CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Revenues	$ 151,941	$ 77,447	$ 104,883
Costs and expenses:
Cost of product sales	3,351	2,651	0
Research and development	207,026	214,577	193,201
Selling, general and administrative	58,949	63,014	42,742
Total costs and expenses	273,359	280,242	235,943
Loss from operations	(121,418)	(202,795)	(131,060)
Other income	1,660	680	1,321
Net loss	(119,758)	(202,115)	(129,739)
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax	56	(54)	(23)
Other comprehensive income (loss):
Comprehensive loss	$ (119,702)	$ (202,169)	$ (129,762)
Basic weighted average number of common shares outstanding (in shares)	61,433,124	59,944,717	52,442,389
Diluted weighted average number of common shares outstanding (in shares)	61,433,124	59,944,717	52,442,389
Cost of manufacturing services	$ 4,033	$ 0	$ 0
Earnings Per Share, Basic	$ (1.95)	$ (3.37)	$ (2.47)
Earnings Per Share, Diluted	$ (1.95)	$ (3.37)	$ (2.47)
Revenue from collaborative agreements
Revenues:
Revenues	$ 119,303	$ 63,294	$ 97,764
Revenue from government agreements
Revenues:
Revenues	1,923	1,804	7,119
Product
Revenues:
Revenues	16,727	12,349	0
Contract Manufacturing
Revenues:
Revenues	$ 13,988	$ 0	$ 0