Exhibit 99.1

Company Contact:

Ronald H. Spair

Chief Financial Officer

610-882-1820

Investorinfo@orasure.com

www.orasure.com

OraSure Technologies Announces 2008 Second Quarter Results

- Significant Milestones Achieved in Clinical Development Programs -

BETHLEHEM, PA – August 5, 2008 – (BW HealthWire) – OraSure Technologies, Inc. (NASDAQ:OSUR), a market leader in oral fluid diagnostics, today announced quarterly revenues of $18.9 million for the three months ended June 30, 2008, compared to $21.4 million in revenues for the three months ended June 30, 2007. Increased sales of the Company’s OraQuick ADVANCE^® rapid HIV-1/2 antibody test and insurance risk assessment products, as well as increased licensing and product development revenue during the second quarter 2008, were offset by expected decreased sales of the Company’s cryosurgical wart removal products and substance abuse testing products.

The Company’s net loss was $2.2 million, or $0.05 per share for the second quarter of 2008, compared to net income of $955,000, or $0.02 per share on a fully-diluted basis for the second quarter of 2007. This decrease is primarily the result of higher research and development expenses associated with the Company’s OraQuick^® HIV OTC and OraQuick^® HCV clinical development programs, coupled with lower sales primarily of cryosurgical products.

For the six months ended June 30, 2008, the Company recorded revenues of $37.0 million, a decrease of 11% when compared to revenues of $41.5 million for the six months ended June 30, 2007. The Company recorded a net loss of $242,000 or $0.01 per share, for the six months ended June 30, 2008, compared to net income of $2.4 million, or $0.05 per share on a fully-diluted basis, during the six months ended June 30, 2007. The 2008 results include a previously announced $4.9 million pre-tax gain related to a settlement and licensing agreement entered into during the first quarter with Schering-Plough Healthcare Products, Inc. The 2007 results include a $1.4 million pre-tax gain from the sale of the Company’s equity interest in a foreign distributor.

Gross margin in the second quarter and the six months ended June 30, 2008 was 59% compared with 63% in the second quarter and six months ended June 30, 2007. Margins in the current periods were primarily impacted by an unfavorable product mix.

Operating expenses for the second quarter of 2008 increased $2.1 million to $15.0 million, from $12.9 million in the comparable period in 2007. Operating expenses for the six months ended June 30, 2008 were $28.6 million, compared to $24.8 million for the comparable period in 2007. These increases are attributable to higher research and development costs associated with the Company’s OraQuick^® HIV OTC and OraQuick^® HCV clinical development programs.

“The ongoing clinical work to obtain FDA approval for an OraQuick^® rapid HIV OTC test continues to go extremely well,” said Douglas A. Michels, President and Chief Executive Officer of OraSure Technologies. “This study was initiated in April, and I am happy to report that we recently completed testing for the first 1,000 subjects, and believe we have met the stopping criteria under our protocol. We have also continued to make good progress in our clinical trials to support a PMA submission for our OraQuick^® rapid HCV test to the FDA.”

Cash, cash equivalents and short-term investments were $91.0 million and working capital was $104.4 million at June 30, 2008, compared to $95.6 million and $105.6 million, respectively, at December 31, 2007. Cash flow used in operating activities for the six months ended June 30, 2008 was $1.9 million compared to $2.7 million provided by operations for the comparable period in 2007.

Third Quarter 2008 Outlook

With respect to the third quarter, the Company expects that revenues will be in the range of $16.0 and $16.5 million and its loss per share will approximate $0.09.

Financial Data

Condensed Financial Data

(In thousands, except per-share

data and percentages)

