Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020
Cash flows from operating activities:
Net loss	$ (208,076)	$ (202,735)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	42,007	33,632
Loss on disposal of property, plant and equipment	639	650
Unrealized gain on equity investments	(2,486)	333
Deferred tax benefit	(244,509)	(3,165)
Stock-based compensation	133,577	69,599
Post-combination expense for acceleration of unvested equity	80,960	0
Realized gain on preferred stock investment	(30,500)	0
Loss on settlement of convertible notes	0	50,819
Amortization of deferred financing costs, convertible note debt discount and issuance costs, and other liabilities	3,282	(32)
Amortization of premium on short-term investments	1,616	503
Amortization of acquired intangible assets	47,014	46,769
Asset acquisition IPR&D expense	85,337	0
Remeasurement of contingent consideration	9,201	0
Non-cash lease expense	11,837	6,860
Changes in assets and liabilities:
Accounts receivable, net	8,995	(30,644)
Inventory, net	4,267	(20,260)
Operating lease liabilities	(7,095)	(4,997)
Accounts payable and accrued liabilities	27,138	(47,587)
Other assets and liabilities	(94)	43,558
Net cash used in operating activities	(36,890)	(56,697)
Cash flows from investing activities:
Purchases of marketable securities	(915,289)	(640,085)
Maturities and sales of marketable securities	325,380	268,483
Purchases of property, plant and equipment	(37,504)	(34,244)
Business combination, net of cash acquired	(415,549)	(6,654)
Asset acquisition	(58,073)	0
Investments in privately held companies	(10,000)	0
Other investing activities	(244)	273
Net cash used in investing activities	(1,111,279)	(412,227)
Cash flows from financing activities:
Proceeds from issuance of convertible notes, net	0	1,125,547
Proceeds from exercise of common stock options	11,617	10,938
Proceeds in connection with the Company’s employee stock purchase plan	12,038	9,799
Payments on settlement of convertible notes	0	(150,054)
Other financing activities	(3,068)	(626)
Net cash provided by financing activities	20,587	995,604
Net increase (decrease) in cash, cash equivalents and restricted cash	(1,127,582)	526,680
Cash, cash equivalents and restricted cash, beginning of period	1,491,594	177,528
Cash, cash equivalents and restricted cash, end of period	364,012	704,208
Supplemental disclosure of non-cash investing and financing activities:
Property, plant and equipment acquired but not paid	15,139	8,684
Unrealized gain (loss) on available-for-sale investments, before tax	(629)	1,564
Issuance of 162,606 and 136,559 shares of common stock to fund the Company’s 401(k) matching contribution for 2020 and 2019, respectively	22,934	12,007
Issuance of 9,510,436 and 382,947 shares of common stock for business combinations and asset acquisition for 2021 and 2020, respectively	1,271,022	28,597
Business combination contingent consideration liability	350,348	0
Supplemental disclosure of cash flow information:
Interest paid	$ 5,414	$ 3,908