10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

þ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the Quarterly Period Ended October 2, 2011

¨ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the transition period from             to            

Commission File Number 000-30361

Illumina, Inc.

(Exact name of registrant as specified in its charter)

Delaware	33-0804655
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)
9885 Towne Centre Drive, San Diego, CA	92121
(Address of principal executive offices)	(Zip Code)

(858) 202-4500

(Registrant’s telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   þ    No   ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes   þ    No  ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.:

Large accelerated filer	þ	Accelerated filer	¨
Non-accelerated filer	¨  (Do not check if a smaller reporting company)	Smaller reporting company	¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).     Yes  ¨    No   þ

As of October 15, 2011, there were 121,439,286 shares of the registrant’s Common Stock outstanding.

ILLUMINA, INC.

INDEX

	Page
PART I. FINANCIAL INFORMATION
Item 1. Financial Statements		3
Condensed Consolidated Balance Sheets as of October 2, 2011 (Unaudited) and January 2, 2011		3
Condensed Consolidated Statements of Income for the Three and Nine Months Ended October  2, 2011 and October 3, 2010 (Unaudited)		4
Condensed Consolidated Statements of Cash Flows for the Nine Months Ended October  2, 2011 and October 3, 2010 (Unaudited)		5
Notes to Condensed Consolidated Financial Statements (Unaudited)		6
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations		19
Item 3. Quantitative and Qualitative Disclosures About Market Risk		30
Item 4. Controls and Procedures		30
PART II. OTHER INFORMATION
Item 1. Legal Proceedings		31
Item 1A. Risk Factors		31
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds		31
Item 3. Defaults upon Senior Securities		32
Item 4. (Removed and Reserved)		32
Item 5. Other Information		32
Item 6. Exhibits		32
SIGNATURES		33

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PART I. FINANCIAL INFORMATION

Item 1. Financial Statements.

ILLUMINA, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands)

	October 2, 2011			January 2, 2011
	(Unaudited)
ASSETS
Current assets:
Cash and cash equivalents	$	229,846		$	248,947
Short-term investments		902,344			645,342
Accounts receivable, net		169,052			165,598
Inventory, net		139,265			142,211
Deferred tax assets, current portion		25,122			19,378
Prepaid expenses and other current assets		38,585			36,922
Total current assets		1,504,214			1,258,398
Property and equipment, net		135,393			129,874
Goodwill		321,853			278,206
Intangible assets, net		109,767			91,462
Deferred tax assets, long-term portion		19,356			39,497
Other assets		56,476			41,676
Total assets	$	2,147,059		$	1,839,113
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	52,249		$	66,744
Accrued liabilities		211,171			156,164
Long-term debt, current portion		33,793			311,609
Total current liabilities		297,213			534,517
Long-term debt		765,077			—
Other long-term liabilities		42,897			28,531
Conversion option subject to cash settlement		6,332			78,390
Stockholders’ equity:
Preferred stock		—			—
Common stock		1,661			1,516
Additional paid-in capital		2,221,980			1,891,288
Accumulated other comprehensive income		2,086			1,765
Accumulated deficit		(80,432	)		(155,335	)
Treasury stock, at cost		(1,109,755	)		(541,559	)
Total stockholders’ equity		1,035,540			1,197,675
Total liabilities and stockholders’ equity	$	2,147,059		$	1,839,113

See accompanying notes to the condensed consolidated financial statements.

3

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF INCOME

(Unaudited)

(In thousands, except per share amounts)

	Three Months Ended						Nine Months Ended
	October 2, 2011			October 3, 2010			October 2, 2011			October 3, 2010
Revenue:
Product revenue	$	220,296		$	224,668		$	756,884		$	596,885
Service and other revenue		15,203			12,641			48,580			44,558
Total revenue		235,499			237,309			805,464			641,443
Cost of revenue:
Cost of product revenue		68,764			72,248			238,719			184,814
Cost of service and other revenue		6,585			5,621			19,178			15,705
Amortization of acquired intangible assets		3,035			2,295			9,055			5,510
Total cost of revenue		78,384			80,164			266,952			206,029
Gross profit		157,115			157,145			538,512			435,414
Operating expense:
Research and development		50,399			44,804			151,400			132,146
Selling, general and administrative		66,031			55,006			200,925			158,420
Acquisition related (gain) expense, net		(2,598	)		—			2,442			1,861
Headquarter relocation expense		6,519			—			11,583			—
Total operating expense		120,351			99,810			366,350			292,427
Income from operations		36,764			57,335			172,162			142,987
Other income (expense):
Interest income		1,388			2,791			4,909			6,746
Interest expense		(8,797	)		(6,190	)		(25,605	)		(18,279	)
Other (expense) income, net		(1,564	)		774			(38,643	)		3,142
Total other expense, net		(8,973	)		(2,625	)		(59,339	)		(8,391	)
Income before income taxes		27,791			54,710			112,823			134,596
Provision for income taxes		7,640			19,263			37,915			48,145
Net income	$	20,151		$	35,447		$	74,908		$	86,451
Net income per basic share	$	0.17		$	0.28		$	0.60		$	0.70
Net income per diluted share	$	0.15		$	0.24		$	0.52		$	0.61
Shares used in calculating basic net income per share		122,079			124,684			124,017			122,816
Shares used in calculating diluted net income per share		135,966			145,205			143,620			140,854

See accompanying notes to the condensed consolidated financial statements.

