8-K

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of

the Securities Exchange Act of 1934

Date of report (Date of earliest event reported):  April 23, 2003

EXACT SCIENCES CORPORATION

(Exact Name of Registrant as Specified in Its Charter)

Delaware

(State or Other Jurisdiction of Incorporation)

000-32179	02-0478229
(Commission File Number)	(IRS Employer Identification No.)
63 Great Road, Maynard, Massachusetts	01754
(Address of Principal Executive Offices)	(Zip Code)

Registrant’s telephone number, including area code:  (978) 897-2800

ITEM 5.  OTHER EVENTS.

On April 23 2003, EXACT Sciences Corporation issued a press release, a copy of which is being filed as Exhibit 99.1 to this Current Report on Form 8-K, such press release being incorporated herein by reference.

ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS

(c) Exhibits

99.1         Press Release dated April 23, 2003.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	EXACT Sciences Corporation
April 24, 2003	By:	/s/  John A. McCarthy, Jr.
		John A. McCarthy, Jr.
		Executive Vice President, Chief
		Operating Officer, Chief Financial
		Officer and Treasurer

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EXHIBIT INDEX

Exhibit Number	Description
99.1	Press Release dated April 23, 2003.

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EX-99.1

Exhibit 99.1

Maynard, Mass. – April 23, 2003 – EXACT Sciences Corporation (NASDAQ: EXAS) announced today that it will host a conference call for its first quarter 2003 financial and operating results on Tuesday, April 29, 2003 at 8:30 a.m. EDT.  A live Webcast of the conference call can be accessed at www.exactsciences.com through the Investor Relations link.  The conference call and the Webcast are open to all interested parties.  An archived version of the Webcast will be available at EXACT Sciences’ Web site, www.exactsciences.com, through the Investor Relations link, for one month.  A replay of the conference call also will be available for 48 hours, following the completion of the live call.

EXACT Sciences will announce its first quarter 2003 financial and operating results on Monday, April 28, 2003, after the close of regular market trading hours.

Information for the call is as follows:

Domestic callers:    877-809-1575

International callers:    706-679-5918

Conference ID #    9672707

The conference call replay information is as follows:

Domestic callers:    800-642-1687

International callers:    706-645-9291

Conference ID #    9672707

The webcast is also being distributed over CCBN’s Investor Distribution Network to both institutional and individual investors.  Individual investors can listen to the call through CCBN’s individual investor center at www.companyboardroom.com or by visiting any of the investor sites in CCBN’s Individual Investor Network. Institutional investors can access the call via CCBN’s password-protected event management site, StreetEvents (www.streetevents.com).

About EXACT Sciences Corporation

EXACT Sciences Corporation is an applied genomics company that has developed proprietary technologies that may be used for the early detection of several common cancers.  EXACT Sciences has selected colorectal cancer as the first application of its technologies.  Colorectal cancer is the most deadly cancer among non-smokers, and is curable if detected early.  Despite the availability of colorectal cancer screening and diagnostic tests for more than 20 years, the rate of early detection of colorectal cancer remains low.  EXACT Sciences believes its genomics-based technologies will enable early detection of colorectal cancer so that more people can be effectively treated.  Founded in 1995, EXACT Sciences is based in Maynard, Mass.  Detailed information on EXACT Sciences can be found on the World Wide Web at www.exactsciences.com.

CONTACT:

Media Contact

Amy Turner, 617/267-8223

turnera@fleishman.com

or

Investor Relations

Amy Hedison, 978/897-2800, x252

ahedison@exactsciences.com