits – foreign currency 2,238 2,057 Confirmed export credits – foreign currency 1,711 1,567 b) Foreign exchange portfolio Assets—other receivables Liabilities – other liabilities (Note 2a) Offsetting accounts

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.45
12/31/2021 12/31/2020
482 542
630 716
248 254
Related to payroll loans 32 38
Related to vehicle financing 4 7
Other 212 209
Credit Card Operating Expenses 194 370
Legal Protection Insurance 127 120
Municipal Tax 1 3
1,227 554
2,909 2,559
2,510 1,502
399 1,057
Current
Non-current
Total
c) Prepaid expenses
Other
Publicity and advertising
Commissions related to software maintenance
Commissions
d)
12/31/2021 12/31/2020
90,876 99,499
45,706 41,808
12,539 15,043
Charging and collection of taxes and similar 376 216
7,470 6,501
1,004 1,623
2,657 3,120
4,679 4,028
3,086 2,930
2,044 1,807
4,405 3,934
1,261 1,326
2,209 2,083
2,411 6,887
180,723 190,805
167,206 172,584
Non-current 13,517 18,221
Liabilities from post-employment benefit plans (Note 17e)
Total
Social and statutory
Funds to be released
Provisions for sundry payments
Other
Obligations on official agreements and rendering of payment services
Current
Other liabilities - Sundry
Foreign exchange portfolio (Note 9b)
Personnel provision
Sundry domestic
Payment transactions
Transactions related to credit assignments (Note 6f)
Trading and intermediation of securities
Sundry foreign
e)
01/01 to
12/31/2021
01/01 to
12/31/2020
16,051 13,816
7,802 8,002
6,217 6,862
5,435 6,211
Ad
782 651
2,848 2,566
1,644 1,232
1,204 1,334
1,928 1,799
3,566 2,867
605 573
2,291 1,898
41,308 38,383
Advisory services and Brokerage
Total
Other
Commissions and Banking Fees
Custody services
Credit and debit cards
Credit operations
Current account services
Funds
Asset management
Consortia
Credit operations and Financial guarantees provided
Financial guarantees provided
Collection services

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.46 f) 01/01 to 12/31/2021 01/01 to 12/31/2020 (8,251) (8,526) (5,133) (3,809) (4,221) (4,019) (3,479) (3,232) (710) (318) (112) (105) (127) (241) (22,033) (20,250) g) 01/01 to 12/31/2021 01/01 to 12/31/2020 (7,315) (7,267) (4,573) (4,159) (3,331) (3,462) (3,990) (3,863) (1,310) (1,053) (465) (321) (56) (79) (1,160) (2,001) (22,200) (22,205) Personnel expenses Other administrative expenses Installations Depreciation and amortization Third party services, financial system services, security and transportation Data processing and telecommunications Compensation Employees’ profit sharing Welfare benefits Payroll charges Dismissals (*) Share-based payment (Note 13f) Training Total (*) Includes the effects of the provision for restructuring (Note 20e). (*) At 12/31/2020 comprises R$ (1,047) related to donations for the initiative “Todos pela Saúde” (All for Health) (Note 20d). Advertising, promotions and publicity Total Materials Travel expenses Other (*) h) 01/01 to 12/31/2021 01/01 to 12/31/2020 (4,942) (4,122) (968) (860) (446) (521) (590) (474) (394) (314) (478) (3,119) (1,917) (1,616) (9,735) (11,026) (*) At 12/31/2020, comprises the effects of impairment of goodwill and intangible assets of Itaú CorpBanca, net of tax effects and ownership interest of non-controlling shareholders total R$ (19). Total Other operating expenses Selling—credit cards Claims losses Impairment (*) Operations without no credit granting characteristics, net of provision Amortization of goodwill Refund of interbank costs Other 15.00% PIS (1) 0.65% 10.00% COFINS (1) 4.00% 25.00% ISS up to 5.00% (2) Law No. 14,183/21 (conversion of Provisional Measure (MP) No. 1,034/21): published on July 15, 2021, sets forth the increase in the rate of Social Contribution on Net Income of banks, which increased to 25%. For insurance, capitalization and other financial companies, it increased to 20% and for non-financial companies it remained at 9%. The increase in rate is applied as from July 1 to December 31, 2021. Social contribution on net income (2) (1) For non-financial subsidiaries that fall into the non-cumulative calculation system, the PIS rate is 1.65% and COFINS rate is 7.60%. Note 10—Taxes Income tax Additional income tax ITAÚ UNIBANCO HOLDING and each one of its subsidiaries calculate separately, in each fiscal year, Income Tax and Social Contribution on Net Income. Taxes are calculated at the rates shown below and consider, for effects of respective calculation bases, the legislation in force applicable to each charge.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.47 III—Tax effects of foreign exchange management of investments abroad In order to minimize the effects on income of foreign exchange variations on investments abroad, net of the respective tax effects, ITAÚ UNIBANCO HOLDING PRUDENTIAL carries out derivative transactions in foreign currency (hedging), as mentioned in Note 20b. The result of these transactions is computed in the calculation of the tax bases, according to their nature and the tax legislation in force, as well as the foreign exchange variation of the portion of hedged investments abroad, that, according to the new regulations established by Law 14,031, of July 28, 2020, should be computed in the proportion of 50% in 2021 and 100% as from 2022. a) I—Income before income tax and social contribution 39,240 3,742 Charges (income tax and social contribution) at the rates in effect (1) (18,626) (1,684) Increase / decrease to income tax and social contribution charges arising from: Equity income in affiliates and joint ventures 2,608 5,045 Foreign exchange variation on investments abroad 392 5,908 Interest on capital 2,876 2,786 Other nondeductible expenses net of non taxable income (2) 7,176 (18,994) Income tax and social contribution expenses (5,574) (6,939) Related to temporary differences Increase / (reversal) for the period (5,773) 19,370 (Expenses) / Income from deferred taxes (5,773) 19,370 Total income tax and social contribution expenses (11,347) 12,431 (1) It considers that in the first half of 2021 the current IRPJ and CSLL rate is equal to 45% and, in the second half of 2021, it is equal to 50%. (2) Includes temporary (additions) and exclusions. 01/01 to 12/31/2020 Expenses for taxes and contributions Breakdown of Income tax and social contribution calculation on net income: Due on operations for the period 01/01 to 12/31/2021 01/01 to 12/31/2021 01/01 to 12/31/2020 PIS and COFINS (5,412) (3,450) ISS (1,425) (1,329) Other (723) (892) Total (7,560) (5,671) II—Tax expenses:

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.48 60,557 (22,599) 15,940 53,898 69,410 73,403 31,554 (6,274) 6,581 31,861 — 3,989 (1,517) 121 2,593 4,952 4,206 1,845 (1,845) 2,164 2,164 2,310 3,436 1,546 (915) 409 1,040 6,099 17,078 8,516 (8,516) 3,096 3,096—115 56 (56) — 650 688 297 (5)—292 13,073 13,052 5,671 (1,878) 1,897 5,690 Civil lawsuits 3,029 3,237 1,311 (581) 505 1,235 Labor claims 7,141 6,870 3,035 (1,176) 1,296 3,155 Tax and social security obligations 2,903 2,945 1,325 (121) 96 1,300 1,695 1,652 727 (35) 61 753 14,102 14,310 6,356 (1,558) 1,611 6,409 1,403 (345) 1,109 2,167 2,188 3 5—1,109 1,114 1,026 1,685 841 (329)—512 1,202 1,240 557 (16)—541 116,707 130,868 61,960 (22,944) 17,049 56,065 65 — 65 Reflected in income Provision for profit sharing Provision for devaluation of securities with permanent impairment Adjustments to fair value of Trading securities and Derivative financial instruments Adjustments of operations carried out on the futures settlement market Provision for loan losses Related to tax losses and social contribution loss carryforwards Goodwill on purchase of investments (2) Deferred Tax Assets are classified in their totality as Non-Current. b) Deferred taxes I—The deferred tax assets balance and its changes, segregated based on its origin and disbursements, are represented by: Deferred Tax Assets 12/31/2020 12/31/2020 Increase 12/31/2021 Realization / Reversal Origin 12/31/2021 Post-employment benefits (1) The accounting records of deferred tax assets on income tax losses and/or social contribution loss carryforwards, as well as those arising from temporary differences, are based on technical feasibility studies which consider the expected generation of future taxable income, considering the history of profitability for each subsidiary individually, and for the consolidated taken as a whole. Legal liabilities Other non-deductible provisions Provision Adjustments to fair value of available for sale securities Cash flow hedge Total (1) (2) Social contribution for offsetting arising from Option established in article 8º of Provisional Measure nº. 2,158-35 of August 24, 2001 Reflected in stockholders’ equity

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.49 II—2,828 (852) 460 2,436 Depreciation in excess – finance lease 145 (8)—137 Adjustment of deposits in guarantee and provisions 1,287 (20) 46 1,313 Post-employment benefits 180 (178) 4 6 Adjustments to fair value of trading securities and derivative financial instruments 145 (145) 56 56 Adjustments of operations carried out on the futures settlement market 488 (488) 252 252 Other 583 (13) 102 672 223 (198) 50 75 Adjustments to fair value of available for sale securities 220 (198) 47 69 Post-employment benefits 3—3 6 3,051 (1,050) 510 2,511 (*) Deferred Tax Liabilities are classified in their totality as Non-Current. Total (*) The provision for deferred tax liabilities and its changes are represented by: Reflected in income Reflected in stockholders’ equity Increase 12/31/2021 Realization / Reversal 12/31/2020

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.50 Projections of future taxable income include estimates of macroeconomic variables, exchange rates, interest rates, volumes of financial operations and service fees and other factors, which can vary in relation to actual data and amounts. Net income in the financial statements is not directly related to the taxable income for income tax and social contribution, due to differences between accounting criteria and the tax legislation, in addition to corporate aspects. Accordingly, it is recommended that changes in realization of deferred tax assets presented below are not considered as an indication of future net income. IV—At 12/31/2021, deferred tax assets not accounted for correspond to R$ 1,909 and result from Management’s evaluation of their perspectives of realization in the long term (R$ 780 at 12/31/2020). III—Temporary differences % Tax loss/social contribution loss carryforwards % Total % % 2022 15,318 28.6% 466 18.0% 15,784 28.2%—0.0% (142) 5.7% 15,642 29.2% 2023 17,246 32.3% 416 16.0% 17,662 31.5%—0.0% (261) 10.4% 17,401 32.5% 2024 10,643 19.9% 386 14.9% 11,029 19.7%—0.0% (54) 2.2% 10,975 20.5% 2025 2,059 3.9% 217 8.4% 2,276 4.1%—0.0% (37) 1.5% 2,239 4.2% 2026 1,923 3.6% 223 8.6% 2,146 3.8%—0.0% (56) 2.2% 2,090 3.9% after 2026 6,283 11.7% 885 34.1% 7,168 12.7% 65 100.0% (1,961) 78.0% 5,272 9.7% Total 53,472 100.0% 2,593 100.0% 56,065 100.0% 65 100.0% (2,511) 100.0% 53,619 100.0% Present value (*) 47,831 2,208 50,039 52 (1,962) 48,129 % (*) The average funding rate, net of tax effects, was used to determine the present value. The estimate of realization and present value of deferred tax assets and social contribution to offset, arising from Provisional Measure 2,158-35 of 08/24/2001 and from the deferred tax liabilities are: Year of realization Deferred tax assets Social contribution for offsetting Deferred tax liabilities Net deferred taxes % 2,256 1,317 3,112 2,158 3,020 3,076 8,388 6,551 5,234 3,067 3,154 3,484 c) Current tax liabilities Taxes and contributions on income payable Other taxes and contributions payable Current Non-current 12/31/2020 Total 12/31/2021 Legal obligation (Note 8b II)

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.51 Note 11—Fixed assets 12/31/2021 12/31/2020 Anual depreciation rates Cost Depreciation Impairment Residual Residual Real Estate 5,911 (3,463) (110) 2,338 2,508 Land—553 — 553 560 Buildings and Improvements 4% to 10% 5,358 (3,463) (110) 1,785 1,948 Other fixed assets 14,019 (10,383) (37) 3,599 3,485 Installations and Furniture and equipament 10% to 20% 3,043 (2,254) (10) 779 916 Data processing systems 20% to 50% 8,753 (6,937) (27) 1,789 1,749 Other (2) 10% to 20% 2,223 (1,192)—1,031 820 Total 19,930 (13,846) (147) 5,937 5,993 (1) The contractual commitments for purchase of the fixed assets totaled R$ 3, achievable by 2022 (2) Other refer to negotiations of Fixed assets in progress and other Communication, Security and Transportation equipment. Fixed assets (1)

