June 23, 2023

Via EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn:	Doris Stacey Gama
	Joe McCann
Re:	Compugen Ltd.
	Registration Statement on Form F-3
	Filed March 30, 2023, as amended on April 14, 2023
	File No. 333-270985
	Acceleration Request
		Requested Date: June 27, 2023
		Requested Time: 4:00 p.m. Eastern Time

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) hereby requests that the Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form F-3 (File No. 333-270985) (as amended to date, the “Registration Statement”), to become effective on June 27, 2023, at 4:00 p.m. Eastern Time, or as soon thereafter as is practicable, or at such later time as the Registrant may orally request via telephone call to the Commission’s staff. The Registrant hereby authorizes Amiti Rothstein of Cooley LLP, counsel to the Registrant, to make such request on its behalf. Once the Registration Statement has been declared effective, please orally confirm that event with Amiti Rothstein of Cooley LLP at (212) 479-6567.

[Signature page follows]

Very truly yours,

Compugen Ltd.

By: /s/ Eran Ben Dor                                

Eran Ben Dor

General Counsel and Corporate Secretary

cc:	Anat Cohen-Dayag, Ph.D., Compugen Ltd.
	Alberto Sessa, Compugen Ltd.
	Daniel Goldberg, Cooley LLP
	Amiti Rothstein, Cooley LLP
	Eric Delgado, Cooley LLP
	Megan Taing, Cooley LLP