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ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(In thousands)

	Nine Months Ended
	October 2, 2011			October 3, 2010
Cash flows from operating activities:
Net income	$	74,908		$	86,451
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense		40,303			24,611
Amortization of acquired intangible assets		9,501			5,510
Share-based compensation expense		70,276			51,804
Accretion of debt discount		23,673			15,904
Loss on extinguishment of debt		37,611			—
Contingent compensation expense		2,897			1,325
Gain on acquisition		—			(2,914	)
Incremental tax benefit related to stock options exercised		(40,387	)		(14,551	)
Deferred income taxes		6,209			18,844
Other non-cash adjustments		8,070			4,567
Changes in operating assets and liabilities:
Accounts receivable		(2,544	)		(12,752	)
Inventory		9,315			(36,463	)
Prepaid expenses and other current assets		(15,474	)		2,571
Other assets		(3,110	)		(2,467	)
Accounts payable		(14,897	)		17,499
Accrued liabilities		41,376			31,288
Other long-term liabilities		4,002			(564	)
Unrealized loss on foreign exchange		(1,889	)		429
Net cash provided by operating activities		249,840			191,092
Cash flows from investing activities:
Purchases of available-for-sale securities		(1,076,674	)		(663,430	)
Sales and maturities of available-for-sale securities		840,107			558,128
Sales and maturities of trading securities		—			54,900
Net cash paid for acquisitions		(58,302	)		(98,210	)
Purchases of investments		(11,384	)		(22,450	)
Purchases of property and equipment		(50,686	)		(37,434	)
Cash paid for intangible assets		(1,100	)		(6,500	)
Net cash used in investing activities		(358,039	)		(214,996	)
Cash flows from financing activities:
Payments on current portion of long-term debt		(349,874	)		—
Proceeds from issuance of convertible notes		903,492			—
Incremental tax benefit related to stock options exercised		40,387			14,551
Common stock repurchases		(570,406	)		(16,006	)
Proceeds from exercises of warrants		5,512			9,587
Proceeds from issuance of common stock		60,057			81,798
Net cash provided by financing activities		89,168			89,930
Effect of exchange rate changes on cash and cash equivalents		(70	)		(108	)
Net (decrease) increase in cash and cash equivalents		(19,101	)		66,134
Cash and cash equivalents at beginning of period		248,947			144,633
Cash and cash equivalents at end of period	$	229,846		$	210,767

See accompanying notes to the condensed consolidated financial statements.

5

Illumina, Inc.

Notes to Consolidated Financial Statements

(Unaudited)

Unless the context requires otherwise, references in this report to “Illumina,” “we,” “us,” the “Company,” and “our” refer to Illumina, Inc. and its consolidated subsidiaries.

1. Summary of Significant Accounting Principles

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation. In management’s opinion, the accompanying financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited financial statements should be read in conjunction with the Company’s audited financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the fiscal year ended January 2, 2011, from which the balance sheet information herein was derived.

The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expenses, and related disclosure of contingent assets and liabilities. Actual results could differ from those estimates.

Fiscal Year

The Company’s fiscal year consists of 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. The three and nine months ended October 2, 2011 and October 3, 2010 were both 13 and 39 weeks, respectively.

Reclassifications

Certain prior period amounts have been reclassified to conform to the current period presentation.

Revenue Recognition

The Company’s revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instrumentation and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from instrument service contracts, genotyping and sequencing services, and research agreements with government grants.

The Company recognizes revenue when persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the price is fixed or determinable, and collectibility is reasonably assured. In instances where final acceptance of the product is required, revenue is deferred until all the acceptance criteria have been met. All revenue is recorded net of discounts.

Revenue for product sales is recognized generally upon transfer of title to the customer, provided that no significant obligations remain and collection of the receivable is reasonably assured. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term, and revenue from genotyping and sequencing services is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer or agreed upon milestones are reached. Revenue from research agreements with government grants is recognized in the period during which the related costs are incurred.

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In order to assess whether the price is fixed or determinable, the Company evaluates whether refund rights exist. If there are refund rights or payment terms based on future performance, the Company defers revenue recognition until the price becomes fixed or determinable. The Company assesses collectibility based on a number of factors, including past transaction history with the customer and the creditworthiness of the customer. If the Company determines that collection of a payment is not reasonably assured, revenue recognition is deferred until receipt of payment.

The Company regularly enters into contracts where revenue is derived from multiple deliverables including any mix of products or services. These products or services are generally delivered within a short time frame, approximately three to six months, after the contract execution date. Revenue recognition for contracts with multiple deliverables is based on the individual units of accounting determined to exist in the contract. A delivered item is considered a separate unit of accounting when the delivered item has value to the customer on a stand-alone basis. Items are considered to have stand-alone value when they are sold separately by any vendor or when the customer could resell the item on a stand-alone basis. Consideration is allocated at the inception of the contract to all deliverables based on their relative selling price. The relative selling price for each deliverable is determined using vendor specific objective evidence (VSOE) of selling price or third-party evidence of selling price if VSOE does not exist. If neither VSOE nor third-party evidence exists, the Company uses its best estimate of the selling price for the deliverable.

In order to establish VSOE of selling price, the Company must regularly sell the product or service on a stand-alone basis with a substantial majority priced within a relatively narrow range. VSOE of selling price is usually the midpoint of that range. If there are not a sufficient number of standalone sales and VSOE of selling price cannot be determined, then the Company considers whether third party evidence can be used to establish selling price. Due to the lack of similar products and services sold by other companies within the industry, the Company has rarely established selling price using third-party evidence. If neither VSOE nor third party evidence of selling price exists, the Company determines its best estimate of selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, the Company relies upon prices set by the Company’s pricing committee adjusted for applicable discounts. The Company recognizes revenue for delivered elements only when it determines there are no uncertainties regarding customer acceptance.