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.52 Note 12—Goodwill and Intangible assets Association for the promotion and offer of financial products and services Software Acquired Internally developed software Other intangible assets (1) Annual amortization rates Up to 20% 8% 20% 20% 10% to 20% Cost Balance at 12/31/2020 24,446 2,812 6,269 7,636 3,201 44,364 Acquisitions (3) - 5 731 3,499 3,413 7,648 Disposals — (62) (2) (200) (264) Exchange variation (989) ( 155) (236)—(20) (1,400) Other (4) - ( 15) (569) — (584) Balance at 12/31/2021 23,457 2,647 6,133 11,133 6,394 49,764 Amortization Balance at 12/31/2020 (18,348) ( 1,338) (3,504) (3,265) (1,378) (27,833) Amortization expenses (2) (962) ( 109) (795) (940) (787) (3,593) Disposals — 24—200 224 Exchange variation 464 67 124—2 657 Other (4) - 14 265 — 279 Balance at 12/31/2021 (18,846) ( 1,366) (3,886) (4,205) (1,963) (30,266) Impairment (Note 9h) Balance at 12/31/2020 (2,235) ( 789) (204) (383) - (3,611) Increase ——(440)—(440) Reversals — 33 — 33 Exchange variation 232 77 ——309 Balance at 12/31/2021 (2,003) ( 712) (171) (823)—(3,709) Book value Balance at 12/31/2021 2,608 569 2,076 6,105 4,431 15,789 Balance at 12/31/2020 3,863 685 2,561 3,988 1,823 12,920 Impairment was recognized in the Consolidated Statement of Income under Other operating expenses (Note 9h). (2) Amortization expenses related to the rights for acquisition of payrolls and associations, in the amount of R$ (860) (R$ (594) from 01/01 to 12/31/2020) are disclosed in the expenses on financial operation. (1) Includes amounts paid for acquisition of rights to provide services of payment of salaries, proceeds, retirement and pension benefits and similar benefits. Goodwill and Intangible Assets from Aquisition are mainly represented by Itaú CorpBanca’s goodwill in the amount of R$ 2,581 (R$ 3,530 at 12/31/2020). ITAÚ UNIBANCO HOLDING PRUDENTIAL recognized on June 30, 2020, adjustments to the recoverable amount of goodwill and intangible assets related to Itaú Corpbanca, in the amounts of R$ 1,593 and R$ 789. The value in use of the Cash Generating Unit (CGU) in which Itáu CorpBanca is allocated was considered and cash flows were based on the result of June 2020 and internal projects of results until 2025. The adjustment to recoverable amount results from economic conditions on June 30, 2020, of Itaú CorpBanca’s market capitalization, discount rates applicable and other changes in variables triggered by the current uncertain macroeconomic condition that, when combined, resulted in a CGU amount lower than its book value. The discount rates used for the impairment test were 10.4% for operations in Chile and 12.3% for operations in Colombia, determined by the cost of capital calculated based on CAPM model. Long-term interest rates considered were 5.2% p.a. and 6.5% p.a. for Chile and Colombia, respectively. The most sensitive assumptions are cost of capital and perpetuity growth rate. (3) Other intangible assets: includes the effect of R$ 2,422 related to acquisition on 07/16/2021 of payroll management of the Government of the State of Minas Gerais. (4) Includes reclassifications of Software licenses necessary to put data processing systems into use, in the net amount of R$ 327. Goodwill and intagible from acquisition Intangible assets Total

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.53 b) Dividends Shareholders are entitled to a minimum mandatory dividend in each fiscal year, corresponding to 25% of adjusted net income, as set forth in the Bylaws. Common and preferred shares participate equally in income distributed, after common shares have received dividends equal to the minimum annual priority dividend payable to preferred shares (R$ 0.022 non-cumulative per share). ITAÚ UNIBANCO HOLDING CONSOLIDATED monthly advances the mandatory minimum dividend, using the share position of the last day of the previous month as the calculation basis, and the payment made on the first business day of the subsequent month in the amount of R$ 0.015 per share. On October 14, 2021, ITAÚ UNIBANCO HOLDING CONSOLIDATED approved the payment of interest on capital, replacing the monthly dividend for November and December, in the net amount of R$ 0.015 per share, having as calculation basis the final ownership position registered on October 29, 2021 and November 30, 2021. Additionally, the payment of interest on supplementary capital was also approved, in the net amount of R$ 0.224868 per share, resulting in the total amount of R$ 2,199 million to be distributed net of taxes. Note 13 – Stockholders’ equity Common Preferred Total Residents in Brazil at 12/31/2020 4,929,824,281 1,820,159,657 6,749,983,938 66,885 Residents abroad at 12/31/2020 28,466,078 3,025,685,332 3,054,151,410 30,263 4,958,290,359 4,845,844,989 9,804,135,348 97,148 4,958,290,359 4,845,844,989 9,804,135,348 90,729 Residents in Brazil at 12/31/2021 4,929,997,183 1,771,808,645 6,701,805,828 62,020 Residents abroad at 12/31/2021 28,293,176 3,074,036,344 3,102,329,520 28,709 - 41,678,452 41,678,452 (907) Result of delivery of treasure shares—(17,433,727) (17,433,727) 379 - 24,244,725 24,244,725 (528) 4,958,290,359 4,821,600,264 9,779,890,623 4,958,290,359 4,804,166,537 9,762,456,896 12/31/2021 Below is the average cost of treasury shares and their market price in reais. In 2021, there was none acquisition of treasury shares. Treasury shares at 12/31/2021 (1) (2) Partial spin-off (Note 2d). (1) Own shares, purchased based on authorization of the Board of Directors, to be held in Treasury, for subsequent cancellation or replacement in the market. Treasury shares at 12/31/2020 (1) Outstanding shares at 12/31/2021 Outstanding shares at 12/31/2020 Shares of capital stock at 12/31/2020 Shares of capital stock at 12/31/2021 (2) Number Amount a) Capital Capital is represented by 9,804,135,348 book-entry shares with no par value, of which 4,958,290,359 are common shares and 4,845,844,989 are preferred shares with no voting rights, but with tag-along rights in a public offering of shares, in an eventual transfer of control, assuring them a price equal to eighty per cent (80%) of the amount paid per voting share in the controlling block, and a dividend at least equal to that of the common shares. The breakdown and change in shares of paid-in capital in the beginning and end of the period are shown below: Common Preferred Average cost—21.76 Market value at 12/31/2021 19.09 20.95 Cost / Market value 12/31/2021

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.54 12/31/2021 26,236 (1,312) 24,924 6,231 6,231 I—Breakdown of dividends and interest on capital Dividend and Interest on Capital Paid / Accrued Statutory individual net income Adjustments: (-) Legal reserve—5% Dividend calculation basis Minimun mandatory dividend—25% Gross value per share (R$) Gross WHT (With holding tax) Net 4,179 (407) 3,772 Dividends—10 monthly installments paid from February to November 2021 0.0150 1,466—1,466 Interest on capital—1 monthly installment paid on December 2021 0.0150 173 (26) 147 Interest on capital—paid on 08/26/2021 0.2207 2,540 (381) 2,159 2,894 (435) 2,459 Interest on capital—1 monthly installment paid on 01/03/2022 0.0150 173 (26) 147 Interest on capital—credited on 11/26/2021 to be paid until 04/29/2022 0.2249 2,587 (388) 2,199 Interest on capital 0.0116 134 (21) 113 Total from 01/01 to 12/31/2021 7,073 (842) 6,231 Total from 01/01 to 12/31/2020 4,988 (485) 4,503 II – Stockholders’ yields Paid / Prepaid Accrued (Recorded in Other Liabilities – Social and Statutory) 12/31/2021 12/31/2020 2,247 2,323 284 284 1,962 2,038 1 1 56,752 40,434 13,651 12,339 43,101 28,095 (1) (2) It purpose is to ensure the integrity of capital, compensate loss or increase capital. Its main purpose is to ensure the remuneration flow to shareholders. c) Capital reserves and profit reserves Capital reserves Premium on subscription of shares Reserves from tax incentives, restatement of equity securities and other Share-based payment plan Profit reserves Legal (1) Statutory (2) d) 01/01 to 12/31/2021 01/01 to 12/31/2020 12/31/2021 12/31/2020 ITAÚ UNIBANCO HOLDING 26,236 18,961 144,564 136,699 Amortization of goodwill - (30) 3 2 Hedge of net investments in foreign operations (267) (241) 63 1 Other 546—27—ITAÚ UNIBANCO HOLDING PRUDENTIAL 26,515 18,690 144,657 136,702 Net income Stockholders’ equity Reconciliation of net income and stockholders’ equity (Note 2b) 12/31/2021 12/31/2020 01/01 to 12/31/2021 01/01 to 12/31/2020 9,075 9,391 (828) 2,801 469 502 (19)—708 576 (177) (119) 559 456 (138) (49) 44 38 (11) (7) 10,855 10,963 (1,173) 2,626 e) Non-controlling interests Itaú CorpBanca Itaú CorpBanca Colombia S.A. Stockholders’ equity Net Income Total Other Luizacred S.A. Soc. de Crédito, Financiamento e Investimento Financeira Itaú CBD S.A. Crédito, Financiamento e Investimento

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.55 f) Share-based payment ITAÚ UNIBANCO HOLDING and its subsidiaries have share-based payment plans aimed at involving its management members and employees in the medium and long term corporate development process. The grant of these benefits is only made in years in which there are sufficient profits to permit the distribution of mandatory dividends, limiting dilution to 0.5% of the total shares held by the controlling and minority stockholders at the balance sheet date. These programs are settled through the delivery of ITUB4 treasury shares to stockholders. l – Partner Plan The program enables employees and managers of ITAÚ UNIBANCO HOLDING to invest a percentage of their bonus to acquire shares and share-based instruments. There is a lockup period of from three to five years, counted from the initial investment date, and the shares are thus subject to market price variations. After complying with the preconditions outlined in the program, beneficiaries are entitled to receive shares as consideration, in accordance with the number of shares indicated in the regulations. The acquisition price of shares and share-based instruments is established every six months as the average of the share price over the last 30 days, which is performed on the seventh business day prior to the remuneration grant date. The fair value of the consideration in shares is the market price at the grant date, less expected dividends. 01/01 to 12/31/2021 01/01 to 12/31/2020 Partner Plan (Note 9f) (127) (241) Share-based plan (370) (489) Total (497) (730) Expenses on share-based payment plans are presented in the table below: Change in the Partner Program 01/01 to 12/31/2021 01/01 to 12/31/2020 Quantity Quantity Opening balance 36,291,760 39,305,211 New (1) 14,583,318 10,488,126 Delivered (11,652,700) (11,408,109) Cancelled (2,278,382) (2,093,468) Closing balance 36,943,996 36,291,760 Weighted average of remaining contractual life (years) 1.80 1.69 Market value weighted average (R$) 16.71 23.37 (1) As a result of the reduction of the minority interest in XP Inc. and subsequent merger of XPart S.A. (Note 2d), as from October 2021, there was an increase in the number of ITUB4 shares to be delivered under the variable compensation plans.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.56 II—01/01 to 12/31/2021 01/01 to 12/31/2020 Quantity Quantity Opening balance 27,407,231 20,220,934 New (1) 21,767,235 18,329,108 Delivered (10,818,958) (10,574,321) Cancelled (1,541,260) (568,490) Closing balance 36,814,248 27,407,231 Weighted average of remaining contractual life (years) 1.04 1.21 Market value weighted average (R$) 23.59 31.22 (1) As a result of the reduction of the minority interest in XP Inc. and subsequent merger of XPart S.A. (Note 2d), as from October 2021, there was an increase in the number of ITUB4 shares to be delivered under the variable compensation plans. Variable Compensation In this plan, part of the administrators variable remuneration is paid in cash and part in shares during a period of three years. Shares are delivered on a deferred basis, of which one-third per year, upon compliance with the conditions provided for in internal regulation. The deferred unpaid portions may be reversed proportionally to a significant reduction in the recurring income realized or the negative income for the period. Management members become eligible for the receipt of these benefits according to individual performance, business performance or both. The benefit amount is established according to the activities of each management member who should meet at least the performance and conduct requirements. The fair value of the share is the market price at its grant date. Change in share-based variable compensation

