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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001209191-10-033715.txt : 20100610
<SEC-HEADER>0001209191-10-033715.hdr.sgml : 20100610
<ACCEPTANCE-DATETIME>20100610201454
ACCESSION NUMBER:		0001209191-10-033715
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100608
FILED AS OF DATE:		20100610
DATE AS OF CHANGE:		20100610

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			WIELAND R RICHARD
		CENTRAL INDEX KEY:			0001126558

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34540
		FILM NUMBER:		10891431

	MAIL ADDRESS:	
		STREET 1:		C/O MEDICHEM LIFE SCIENCES INC
		STREET 2:		12305 SOUTH NEW AVENUE
		CITY:			LEMONT
		STATE:			IL
		ZIP:			60439

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Unilife Corp
		CENTRAL INDEX KEY:			0001476170
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				271049354
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
		BUSINESS PHONE:		(717)938-9323

	MAIL ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c02181_4x0.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-06-08</periodOfReport>

    <issuer>
        <issuerCik>0001476170</issuerCik>
        <issuerName>Unilife Corp</issuerName>
        <issuerTradingSymbol>UNIS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001126558</rptOwnerCik>
            <rptOwnerName>WIELAND R RICHARD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 633 LOWTHER ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LEWISBERRY</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>17339</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-06-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>80000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>80000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5.28</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2010-06-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>240000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-06-08</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>240000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>240000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">20,000 shares will vest on the third trading day after the release of earnings for the fiscal quarter which includes the first anniversary of the grant date.  20,000 shares will vest on the third trading day after the release of earnings for the fiscal quarter which includes the second anniversary of the grant date.  40,000 shares will vest on the third trading day after the release of earnings for the fiscal quarter which includes the third anniversary of the grant date.</footnote>
        <footnote id="F2">Not applicable</footnote>
        <footnote id="F3">60,000 options to purchase common stock will vest upon the Company's market capitalization reaching $500 million or more for 20 consecutive trading days.  60,000 options to purchase common stock will vest upon the Company's market capitalization reaching $750 million or more for 20 consecutive trading days.  60,000 options to purchase common stock will vest upon the Company's market capitalization reaching $1,250 million or more for 20 consecutive trading days.  60,000 options to purchase common stock will vest upon the Company's market capitalization reaching $1,500 million or more for 20 consecutive trading days.</footnote>
    </footnotes>

    <remarks>Chief Financial Officer and Executive Vice President</remarks>

    <ownerSignature>
        <signatureName>/s/ Deborah Karlak, as Attorney-in-Fact</signatureName>
        <signatureDate>2010-06-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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