In the first quarter of 2010, the Company offered an incentive with the HiSeq 2000 launch that enabled existing Genome Analyzer customers to trade in their Genome Analyzer and receive a discount on the purchase of a HiSeq 2000. The incentive was limited to customers who had purchased a Genome Analyzer as of the date of the announcement and was the first significant trade-in program offered by the Company. The Company accounts for HiSeq 2000 discounts related to the Genome Analyzer trade-in program as reductions to revenue upon recognition of the HiSeq 2000 sales revenue, which is later than the date the trade-in program was launched.

In certain markets within Europe, the Asia-Pacific region, Latin America, the Middle East, and South Africa, the Company sells products and provides services to customers through distributors that specialize in life science products. In most sales through distributors, the product is delivered directly to customers. In cases where the product is delivered to a distributor, revenue recognition is deferred until acceptance is received from the distributor, and/or the end-user, if required by the applicable sales contract. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers. These transactions are accounted for in accordance with the Company’s revenue recognition policy described herein.

Goodwill, Intangible Assets, and Other Long-Lived Assets

Goodwill represents the excess of cost over fair value of net assets acquired. The change in the carrying value of goodwill during the nine months ended October 2, 2011 was due to goodwill recorded in connection with the Company’s acquisition of Epicentre Technologies Corporation (Epicentre) in January 2011.

The Company’s identifiable intangible assets are comprised primarily of in-process research and development (IPR&D), licensed technology, acquired core technologies, customer relationships, trade names, and license agreements. Except IPR&D, the cost of all identifiable intangible assets is amortized on a straight-line basis over their respective useful lives. The Company regularly performs reviews to determine if the carrying values of its long-lived assets are impaired. A review of intangible assets that have finite useful lives and other long-lived assets is performed when an event occurs indicating the potential for impairment. If indicators of impairment exist, the Company assesses the recoverability of the affected long-lived assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows associated with such assets. If impairment is indicated, the

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Company compares the carrying amount to the estimated fair value of the affected assets and adjusts the value of such assets accordingly. Factors that would necessitate an impairment assessment include a significant decline in the Company’s stock price and market capitalization compared to its net book value, significant changes in the ability of a particular asset to generate positive cash flows, and significant changes in the Company’s strategic business objectives and utilization of a particular asset. The Company performed quarterly reviews of its long-lived assets and noted no indications of impairment for the three and nine months ended October 2, 2011.

Goodwill and IPR&D, which have indefinite useful lives, are reviewed for impairment at least annually during the second fiscal quarter, or more frequently if an event occurs indicating the potential for impairment. The performance of the goodwill impairment test is a two-step process. The first step of the impairment test involves comparing the estimated fair value of the reporting unit with its carrying value, including goodwill. If the carrying amount of the reporting unit exceeds its fair value, the Company performs the second step of the goodwill impairment test to determine the amount of loss, which involves comparing the implied fair value of the goodwill with the carrying value of the goodwill. The Company performed its annual impairment test of goodwill in the second fiscal quarter of 2011, noting no impairment. In its impairment test, the Company concluded that it has a single reporting unit and that its fair value exceeded its book value, using market capitalization as a reference for the Company’s fair value. Therefore, the first step recoverability test was passed and the second step analysis was not required.

The IPR&D impairment test requires the Company to assess the fair value of the asset as compared to its carrying value, and if the carrying value exceeds the fair value, record an impairment charge. The Company performed its annual impairment test of its IPR&D in the second fiscal quarter of 2011, noting no impairment. In its impairment test, the Company assessed the fair value of IPR&D using an income approach, taking into consideration various factors such as future revenue contributions, additional research and development costs to be incurred, and contributory asset charges. The rate used to discount net future cash flows to their present values was based on a risk-adjusted rate of return.

Fair Value Measurements

The Company determines the fair value of its assets and liabilities based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value maximize the use of observable inputs and minimize the use of unobservable inputs. The Company uses a fair value hierarchy with three levels of inputs, of which the first two are considered observable and the last unobservable, to measure fair value:

• Level 1 — Quoted prices in active markets for identical assets or liabilities.

• Level 2 — Inputs, other than Level 1, that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

• Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The carrying amounts of financial instruments such as cash and cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable, and accrued liabilities, excluding acquisition related contingent consideration liabilities, approximate the related fair values due to the short-term maturities of these instruments.

Derivatives

The Company is exposed to foreign exchange rate risks in the normal course of business. To manage a portion of the accounting exposure resulting from changes in foreign currency exchange rates, the Company enters into foreign exchange contracts to hedge monetary assets and liabilities that are denominated in currencies other than the United States dollar. These foreign exchange contracts are carried at fair value and are not designated as hedging instruments. Changes in the value of the foreign exchange contracts are recognized in other (expense) income, net, in the consolidated statements of income for the current period, along with an offsetting gain or loss on the underlying monetary assets or liabilities.

As of October 2, 2011, the Company had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, and Australian dollar. As of October 2, 2011, the total notional amount of outstanding forward contracts in place for foreign currency purchases was approximately $26.4 million. Gains and losses related to the non-designated foreign exchange forward contracts for the three and nine months ended October 2, 2011 were immaterial.

8

Leases

Leases are reviewed and classified as capital or operating at their inception. For leases that contain rent escalations, the Company records rent expense on a straight-line basis over the term of the lease, which includes the construction build-out period and lease extension periods, if appropriate. The difference between rent payments and straight-line rent expense is recorded as deferred rent in accrued liabilities and other long-term liabilities. Landlord allowances are amortized on a straight-line basis over the lease term as a reduction to rent expense. The Company capitalizes leasehold improvements and amortizes them over the shorter of the lease term or their expected useful lives.