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.57 Note 14 – Related parties Transactions between related parties are carried out for amounts, terms and average rates in accordance with normal market practices during the period, and under reciprocal conditions. Transactions between companies and investment funds, included in consolidation (Note 2b), have been eliminated and do not affect the consolidated statements. The principal unconsolidated related parties are as follows: • Itaú Unibanco Participações S.A. (IUPAR), Companhia E. Johnston de Participações S.A. (shareholder of IUPAR) and ITAÚSA, direct and indirect shareholders of ITAÚ UNIBANCO HOLDING. • The associates, non-financial subsidiaries and joint ventures of ITAÚSA, in particular: Dexco S.A. (1), Copagaz – Distribuidora de Gás S.A., Aegea Saneamento e Participações S.A., Águas do Rio 1 SPE S.A., Águas do Rio 4 SPE S.A., Alpargatas S.A. and XP Inc. (Note 2d). • Investments in associates and joint ventures, in particular Porto Seguro Itaú Unibanco Participações S.A., BSF Holding S.A. and XP Inc. (Note 2d). • Pension Plans: Fundação Itaú Unibanco—Previdência Complementar and FUNBEP – Fundo de Pensão Multipatrocinado, closed-end supplementary pension entities, that administer retirement plans sponsored by ITAÚ UNIBANCO HOLDING PRUDENTIAL, created exclusively for employees. • Associations: Associação Cubo Coworking Itaú – a partner entity of ITAÚ UNIBANCO HOLDING PRUDENTIAL its purpose is to encourage and promote the discussion and development of alternative and innovative technologies, business models and solutions; the produce and disseminate the resulting technical and scientific knowledge; the attract and bring in new information technology talents that may be characterized as startups; and to research, develop and establish ecosystems for entrepreneur and startups. • Foundations and Institutes maintained by donations from ITAÚ UNIBANCO HOLDING and by the proceeds generated by their assets, so that they can accomplish their objectives and to maintain their operational and administrative structure: Fundação Itaú para a Educação e Cultura – promotes education, culture, social assistance, defense and guarantee of rights, and strengthening of civil society. Instituto Unibanco – supports projects focused on social assistance, particularly education, culture, promotion of integration into the labor market, and environmental protection, directly or as a supplement to civil institutions. Instituto Unibanco de Cinema – promotes culture in general and provides access of low-income population to cinematography, videography and similar productions, for which it should maintain movie theaters and movie clubs owned or managed by itself to screen films, videos, video-laser discs and other related activities, as well as to screen and disseminate movies in general, especially those produced in Brazil. Associação Itaú Viver Mais – provides social services for the welfare of beneficiaries, on the terms defined in its Internal Regulations, and according to the funds available. These services may include the promotion of cultural, educational, sports, entertainment and healthcare activities. (1) New legal name of Duratex S.A.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.58 12/31/2021 12/31/2020 01/01 to 12/31/2021 01/01 to 12/31/2020 2,301 18,539 84 63 Other 9.15% 2,301 18,539 84 63 5,214 1,609 269 (7) Copagaz—Distribuidora de Gás S.A. CDI + 1.7% to 2.95% 1,082 950 71 1 Itaúsa S.A. CDI + 2% to 2.4% 1,200 771 74 1 Águas do Rio 4 SPE S.A. CDI + 3.5% 1,574—60—Aegea Saneamento e Participações S.A. CDI + 1.5% to 2.9% 844—34—Other CDI + 3.5% 514 (112) 30 (9) 667 727 38 57 Alpargatas S.A. 100% CDI / 2.5% to 6% 105 65 4 36 Dexco S.A. CDI + 1.45% 546 515 31 19 Other CDI + 1.5% 16 147 3 2 Foreign exchange portfolio (assets and liabilities)—34 (2) 34 Itaú Europa Luxembourg S.A.—34 (2) 34 Deposits received under securities repurchase agreements (495) (5,304) (72) (27) ITB Holding Brasil Participações Ltda.—(4,915) (33) (6) Itaú Rent Administração e Participações Ltda. 100% SELIC (46) (128) (3) (3) Dexco S.A. 82% to 99% CDI (15) (49) (1) (2) Alpargatas S.A. 99% to 101% CDI (22) (107) (1) (11) Águas do Rio 4 SPE S.A. 99% CDI (32)—(3)—Águas do Rio 1 SPE S.A. 99% CDI (13)—(1)—Aegea Saneamento e Participações S.A. 97% to 99.3% CDI (158)—(5)—Other 100% SELIC / 100% CDI / 75% to 96% (209) (105) (25) (5) Deposits (9,178) (5,142) (156) (263) Itauseg Participações S.A. 100% CDI (2,934) (838) (19) (155) Itaú Corretora de Seguros S.A. 100% CDI (766) (1,044) (32) (26) ITB Holding Brasil Participações Ltda. 100% CDI (358) (191) (13) (11) Itaú Rent Administração e Participações Ltda. 100% CDI (194) (864) (11) (21) Itau Chile Inversiones, Servicios Y Administracion S.A. 100% CDI (543) (596) (5) (3) Provar Negócios de Varejo Ltda. 100% CDI (2,143) (239) (3) (7) Other 100% CDI (2,240) (1,370) (73) (40) (752) (187) (816) (32) Itaú Seguros S.A. (141) (117) 414 407 Instituto Unibanco—123 3 3 Fundação Itaú Unibanco—Previdência Complementar (78) (93) 37 30 FUNBEP—Fundo de Pensão Multipatrocinado (158) (1) (172) 6 ConectCar Soluções de Mobilidade Eletrônica S.A. (8) (46) (4) 7 Águas do Rio 4 SPE S.A. (20) ——Águas do Rio 1 SPE S.A. (12) ——Itaúsa S.A. (10) 1 13 12 Other (325) (54) (1,107) (497) Rent — (271) (261) Itaú Rent Administração e Participações Ltda. — (160) (154) Itaú Seguros S.A. — (36) (37) Fundação Itaú Unibanco—Previdência Complementar — (34) (28) FUNBEP—Fundo de Pensão Multipatrocinado — (3) (3) Other — (38) (39) Sponsorship 12 12 (14) (16) Associação Cubo Coworking Itaú 12 12 (14) (16) Donation—(500)—(828) Fundação Itaú para Educação e Cultura—(500)—(826) Other ——(2) Securities and derivative financial instruments (assets and liabilities) Loan operations Amounts receivable (payable) / Commissions and banking fees, Administrative expenses and/or Other operational a) Transactions with related parties: Annual rate Assets / (Liabilities) Revenues / (Expenses) Interbank investments b) 01/01 to 12/31/2021 01/01 to 12/31/2020 (435) (575) (205) (109) (9) (9) (119) (228) (768) (921) Total amounts related to share-based payment plan, personnel expenses and post-employment benefits are detailed in Notes 13f, 9f and 17, respectively. Fees Compensation and Benefits of Key Management Personnel Total Post-employment benefits Share-based payment plan Profit sharing Compensation and benefits attributed to Management Members, members of the Audit Committee and the Board of Directors of ITAÚ UNIBANCO HOLDING PRUDENTIAL in the period correspond to:

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.59 The methods and assumptions used to estimate the fair value are defined below: a) Central Bank of Brazil Deposits, Money market and Deposits received under securities repurchase agreements—The carrying amounts for these instruments are close to their fair values. b) Interbank deposits, Deposits, Funds from Acceptances and Issuance of Securities, Borrowings and Onlending and Subordinate Debts – They are calculated by discounting estimated cash flows at market interest rates. c) Securities and Derivatives Financial instruments—Under normal conditions, the prices quoted in the market are the best indicators of the fair values of these financial instruments. However, not all instruments have liquidity or quoted market prices and, in such cases, it is necessary to adopt present value estimates and other techniques to establish their fair value. In the absence of prices quoted by the Brazilian Association of Financial and Capital Markets Entities (ANBIMA), the fair values of government securities are calculated by discounting estimated cash flows at market interest rates, as well as corporate securities. d) Loan, lease and other credit operations – Fair value is estimated for groups of loans with similar financial and risk characteristics, using valuation models. The fair value of fixed-rate loans was determined by discounting estimated cash flows, at interest rates applicable to similar loans. For the majority of loans at floating rates, the carrying amount was considered to be close to their market value. The fair value of loan and lease operations not overdue was calculated by discounting the expected payments of principal and interest to maturity. The fair value of overdue loan and lease transactions was based on the discount of estimated cash flows, using a rate proportional to the risk associated with the estimated cash flows, or on the underlying collateral. The assumptions for cash flows and discount rates rely on information available in the market and knowledge of the individual debtor. Trading securities and Available for sale securities Level 1: Securities with liquid prices available in an active market and derivatives traded on stock exchanges. This classification level includes most of the Brazilian government securities, government securities from other countries, shares, debentures with price published by ANBIMA and other securities traded in an active market. The following table summarizes the book values and estimated fair values for financial instruments: Book value Fair value Book value Fair value (*) Assets Central Bank of Brazil Deposits (a) 104,592 104,592 90,059 90,059 Money market (a) 166,140 166,140 237,668 237,668 Voluntary investments with the Central Bank of Brazil (a) 5,800 5,800 — Interbank deposits (b) 69,661 69,831 55,553 55,751 Trading securities (c) 121,460 121,460 167,625 167,625 Available for sale securities (c) 154,375 154,375 197,779 197,779 Held to maturity securities (c) 140,956 139,884 42,677 45,207 Derivatives financial instruments (c) 68,881 68,881 76,104 76,104 Loan, lease and other credit operations (d) 819,993 821,102 711,441 719,712 (Provision for loan losses) (44,198) (44,198) (47,967) (47,967) Liabilities Deposits (b) 860,024 859,929 814,689 814,644 Deposits received under securities repurchase agreements (a) 271,104 271,104 285,680 285,680 Funds from acceptances and issuance of securities (b) 143,138 143,057 136,638 136,698 Borrowings and onlending (b) 97,005 97,041 83,200 83,271 Derivatives financial instruments (c) 63,974 63,974 79,620 79,620 Subordinated debts (b) 75,036 75,707 74,916 77,097 Allowance for financial guarantees provided and loan commitments 4,784 4,784 4,250 4,250 (*) In the period, the result of Derivative Financial Instruments, as well as Adjustment to Fair Value of Securities (particularly private securities) had their amounts affected by oscillations of rates and other market variables arising from the impact of the COVID-19 pandemic on the macroeconomic scenario in the period (Note 20d). 12/31/2021 12/31/2020 Note 15 – Fair value of financial instruments In cases where market prices are not available, fair values are based on estimates using discounted cash flows or other valuation techniques. These techniques are significantly affected by the assumptions adopted, including the discount rate and estimate of future cash flows. The estimated fair value obtained through these techniques cannot be substantiated by comparison with independent markets and, in many cases, cannot be achieved on immediate settlement of the instrument.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.60 Level 2: Bonds, securities and derivatives that do not have price information available and are priced based on conventional or internal models. The inputs used by these models are captured directly or built from observations of active markets. Most of derivatives traded over-the-counter, certain Brazilian government bonds, debentures and other private securities whose credit component effect is not considered relevant, are at this level. Level 3: Bonds, securities and derivatives for which pricing inputs are generated by statistical and mathematical models. Debentures and other private securities that do not fit into level 2 rule and derivatives with maturities greater than the last observable vertices of the discount curves are at this level. All the above methods may result in a fair value that is not indicative of the net realizable value or future fair values. However, ITAÚ UNIBANCO HOLDING PRUDENTIAL believes that all the method used are appropriate and consistent with other market participants. Moreover, the adoption of different methods or assumptions to estimate fair value may result in different fair value estimates at the balance sheet date. Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Total Trading securities 109,426 12,026 8 121,460 156,381 11,199 45 167,625 Government securities—Brazil 95,440 1,979—97,419 141,965 6,836—148,801 Financial treasury bills 19,302 — 19,302 27,871 — 27,871 National treasury bills 29,434 — 29,434 72,843 — 72,843 National treasury notes 44,323 1,979—46,302 38,199 6,836—45,035 Brazilian external debt bonds 2,381 — 2,381 3,052 — 3,052 Government securities—abroad 5,017 — 5,017 8,171 3—8,174 Argentina 928 — 928 1,475 — 1,475 Chile 368 — 368 825 3—828 Colombia 1,059 — 1,059 3,603 — 3,603 United States 2,599 — 2,599 2,085 — 2,085 Italy — — 130 — 130 Mexico 19 — 19 5 — 5 Paraguay 10 — 10 3 — 3 Peru 7 — 7 4 — 4 Uruguay 27 — 27 41 — 41 Corporate securities 8,969 10,047 8 19,024 6,245 4,360 45 10,650 Shares 2,462 — 2,462 2,848 348—3,196 Bank deposit certificates - 74—74—65—65 Real estate receivables certificates - 121—121 — 45 45 Fund quotas 627 8,489—9,116 552 3,402—3,954 Credit rights - 6,502—6,502—2,353—2,353 Fixed income 7 1,664—1,671 9 972—981 Variable income 620 323—943 543 77—620 Debentures 447 863—1,310 643 477—1,120 Eurobonds and other 5,433—8 5,441 2,202 — 2,202 Financial bills - 42—42—3—3 Other - 458—458—65—65 Available for sale securities 81,292 70,798 2,285 154,375 101,839 92,514 3,426 197,779 Government securities—Brazil 32,467 5,556 140 38,163 64,279 1,118 184 65,581 Financial treasury bills 3,879 — 3,879 1 — 1 National treasury bills 2,884 — 2,884 24,262 — 24,262 National treasury notes 21,164 5,556—26,720 26,476 1,118—27,594 National treasury / securitization — 140 140 — 184 184 Brazilian external debt bonds 4,540 — 4,540 13,540 — 13,540 Government securities—abroad 37,123 — 37,123 22,531 30,455—52,986 Argentina 405 — 405 2 — 2 Chile 15,269 — 15,269 739 21,649—22,388 Colombia 1,847 — 1,847 3,986 — 3,986 Korea — ——3,936—3,936 Spain — ——4,870—4,870 United States 4,591 — 4,591 3,750 — 3,750 Mexico 12,389 — 12,389 10,227 — 10,227 Paraguay 1,447 — 1,447 2,947 — 2,947 Uruguay 1,175 — 1,175 880 — 880 Corporate securities 11,702 65,242 2,145 79,089 15,029 60,941 3,242 79,212 Shares 117 4,171—4,288 123 2,990—3,113 Rural product note - 12,671 82 12,753—5,770 64 5,834 Bank deposit certificates - 99—99—303—303 Real estate receivables certificates - 1,032—1,032 — 1,010 1,010 Fixed income fund quotas — ——264—264 Debentures 7,264 37,017 2,063 46,344 11,669 40,592 2,168 54,429 Eurobonds and other 4,309 453—4,762 3,237 2,166—5,403 Financial bills - 1,097—1,097—636—636 Promissory notes - 7,257—7,257—7,222—7,222 Other 12 1,445—1,457—998—998 Distribution by Levels The following table presents the breakdown of fair value hierarchy levels. 12/31/2021 12/31/2020

