Accrued Expenses (Details) - USD ($) $ in Thousands	1 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Restructuring Cost and Reserve [Line Items]
Professional Fees	$ 216
Employee compensation and benefits	646	$ 713
Commercial manufacturing	489	939
Professional services	335	459
Other	829	591
Total accrued expenses	$ 2,299	2,702
Employee severance
Restructuring Cost and Reserve [Line Items]
Restructuring Reserve		$ 626