In December 2010, the Company agreed to lease a facility in San Diego, California that will serve as its new corporate headquarters. The Company started recording rent expense upon obtaining control of the new facility in July 2011. The Company incurs additional rent expense on the new facility during the transition period of occupying both the current and new facility, until vacating the current facility, which is expected to be substantially completed near the end of 2011. In addition, the Company records accelerated depreciation expense for leasehold improvements at its current headquarter facility based on the reassessed useful lives of less than a year. During the three and nine months ended October 2, 2011, the Company recorded headquarter relocation expense of $6.5 million and $11.6 million, respectively, which primarily consisted of accelerated depreciation expense and additional rent expense during the transition period. In addition, the Company will also record a cease-use loss in headquarter relocation expense upon vacating its current headquarter facility. The cease-use loss will be calculated as the present value of the expected difference between the remaining lease payments obligation and estimated sublease rental during the remaining lease period, adjusted for deferred items and leasehold improvements.

Net Income per Share

Basic net income per share is computed by dividing net income by the weighted average number of common shares outstanding during the reporting period. Diluted net income per share is computed by dividing net income by the weighted average number of common shares outstanding during the reporting period increased to include dilutive potential common shares calculated using the treasury stock method. Diluted net income per share reflects the potential dilution from outstanding stock options, restricted stock units, employee stock purchase plan (ESPP), warrants, shares subject to forfeiture, and convertible senior notes. Under the treasury stock method, convertible senior notes will have a dilutive impact when the average market price of the Company’s common stock is above the applicable conversion price of the respective notes. In addition, the following amounts are assumed to be used to repurchase shares: the amount that must be paid to exercise stock options and warrants and purchase shares under the ESPP; the amount of compensation expense for future services that the Company has not yet recognized for stock options, restricted stock units, ESPP, and shares subject to forfeiture; and the amount of tax benefits that will be recorded in additional paid-in capital when the expenses related to respective awards become deductible.

The following table presents the calculation of weighted average shares used to calculate basic and diluted net income per share (in thousands):

	Three Months Ended				Nine Months Ended
	October 2, 2011		October 3, 2010		October 2, 2011		October 3, 2010
Weighted average shares outstanding		122,079		124,684		124,017		122,816
Effect of dilutive potential common shares:
Dilutive convertible senior notes		1,292		9,292		4,885		8,381
Dilutive equity awards		4,549		4,734		5,315		4,407
Dilutive warrants sold in connection with convertible senior notes		8,046		5,662		9,403		4,316
Dilutive warrants assumed in an acquisition		—		833		—		934
Weighted average shares used in calculation of diluted net income per share		135,966		145,205		143,620		140,854
Potentially dilutive shares excluded from calculation due to anti-dilutive effect		1,543		2,518		1,189		2,350

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Comprehensive Income

Total comprehensive income consisted of the following (in thousands):

	Three Months Ended						Nine Months Ended
	October 2, 2011			October 3, 2010			October 2, 2011		October 3, 2010
Net income	$	20,151		$	35,447		$	74,908	$	86,451
Unrealized gain (loss) on available-for-sale securities, net of deferred tax		(261	)		(48	)		321		(265	)
Total comprehensive income	$	19,890		$	35,399		$	75,229	$	86,186

Recent Accounting Pronouncements

In September 2011, the Financial Accounting Standards Board (FASB) issued an update to the Intangibles – Goodwill and Other topic of the Accounting Standards Codification (ASC). The updated guidance will allow companies to assess qualitative factors to determine if it is more likely than not that goodwill might be impaired and whether it is necessary to perform the two-step goodwill impairment test required under current accounting standards. This new guidance is effective for the Company beginning January 2, 2012, with early adoption permitted. The Company is currently evaluating this guidance, but does not expect the adoption will have a material effect on its consolidated financial statements.

In June 2011, the FASB issued an update to the Comprehensive Income topic of the ASC. This update requires an entity to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. This update eliminates the option to present the components of other comprehensive income as part of the statement of equity. It is effective for the Company beginning January 2, 2012 and should be applied retrospectively. The update is to be adopted prospectively and early adoption is permitted. The Company does not believe that adoption of this update will have an impact on its consolidated financial statements.

In May 2011, the FASB issued an amendment to the Fair value Measurements and Disclosures topic of the ASC. The amendment clarifies the application of certain existing fair value measurement guidance and expands the disclosure requirements for fair value measurements that are estimated using significant unobservable (Level 3) inputs. This amendment is effective for the Company in first quarter of fiscal 2012. The amendment is to be adopted prospectively and early adoption is not permitted. The Company does not believe that adoption of the amendment will have a significant impact on its consolidated financial statements.

2. Balance Sheet Account Details

Short-Term Investments

The following is a summary of short-term investments (in thousands):

	October 2, 2011									January 2, 2011
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
Available-for-sale securities:
Debt securities in government sponsored entities	$	401,007	$	501	$	(189	)	$	401,319	$	261,890	$	106	$	(299	)	$	261,697
Corporate debt securities		453,771		1,290		(601	)		454,460		329,823		1,170		(235	)		330,758
U.S. Treasury securities		46,355		217		(7	)		46,565		52,938		70		(121	)		52,887
Total available-for-sale securities	$	901,133	$	2,008	$	(797	)	$	902,344	$	644,651	$	1,346	$	(655	)	$	645,342

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As of October 2, 2011, the Company had 118 available-for-sale securities in a gross unrealized loss position, all of which had been in such position for less than twelve months. There was no impairment considered other-than-temporary as it is more likely than not the Company will hold the securities until maturity or a recovery of the cost basis. The following table shows the fair values and the gross unrealized losses of the Company’s available-for-sale securities that were in unrealized loss positions as of October 2, 2011 and January 2, 2011 aggregated by investment category (in thousands):

	October 2, 2011					January 2, 2011
	Fair Value		Gross Unrealized Losses			Fair Value		Gross Unrealized Losses
Debt securities in government sponsored entities	$	157,455	$	(189	)	$	127,756	$	(299	)
Corporate debt securities		168,979		(601	)		92,199		(235	)
U.S. Treasury securities		6,093		(7	)		13,490		(121	)
Total	$	332,527	$	(797	)	$	233,445	$	(655	)

Realized gains and losses are determined based on the specific identification method and are reported in interest income in the consolidated statements of income. Gross realized gains and losses on sales of available-for-sale securities for the three months ended October 2, 2011 and October 3, 2010 and gross realized losses for the nine months ended October 2, 2010 were immaterial. Gross realized gains for the nine months ended October 2, 2011 were $1.0 million.