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.61 Governance of Level 3 recurring fair value measurement The departments in charge of defining and applying the pricing models are segregated from the business areas. The models are documented, submitted to validation by an independent area and approved by a specific committee. The daily process of price capture, calculation and disclosure is periodically checked according to formally defined tests and criteria and the information is stored in a single corporate data base. The most frequent cases of assets classified as Level 3 are justified by the discount factors used and corporate bonds whose credit component is relevant. Factors such as the fixed interest curve in Brazilian Reais and the TR coupon curve – and, as a result, their related factors – have inputs with terms shorter than the maturities of fixed-income assets. Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Total Assets 6 68,723 152 68,881 23 75,976 105 76,104 Swap contracts – Adjustment receivable—37,948 90 38,038—45,926 93 46,019 Option contracts 3 21,165 62 21,230 4 20,125 12 20,141 Forward contracts—2,941—2,941—1,959—1,959 Credit derivatives—242—242—156—156 NDF—Non Deliverable Forwards—5,943—5,943—7,596—7,596 Other derivative financial instruments 3 484—487 19 214—233 Liabilities (3) (63,846) (125) (63,974) (22) (79,488) (110) (79,620) Swap contracts – Adjustment payable—(34,540) (111) (34,651)—(51,716) (109) (51,825) Option contracts (2) (23,296) (14) (23,312) (13) (20,318) (1) (20,332) Forward contracts—(762)—(762)—(905)—(905) Credit derivatives—(198)—(198)—(76)—(76) NDF—Non Deliverable Forwards—(4,896)—(4,896)—(6,426)—(6,426) Other derivative financial instruments (1) (154)—(155) (9) (47)—(56) 12/31/2021 12/31/2020 There were no significant transfers between Level 1 and Level 2 in the periods of 12/31/2021 and 12/31/2020. Transfers to and from Level 3 are presented in movements of Level 3. The following table presents the breakdown of fair value hierarchy levels for derivative assets and liabilities. Recognized in income Recognized in Other comprehensive income Trading securities 45 (137)—417 (189) (128) 8 (2) Corporate securities 45 (137)—417 (189) (128) 8 (2) Real estate receivable certificate 45 6—220 (163) (108) — Debentures—(133)—173 (20) (20) — Eurobonds and other—(10)—24 (6)—8 (2) Available for sale securities 3,426 (657) 247 1,009 (406) (1,334) 2,285 (471) Government securities—Brazil 184 (24) (20) ——140 30 Corporate securities 3,242 (633) 267 1,009 (406) (1,334) 2,145 (501) Rural product note 64 (18) (3) 88 (45) (4) 82 (28) Real estate receivable certificate 1,010 (192) (24) 361 (144) (1,011) — Debentures 2,168 (423) 294 560 (217) (319) 2,063 (473) Total gains or losses (Realized/ unrealized) Recurring changes in fair value of Level 3 The tables below show balance sheet changes for financial instruments classified by ITAÚ UNIBANCO HOLDING PRUDENTIAL in Level 3 of the fair value hierarchy. Derivative financial instruments classified in Level 3 correspond to other derivatives indexed to shares. Fair value at 12/31/2020 Total gains or losses (Realized/unrealized) Purchases Settlements Transfers in and/or out of Level Fair value at 12/31/2021 Recognized in income Recognized in Other comprehensive income Derivatives—Assets 105 46—327 (284) (42) 152 56 Swap contracts – Adjustment receivable 93 26—56 (43) (42) 90 90 Option contracts 12 20—271 (241)—62 (34) Derivatives—Liabilities (110) 72—(233) 148 (2) (125) (24) Swap contracts – Adjustment payable (109) 8—(30) 22 (2) (111) (46) Option contracts (1) 64—(203) 126—(14) 22 Total gains or losses (Realized/ unrealized) Fair value at 12/31/2020 Total gains or losses (Realized/Unrealized) Purchases Settlements Transfers in and/or out of Level Fair value at 12/31/2021

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.62 Sensitivity – Level 3 Operations Income Stockholders’ equity Income Stockholders’ equity I (1.07) (0.57) (0.06) (1.17) II (26.87) (14.26) (1.39) (28.93) III (53.92) (28.37) (1.89) (57.44) I — — II — — I (56.04)—(10.85)—II (93.84)—(14.60)—Interest rate Commodities, Index and Shares Nonlinear Sensitivity Analysis of Level 3 Operations The fair value of financial instruments classified in Level 3 is measured through valuation techniques based on correlations and associated products traded in active markets, internal estimates and internal models. Significant unobservable inputs used for measurement of the fair value of instruments classified in Level 3 are: interest rates, underlying asset prices and volatility. Significant variations in any of these inputs separately may give rise to substantial changes in the fair value. The table below shows the sensitivity of these fair values in scenarios of changes of interest rates or, asset prices, or in scenarios with varying shocks to prices and volatilities for nonlinear assets: 12/31/2021 12/31/2020 Scenarios Impacts Impacts Market risk factor groups Scenario I: Based on reasonably possible changes in assumptions of 5 percentage points on prices and 25 percentage points on the volatility level, both up and down, taking the largest losses resulting in each scenario. Scenario II: Based on reasonably possible changes in assumptions of 10 percentage points on prices and 25 percentage points on the volatility level, both up and down, taking the largest losses resulting in each scenario. The following scenarios are used to measure sensitivity: Based on reasonably possible changes in assumptions of 1, 25 and 50 basis points (scenarios I, II and III respectively) applied to the interest curves, both up and down, taking the largest losses resulting in each scenario. Interest rate Commodities, Index and Shares Nonlinear Based on reasonably possible changes in assumptions of 5 and 10 percentage points (scenarios I and II respectively) applied to share prices, both up and down, taking the largest losses resulting in each scenario.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.63 01/01 to 12/31/2021 01/01 to 12/31/2020 26,515 18,690 Minimum non-cumulative dividends on preferred shares (106) (106) Retained earnings to be distributed to common equity owners in an amount per share equal to the minimum dividend payable to preferred equity owners (109) (109) 26,300 18,475 Common 13,338 9,386 Preferred 12,962 9,089 Common 13,447 9,495 Preferred 13,068 9,195 Common 4,958,290,359 4,958,290,359 Preferred 4,818,741,579 4,801,324,161 Common 2.71 1.92 Preferred 2.71 1.92 a) Basic earnings per share Note 16 – Earnings per share Basic earnings per share – R$ Weighted average number of shares outstanding Retained earnings to be distributed, on a pro rata basis, to common and preferred equity owners: Net income attributable to owners of the parent company Total net income available to equity owners: Net income attributable to ITAÚ UNIBANCO HOLDING PRUDENTIAL’s shareholders is divided by the average number of outstanding shares in the period, excluding treasury shares. 01/01 to 12/31/2021 01/01 to 12/31/2020 13,068 9,195 74 41 13,142 9,236 13,447 9,495 (74) (41) 13,373 9,454 4,958,290,359 4,958,290,359 4,873,042,114 4,843,233,835 Preferred 4,818,741,579 4,801,324,161 Incremental as per share-based payment plans 54,300,535 41,909,674 Common 2.70 1.91 Preferred 2.70 1.91 Net income available to preferred equity owners considering preferred shares after the dilution effect b) Diluted earnings per share Calculated similarly to the basic earnings per share; however, it includes the conversion of all preferred shares potentially dilutable in the denominator. There was no potentially antidulitive effect of the shares in share-based payment plans in both periods. Diluted earnings per share – R$ Net income available to preferred equity owners Net income available to ordinary equity owners considering preferred shares after the dilution effect Net income available to ordinary equity owners Adjusted weighted average of shares Dividends on preferred shares after dilution effects Dividend on preferred shares after dilution effects Preferred Common

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.64 Note 17 – Post-employment benefits ITAÚ UNIBANCO HOLDING PRUDENTIAL, through its subsidiaries, sponsors retirement plans to its employees. Retirement plans are managed by Closed-end Private Pension Entities (EFPC) and are closed to new adhesions. These entities have an independent structure and manage their plans according to the characteristics of their regulations. There are three types of retirement plans: • Defined Benefit Plans (BD): plans which scheduled benefits have their value established in advance, based on salaries and/or length of service of employees, and its cost is actuarially determined; • Defined Contribution Plans (CD): are those plans which scheduled benefits have their value permanently adjusted to the investments balance, kept in favor of the participant, including in the benefit concession phase, considering net proceedings of its investment, amounts contributed and benefits paid; and • Variable Contribution Plans (CV): in this type of plan, scheduled benefits present a combination of characteristics of defined contribution and defined benefit modalities, and the benefit is actuarially determined based on the investments accumulated balance by the participant on the retirement date. Below is a list of benefit plans and their modalities: Entity Benefit Plan Modality Fundação Itaú Unibanco – Previdência Complementar—FIU Supplementary Retirement Plan Defined Benefit Supplementary Retirement Plan – Flexible Premium Annuity Franprev Benefit Plan 002 Benefit Plan Prebeg Benefit Plan UBB PREV Defined Benefit Plan Benefit Plan II Itaulam Basic Plan Itaucard Defined Benefit Plan Itaú Unibanco Main Retirement Plan Itaubanco Defined Contribution Plan Itaubank Retirement Plan Defined Contribution Redecard Pension Plan Unibanco Pension Plan – Intelligent Future Variable Contribution Itaulam Supplementary Plan Itaucard Variable Contribution Plan Itaú Unibanco Supplementary Retirement Plan FUNBEP – Fundo de Pensão Multipatrocinado Benefit Plan l Defined Benefit Benefit Plan ll Variable Contribution Defined Contribution plans include pension funds consisting of the portions of sponsor’s contributions not included in a participant’s account balance due to loss of eligibility for the benefit, and of monies arising from the migration of retirement plans in defined benefit modality. These funds are used for future contributions to individual participants’ accounts, according to the respective benefit plan regulations.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.65 b) Risk Management The EFPCs sponsored by ITAÚ UNIBANCO HOLDING are regulated by the National Council for Complementary Pension (CNPC) and PREVIC, has an Executive Board, Advisory and Tax Councils. Benefits offered have long-term characteristics and the main factors involved in the management and measurement of their risks are financial risk, inflation risk and demographic risk. - Financial Risk – the actuarial liability of the plan is calculated by adopting a discount rate, which may differ from rates earned in investments. If real income from plan investments is lower than yield expected, this may give rise to a deficit. To mitigate this risk and assure the capacity to pay long-term benefits, the plans have a significant percentage of fixed-income securities pegged to the plan commitments, aiming at minimizing volatility and risk of mismatch between assets and liabilities. Additionally, adherence tests are carried out in financial assumptions to ensure their adequacy to obligations of respective plans. - Inflation risk – a large part of liabilities is pegged to inflation risk, making actuarial liabilities sensitive to increase in rates. To mitigate this risk, the same financial risks mitigation strategies are used. - Demographic Risk – plans that have any obligation actuarially assessed are exposed to demographic risk. In the event the mortality tables used are not adherent to the mass of plan participants, a deficit or surplus may arise in actuarial evaluation. To mitigate this risk, adherence tests to demographic assumptions are conducted to ensure their adequacy to liabilities of respective plans. For purposes of registering in the balance sheet the EFPCs that manage them, actuarial liabilities of plans use discount rate adherent to its asset portfolio and income and expense flows, according to a study prepared by an independent consulting company. The actuarial method used is the aggregate method, through which the plan costing Is defined by the difference between its equity coverage and the current value of its future liabilities. Observing the methodology established in the respective actuarial technical note. When deficit in the concession period above the legally defined limits is noted, debt agreements are entered into with the sponsor according to costing policies, which affect the future contributions of the plan, and a plan for solving such deficit is established respecting the guarantees set forth by the legislation in force. The plans that are in this situation are resolved through extraordinary contributions that affect the values of the future contribution of the plan. 12/31/2021 12/31/2020 Mortality table (1) AT-2000 AT-2000 Discount rate (2) 9.46% p.a. 7.64% p.a. Inflation (3) 4.00% p.a. 4.00% p.a. Actuarial method Projected Unit Credit Projected Unit Credit (3) Refers to estimated long-term projection. Retired plans sponsored by foreign subsidiaries—Banco Itaú (Suisse) S.A., Itaú CorpBanca Colombia S.A.—are structured as Defined Benefit modality and adopt actual assumptions adequate to masses of participants and the economic scenario of each country. a) Main Actuarial Assumptions Actuarial assumptions of demographic and financial nature should reflect the best estimated about the variables that determine the post-employment benefit obligations. The most relevant demographic assumption comprise of mortality table and the most relevant financial assumptions include: discount rate and inflation. (1) Correspond to those disclosed by SOA – “Society of Actuaries”, by applying a 10% increase in the probabilities of survival regarding the respective basic tables (2) Determined based on market yield relating to National Treasury Notes (NTN-B) and compatible with the economic scenario observed on the balance sheet closing date, considering the volatility of interest market and models used.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.66 c) Asset management 12/31/2021 12/31/2020 12/31/2021 12/31/2020 Fixed income securities 19,904 21,172 90.8% 91.2% Quoted in an active market 19,508 20,804 89.0% 89.6% Non quoted in an active market 396 368 1.8% 1.6% Variable income securities 1,323 1,387 6.0% 5.9% Quoted in an active market 1,312 1,378 6.0% 5.9% Non quoted in an active market 11 9 0.1% 0.0% Structured investments 150 82 0.7% 0.4% Non quoted in an active market 150 82 0.7% 0.4% Real estate 462 506 2.1% 2.2% Loans to participants 73 78 0.3% 0.3% Total 21,912 23,225 100.00% 100.00% d) Other post-employment benefits ITAÚ UNIBANCO HOLDING PRUDENTIAL does not have additional liabilities related to post-employment benefits, except in cases arising from maintenance commitments assumed in acquisition agreements occurred over the years, as well as those benefits originated from court decision in the terms and conditions established, in which there is total or partial sponsorship of health care plan for a specific mass of former employees and their beneficiaries. Its costing is actuarially determined so as to ensure coverage maintenance. These plans are closed to new applicants. Assumptions for discount rate, inflation, mortality table and actuarial method are the same used for retirement plans. ITAÚ UNIBANCO HOLDING PRUDENTIAL used the percentage of 4% p.a. for medical inflation, additionally considering, inflation rate of 4% p.a. Particularly in other post-employment benefits, there is medical inflation risk associated to increase in medical costs above expectation. To mitigate this risk, the same financial risks mitigation strategies are used. The purpose of the management of the funds is the long-term balance between pension assets and liabilities with payment of benefits by exceeding actuarial goals (discount rate plus benefit adjustment index, established in the plan regulations). Below is a table with the allocation of assets by category, segmented into Quoted in an Active Market and Not Quoted in an Active Market: The defined benefit plan assets include shares of ITAÚ UNIBANCO HOLDING, its main parent company (ITAÚSA) and of subsidiaries of the latter, with a fair value of R$ 11 (R$ 11 at 12/31/2020), and real estate rented to Group companies, with a fair value of R$ 374 (R$ 410 at 12/31/2020). Fair value % Allocation Types

