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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 QkfuzgVefe+GTAJkGjF7vFG5K+3Y3Ehxhcqzn6yl8PfJFySHrFTUIIEXPcQMB948
 rTuSiOsNtceRcj/rK4wlQw==

<SEC-DOCUMENT>9999999995-11-000128.txt : 20110112
<SEC-HEADER>9999999995-11-000128.hdr.sgml : 20110112
<ACCEPTANCE-DATETIME>20110112001517
ACCESSION NUMBER:		9999999995-11-000128
CONFORMED SUBMISSION TYPE:	EFFECT
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20110111
DATE AS OF CHANGE:		20110112
EFFECTIVENESS DATE:		20110111

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TARGACEPT INC
		CENTRAL INDEX KEY:			0001124105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		EFFECT
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-171346
		FILM NUMBER:		11524265

	BUSINESS ADDRESS:	
		STREET 1:		200 EAST FIRST STREET
		STREET 2:		SUITE 300
		CITY:			WINSTON-SALEM
		STATE:			NC
		ZIP:			27101
		BUSINESS PHONE:		3364802100

	MAIL ADDRESS:	
		STREET 1:		200 EAST FIRST STREET
		STREET 2:		SUITE 300
		CITY:			WINSTON-SALEM
		STATE:			NC
		ZIP:			27101
</SEC-HEADER>
<DOCUMENT>
<TYPE>EFFECT
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0101</schemaVersion>

    <submissionType>EFFECT</submissionType>

    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2011-01-11</finalEffectivenessDispDate>
        <finalEffectivenessDispTime>12:00:00</finalEffectivenessDispTime>
        <form>S-3</form>
        <filer>
            <cik>0001124105</cik>
            <entityName>TARGACEPT INC</entityName>
            <fileNumber>333-171346</fileNumber>
        </filer>
    </effectiveData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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