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Reconciliation of Federal Income Tax Rate to Company's Effective Tax Rate (Detail)
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12 Months Ended | ||
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Dec. 31, 2012
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Dec. 31, 2011
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Dec. 31, 2010
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| Income Tax Examination [Line Items] | |||
| Expected federal income tax benefit/expense at statutory rate | 35.00% | 35.00% | 35.00% |
| Increase (decrease) resulting from: | |||
| Research and development credits | 19.00% | (12.00%) | |
| Stock-based compensation | (15.00%) | (13.00%) | 4.00% |
| State income tax expense, net of federal benefit | 2.00% | 3.00% | 3.00% |
| Qualifying Therapeutic Drug Project grant | (3.00%) | ||
| Change in unrecognized tax benefit reserves | (3.00%) | ||
| Change in valuation allowance | (25.00%) | (85.00%) | (1.00%) |
| Other | 4.00% | 41.00% | 1.00% |
| Effective Income Tax Rate Reconciliation, Nondeductible Expense, Total | 1.00% | 24.00% | |
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- Definition
Effective Income Tax Rate Reconciliation Revaluation Of Unrecognized Tax Benefits Reserve Requirements No definition available.
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- Details
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- Definition
The domestic federal statutory tax rate applicable under enacted tax laws to the Company's pretax income from continuing operations for the period. The "statutory" tax rate is the regular tax rate if there are alternative tax systems. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The portion of the difference between the effective income tax rate and domestic federal statutory income tax rate attributable to changes in the valuation allowance for deferred tax assets. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The sum of the differences between the effective income tax rate and domestic federal statutory income tax rate attributable to all nondeductible expenses under enacted tax laws. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The portion of the difference between the effective income tax rate and domestic federal statutory income tax rate attributable to nondeductible expenses under enacted tax laws, or differences in the methodologies used to determine expense amounts for financial statements prepared in accordance with generally accepted accounting principles, not otherwise listed in the existing taxonomy. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The portion of the difference between the effective income tax rate and domestic federal statutory income tax rate attributable to differences in the deductibility or nondeductibility of incentive stock options and other equity-based compensation costs in accordance with generally accepted accounting principles and enacted tax laws. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The portion of the difference between the effective income tax rate and domestic federal statutory income tax rate attributable to all other items not otherwise listed in the existing taxonomy. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The portion of the difference between the effective income tax rate and domestic federal statutory income tax rate that can be explained by the state and local income tax expense or benefit, net of the federal tax benefit (expense) thereon, recorded during the period. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The portion of the difference between the effective income tax rate and domestic federal statutory income tax rate that can be explained by research tax credits generated or utilized under enacted tax laws during the period. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Details
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