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.67 e) Change in the net amount recognized in the balance sheet: Ohter postemployment benefit Total Net assets Actuarial liabilities Asset ceiling Recognized amount Pension plan fund Asset ceiling Recognized amount Liabilities Recognized amount Amounts at the beginning of the period 23,225 (20,662) (3,642) (1,079) 1,454 (951) 503 (922) (1,498) Amounts recognized in income (1+2+3+4) 1,722 (1,575) (278) (131) 41 (68) (27) (66) (224) 1—Cost of current service—(53)—(53) — — (53) 2—Cost of past service — — — ——3—Net interest (1) 1,722 (1,522) (278) (78) 104 (68) 36 (66) (108) 4—Other expenses (2) — — (63)—(63)—(63) Amounts recognized in stockholders´ equity—other comprehensive income (5+6+7) (1,764) 817 665 (282) (725) 1,017 292 81 91 5—Effects on asset ceiling (4) — 665 665 (484) 1,017 533—1,198 6—Remeasurements (1,766) 801—(965) (241)—(241) 81 (1,125) Changes in demographic assumptions—4—4 — — 4 Changes in financial assumptions—3,708—3,708 ——113 3,821 Experience of the plan (3) (1,766) (2,911)—(4,677) (241)—(241) (32) (4,950) 7—Exchange variation 2 16—18 — — 18 Other (8+9+10) (1,271) 1,381—110 (323)—(323) 128 (85) 8—Receipt by destination of resources (4) — — (323)—(323)—(323) 9—Benefits paid (1,381) 1,381 — ——128 128 10—Contributions and investments from sponsor 110 — 110 — — 110 Amounts end of the period 21,912 (20,039) (3,255) (1,382) 447 (2) 445 (779) (1,716) Amount recognized in Assets (Note 9a) 48 445—493 Amount recognized in Liabilities (Note 9d) (1,430)—(779) (2,209) Ohter postemployment benefit Total Net assets Actuarial liabilities Asset ceiling Recognized amount Pension plan fund Asset ceiling Recognized amount Liabilities Recognized amount Amounts at the beginning of the period 22,732 (19,659) (3,761) (688) 1,475 (849) 626 (967) (1,029) Amounts recognized in income (1+2+3+4) 1,731 (1,578) (287) (134) 20 (65) (45) (76) (255) 1—Cost of current service—(80)—(80) — — (80) 2—Cost of past service—(1)—(1) — — (1) 3—Net interest (1) 1,731 (1,497) (287) (53) 112 (65) 47 (76) (82) 4—Other expenses (2) — — (92)—(92)—(92) Amounts recognized in stockholders´ equity—other comprehensive income (5+6+7) (75) (669) 406 (338) (41) (37) (78) 6 (410) 5—Effects on asset ceiling — 406 406—(37) (37)—369 6—Remeasurements (113) (588)—(701) (41)—(41) 6 (736) Changes in demographic assumptions—(11)—(11) — — (11) Changes in financial assumptions—13—13 ——12 25 Experience of the plan (3) (113) (590)—(703) (41)—(41) (6) (750) 7—Exchange variation 38 (81)—(43) — — (43) Other (8+9) (1,163) 1,244—81 — - 115 196 8—Benefits paid (1,244) 1,244 — ——115 115 9—Contributions and investments from sponsor 81 — 81 — — 81 Amounts end of the period 23,225 (20,662) (3,642) (1,079) 1,454 (951) 503 (922) (1,498) Amount recognized in Assets (Note 9a) 82 503—585 Amount recognized in Liabilities (Note 9d) (1,161)—(922) (2,083) The net amount recognized in the Balance Sheet is limited by the asset ceiling and it is computed based on estimated future contributions to be realized by the sponsor, so that it represents the maximum reduction amount in the contributions to be made. (1) Corresponds to the amount calculated at 01/01/2021 based on the initial amount (Net Assets, Actuarial Liabilities and Asset Ceiling), taking into account the estimated amount of payments/ receipts of benefits/ contributions, multiplied by the discount rate of 7.64% p.a. (At 01/01/2020 the rate used was 7.64% p.a.). (2) Corresponds to the use of asset amounts allocated in pension funds of the defined contribution plans. (3) Correspond to the income obtained above/below the expected return and comprise the contributions made by participants. (4) Includes the effects of the allocation of the surplus from the pension fund of Itaubanco Defined Contribution Plan. 12/31/2021 BD and CV plans CD plans 12/31/2020 BD and CV plans CD plans

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.68 f) Defined benefit contribution Estimated contribution 2022 01/01 to 12/31/2021 01/01 to 12/31/2020 Pension plan—FIU 34 43 45 Pension plan—FUNBEP 22 32 5 Total 56 75 50 g) Maturity profile of defined benefit liabilities Duration (*) 2022 2023 2024 2025 2026 2027 to 2031 Pension plan—FIU 9.80 1,050 943 984 1,025 1,072 5,862 Pension plan—FUNBEP 9.10 594 614 634 652 667 3,541 Other post-employment benefits 7.09 140 157 149 36 37 209 Total 1,784 1,714 1,767 1,713 1,776 9,612 (*) Average duration of plan´s actuarial liabilities. Present value of liability Income Stockholders´ equity (*) Present value of liability Income Stockholders´ equity (*) Discount rate Increase by 0.5% (835)—308 (24)—24 Decrease by 0.5% 905—(420) 27—(27) Mortality table Increase by 5% (234)—87 (10)—10 Decrease by 5% 245—(91) 11—(11) Medical inflation Increase by 1% ——63—(63) Decrease by 1% ——(53)—53 (*) Net of effects of asset ceiling. Contributions made h) Sensitivity analysis To measure the effects of changes in the key assumptions, sensitivity tests were conducted in actuarial liabilities. The sensitivity analysis considers a vision of the impacts caused by changes in assumptions, which could affect the income for the period and stockholders’ equity at the balance sheet date. This type of analysis is usually carried out under the ceteris paribus condition, in which the sensitivity of a system is measured when only one variable of interest is changed and all the others remain unchanged. The results obtained are shown in the table below: BD and CV plans Other post-employment benefits Main assumptions

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.69 Note 19 – Risk, Capital Management and Fixed Assets Limits a) Corporate Governance ITAÚ UNIBANCO HOLDING CONSOLIDATED invests in robust risk management processes and capital management that are the basis for its strategic decisions to ensure business sustainability and maximize shareholder value creation. These processes are aligned with the guidelines of the Board of Directors and Executive which, through collegiate bodies, define the global objectives expressed as targets and limits for the business units that manage risk. Control and capital management units, in turn, support ITAÚ UNIBANCO HOLDING CONSOLIDATED’s management by monitoring and analyzing risk and capital. The Board of Directors is the main body responsible for establishing guidelines, policies and approval levels for risk and capital management. The Risk and Capital Management Committee (CGRC), in turn, is responsible for supporting the Board of Directors in managing capital and risk. At the executive level, collegiate bodies, presided over by the Chief Executive Officer (CEO) of ITAÚ UNIBANCO HOLDING CONSOLIDATED, are responsible for capital and risk management, and their decisions are monitored by the CGRC. Additionally, ITAÚ UNIBANCO HOLDING CONSOLIDATED has collegiate bodies with capital and risk management responsibilities delegated to them, under the responsibility of CRO (Chief Risk Officer). To support this structure, the Risk Area has departments to ensure, on an independent and centralized basis, that the institution’s risks and capital are managed in compliance with defined policies and procedures. b) Risk Management Risk Appetite The risk appetite of ITAÚ UNIBANCO HOLDING CONSOLIDATED is based on the Board of Director’s statement: “We are a universal bank, operating mainly in Latin America. Supported by our risk culture, we insist on with strict ethical standards and regulatory compliance, seeking high and increasing returns, with low volatility, through lasting relationships with our customers, accurate risk pricing, widespread funding and proper use of capital.” 01/01 to 12/31/2021 01/01 to 12/31/2020 6,628 (110) Note 18 – Information on foreign subsidiaries ITAÚ UNIBANCO HOLDING PRUDENTIAL has subsidiaries abroad, basically compose of: Itaú Unibanco S.A.—Grand Cayman Branch, Miami Branch, Nassau Branch, Itaú Unibanco Holding S.A.—Grand Cayman Branch, Itau Bank, Ltd., ITB Holding Ltd., Banco Itaú Argentina S.A., Banco Itaú Uruguay S.A., Itaú CorpBanca Colombia S.A., Itaú CorpBanca S.A., Banco Itaú Paraguay S.A. and Itau BBA International plc; only at 12/31/2020 New York Branch and Tokyo Branch. Net income Foreign consolidated

