<SEC-DOCUMENT>0000814133-13-000022.txt : 20130214
<SEC-HEADER>0000814133-13-000022.hdr.sgml : 20130214
<ACCEPTANCE-DATETIME>20130214154923
ACCESSION NUMBER:		0000814133-13-000022
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20130214
DATE AS OF CHANGE:		20130214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
		CENTRAL INDEX KEY:			0001124140
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				204782291
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-62447
		FILM NUMBER:		13613244

	BUSINESS ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719
		BUSINESS PHONE:		608-284-5700

	MAIL ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXACT CORP
		DATE OF NAME CHANGE:	20000919

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			WASATCH ADVISORS INC
		CENTRAL INDEX KEY:			0000814133
		IRS NUMBER:				870319391
		STATE OF INCORPORATION:			UT
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		150 SOCIAL HALL AVENUE
		STREET 2:		SUITE 400
		CITY:			SALT LAKE CITY
		STATE:			UT
		ZIP:			84111
		BUSINESS PHONE:		8015330777

	MAIL ADDRESS:	
		STREET 1:		150 SOCIAL HALL AVENUE
		STREET 2:		SUITE 400
		CITY:			SALT LAKE CITY
		STATE:			UT
		ZIP:			84111
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>exas213.txt
<TEXT>
SCHEDULE 13G
Amendment No. 2
Name of Issuer: Exact Sciences Corp.
Title of Class of Securities: Common Stock
CUSIP Number: 30063P105
Item 1: Reporting Person: Wasatch Advisors, Inc. 87-0319391
Item 2: Check Box If Member of Group: Not Applicable
Item 3: SEC Use
Item 4: Place of Organization: Utah
Items 5-8: Number of Shares Owned With:
Item 5: Sole Voting Power: 3,565,413
Item 6: Shared Voting Power: 0
Item 7: Sole Dispositive Power: 3,565,413
Item 8: Shared Dispositive Power: 0
Item 9: Aggregate Amount Owned: 3,565,413
Item 10: Check Box If Aggregate Amount Excludes Certain Shares: N/A
Item 11: Percent of Class Owned: 5.6%
Item 12: Type of Reporting Person: IA

Item 1(a): Name of Issuer: Exact Sciences Corp.
Item l(b): Address of Issuer:
441 Charmany Drive, Madison, WI 53719
Item 2(a): Name of Person Filing: Wasatch Advisors, Inc.
Item 2(b): Address: 150 Social Hall Avenue, Salt Lake City, UT 84111
Item 2(c): Citizenship: Not Applicable
Item 2(d): Title of Class of Securities: Common Stock
Item 2(e): CUSIP Number: 30063P105
Item 3(e): Investment Adviser registered under section 203 of the Investment
Advisers Act of 1940
Item 4(a): 	Amount Owned: 3,565,413
Item 4(b): 	Percent of Class Owned: 5.6%
Item 4(c)(i): Sole Voting Power: 3,565,413
Item 4(c)(ii): Shared Voting Power: 0
Item 4(c)(iii): Sole Dispositive Power: 3,565,413
Item 4(c)(iv): Shared Dispositive Power: 0
Item 5: Check Box If Ownership Is 5% or Less of Class: [ ]
Item 6. Ownership of More Than 5% on Behalf of Another Person: N/A
Item 7: Identification of Subsidiary: Not Applicable
Item 8: Identification of Members of Group: Not Applicable
Item 9: Notice of Dissolution of Group: Not Applicable
Item 10: Certification:
By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were acquired in the ordinary course of
business and were not acquired for the purpose of and do not have the effect
of changing or influencing the control of the issuer of such securities and
were not acquired in connection with or as a participant in any transaction
having such purpose or effect.

SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct as of December 31, 2012.
Date: 02/14/13
Signature: /s/Jeff S. Cardon
Name/Title: Jeff S. Cardon/CEO
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>