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Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2013
Stock-Based Compensation  
Summary of the activity related to the shares of common stock covered by outstanding options under the plans
 
  Number of
Shares
  Weighted Average
Exercise Price
  Remaining
Contractual Term
(in years)
  Aggregate
Intrinsic value
 

Balance at December 31, 2012

    5,579,042   $ 6.68              

Granted

    1,654,315     1.64              

Exercised

    (7,550 )   1.82              

Forfeited

    (670,291 )   2.11              

Expired

    (354,087 )   9.26              
                         

Balance at December 31, 2013

    6,201,429     5.68     6.09   $  
                         
                         

Vested and expected to vest at December 31, 2013

    6,009,973     5.79     6.04      

Exercisable at December 31, 2013

    3,913,834     7.49     5.18      
Summary of information about the shares of common stock covered by outstanding and exercisable options under the plans

A summary of information about the shares of common stock covered by outstanding and exercisable options under the Plans at December 31, 2013 follows:

 
  Stock Options Outstanding   Stock Options Exercisable  
Range of
exercise prices
  Number
of shares
  Weighted
average
remaining
contractual life
(in years)
  Weighted
average
exercise price
per share
  Number of
shares
  Weighted
average
exercise price
per share
 
$1.27 - 1.48     240,400     9.65   $ 1.41     15,610   $ 1.40  
1.55 - 1.55     1,045,000     7.56     1.55     600,000     1.55  
1.56 - 1.69     1,038,479     6.69     1.68     358,018     1.66  
1.74 - 2.46     360,014     7.41     2.09     190,189     2.11  
2.66 - 2.66     866,949     6.60     2.66     380,256     2.66  
2.72 - 7.25     737,997     5.15     5.98     561,599     6.12  
7.31 - 9.77     668,092     5.26     8.95     602,927     8.93  
10.08 - 14.49     872,086     4.07     12.49     832,823     12.42  
14.53 - 23.99     342,412     3.72     18.86     342,412     18.86  
24.97 - 24.97     30,000     3.39     24.97     30,000     24.97  
                             
      6,201,429     6.09     5.68     3,913,834     7.49  
                             
                             
Schedule of assumptions used in determining fair value of stock options granted using the Black-Scholes option pricing model
 
  Year Ended December 31,
 
  2013   2012   2011

Expected dividend yield

     

Risk-free rate

  0.71% - 2.05%   0.67% - 1.15%   0.88% - 2.38%

Expected option term (in years)

  6.0 - 6.1   5.3 - 5.5   5.5 - 5.6

Volatility

  84% - 85%   84% - 87%   77% - 80%