Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Genomic Health, Inc. 2005 Stock Incentive Plan, of our reports dated March 12, 2015, with respect to the consolidated financial statements of Genomic Health, Inc. and the effectiveness of internal control over financial reporting of Genomic Health, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2014, filed with the Securities and Exchange Commission.

/s/ ERNST & YOUNG LLP

Redwood City, CA

November 5, 2015