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Leases
 12 Months Ended
Dec. 31, 2021
Leases [Abstract]  
Leases Leases    
The Company has non-cancelable operating leases for manufacturing, laboratory, office and warehouse space in Maryland and a non-cancelable operating lease for laboratory and office space in California. A portion of the space under one of these leases is subleased to a third party. All of these leases include one or more options to renew, with those renewal periods ranging from five to fourteen years.
The table below presents supplemental balance sheet information related to operating leases:
December 31,
20212020
Weighted-average remaining lease term (in years)5.15.9
Weighted-average discount rate9.7 %9.7 %
During the years ended December 31, 2021 and 2020, the Company made cash payments for operating leases of $6.7 million and $5.9 million, respectively. As of December 31, 2021 and 2020, the Company’s ROU assets were valued at $16.6 million and $19.3 million, respectively, and are included in other non current assets on the consolidated balance sheet.
The components of lease cost for the years ended December 31, 2021 and 2020 were as follows (in thousands):
December 31,
20212020
Operating lease cost
$5,613 $5,410 
Variable lease cost960 1,083 
Sublease income
(814)(770)
Net lease cost$5,759 $5,723 
As of December 31, 2021, the maturities of the Company’s operating lease liabilities were as follows (in thousands):
20226,940 
20236,796 
20245,856 
20255,084 
20264,210 
Thereafter3,554 
Total lease payments32,440 
Less: imputed interest(6,972)
Total lease liabilities$25,468