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.70 Based on this statement, five dimensions have been defined (Capitalization, Liquidity, Composition of Earnings, Operating Risk and Reputation). Each dimension consists of a set of metrics associated with the main risks involved, combining supplementary measurement methods, to give a comprehensive vision of our exposure. The Board of Directors is responsible for approving guidelines and limits for risk appetite, with the support of CGRC and the CRO (Chief Risk Officer). The limits for risk appetite are monitored regularly and reported to risk committees and to the Board of Directors, which will oversee the preventive measures to be taken to ensure that exposure is aligned with the strategies of ITAÚ UNIBANCO HOLDING CONSOLIDATED. Foremost among BACEN’s requirements for proper risk and capital management are the Risk Appetite Statement (RAS) and the implementation of a continuous, integrated risk management structure, the stress test program, the establishment of a Risk Committee, and the nomination at BACEN of a Chief Risk Officer (CRO), with roles and responsibilities assigned, and requirements for independence. Risk appetite, risk management and guidelines for employees of ITAÚ UNIBANCO HOLDING CONSOLIDATED for routine decision-making purposes are based on: • Sustainability and customer satisfaction: ITAÚ UNIBANCO HOLDING CONSOLIDATED’s vision is to be the leading bank in sustainable performance and customer satisfaction and, accordingly, we are committed to creating shared value for staff, customers, stockholders and society, ensuring the continuity of the business. ITAÚ UNIBANCO HOLDING CONSOLIDATED is committed to doing business that is good both for the customer and the institution itself; • Risk culture: ITAÚ UNIBANCO HOLDING CONSOLIDATED’s risk culture goes beyond policies, procedures or processes, reinforcing the individual and collective responsibility of all employees so that they will do the right thing at the right time and in the proper manner, respecting the ethical way of doing business; • Risk pricing: ITAÚ UNIBANCO HOLDING CONSOLIDATED’s operates and assumes risks in business that it knows and understands, avoids the ones that are unknown or that do not provide competitive advantages, and carefully assesses risk-return ratios; • Diversification: ITAÚ UNIBANCO HOLDING CONSOLIDATED has little appetite for volatility in earnings, and it therefore operates with a diverse base of customers, products and business, seeking to diversify risks and giving priority to lower risk business; • Operational excellence: It is the wish of ITAÚ UNIBANCO HOLDING CONSOLIDATED to be an agile bank, with a robust and stable infrastructure enabling us to offer top quality services; • Ethics and respect for regulation: for ITAÚ UNIBANCO HOLDING CONSOLIDATED, ethics is nonnegotiable, and it therefore promotes an institutional environment of integrity, encouraging staff to cultivate ethics in relationships and business and to respect the rules, thus caring for the institution’s reputation. ITAÚ UNIBANCO HOLDING CONSOLIDATED has various ways of disseminating risk culture, based on four principles: conscious risk-taking, discussion of the risks the institution faces, the corresponding action taken, and the responsibility of everyone for managing risk. These principles serve as a basis for ITAÚ UNIBANCO HOLDING CONSOLIDATED’s guidelines, helping employees to conscientiously understand, identify, measure, manage and mitigate risks. I—Credit risk The possibility of losses arising from failure by a borrower, issuer or counterparty to meet their financial obligations, the impairment of a loan due to downgrading of the risk rating of the borrower, the issuer or the counterparty, a decrease in earnings or remuneration, advantages conceded on renegotiation or the costs of recovery. There is a credit risk control and management structure, centralized and independent from the business units, that provides for operating limits and risk mitigation mechanisms, and also establishes processes and tools to measure, monitor and control the credit risk inherent in all products, portfolio concentrations and impacts of potential changes in the economic environment.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.71 The credit policy of ITAÚ UNIBANCO HOLDING CONSOLIDATED is based on internal criteria such as: classification of customers, portfolio performance and changes, default levels, rate of return and economic capital allocated, and external factors such as interest rates, market default indicators, inflation, changes in consumption, and so on. In compliance with CMN Resolution 4,557, of February 23, 2017, the document “Public Access Report – Credit Risk”, which includes the guidelines established by our credit risk control policy, can be viewed at www.itau.com.br/investor-relations, in the section Itaú Unibanco, under Corporate Governance, Regulations and Policies, Reports. II—Market risk The possibility of incurring financial losses from changes in the market value of positions held by a financial institution, including the risks of transactions subject to fluctuations in currency rates, interest rates, share prices, price indexes and commodity prices, as set forth by CMN. Price Indexes are also treated as a risk factor group. Market risk is controlled by an area independent from the business areas, which is responsible for the daily activities of (i) risk measurement and assessment, (ii) monitoring of stress scenarios, limits and alerts, (iii) application, analysis and testing of stress scenarios, (iv) risk reporting to those responsible within the business areas, in compliance with the governance of ITAÚ UNIBANCO HOLDING CONSOLIDATED, (v) monitoring of actions required to adjust positions and risk levels to make them realistic, and (vi) providing support for the safe launch of new financial products. The market risk structure categorizes transactions as part of either the banking portfolio or the trading portfolio, in accordance with general criteria established by CMN Resolution 4,557, of February 23, 2017, and BACEN Circular 3,354, of June 27, 2007. The trading portfolio consists of all transactions involving financial instruments and commodities, including derivatives, which are held for trading. The banking portfolio is basically characterized by transactions for the banking business, and transactions related to the management of the balance sheet of the institution, where there is no intention of sale and time horizons are medium and long term. Market risk management is based on the following metrics: • Value at risk (VaR): a statistical measure that estimates the expected maximum potential economic loss under normal market conditions, considering a certain time horizon and confidence level; • Losses in stress scenarios (Stress Test): simulation technique to assess the behavior of assets, liabilities and derivatives of a portfolio when several risk factors are taken to extreme market situations (based on prospective and historical scenarios); • Stop loss: metric used to revise positions, should losses accumulated in a fixed period reach a certain level; • Concentration: cumulative exposure of a certain financial instrument or risk factor, calculated at fair value (MtM – Mark to Market); and • Stressed VaR: statistical metric derived from the VaR calculation, with the purpose is of simulating higher risk in the trading portfolio, taking returns that can be seen in past scenarios of extreme volatility. Management of interest rate risk in the Banking Book (IRRBB) is based on the following metrics: • ΔEVE (Delta Economic Value of Equity): difference between the present value of the sum of repricing flows of instruments subject to IRRBB in a base scenario and the present value of the sum of repricing flows of these instruments in a scenario of shock in interest rates; • ΔNII (Delta Net Interest Income): difference between the result of financial intermediation of instruments subject to IRRBB in a base scenario and the result of financial intermediation of these instruments in a scenario of shock in interest rates. In addition, sensitivity and loss control measures are also analyzed. They include: • Mismatching analysis (GAPS): accumulated exposure by risk factor of cash flows expressed at fair value, allocated at the maturity dates; • Sensitivity (DV01- Delta Variation): impact on the fair value of cash flows when a 1 basis point change is applied to current interest rates or on the index rates; and

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.72 ï,· Sensitivity to Sundry Risk Factors (Greeks): partial derivatives of an option portfolio in relation to the prices of underlying assets, implied volatilities, interest rates and time. In order to operate within the defined limits, ITAÚ UNIBANCO HOLDING CONSOLIDATED hedges transactions with customers and proprietary positions, including its foreign investments. Derivatives are commonly used for these hedging activities, which can be either accounting or economic hedges, both governed by the institutional polices of ITAÚ UNIBANCO HOLDING CONSOLIDATED (Note 5 – Securities and derivative financial instruments). The structure of limits and alerts obeys the Board of Directors’ guidelines, and it is reviewed and approved on an annual basis. This structure has specific limits aimed at improving the process of monitoring and understanding risk, and at avoiding concentration. These limits are quantified by assessing the forecast balance sheet results, the size of stockholders’ equity, market liquidity, complexity and volatility, and ITAU UNIBANCO HOLDING CONSOLIDATED’s appetite for risk. The consumption of market risk limits is monitored and disclosed daily through exposure and sensitivity maps. The market risk area analyzes and controls the adherence of these exposures to limits and alerts and reports them timely to the Treasury desks and other structures foreseen in the governance. ITAÚ UNIBANCO HOLDING CONSOLIDATED uses proprietary systems to measure the consolidated market risk. The processing of these systems occurs in a high-availability access-controlled environment, which has data storage and recovery processes and an infrastructure that ensures business continuity in contingency (disaster recovery) situations. At 12/31/2021, ITAÚ UNIBANCO HOLDING CONSOLIDATED presented a Total VaR of R$ 696, an increase in relation to prior year (R$ 223 at 12/31/2020) due to higher exposure and higher volatility in interest rates. The document “Public Access Report – Market Risk Management and Control Policy“, which includes which includes our internal policy guidelines for market risk control, is not an integral part of the financial statements, but can be viewed at www.itau.com.br/investor-relations, in the section Itaú Unibanco, Corporate Governance, Regulations and Policies, Reports. III – Liquidity risk The possibility that the institution may be unable to efficiently meet its expected and unexpected obligations, both current and future, including those arising from guarantees issued, without affecting its daily operations and without incurring significant losses. Liquidity risk is controlled by an area independent from the business area and responsible for establishing the reserve composition, estimating the cash flow and exposure to liquidity risk in different time horizons, and for monitoring the minimum limits to absorb losses in stress scenarios for each country where ITAÚ UNIBANCO HOLDING CONSOLIDATED operates. All activities are subject to verification by independent validation, internal control and audit areas. The document Public Access Report—Liquidity Risk Management and Control Policy, which includes our internal policy guidelines for liquidity risk control, is not an integral part of the financial statements, but can be viewed on the website www.itau.com.br/investor-relations, in the section Itaú Unibanco, Corporate Governance, Regulations and Policies, Reports.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.73 IV – Operating risk Defined as the possibility of losses from failures, defects or shortcomings in internal processes, people or systems, or from external events impacting the realization of strategic, tactical or operational objectives. It includes the legal risk of inadequacies or defects in agreements signed by the institution, as well as sanctions for failing to comply with legal provisions and compensation to third parties for losses arising from the institution’s activities. The managers of executive areas use corporate methods developed and supplied by the internal controls, compliance and operating risk area. As part of governance of the risk management process, consolidated reports on risk monitoring, controls, action plans and operating losses are periodically presented to the business areas’ executives. In line with the principles of CMN Resolution 4,557, of February, 23, 2017, the document entitled “Public Access Report – Integrated Operational Risk Management and Internal Controls”, a summarized version of the institutional operating risk management policy, may be viewed on the website www.itau.com.br/investor-relations, in the section Itaú Unibanco, Corporate Governance, Regulations and Policies, Reports. V—Insurance, private pension and premium bonds risks The main risks related to Insurance, Private Pension and Premium Bonds portfolios are described below and defined in their respective chapters. • Underwriting risk: possibility of losses arising from insurance, pension plan and premium bonds operations contrary to the institution’s expectations of ITAÚ UNIBANCO HOLDING CONSOLIDATED, directly or indirectly associated with technical and actuarial bases adopted to calculate premiums, contributions and provisions; • Credit risk; • Market risk; • Liquidity risk; • Operating risk. These risks are managed independently, according to their special characteristics. VI—Emerging risks They are those with a potentially material impact on the business in the medium and long terms, but for which there are not enough elements yet for their complete assessment and mitigation due to the number of factors and impacts not yet totally known, such as technological alternatives in replacement of traditional banking services and the demographic transition of clients in contrast to technological innovations. Their causes can be originated by external events and result in the emergence of new risks or in the intensification of risks already monitored by ITAÚ UNIBANCO HOLDING CONSOLIDATED. The identification and monitoring of Emerging Risks are ensured by ITAÚ UNIBANCO HOLDING CONSOLIDATED’s governance, allowing these risks to be incorporated into risk management processes too. VII – Social and Environmental Risk and Climate Risk Social and Environmental risk is the possibility of losses due to exposure to social and/or environmental events related to the activities developed by the ITAÚ UNIBANCO HOLDING CONSOLIDATED. Social and environmental factors are considered relevant to the business of ITAÚ UNIBANCO HOLDING CONSOLIDATED, since they may affect the creation of shared value in the short, medium and long term. The Policy on Sustainability and Social and Environmental Responsibility (PRSA) establishes the guidelines, strategies and underlying principles for social and environmental risk management, based on institutional issues and addressing, through specific procedures, the most significant risks for the Institution’s operation.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.74 Actions to mitigate the Social and Environmental Risk are taken based on the mapping of processes, risks and controls, monitoring of new standards related to the theme and record of occurrence in internal systems. In addition to the identification, the phases of prioritization, response to risk, mitigation, monitoring and reporting of assessed risks supplement the management of this risk at ITAÚ UNIBANCO HOLDING CONSOLIDATED. The management of social and environmental risk adopts the strategy of three defense lines: the first defense line (business areas) manages the risk in its daily activities, following the PRSA guidelines, specific processes, with the support of specialized assessment from dedicated technical teams located in Corporate Compliance, Credit Risk and Modeling, and Institutional Legal teams, that act on an integrated way in the management of all dimensions of the Social and Environmental Risk related to the conglomerate’s activities. As an example of the specific guidelines to manage this risk, business units count on the governance for approval of new products and services, which contemplates, in its assessments, the Social and Environmental Risk, ensuring the compliance with this requirement in new products approved by the Institution, as well as specific social and environmental procedures for the Institution’s operation (stockholders’ equity, branch infrastructure and technology), suppliers, credit, investments and key controls. The second line of defense, in turn, is represented by the Credit Risk and Modeling, by Internal Controls, as well as Compliance, through the Corporate Social and Environmental Risk Management, which supports and ensures the governance of the first line’s activities. The third line of defense composed of the Internal Audit, acts on an independent manner, mapping and assessing risk management, controls and governance. Governance also counts on the Social and Environmental Risk Committee, whose main responsibility is to assess and deliberate about institutional and strategic matters, as well as to resolve on products, operations, and services, among others involving the Social and Environmental Risk, including Climate Risk. Climate Risk includes: (i) physical risks, arising from changes in weather patterns, such as increased rainfall and temperature and extreme weather events, and (ii) transition risks, resulting from changes in the economy as a result of climate actions, such as carbon pricing, climate regulation, market risks and reputational risks. Considering its relevance, climate risk has become one of the main priorities for ITAÚ UNIBANCO HOLDING CONSOLIDATED, which supports the Task Force on Climate-related Financial Disclosures (TCFD) and it is committed to its implementation of its recommendations. With this purpose, ITAÚ UNIBANCO HOLDING CONSOLIDATED is strengthening the governance and strategy related to Climate Risk and developing tools and methodologies to assess and manage these risks. ITAÚ UNIBANCO HOLDING CONSOLIDATED measures the sensitivity of the credit portfolio to climate risks by applying the Climate Risk Sensitivity Assessment Tool, developed by Febraban. The tool combines relevance and proportionality criteria to identify the sectors and clients within the portfolio that are more sensitive to climate risks, considering physical and transition risks. The sectors with the highest probability of suffering financial impacts from climate change for ITAÚ UNIBANCO HOLDING CONSOLIDATED are: energy, transport, materials and construction, agriculture, food and forestry products. Further details on environmental and social risk, which is not an integral part of the financial statements, can be viewed at www.itau.com.br/investor-relations, section Results and Reports, Regulatory Reports, Pillar 3 and Global Systemically Important Banks / Risk and Capital Management – Pillar 3. c) Capital management governance ITAÚ UNIBANCO HOLDING CONSOLIDATED is subject to the regulations of BACEN, which determines minimum capital requirements, procedures to obtain information to assess the global systemic importance of banks, fixed asset limits, loan limits and accounting practices, and requires banks to conform to the regulations based on the Basel Accord for capital adequacy. Additionally, CNSP and SUSEP issue regulations on capital requirements that affect our insurance operations and private pension and premium bonds plans. The capital statements were prepared in accordance with BACEN’s regulatory requirements and with internationally accepted minimum requirements according to the Bank for International Settlements (BIS).

