EXHIBIT 21.1

SUBSIDIARIES OF PROASSURANCE CORPORATION

PRA Professional Liability Group, Inc. (Delaware)

ProAssurance Indemnity Company, Inc. (Alabama)

ProAssurance American Mutual, A Risk Retention Group (District of Columbia)⁽¹⁾ 

ProAssurance Casualty Company (Michigan)

ProAssurance Specialty Insurance Company, Inc. (Alabama)

ProAssurance General Insurance Company, Ltd. (Bermuda)

ProAssurance Insurance Company of America (Illinois)⁽²⁾ 

ProAssurance Mid-Continent Underwriters, Inc. (Texas)

IAO, Inc. (Alabama)

PRA Group Holdings, Inc. (Delaware)

PRA Services Corporation (Michigan)

Medmarc Casualty Insurance Company (Vermont)

Hamilton Resources Corporation (Delaware)

Noetic Specialty Insurance Company (Vermont)

PRACCL, Ltd. (United Kingdom)

PRA Corporate Capital, Ltd. (United Kingdom)

ProAssurance Group Services Corporation (Alabama)    

Eastern Insurance Holdings, Inc. (Pennsylvania)

Eastern Re Ltd, S.P.C. (Cayman Islands)

Inova Re Ltd, S.P.C. (Cayman Islands)

Eastern Advantage Assurance Company (Pennsylvania)

Allied Eastern Indemnity Company (Pennsylvania)

Eastern Alliance Insurance Company (Pennsylvania)

⁽¹⁾ Organized on January 1, 2015 by PRA Indemnity. PRA Indemnity officers currently serve as the Risk Retention Group’s (RRG) directors. PRA Indemnity provides all necessary services for the RRG and is the primary capital provider through a $10 million surplus note.

⁽²⁾ Effective December 31, 2019, PACO Assurance Company, Inc. merged into ProAssurance Insurance Company of America, formerly known as Podiatry Insurance Company of America.