CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenues:
Revenues	$ 13,136	$ 26,007	$ 37,632	$ 37,108
Costs and expenses:
Cost of product sales	258	180	371	228
Cost of manufacturing services	919	2,222	4,329	2,222
Research and development	43,229	51,744	89,101	113,182
Selling, general and administrative	13,692	13,669	27,219	29,922
Total costs and expenses	58,098	67,815	121,020	145,554
Loss from operations	(44,962)	(41,808)	(83,388)	(108,446)
Gain on modification of debt	100,930	0	100,930	0
Interest and other income	2,275	504	3,348	699
Interest expense	(774)	0	(1,430)	0
Net loss	57,469	(41,304)	19,460	(107,747)
Other comprehensive income (loss):
Unrealized loss on investments	(80)	(43)	(67)	(265)
Comprehensive income (loss)	$ 57,389	$ (41,347)	$ 19,393	$ (108,012)
Net income (loss) per common share:
Basic net loss per common share (in usd per share)	$ 0.93	$ (0.67)	$ 0.31	$ (1.76)
Diluted net loss per common share (in usd per share)	$ 0.92	$ (0.67)	$ 0.31	$ (1.76)
Weighted average common shares outstanding:
Basic weighted average common shares outstanding (in shares)	61,880,096	61,384,943	61,845,151	61,354,721
Diluted weighted average common shares outstanding (in shares)	62,261,646	61,384,943	62,030,710	61,354,721
Collaborative and other agreements
Revenues:
Revenues	$ 6,021	$ 16,863	$ 22,708	$ 23,956
Product sales, net
Revenues:
Revenues	5,062	4,672	8,552	8,252
Government agreements
Revenues:
Revenues	466	480	749	908
Contract Manufacturing
Revenues:
Revenues	1,587	3,992	5,202	3,992
RevenueFromRoyalityAgreementsMember
Revenues:
Revenues	$ 0	$ 0	$ 421	$ 0