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.75 I – Composition and Capital Adequacy The Board of Directors is the body responsible for approving the institutional capital management policy and guidelines for the capitalization level of ITAÚ UNIBANCO HOLDING CONSOLIDATED. The Board is also responsible for the full approval of the ICAAP (Internal Capital Adequacy Assessment Process) report, the purpose of which is to assess the capital adequacy of ITAÚ UNIBANCO HOLDING CONSOLIDATED. The result of the last ICAAP, which comprises stress tests – which was dated December 2020 – indicated that ITAÚ UNIBANCO HOLDING CONSOLIDATED has, in addition to capital to cover all material risks, a significant capital surplus, thus assuring the solidity of the institution’s equity position. In order to ensure that ITAÚ UNIBANCO HOLDING CONSOLIDATED is sound and has the capital needed to support business growth, the institution maintains PR levels above the minimum level required to face risks, as demonstrated by the Common Equity, Tier I Capital and Basel ratios. As of December 31, 2021 the amount of perpetual subordinated debt that makes up Tier I capital is R$ 18,167 (R$17,078 as of December 31, 2020) and the amount of subordinated debt that makes up Tier II capital is R$19,469 (R$14,024 as of December 31, 2020). The Basel Ratio reached 14.7% on December 31, 2021, with an increase of 0.2 percentage point as compared to 12/31/2020. The main change was the income for the period offset by the increase in loan portfolio. Additionally, ITAÚ UNIBANCO HOLDING CONSOLIDATED has a surplus over the required minimum Referential Equity of R$ 77,490 (R$ 67,867 at 12/31/2020), well above the ACP of R$ 34,615 (R$ 23,450 at 12/31/2020), generously covered by available capital. The fixed assets ratio shows the commitment percentage of adjusted Referential Equity with adjusted permanent assets. ITAÚ UNIBANCO HOLDING CONSOLIDATED falls within the maximum limit of 50% of adjusted PR, established by BACEN. At 12/31/2021, fixed assets ratio reached 16.9% (24.0% at 12/31/2020), showing a surplus of R$ 56,280 (R$ 39,274 at 12/31/2020). Further details on Risk and Capital Management of ITAÚ UNIBANCO HOLDING CONSOLIDATED and indicators of the Global Systemic Importance Index, which are not included in the financial statements, may be viewed on www.itau.com.br/investor-relations, section Results and Reports, Regulatory Reports, Pillar 3 and Global Systemically Important Banks. 12/31/2021 12/31/2020 Available capital (amounts) Common Equity Tier 1 130,716 119,960 Tier 1 149,912 137,157 Total capital (PR) 169,797 151,244 Risk-weighted assets (amounts) Total risk-weighted assets (RWA) 1,153,841 1,042,207 Risk-based capital ratios as a percentage of RWA Common Equity Tier 1 ratio (%) 11.3% 11.5% Tier 1 ratio (%) 13.0% 13.2% Total capital ratio (%) 14.7% 14.5% Additional CET1 buffer requirements as a percentage of RWA Capital conservation buffer requirement (%) (*) 2.00% 1.25% Countercyclical buffer requirement (%) 0.0% 0.0% Bank G-SIB and/or D-SIB additional requirements (%) 1.0% 1.0% Total of bank CET1 specific buffer requirements (%) 3.00% 2.25% (*) For purposes of calculating the Conservation capital buffer, BACEN Resolution 4,783 establishes, for defined periods, percentages to be applied to the RWA value with a gradual increase until April/2022, when it reaches 2.5%.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.76 II—Risk-Weighted Assets (RWA) For calculating minimum capital requirements, RWA must be obtained by taking the sum of the following risk exposures: RWA = RWACPAD + RWAMINT + RWAOPAD • portion related to exposures to credit risk, calculated using the standardized approach; • portion related to capital required for market risk, composed of the maximum between the internal model and 80% of the standardized model, regulated by BACEN Circulars nº 3,646 and nº 3,674; • = portion related to capital required for operational risk, calculated based on the standardized approach. a b 12/31/2021 12/31/2020 Credit Risk standardized approach 1,044,344 921,934 Credit risk (excluding counterparty credit risk) 922,824 778,153 Counterparty credit risk (CCR) 42,898 45,674 Of which: standardized approach for counterparty credit risk (SA-CCR) 27,616 27,119 Of which: other CCR 15,282 18,555 Credit valuation adjustment (CVA) 8,102 5,960 Equity investments in funds—look-through approach 5,001 4,897 Equity investments in funds—mandate-based approach 95 623 Equity investments in funds—fall-back approach 824 716 Securitisation exposures—standardized approach 2,195 1,506 Amounts below the thresholds for deduction 62,405 84,405 Market Risk 22,985 27,481 Of which: standardized approach (RWAMPAD) 28,731 34,351 Of which: internal models approach (RWAMINT) 14,751 22,362 Operational Risk 86,512 92,792 Total 1,153,841 1,042,207 RWA

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.77 III—Recovery Plan In response to the latest international crises, the Central Bank published Resolution No. 4,502, which requires the development of a Recovery Plan by financial institutions within Segment 1, with total exposure to GDP of more than 10%. This plan aims to reestablish adequate levels of capital and liquidity above regulatory operating limits in the face of severe systemic or idiosyncratic stress shocks. In this way, each institution could preserve its financial viability while also minimizing the impact on the National Financial System. More details on the Recovery Plan can be viewed at www.itau.com.br/investor-relations, section Results and Reports, Regulatory Reports, Pillar 3 and Risk and Capital Management – Pillar 3. IV—Stress testing The stress test is a process of simulating extreme economic and market conditions on ITAÚ UNIBANCO HOLDING CONSOLIDATED’s results, liquidity and capital. The institution has been carrying out this test in order to assess its solvency in plausible scenarios of crisis, as well as to identify areas that are more susceptible to the impact of stress that may be the subject of risk mitigation. For the purposes of the test, the economic research area estimates macroeconomic variables for each stress scenario. The elaboration of stress scenarios considers the qualitative analysis of the Brazilian and the global conjuncture, historical and hypothetical elements, short and long term risks, among other aspects, as defined in CMN Resolution 4,557. In this process, the main potential risks to the economy are assessed based on the judgment of the bank’s team of economists, endorsed by the Chief Economist of ITAÚ UNIBANCO HOLDING CONSOLIDATED and approved by the Board of Directors. Projections for the macroeconomic variables (such as GDP, basic interest rate, exchange rates and inflation) and for variables in the credit market (such as raisings, lending, rates of default, margins and charges) used are based on exogenous shocks or through use of models validated by an independent area. Then, the stress scenarios adopted are used to influence the budgeted result and balance sheet. In addition to the scenario analysis methodology, sensitivity analysis and the Reverse Stress Test are also used. ITAÚ UNIBANCO HOLDING CONSOLIDATED uses the simulations to manage its portfolio risks, considering Brazil (segregated into wholesale and retail) and External Units, from which the risk-weighted assets and the capital and liquidity ratios are derived. The stress test is also an integral part of the ICAAP, the main purpose of which is to assess whether, even in severely adverse situations, the institution would have adequate levels of capital and liquidity, without any impact on the development of its activities. This information enables potential offenders to the business to be identified and provides support for the strategic decisions of the Board of Directors, the budgeting and risk management process, as well as serving as an input for the institution’s risk appetite metrics. V – Leverage Ratio The Leverage Ratio is defined as the ratio of Capital Tier I to Total Exposure, calculated pursuant to BACEN Circular 3,748, of February 27, 2015. The purpose of this ratio is to be a simple measure of leverage not sensitive to risk, thus it does not consider weighting or mitigation factors. According to instructions in BACEN Circular Letter 3,706, of May 5, 2015, ITAÚ UNIBANCO HOLDING CONSOLIDATED has sent the Leverage Ratio monthly to BACEN, whose minimum requirement is 3%.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.78 Note 20 – Supplementary information a) Insurance policy—ITAÚ UNIBANCO HOLDING PRUDENTIAL, despite the reduced risk exposure due to the low physical concentration of its assets, has a policy of insuring valuables and assets at amounts considered sufficient to cover possible losses. c) Agreements for offsetting and settlement of liabilities within the scope of the National Financial System Offset agreements are in force in relation to derivative contracts, as well as agreements for the offsetting and settlement of receivables and payables pursuant to CMN Resolution 3,263, of February 24, 2005, the purpose of which is to enable the offsetting of credits and debits with the same counterparty, and where the maturity dates of receivables and payables can be brought forward to the date of an event of default by one of the parties or in the event of bankruptcy of the debtor. d) “Coronavirus” COVID-19 relief efforts ITAÚ UNIBANCO HOLDING PRUDENTIAL monitors the economic effects of this COVID-19 pandemic in Brazil and the other countries where it operates, which may adversely affect its Profit or Loss. At the beginning of the COVID-19 outbreak, the Institutional Crisis Management Committee was set up. The Executive Committee established an intensified agenda to manage the crisis, which is responsible for the monitoring the pandemic and its impacts on its operations, in addition to the government actions to mitigate the effects of this pandemic. In Brazil, measures were taken to mitigate the impacts caused by COVID-19 throughout 2020 and 2021, by the Federal Government, the National Monetary Council (CMN) and the Central Bank of Brazil (BACEN), particularly: i) CMN Resolution No. 4,782/20, and amendments made by CMN Resolutions No. 4,791/20 and No. 4,856/20, which established, for a determined period of time, criteria for characterization of restructuring of loan operations; ii) CMN Resolution No. 4,803/20 and Resolution No. 4,855/20, which establish criteria for measurement of the allowance for loan losses of renegotiated operations and transactions carried out under programs established to face the effects of the COVID-19 pandemic on economy; iii) CMN Resolution No. 4,838/20, which regulates the Working Capital Program for Business Preservation (CGPE), which contracting term ended in the fourth quarter of 2020; iv) CMN Resolution No. 4,846/20 which provides for loan operations for financing of payroll carried out by financial institutions, under the Emergency Employment Support Program (PESE); v) CMN Resolution No. 4,937/21 which regulates the Credit Incentive Program (PEC) established by Provisional Measure No. 1,057/21, with conditions similar to those of the CGPE and contracting term scheduled until December 31, 2021; vi) Law No. 13,999/20, and amendments made by Law No. 14,161/21, that instituted the National Support Program for Micro and Small Companies (PRONAMPE) with the purpose of developing and strengthening small businesses; vii) Law No. 14,042/20 that established the Emergency Program for Access to Credit (PEAC), with the purpose of making easier the access to credit and preserving companies, for the protection of jobs and income. The PEAC has two modalities: Emergency Program for Access to Credit in the modality of guarantee (PEAC-FGI) and Emergency Program for Access to Credit in the modality guarantee of receivables (PEAC-Maquininha); b) Foreign currency – The balances in Reais linked to the foreign currencies were as follows: 12/31/2021 12/31/2020 46,438 38,739 (55,111) (82,241) Net foreign exchange position (8,673) (43,502) The net foreign exchange position, considering the tax effects on the net balance of other assets and liabilities indexed to foreign currencies, reflects the low exposure to exchange variations. Permanent foreign investments Net amount of other assets and liabilities indexed to foreign currency, including derivatives

