Potential Development and Regulatory Milestone Payments Under Agreement

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- Definition

Right of Use asset and Lease Liability Increase

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No definition available.

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- Definition

Amount of lease cost recognized by lessee for lease contract.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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- Definition

Discount rate used by lessee to determine present value of operating lease payments.

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- Definition

Amount of lessee's undiscounted obligation for lease payment for operating lease.

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- Definition

Amount of lessee's undiscounted obligation for lease payment for operating lease due after fifth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).

+ References

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- Definition

Amount of lessee's undiscounted obligation for lease payment for operating lease to be paid in next fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).

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- Definition

Amount of lessee's undiscounted obligation for lease payment for operating lease to be paid in fifth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).

+ References

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- Definition

Amount of lessee's undiscounted obligation for lease payment for operating lease to be paid in fourth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).

+ References

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- Definition

Amount of lessee's undiscounted obligation for lease payment for operating lease to be paid in third fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).

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Amount of lessee's undiscounted obligation for lease payment for operating lease to be paid in second fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).

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- Definition

Amount of lessee's undiscounted obligation for lease payments in excess of discounted obligation for lease payments for operating lease.

+ References

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- Definition

Term of lessee's operating lease renewal, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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- Definition

Amount of single lease cost, calculated by allocation of remaining cost of lease over remaining lease term. Includes, but is not limited to, single lease cost, after impairment of right-of-use asset, calculated by amortization of remaining right-of-use asset and accretion of lease liability.

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- Definition

Present value of lessee's discounted obligation for lease payments from operating lease.

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- Definition

Amount of cash outflow from operating lease, excluding payments to bring another asset to condition and location necessary for its intended use.

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Amount of lessee's right to use underlying asset under operating lease.

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- Definition

Weighted average remaining lease term for operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Amount of sublease income excluding finance and operating lease expense.

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Amount of variable lease cost, excluded from lease liability, recognized when obligation for payment is incurred for finance and operating leases.

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Commitments and Contingencies (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Jan. 31, 2022
Lessee, Lease, Description [Line Items]
Right of Use asset and Lease Liability Increase	$ 14,000
Operating lease payments	6,900	$ 6,700
Operating lease, ROU Assets	27,335	16,614
Operating lease cost	5,597	5,613
Variable lease cost	1,451	960
Sublease Income	(1,076)	(814)
Lease, Cost	5,972	$ 5,759
2023	4,999
2024	4,004
2025	5,084
2026	4,209
2027	4,927
Thereafter	52,053
Lessee, Operating Lease, Liability, Payments, Due	75,276
Lessee, Operating Lease, Liability, Undiscounted Excess Amount	(40,444)
Operating lease liabilities	$ 34,832
Weighted average lease term (in years)	11 years 1 month 6 days	5 years 1 month 6 days
Discount rate	12.00%	9.70%
Research and development	$ 207,026	$ 214,577	$ 193,201
Minimum
Lessee, Lease, Description [Line Items]
Lease renewal term (in years)	5 years
Synaffix B.V.
Lessee, Lease, Description [Line Items]
Potential development and regulatory milestone payments				$ 585,000
Research and development	$ 1,000