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Collaboration and License Agreements - Additional Information 6 (Detail) (USD $)
1 Months Ended 3 Months Ended 9 Months Ended
Jun. 30, 2010
Sep. 30, 2014
Sep. 30, 2013
Sep. 30, 2014
Sep. 30, 2013
Dec. 31, 2013
License And Collaboration Agreements [Line Items]            
Deferred revenue included in current liabilities   $ 15,617,000   $ 15,617,000   $ 20,267,000
Deferred revenue included in long-term liabilities   19,052,000   19,052,000   7,136,000
Green Cross [Member]
           
License And Collaboration Agreements [Line Items]            
Collaboration agreement date       June 2010    
Term of the agreement       2020-06    
Non-refundable upfront payment 1,000,000          
Additional clinical, regulatory and sales milestone payments       1,300,000    
Recognized revenue under agreement   112,500 25,000 1,600,000 75,000  
Milestones achieved   0 0 0 0  
Deferred revenue           650,000
Unbilled receivable balance   412,500   412,500    
Deferred revenue included in current liabilities           100,000
Deferred revenue included in long-term liabilities           550,000
Green Cross [Member] | Maximum [Member]
           
License And Collaboration Agreements [Line Items]            
Aggregate potential future cost reimbursement       5,500,000    
Clinical milestone payments   $ 2,500,000   $ 2,500,000