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Collaboration and License Agreements - Additional Information 5 (Detail) (USD $)
1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2014
Dec. 31, 2013
Oct. 31, 2010
Pfizer [Member]
Molecule
Sep. 30, 2013
Pfizer [Member]
Sep. 30, 2014
Pfizer [Member]
Program
Sep. 30, 2013
Pfizer [Member]
License And Collaboration Agreements [Line Items]            
Collaboration agreement date         October 2010  
Period of agreement         3 years  
Commercialization of molecules     2      
Non-refundable upfront payment     $ 5,000,000      
Clinical milestone payments         17,000,000  
Sales milestone payments         195,000,000  
DART program         1  
Research obligation completion date         2014-01  
Recognized revenue under agreement       900,000   3,200,000
Deferred revenue $ 15,617,000 $ 20,267,000     $ 0