Unaudited

	Three months ended June 30,					Six months ended June 30,
	2008			2007		2008			2007
Results of Operations
Revenues	$	18,946		$	21,352	$	37,035		$	41,461
Cost of products sold		7,803			7,889		15,249			15,474
Gross profit		11,143			13,463		21,786			25,987
Operating expenses:
Research and development		6,099			3,304		10,697			6,224
Sales and marketing		4,962			5,249		10,178			10,020
General and administrative		3,890			4,325		7,731			8,562
Total operating expenses		14,951			12,878		28,606			24,806
Operating income (loss)		(3,808	)		585		(6,820	)		1,181
Other income, net		745			969		6,490			3,358
Income tax provision (benefit)		(820	)		599		(88	)		2,098
Net income (loss)	$	(2,243	)	$	955	$	(242	)	$	2,441
Earnings (loss) per share:
Basic and Diluted	$	(0.05	)	$	0.02	$	(0.01	)	$	0.05
Weighted average shares:
Basic		46,847			46,215		46,815			46,165
Diluted		46,847			46,629		46,815			46,592

	Three months ended June 30,
	Dollars				% Change		Percentage of Total Revenues
	2008		2007				2008		2007
Market Revenues
Infectious disease testing	$	10,033	$	9,185	9	%	53	%	43	%
Substance abuse testing		3,697		4,396	(16	)	20		21
Cryosurgical systems		2,719		5,772	(53	)	14		27
Insurance risk assessment		1,693		1,350	25		9		6
Product revenues		18,142		20,703	(12	)	96		97
Licensing and product development		804		649	24		4		3
Total revenues	$	18,946	$	21,352	(11	)%	100	%	100	%

	Six months ended June 30,
	Dollars				% Change		Percentage of Total Revenues
	2008		2007				2008		2007
Market Revenues
Infectious disease testing	$	19,512	$	18,117	8	%	53	%	44	%
Substance abuse testing		6,974		8,325	(16	)	19		20
Cryosurgical systems		6,055		11,452	(47	)	16		28
Insurance risk assessment		3,236		2,239	45		9		5
Product revenues		35,777		40,133	(11	)	97		97
Licensing and product development		1,258		1,328	(5	)	3		3
Total revenues	$	37,035	$	41,461	(11	)%	100	%	100	%

	Three months ended June 30,				% Change		Six months ended June 30,				% Change
	2008		2007				2008		2007
OraQuick® Revenues
Direct to U.S. Public Health	$	6,899	$	5,502	25	%	$	13,183	$	9,846	34	%
Abbott		1,698		1,778	(4	)		3,622		3,928	(8	)
SAMHSA/CDC		—		485	N/A			—		1,434	N/A
International		701		514	36			1,347		1,260	7
Total OraQuick® revenues	$	9,298	$	8,279	12	%	$	18,152	$	16,468	10	%
	Three months ended June 30,				% Change		Six months ended June 30,				% Change
	2008		2007				2008		2007
Intercept® Revenues
Workplace testing	$	1,272	$	1,977	(36	)%	$	2,287	$	3,523	(35	)%
Criminal Justice		708		661	7			1,327		1,306	2
International		564		633	(11	)		1,089		1,233	(12	)
Direct		330		264	25			601		466	29
Total Intercept® revenues	$	2,874	$	3,535	(19	)%	$	5,304	$	6,528	(19	)%
	Three months ended June 30,				% Change		Six months ended June 30,				% Change
	2008		2007				2008		2007
Cryosurgical Systems Revenues
Professional domestic	$	1,004	$	1,360	(26	)%	$	2,037	$	2,413	(16	)%
Professional international		665		510	30			1,404		977	44
OTC domestic		—		983	N/A			—		3,133	N/A
OTC international		1,050		2,919	(64	)		2,614		4,929	(47	)
Total cryosurgical systems revenues	$	2,719	$	5,772	(53	)%	$	6,055	$	11,452	(47	)%

	Unaudited
	June 30, 2008		December 31, 2007
Balance Sheets
Assets
Cash, cash equivalents and short-term investments	$	91,047	$	95,566
Accounts receivable, net		12,780		11,296
Inventories		10,286		9,410
Current portion of deferred income taxes		2,384		5,061
Other current assets		1,717		2,456
Property and equipment, net		21,276		20,911
Deferred income taxes		20,060		17,266
Other non-current assets		4,870		5,387
Total assets	$	164,420	$	167,353
Liabilities and Stockholders’ Equity
Current portion of long-term debt	$	557	$	557
Accounts payable		4,210		5,616
Accrued expenses		9,090		11,995
Long-term debt		8,581		8,818
Other liabilities		7		312
Stockholders’ equity		141,975		140,055
Total liabilities and stockholders’ equity	$	164,420	$	167,353
	As of June 30,
	2008		2007
Additional Financial Data
Capital expenditures	$	1,314	$	2,597
Depreciation and amortization	$	1,387	$	1,321
Accounts receivable – days sales outstanding		61 days		63 days