Contractual maturities of available-for-sale securities as of October 2, 2011 were as follows (in thousands):

	Estimated Fair Value
Due within one year	$	278,464
After one but within five years		623,880
Total	$	902,344

Inventory

Inventory, net, consists of the following (in thousands):

	October 2, 2011		January 2, 2011
Raw materials	$	62,916	$	54,762
Work in process		57,146		64,862
Finished goods		19,203		22,587
Total inventory, net	$	139,265	$	142,211

Cost-Method Investments

As of October 2, 2011 and January 2, 2011, the aggregate carrying amounts of the Company’s cost-method investments in non-publicly traded companies were $43.5 million and $32.0 million, respectively, which were included in other long-term assets in the consolidated balance sheets. The Company assesses all cost-method investments for impairment quarterly. No impairment loss was recorded during the three and nine months ended October 2, 2011 or October 3, 2010. The Company does not reassess the fair value of cost-method investments if there are no identified events or changes in circumstances that may have a significant adverse effect on the fair value of the investments.

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Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

	October 2, 2011		January 2, 2011
Deferred revenue, current portion	$	51,655	$	45,863
Accrued compensation expenses		46,031		49,368
Unsettled short-term investment purchases		26,373		—
Accrued taxes payable		25,995		13,277
Customer deposits		16,948		14,900
Reserve for product warranties		15,868		16,761
Deferred rent, current portion		11,542		—
Accrued royalties		4,855		2,781
Acquisition related contingent consideration liability, current portion		2,215		3,738
Other accrued expenses		9,689		9,476
Total accrued liabilities	$	211,171	$	156,164

3. Acquisitions

Epicentre

On January 10, 2011, the Company acquired Epicentre, a provider of nucleic acid sample preparation reagents and specialty enzymes used in sequencing and microarray applications. Total consideration for the acquisition was $71.4 million, which included $59.4 million in net cash payments made at closing, $4.6 million in the fair value of contingent consideration settled in stock that is subject to forfeiture if certain non-revenue based milestones are not met, and $7.4 million in the fair value of contingent cash consideration of up to $15 million based on the achievement of certain revenue based milestones by January 10, 2013.

The Company estimated the fair value of contingent stock consideration based on the closing price of its common stock as of the acquisition date. Approximately 229,000 shares of common stock were issued to Epicentre shareholders in connection with the acquisition, which are subject to forfeiture if certain non-revenue-based milestones are not met. One third of these shares issued with an assessed fair value of $4.6 million were determined to be part of the purchase price. The remaining shares with an assessed fair value of $10.5 million were determined to be compensation for post-acquisition service, the cost of which will be recognized as contingent compensation expense over a period of two years in research and development expense or selling, general and administrative expense.

The Company estimated the fair value of contingent cash consideration using a probability weighted discounted cash flow approach, a Level 3 measurement based on unobservable inputs that are supported by little or no market activity and reflect the Company’s own assumptions in measuring fair value. The Company used a discount rate of 21% in the assessment of the acquisition date fair value for the contingent cash consideration. Future changes in significant inputs such as the discount rate and estimated probabilities of milestone achievements could have a significant effect on the fair value of the contingent consideration.

The Company allocated approximately $0.9 million of the total consideration to tangible assets, net of liabilities, and $26.9 million to identified intangible assets, including additional developed technologies of $23.3 million, customer relationships of $1.1 million, and a trade name of $2.5 million, with weighted average useful lives of approximately nine, three, and ten years, respectively. The Company recorded the excess consideration of approximately $43.6 million as goodwill.

Other Acquisitions

During 2010, the Company completed several acquisitions that were not individually or collectively material to its overall consolidated financial statements. These acquisitions were included in the 2010 consolidated financial statements from the respective dates of the acquisitions. As a result of one of the acquisitions, the fair value of cash contingent consideration that could range from $0 to $35 million, based on the achievement of certain revenue-based milestones by December 31, 2011, was recorded as a liability. In addition, the Company completed the acquisition of a development-stage company in 2008. In accordance with the applicable accounting guidance effective at that time, the Company recorded a charge of $24.7 million for purchased IPR&D. As part of the acquisition agreement, the Company agreed to pay the former shareholders of the entity up to an additional $35.0 million in contingent cash consideration based on the achievement of certain product-related and employment-related milestones.

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As of October 2, 2011, the Company’s remaining gross milestone obligations related to these prior year acquisitions consisted of potential employment-related milestone payments of $1.4 million. Employment-related contingent compensation expense is recorded in operating expense.