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.79 viii) Law No. 14,148/21 which established the Emergency Program for the Recovery of the Events Sector (PERSE), which aims at creating conditions for the events sector to mitigate losses arising from the state of calamity and the Guarantee Program for Critical Sectors (PGSC), guaranteeing loan operations contracted within 180 days after the law becomes effective; and ix) BACEN Circular No. 3,990/20 and amendments made by BACEN Circular 3,992/20 which permits to carry out repurchase agreements in foreign currency by BACEN; ITAÚ UNIBANCO HOLDING PRUDENTIAL identified the following impacts on its results, as well as effects on estimates and critical judgments for the preparation of the Consolidated Financial Statements: (a) increase in 2020 and 2021 in loan and financing operations, especially for micro, small and mediumsized companies due to the measures adopted for mitigation of the impacts of COVID-19 by the authorities with the creation of programs such as PESE, PRONAMPE, PEAC-FGI and CGPE, which balance in December 2021 is R$ 21,492. Through timely monitoring of credit standards and behavior of clients, ITAÚ UNIBANCO HOLDING PRUDENTIAL maintained the regularity of its operations, despite the adverse conditions, and helped clients in the sustainable search for their financial rebalancing; (b) with the purpose of treating indebtedness in a structured way and giving financial impetus to clients, initiatives were established that allowed the extension of grace periods, terms and better interest rate conditions for individuals, and micro and small business clients. In December 2021 this portfolio amount to R$ 31.1 billion. In March 2020, the Program 60+ was established, which, among other measures, allowed a 60-day grace period for defaulting agreements and in mid-April the Travessia (Crossing) Program. Travessia allowed the extension of grace periods between 120 and 180 days and terms of operations between 5 and 6 years, respectively, for individual and micro and small companies clients, under better interest rate conditions; (c) 5.4% decrease at the current period in applications of renegotiation and extension of terms for loan operations as the economic situation changed. In December 2021, 80.1% of the loan operations portfolio generated by means of these initiatives was current, 1.8% was in a grace period, 6.5% was past due between 15 and 90 days and 11.6% was past due for over 90 days; (d) the allowance for loan losses in the amount of R$ 49,482 was affected due to the level of risk and default, due to the changes in the financial perspectives of clients and the visible deterioration of macroeconomic variables. To fully reflect the risk of its loan operations, ITAÚ UNIBANCO HOLDING PRUDENTIAL adopts the expected loss model for provisioning of operations since the moment they are granted and it is periodically updated according to the macroeconomic variables and circumstances of the client, and in 2020, in view of the pandemic, a weighting in the economic scenarios was added. In December 2021, the level of coverage of provisions in the loan portfolio of ITAÚ UNIBANCO HOLDING PRUDENTIAL accounted for 241% as compared to 320% in December 2020. Specifically for the expected loss of operations that have not shown any signs of deterioration so far (default or downgrading of the client’s rating), provisioning presented a decrease of 16.9% at the current period. The credit risk governance allowed ITAÚ UNIBANCO HOLDING PRUDENTIAL a quick response for monitoring the impacts of the COVID-19 pandemic on the loan portfolio, permitting quick access to the information needed for discussions and actions of the crisis management daily forums; (e) the mark-to-market component of the securities portfolio was -2.0% in the first quarter of 2020, partially due to rate fluctuations and high price volatility in the markets in the beginning of the pandemic, influencing the measurement of items stated at fair value in their different levels. In subsequent periods, variations observed in the mark-to-market component are not necessarily related to the effects of the pandemic; (f) due to the COVID-19 pandemic, during 2020, the instability in the variable income market was noted causing a migration to fixed income instruments with liquidity. This movement resulted in the increase in the Bank Deposit Certificates portfolio; however, over 2021, variation in the portfolio was noted, with changes not necessarily related to the effects of the pandemic. With the purpose of mitigating the system’s liquidity risk, BACEN made available in 2020 to financial institutions credit lines through repurchase agreements in foreign currency and purchase of financial bills with guarantee, and operations in the total amount of R$ 30,547 were contracted during the period of life of these lines; and (g) increase in the recognition of deferred income tax and social contribution in 2020 due to the greater volume of deductible temporary differences recorded for the period. The pandemic reduced the projections of taxable income, however, it was not responsible for the generation of tax loss and social contribution loss carryforwards in ITAÚ UNIBANCO HOLDING PRUDENTIAL. In the period, there were no significant impacts of the pandemic in the recognition of deferred income tax and social contribution in ITAÚ UNIBANCO HOLDING PRUDENTIAL.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.80 There was a reduction in the face-to-face service staff and an increase in the spacing between people in call centers to reduce the circulation of people and the possibilities of contagion. The average number of people circulating in administrative centers was reduced, since they started to work remotely. Employees in the central management, service centers and digital branches are substantially working from home. It should be noted that despite the aforementioned measures, ITAÚ UNIBANCO HOLDING PRUDENTIAL maintains its operating activities. In order to reduce the effects of the crisis and ensure the employee’s health and safety, self-declaration was encouraged for employees who consider themselves at risk and those who cannot work remotely were put on vacation. In 2020, with the purpose of supporting those who possibly had additional expenses due to the current crisis, the 13th salary was advanced in full. Additionally, a process of communication and transparency with employees was established through e-mails, internal employee’s portal and periodic videos prepared by our Chief Executive Officer communicating news related to COVID-19. At the branches, masks were delivered to all employees who work in customer service, acrylic protections were implemented and cleaning protocols were reviewed. The adaptation of ITAÚ UNIBANCO HOLDING PRUDENTIAL in the crisis is the result not only of investments in technology, which allows for these virtual interactions, but also of investments in flexibility in the work environment, such as work from home, communities integrated between different areas of the bank and new layouts in the administrative centers that promote the employees’ mobility. In 2020, ITAÚ UNIBANCO HOLDING CONSOLIDATED created the initiative “Todos pela Saúde” (All for Health) from the donation of R$ 1 billion, with the purpose of combating the new Coronavirus and its effects on Brazilian society. “Todos Pela Saúde” is conducted based on four axes: Informing, Protecting, Caring, and Resuming. In February 2021, the “Todos pela Saúde” initiative was formalized as an Institute, and ongoing actions are being maintained. The mission of the “Todos pela Saúde” Institute is to contribute to strengthening and innovation in the health surveillance area in Brazil. The activities to be developed include both research funding and genomic (or metagenomic) surveys, in addition to the training of field epidemiologists. In April 2021, ITAÚ UNIBANCO HOLDING CONSOLIDATED worked together with competitors to combat hunger resulting from the pandemic and the economic crisis. ITAÚ UNIBANCO HOLDING CONSOLIDATED contributed for the purchase and distribution of food staples.

Itaú Unibanco Holding S.A. – Prudencial Financial Statements – December 31, 2021 4.81 e) 01/01 to 12/31/2021 01/01 to 12/31/2020 Regulatory non-recurring result (1,307) 1,340 Provision for restructuring (747) (220) Gain on the partial disposal of interest in XP INC—3,193 Mark to market of collateralized securities—(1,031) Donation to “Todos pela Saúde” (“All for Health”)—(834) Reclassification—Investment IRB—379 Increase in the rate Social Contribution (233)—Impairment, provision for property return and amortization (445)—Impairment of goodwill and intangible assets – Itaú CorpBanca—(19) Other 118 (128) f) Subsequent event Regulatory non-recurring result Presentation of regulatory non-recurring result of ITAÚ UNIBANCO HOLDING PRUDENTIAL, net of tax effects, in accordance with the criteria established by BCB Resolution No. 2/2020: Acquisition of Ideal Holding Financeira S.A. On January 13, 2022, ITAÚ UNIBANCO HOLDING PRUDENTIAL entered into a purchase and sale agreement of up to 100% of capital of Ideal Holding Financeira S.A. (IDEAL). The purchase will be carried out in three phases over five years. In the first phase, ITAÚ UNIBANCO HOLDING PRUDENTIAL will acquire 50.1% of IDEAL’s total voting capital for approximately R$ 650, then holding the company’s control. In the second phase, after five years, ITAÚ UNIBANCO HOLDING PRUDENTIAL may exercise the right to purchase the remaining ownership interest, in order to reach 100% of IDEAL’s capital. IDEAL is a 100% digital broker and currently offers electronic trading and DMA (direct market access) solutions, within a flexible and cloud-based platform. The management and development of IDEAL’s business will continue to be autonomous in relation to ITAÚ UNIBANCO HOLDING PRUDENTIAL, according to the terms and conditions of the Shareholders’ Agreement for this transaction and ITAÚ UNIBANCO HOLDING PRUDENTIAL will not have exclusivity in the provision of services. The effective acquisitions and financial settlements will occur after the required regulatory approvals. .

(A free translation of the original in Portuguese) www.pwc.com.br Corporativo | Interno Itaú Unibanco Holding S.A. and subsidiaries—Prudential Conglomerate Financial statements at December 31, 2021 and independent auditor’s report

PricewaterhouseCoopers, Av. Francisco Matarazzo 1400, Torre Torino, São Paulo, SP, Brasil 05001-903, Caixa Postal 61005 T: (11) 3674-2000, www.pwc.com/br 2 Corporativo | Interno (A free translation of the original in Portuguese) Independent auditor’s report on the consolidated financial statements of the Prudential Conglomerate To the Board of Directors and Stockholders Itaú Unibanco Holding S.A. Opinion We have audited the accompanying consolidated financial statements of the Prudential Conglomerate of Itaú Unibanco Holding S.A. (the “Bank”), which comprise the prudential consolidated balance sheet as at December 31, 2021 and the prudential consolidated statements of income, comprehensive income, changes in stockholders’ equity and cash flows for the six-month period and year then ended, and notes to the financial statements, including significant accounting policies and other explanatory information. These special purpose consolidated financial statements were prepared in accordance with specified procedures as established in Resolution 4,280, from October 31, 2013, issued by National Monetary Council (CMN), and supplementary regulations of the Brazilian Central Bank (BACEN), described in Note 2—“Presentation of the Consolidated Financial Statements”. In our opinion, the consolidated financial statements of the Prudential Conglomerate referred to above present fairly, in all material respects, the consolidated financial position of the Prudential Conglomerate of Itaú Unibanco Holding S.A. as at December 31, 2021, and the consolidated financial performance and cash flows for the six-month period and year then ended, in accordance with the provisions for the preparation of consolidated financial statements of prudential conglomerates established by Resolution 4,280 of the CMN and supplementary regulations of BACEN, for the preparation of these special purpose consolidated financial statements, as described in the Notes 2—“Presentation of the Consolidated Financial Statements” and 3—“Significant Accounting Policies” to the consolidated financial statements. Basis for opinion We conducted our audit in accordance with Brazilian and International Standards on Auditing. Our responsibilities under those standards are further described in the “Auditor’s responsibilities for the audit of the consolidated financial statements”. We are independent of the Bank and of its subsidiaries in accordance with the ethical requirements established in the Accountant’s Code of Professional Ethics and Professional Standards issued by the Brazilian Federal Accounting Council, and we have fulfilled other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our audit opinion.

PricewaterhouseCoopers, Av. Francisco Matarazzo 1400, Torre Torino, São Paulo, SP, Brasil 05001-903, Caixa Postal 61005 T: (11) 3674-2000, www.pwc.com/br 2 Corporativo | Interno (A free translation of the original in Portuguese) Independent auditor’s report on the consolidated financial statements of the Prudential Conglomerate To the Board of Directors and Stockholders Itaú Unibanco Holding S.A. Opinion We have audited the accompanying consolidated financial statements of the Prudential Conglomerate of Itaú Unibanco Holding S.A. (the “Bank”), which comprise the prudential consolidated balance sheet as at December 31, 2021 and the prudential consolidated statements of income, comprehensive income, changes in stockholders’ equity and cash flows for the six-month period and year then ended, and notes to the financial statements, including significant accounting policies and other explanatory information. These special purpose consolidated financial statements were prepared in accordance with specified procedures as established in Resolution 4,280, from October 31, 2013, issued by National Monetary Council (CMN), and supplementary regulations of the Brazilian Central Bank (BACEN), described in Note 2—“Presentation of the Consolidated Financial Statements”. In our opinion, the consolidated financial statements of the Prudential Conglomerate referred to above present fairly, in all material respects, the consolidated financial position of the Prudential Conglomerate of Itaú Unibanco Holding S.A. as at December 31, 2021, and the consolidated financial performance and cash flows for the six-month period and year then ended, in accordance with the provisions for the preparation of consolidated financial statements of prudential conglomerates established by Resolution 4,280 of the CMN and supplementary regulations of BACEN, for the preparation of these special purpose consolidated financial statements, as described in the Notes 2—“Presentation of the Consolidated Financial Statements” and 3—“Significant Accounting Policies” to the consolidated financial statements. Basis for opinion We conducted our audit in accordance with Brazilian and International Standards on Auditing. Our responsibilities under those standards are further described in the “Auditor’s responsibilities for the audit of the consolidated financial statements”. We are independent of the Bank and of its subsidiaries in accordance with the ethical requirements established in the Accountant’s Code of Professional Ethics and Professional Standards issued by the Brazilian Federal Accounting Council, and we have fulfilled other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our audit opinion.

4 Corporativo | Interno In preparing the consolidated financial statements, management is responsible for assessing the Bank’s ability to continue as going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless management either intends to liquidate the Bank or to cease operations, or has no realistic alternative but to do so. Those charged with governance in the Bank are responsible for overseeing the financial reporting process for the preparation of the consolidated financial statements of the Prudential Conglomerate. Auditor’s responsibilities for the audit of the consolidated financial statements Our objectives are to obtain reasonable assurance about whether the consolidated financial statements of the Prudential Conglomerate, prepared in accordance with Resolution 4,280 of CMN, and supplementary regulations of BACEN, as a whole, are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that the audit conducted in accordance with the Brazilian and International Standards on Auditing will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these consolidated financial statements. As part of an audit in accordance with Brazilian and International Standards on Auditing, taking into consideration the NBC TA 800 (Special Conditions – Audit Financial Statements in accordance with special purpose accounting conceptual structures), we exercise professional judgment and maintain professional skepticism throughout the audit. We also: • Identify and assess the risks of material misstatement of the consolidated financial statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control. • Obtain an understanding of internal controls relevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the internal controls of the Bank and its subsidiaries. • Evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by management. • Conclude on the appropriateness of management’s use of the going concern basis of accounting and, based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Bank’s ability to continue as going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor’s report to the related disclosures in the consolidated financial statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor’s report. However, future events or conditions may cause the Bank to cease to continue as going concern.

5 Corporativo | Interno • Evaluate the overall presentation, structure and content of the consolidated financial statements, including the disclosures, and whether the consolidated financial statements represent the underlying transactions and events in a manner that achieves fair presentation. • Obtain sufficient appropriate audit evidence regarding the financial information of associates and joint ventures to express an opinion on the Bank’s financial statements. We are responsible for the direction, supervision and performance of the audit, considering these investees. We remain solely responsible for our audit opinion. We communicate with those charged with governance regarding, among other things, the scope and timing of planned audit engagements and significant audit findings, including significant deficiencies in internal controls that may have been identified during our engagements. São Paulo, February 25, 2022 PricewaterhouseCoopers Auditores Independentes Ltda. CRC 2SP000160/O-5 Emerson Laerte da Silva Contador CRC 1SP171089/O-3