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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Revenues:        
Contract revenue $ 653 $ 2,271 $ 3,722 $ 6,104
Collaboration and licensing revenue 0 0 0 1,548
Total revenues 653 2,271 3,722 7,652
Operating expenses:        
Research and development 12,247 26,495 46,942 65,867
General and administrative 5,827 8,524 19,359 21,812
Total operating expenses 18,074 35,019 66,301 87,679
Loss from operations (17,421) (32,748) (62,579) (80,027)
Interest income, net 396 299 1,146 498
Net loss (17,025) (32,449) (61,433) (79,529)
Other comprehensive loss:        
Unrealized (loss) gain on investments, net (98) (1,448) 398 321
Comprehensive loss $ (17,123) $ (33,897) $ (61,035) $ (79,208)
Per share information:        
Net loss, basic and diluted (in dollars per share) $ (0.37) $ (0.70) $ (1.33) $ (1.84)
Weighted-average shares outstanding, basic and diluted (in shares) 46,236,749 46,059,112 46,211,748 43,112,314