Contingent compensation expenses and IPR&D charges as a result of acquisitions consist of the following (in thousands):

	Three Months Ended					Nine Months Ended
	October 2, 2011			October 3, 2010		October 2, 2011		October 3, 2010
Contingent compensation expense, included in research and development expense	$	775		$	919	$	4,067	$	2,757
Contingent compensation expense, included in selling, general and administrative expense		(279	)		—		1,259		—
Total contingent compensation expense	$	496		$	919	$	5,326	$	2,757
IPR&D, included in acquisition related (gain) expense, net	$	—		$	—	$	5,425	$	1,325

4. Fair Value Measurements

The following table presents the Company’s hierarchy for assets and liabilities measured at fair value on a recurring basis as of October 2, 2011 and January 2, 2011 (in thousands):

	October 2, 2011
	Quoted Prices in Active  Markets for Identical Assets (Level 1)		Significant Other Observable  Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Total
Assets:
Money market funds (cash equivalent)	$	120,569	$	—	$	—	$	120,569
Debt securities in government sponsored entities		—		401,319		—		401,319
Corporate debt securities		—		454,460		—		454,460
U.S. Treasury securities		46,565		—		—		46,565
Total assets measured at fair value	$	167,134	$	855,779	$	—	$	1,022,913
Liability:
Contingent consideration	$	—	$	—	$	8,162	$	8,162

	January 2, 2011
	Quoted Prices in Active  Markets for Identical Assets (Level 1)		Significant Other Observable  Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Total
Assets:
Money market funds (cash equivalent)	$	148,822	$	—	$	—	$	148,822
Debt securities in government sponsored entities		—		261,697		—		261,697
Corporate debt securities		—		330,758		—		330,758
U.S. Treasury securities		52,887		—		—		52,887
Total assets measured at fair value	$	201,709	$	592,455	$	—	$	794,164
Liability:
Contingent consideration	$	—	$	—	$	3,738	$	3,738

The Company measures the fair value of debt securities in government sponsored entities and corporate debt securities on a recurring basis primarily using quoted prices for similar assets in active markets.

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At October 2, 2011, the Company reassessed the fair value of the contingent consideration settled in cash related to acquisitions using the income approach. These fair value measurements are Level 3 measurements. Significant assumptions used in the measurement include probabilities of achieving the remaining milestones and the discount rates, which depends on the milestone risk profiles. Due to changes in the estimated probabilities to achieve the relevant milestones and a shorter discounting period, the fair value of the contingent consideration liabilities changed, resulting in a gain of $2.6 million and $3.0 million recorded in acquisition related (gain) expense, net, in the consolidated statements of income during the three and nine months ended October 2, 2011, respectively.

Changes in estimated fair value of contingent consideration liabilities from January 2, 2011 through October 2, 2011 are as follows (in thousands):

	Contingent Consideration Liability (Level 3 Measurement)
Balance at January 2, 2011	$	3,738
Acquisition of Epicentre		7,400
Gain recorded in acquisition related (gain) expense, net		(2,976	)
Balance at October 2, 2011	$	8,162

5. Warranties

The Company generally provides a one-year warranty on instruments. Additionally, the Company provides a warranty on its consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. The Company establishes an accrual for estimated warranty expenses based on historical experience as well as anticipated product performance. The Company periodically reviews the adequacy of its warranty reserve and adjusts, if necessary, the warranty percentage and accrual based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue. Expenses associated with instrument service contracts are recorded as a cost of service and other revenue as incurred.

Changes in the Company’s reserve for product warranties from January 2, 2011 through October 2, 2011 are as follows (in thousands):

Balance as of January 2, 2011	$	16,761
Additions charged to cost of revenue		18,477
Repairs and replacements		(19,370	)
Balance as of October 2, 2011	$	15,868

6. Convertible Senior Notes

0.25% Convertible Senior Notes due 2016

In March 2011, the Company issued $800 million aggregate principal amount of 0.25% convertible senior notes due 2016 (the 2016 Notes) in an offering conducted in accordance with Rule 144A under the Securities Act of 1933, as amended. The 2016 Notes were issued at 98.25% of par value. Debt issuance costs of approximately $0.4 million primarily comprised legal, accounting, and other professional fees, the majority of which were recorded in other noncurrent assets and are being amortized to interest expense over the five-year term of the 2016 Notes. The Company issued an additional $120 million aggregate principal amount of 2016 Notes in April 2011. The net proceeds from the initial issuance and subsequent issuance, after deducting the initial purchasers’ discount and the estimated offering expenses payable by the Company, were $785.6 million and $117.9 million, respectively.

The 2016 Notes will be convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at the Company’s election, based on an initial conversion rate, subject to adjustment, of 11.9687 shares per $1,000 principal amount of the 2016 Notes (which represents an initial conversion price of approximately $83.55 per share), only in the following circumstances and to the following extent: (1) during the five business-day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per 2016 Note for each day of such measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such day; (2) during any calendar quarter

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(and only during that quarter) after the calendar quarter ending March 31, 2011, if the last reported sale price of the Company’s common stock for 20 or more trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; (3) upon the occurrence of specified events described in the indenture for the 2016 Notes; and (4) at any time on or after December 15, 2015 through the second scheduled trading day immediately preceding the maturity date.

As noted in the indenture for the 2016 Notes, it is the Company’s intent and policy to settle conversions through combination settlement, which essentially involves repayment of an amount of cash equal to the “principal portion” and delivery of the “share amount” in excess of the conversion value over the principal portion in shares of common stock. In general, for each $1,000 in principal, the “principal portion” of cash upon settlement is defined as the lesser of $1,000, and the conversion value during the 20-day observation period as described in the indenture for the 2016 Notes. The conversion value is the sum of the daily conversion value which is the product of the effective conversion rate divided by 20 days and the daily volume weighted average price (“VWAP”) of the Company’s common stock. The “share amount” is the cumulative “daily share amount” during the observation period, which is calculated by dividing the daily VWAP into the difference between the daily conversion value (i.e., conversion rate x daily VWAP) and $1,000.

