Warrants (Details) - $ / shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Warrants
Number of securities to each class of warrant (in shares)	3,057,560
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	681,614
Warrants Exercised (in shares)	(165,000)	(3,057,560)
Warrants Expired (in shares)	(16,506)
Balance at end of the period (in shares)	500,108	681,614
Exercise price $2,587.50
Warrants
Warrant exercise price (in dollars per share)	$ 2,587.50
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	430
Warrants Expired (in shares)	(430)
Balance at end of the period (in shares)		430
Exercise price $1,107
Warrants
Warrant exercise price (in dollars per share)	$ 1,107.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	14,187
Warrants Expired (in shares)	(14,187)
Balance at end of the period (in shares)		14,187
Exercise price $2,25 expiring July 2021
Warrants
Warrant exercise price (in dollars per share)	$ 2.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	26
Balance at end of the period (in shares)	26	26
Exercise price $24 expiring December 2022
Warrants
Warrant exercise price (in dollars per share)	$ 24.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	26,189
Balance at end of the period (in shares)	26,189	26,189
Exercise price $211.50
Warrants
Warrant exercise price (in dollars per share)	$ 211.50
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	333
Warrants Expired (in shares)	(333)
Balance at end of the period (in shares)		333
Exercise price $317.25
Warrants
Warrant exercise price (in dollars per share)	$ 317.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	556
Warrants Expired (in shares)	(556)
Balance at end of the period (in shares)		556
Exercise price $116.8425
Warrants
Warrant exercise price (in dollars per share)	$ 116.8425
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	1,000
Warrants Expired (in shares)	(1,000)
Balance at end of the period (in shares)		1,000
Exercise price $2.25 no expiration
Warrants
Warrant exercise price (in dollars per share)	$ 2.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	3,522
Balance at end of the period (in shares)	3,522	3,522
Exercise price $24.00
Warrants
Warrant exercise price (in dollars per share)	$ 24.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	120,407
Balance at end of the period (in shares)	120,407	120,407
Exercise price $2.25 II
Warrants
Warrant exercise price (in dollars per share)	$ 2.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	4,974
Balance at end of the period (in shares)	4,974	4,974
Exercise price $30.00
Warrants
Warrant exercise price (in dollars per share)	$ 30.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	7,306
Balance at end of the period (in shares)	7,306	7,306
Exercise price $3.00
Warrants
Warrant exercise price (in dollars per share)	$ 3.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	409,500
Warrants Exercised (in shares)	(165,000)
Balance at end of the period (in shares)	244,500	409,500
Exercise price $6.54375
Warrants
Warrant exercise price (in dollars per share)	$ 6.54375
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	16,953
Balance at end of the period (in shares)	16,953	16,953
Exercise price $6.75450
Warrants
Warrant exercise price (in dollars per share)	$ 6.75450
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	46,263
Balance at end of the period (in shares)	46,263	46,263
Exercise price $6.77850
Warrants
Warrant exercise price (in dollars per share)	$ 6.77850
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	29,968
Balance at end of the period (in shares)	29,968	29,968