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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Cash flows from operating activities:    
Net loss $ (26,260) $ (22,266)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation of property and equipment 267 114
Amortization of debt costs 0 26
Amortization of premium/discount on investments 397 425
Share-based compensation 3,915 2,402
Amortization of deferred lease obligations (12) (12)
Loss on disposition of assets 4 0
Changes in operating assets and liabilities:    
Accounts receivable 1,879 (871)
Prepaid expenses and other assets 1,160 832
Accounts payable and accrued liabilities (9,985) 511
Net cash used in operating activities (28,635) (18,839)
Cash flows from investing activities:    
Purchases of property and equipment (232) (133)
Purchases of short-term investments 0 (26,709)
Purchases of long-term investments 0 (65,232)
Sales of short-term investments 0 1,003
Maturities of short-term investments 35,599 36,352
Net cash provided by (used in) investing activities 35,367 (54,719)
Cash flows from financing activities:    
Proceeds from exercise of stock options 133 665
Proceeds from employee stock purchase plan stock purchases 33 461
Proceeds from exercise of warrants 0 1,000
Repayment of debt 0 (1,425)
Net cash provided by financing activities 166 701
Net increase (decrease) in cash and cash equivalents 6,898 (72,857)
Cash and cash equivalents, beginning of period 20,605 128,462
Cash and cash equivalents, end of period 27,503 55,605
Supplemental disclosure of cash flow information:    
Cash paid for interest $ 0 $ 70