The Company will pay 0.25% interest per annum on the principal amount of the 2016 Notes, payable semiannually in arrears in cash on March 15 and September 15 of each year, beginning September 15, 2011. The 2016 Notes mature on March 15, 2016. If a designated event, as defined in the indenture for the 2016 Notes, occurs prior to the maturity date, subject to certain limitations, holders of the 2016 Notes may require the Company to repurchase all or a portion of their 2016 Notes for cash at a repurchase price equal to 100% of the principal amount of the 2016 Notes to be repurchased, plus any accrued and unpaid interest to, but excluding, the repurchase date.

The Company accounts separately for the liability and equity components of the 2016 Notes in accordance with authoritative guidance for convertible debt instruments that may be settled in cash upon conversion. The guidance requires the carrying amount of the liability component to be estimated by measuring the fair value of a similar liability that does not have an associated conversion feature. Because the Company has no outstanding non-convertible public debt, the Company determined that senior, unsecured corporate bonds traded on the market represent a similar liability to the convertible senior notes without the conversion option. Based on market data available for publicly traded, senior, unsecured corporate bonds issued by companies in the same industry and with similar maturity, the Company estimated the implied interest rate of its 2016 Notes to be 4.5%, assuming no conversion option. Assumptions used in the estimate represent what market participants would use in pricing the liability component, including market interest rates, credit standing, and yield curves, all of which are defined as Level 2 observable inputs. The estimated implied interest rate was applied to the 2016 Notes, which resulted in a fair value of the liability component of $748.5 million upon issuance, calculated as the present value of implied future payments based on the $920.0 million aggregate principal amount. The $155.4 million difference between the cash proceeds of $903.9 million and the estimated fair value of the liability component was recorded in additional paid-in capital as the 2016 Notes are not considered currently redeemable at the balance sheet date.

The interest expense recognized during the three and nine months ended October 2, 2011 includes $0.7 million and $1.3 million, respectively, for the contractual coupon interest, and $7.8 million and $16.6 million, respectively, for the accretion of discount on the liability component. If the 2016 Notes were converted as of October 2, 2011, the if-converted value would not exceed the principal amount. As a policy election under applicable guidance related to the calculation of diluted net income per share, the Company elected the combination settlement method as its stated settlement policy and applied the treasury stock method in the calculation of dilutive impact of the 2016 Notes, which was anti-dilutive for the three and nine months ended October 2, 2011.

The Company used $314.3 million of the net proceeds to purchase 4,890,500 shares of its common stock in privately negotiated transactions concurrently with the issuance. The Company also used part of the net proceeds for the extinguishment of $9.0 million and $349.9 million principal amount of its outstanding 0.625% convertible senior notes due 2014 upon conversions during the three and nine months ended October 3, 2011, respectively.

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0.625% Convertible Senior Notes due 2014

In February 2007, the Company issued $400.0 million principal amount of 0.625% convertible senior notes due 2014 (the 2014 Notes). The Company pays 0.625% interest per annum on the principal amount of the 2014 Notes, payable semi-annually in arrears in cash on February 15 and August 15 of each year. The Company made an interest payment of $1.2 million in February 2011. Interest payment in August 2011 was immaterial due to conversions prior to the payment date. The 2014 Notes mature on February 15, 2014.

The Company entered into a hedge transaction concurrently with the issuance of the 2014 Notes under which the Company is entitled to purchase up to 18,322,320 shares of the Company’s common stock at a strike price of approximately $21.83 per share, subject to adjustment. In addition, the Company sold to the hedge counterparties warrants exercisable, on a cashless basis, for up to 18,322,320 shares of the Company’s common stock at a strike price of $31.435 per share, subject to adjustment.

The 2014 Notes became convertible into cash and shares of the Company’s common stock in various prior periods and continue to be convertible through, and including, December 31, 2011. During the three and nine months ended October 2, 2011, the principal amount of any 2014 Notes converted were repaid with cash and the excess of the conversion value over the principal amount was paid in shares of common stock. The equity dilution resulting from the issuance of common stock related to the conversion of the 2014 Notes was offset by repurchase of the same amount of shares under the convertible note hedge transactions.

As a result of the conversions during the three and nine months ended October 2, 2011, the Company recorded losses on extinguishment of debt calculated as the difference between the estimated fair value of the debt and the carrying value of the notes as of the settlement dates. To measure the fair value of the converted notes as of the settlement dates, the applicable interest rates were estimated using Level 2 observable inputs and applied to the converted notes using the same methodology as in the issuance date valuation.

The following table summarizes information about the conversions of the 2014 Notes during the three and nine months ended October 2, 2011 (in thousands):

	Three Months Ended		Nine Months Ended
Cash paid for principal of notes converted	$	8,965	$	349,874
Conversion value over principal amount paid in shares of common stock	$	11,185	$	727,618
Number of shares of common stock issued upon conversion		244		10,733
Loss on extinguishment of debt	$	754	$	37,611
Effective interest rates used to measure fair value of converted notes		3.5% - 4.3%		3.5% - 4.3%

The following table summarizes information about the equity and liability components of the 2014 and 2016 Notes (in thousands). The fair values of the respective notes outstanding were measured based on quoted market prices.