Conference Call

The Company will host a conference call and audio webcast today to discuss the Company’s 2008 second quarter financial results, business developments and the Company’s 2008 third quarter outlook, beginning at 5:00 p.m. Eastern Time (2:00 p.m. Pacific Time). On the call will be Douglas A. Michels, President and Chief Executive Officer, and Ronald H. Spair, Chief Operating Officer and Chief Financial Officer. The call will include remarks by management and a question and answer session.

In order to listen to the conference call, please dial 888-742-2024 (Domestic) or 706-643-0033 (International) and reference 56781070 or go to OraSure Technologies’ web site, www.orasure.com, and click on the Investor Info link. A replay of the call will be archived on OraSure Technologies’ web site shortly after the call has ended and will be available for seven days. A replay of the call can also be accessed until August 12, 2008, by dialing 800-642-1687 (Domestic) or 706-645-9291 (International) and entering the Conference ID #56781070.

About OraSure Technologies

OraSure Technologies develops, manufactures and markets oral fluid specimen collection devices and tests and other diagnostic products using proprietary technologies, including immunoassays and other in vitro diagnostic tests and other medical devices. These products are sold in the United States and certain foreign countries to clinical laboratories, hospitals, clinics, community-based organizations and other public health organizations, distributors, government agencies, physicians’ offices, and commercial and industrial entities. For more information on the Company, please visit www.orasure.com.

Important Information

This press release contains certain forward-looking statements, including with respect to revenues, net income, earnings/loss per share and products. Actual results could be significantly different. Factors that could affect results include the ability to market and sell products; changes in relationships, including disputes or disagreements, with strategic partners and reliance on strategic partners for the performance of critical activities under collaborative arrangements; failure of distributors or other customers to meet purchase forecasts or minimum purchase requirements for the Company’s products; impact of replacing distributors; inventory levels at distributors and other customers; impact of replacing distributors; inventory levels at distributors and other customers; impact of competitors, competing products and technology changes; ability to develop, commercialize and market new products; market acceptance of oral fluid testing or other products; changes in market acceptance of products based on product performance; continued bulk purchases by customers, including governmental agencies, and the ability to fully deploy those purchases in a timely manner; ability to fund research and development and other products and operations; ability to obtain and maintain new or existing product distribution channels; reliance on sole supply sources for critical product components; availability of related products produced by third parties or products required for use of our products; ability to obtain, and timing and cost of obtaining, necessary regulatory approvals for new products or new indications or applications for existing products; ability to comply with applicable regulatory requirements; history of losses and ability to achieve sustained profitability; volatility of the Company’s stock price; uncertainty relating to patent protection and potential patent infringement claims; uncertainty and costs of litigation relating to patents and other intellectual property; availability of licenses to patents or other technology; ability to enter into international manufacturing agreements; obstacles to international marketing and manufacturing of products; ability to sell products internationally, including changes in international funding sources; loss or impairment of sources of capital; ability to meet financial covenants in agreements with financial institutions; ability to retain qualified personnel; exposure to patent infringement, product liability, and other types of litigation; changes in international, federal or state laws and regulations; customer consolidations and inventory practices; equipment failures and ability to obtain needed raw materials and components; the impact of terrorist attacks and civil unrest; ability to identify, complete and realize the full benefits of potential acquisitions; and general political, business and economic conditions. These and other factors are discussed more fully in the Securities and Exchange Commission (“SEC”) filings of OraSure Technologies, including its registration statements, its Annual Report on Form 10-K for the year ended December 31, 2007, its Quarterly Reports on Form 10-Q, and its other filings with the SEC. Although forward-looking statements help to provide complete information about future prospects, readers should keep in mind that forward-looking statements may not be reliable. The forward-looking statements are made as of the date of this press release and OraSure Technologies undertakes no duty to update these statements.

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