	October 2, 2011						January 2, 2011
	0.25% Convertible Senior  Notes due 2016			0.625% Convertible Senior  Notes due 2014			0.625% Convertible Senior  Notes due 2014
Principal amount of convertible notes outstanding	$	920,000		$	40,125		$	389,999
Unamortized discount of liability component		(154,923	)		(6,332	)		(78,390	)
Net carrying amount of liability component		765,077			33,793			311,609
Less: current portion		—			(33,793	)		(311,609	)
Long-term debt	$	765,077		$	—		$	—
Conversion option subject to cash settlement		—		$	6,332		$	78,390
Carrying value of equity component, net of debt issuance cost	$	155,366		$	113,429		$	71,199
Fair value of outstanding notes	$	806,017		$	72,513		$	1,157,450
Remaining amortization period of discount on the liability component		4.5 years			2.4 years			3.1 years

7. Share-based Compensation Expense

Share-based compensation expense for employee stock options, restricted stock units, and stock purchases under the ESPP consists of the following (in thousands):

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	Three Months Ended						Nine Months Ended
	October 2, 2011			October 3, 2010			October 2, 2011			October 3, 2010
Cost of product revenue	$	1,955		$	1,359		$	5,267		$	3,869
Cost of service and other revenue		194			137			536			394
Research and development		8,621			6,521			24,810			18,451
Selling, general and administrative		13,801			9,943			39,663			29,090
Share-based compensation expense before taxes		24,571			17,960			70,276			51,804
Related income tax benefits		(8,464	)		(6,107	)		(24,424	)		(17,639	)
Share-based compensation expense, net of taxes	$	16,107		$	11,853		$	45,852		$	34,165

The assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted in connection with the ESPP during the nine months ended October 2, 2011 are as follows:

	Employee  Stock Options			Employee Stock Purchase  Rights
Interest rate		2.22 — 2.23	%		0.16 — 0.28	%
Volatility		41 — 43	%		43 — 46	%
Expected life		5.5 years			0.5 — 1.0 year
Expected dividend yield		0	%		0	%
Weighted average fair value per share	$	29.53		$	19.93

As of October 2, 2011, approximately $154.1 million of unrecognized compensation cost related to stock options, restricted stock units, and ESPP shares is expected to be recognized over a weighted average period of approximately 2.2 years.

8. Stockholders’ Equity

Stock Options

The Company’s stock option activity under all stock option plans during the nine months ended October 2, 2011 is as follows:

	Options			Weighted Average Exercise Price per Share		Weighted Average Grant-Date Fair Value per Share
	(in thousands)
Outstanding at January 2, 2011		11,882		$	22.83	$	12.82
Granted		1,226			70.06		29.53
Exercised		(2,647	)		18.20		10.66
Cancelled		(41	)		21.07		13.17
Outstanding at October 2, 2011		10,420		$	29.57	$	15.33

At October 2, 2011, outstanding options to purchase approximately 6,631,000 shares were exercisable with a weighted average per share exercise price of $22.45.

Employee Stock Purchase Plan

The price at which common stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first or last day of the offering period, whichever is lower. During the nine months ended October 2, 2011, approximately 328,000 shares were issued under the ESPP. As of October 2, 2011, there were approximately 15,734,000 shares available for issuance under the ESPP.

Restricted Stock Units

A summary of the Company’s restricted stock unit activity and related information for the nine months ended October 2, 2011 is as follows:

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	Restricted Stock  Units(1)			Weighted Average Grant-Date Fair Value per Share
	(in thousands)
Outstanding at January 2, 2011		3,109		$	40.39
Awarded		528			68.07
Vested		(355	)		36.97
Cancelled		(158	)		41.30
Outstanding at October 2, 2011		3,124		$	45.41

(1) The fair value of each restricted stock unit represents the fair market value of one share of the Company’s common stock.

Warrants

In conjunction with an acquisition in January 2007, the Company assumed a certain number of warrants, the majority of which were exercised in periods prior to 2011. During the first quarter of 2011, the remaining assumed warrants to purchase approximately 505,000 shares of the Company’s common stock were exercised, resulting in cash proceeds to the Company of approximately $5.5 million. As of October 2, 2011, warrants to purchase approximately 18,322,000 shares of common stock were outstanding with an exercise price of $31.44, which were all sold in connection with the offering of the Company’s 2014 Notes as discussed in note “6. Convertible Senior Notes.” All outstanding warrants expire on February 15, 2014.

Share Repurchases

In August 2011, the Company’s board of directors authorized a $100 million discretionary repurchase program. During the three months ended October 2, 2011, the Company utilized the authorized amount in its entirety and repurchased approximately 1,894,000 shares under this program.

In July 2010, the Company’s board of directors authorized a $200 million stock repurchase program, with $100 million allocated to repurchasing Company common stock under a 10b5-1 plan over a 12 month period and $100 million allocated to repurchasing Company common stock at management’s discretion during open trading windows. During the three and nine months ended October 2, 2011, the Company repurchased approximately 1,692,000 shares for $104.0 million and 2,438,000 shares for $156.0 million, respectively. The authorized repurchase amount had been utilized completely as of October 2, 2011.

Concurrently with the issuance of the Company’s 2016 Notes on March 18, 2011, 4,890,500 shares were repurchased for $314.3 million.

9. Income Taxes

The Company’s effective tax rate may vary from the U.S statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income. The effective tax rates for the three and nine months ended October 2, 2011 were 27.5% and 33.6 %, respectively. For the three months ended October 2, 2011, the variance from the U.S statutory rate of 35% was primarily attributable to adjustments related to tax returns for prior years in various jurisdictions and the tax benefit related to the loss on the extinguishment of debt. For the nine months ended October 2, 2011, the variance from the U.S statutory rate of 35% was primarily attributable to the same factors as in the three month period, partially offset by non-deductible additional IPR&D recorded in acquisition related (gain) expense, net.

10. Legal Proceedings

The Company is involved in various lawsuits and claims arising in the ordinary course of business. Because of the uncertainties related to the occurrence, amount, and range of loss on any pending litigation or claim, management is currently unable to predict their ultimate outcome, to determine whether a liability has been incurred, or to make a meaningful estimate of the reasonably possible loss or range of loss that could result from an unfavorable outcome. The Company believes, however, that the liability, if any, resulting from the aggregate amount of losses for any outstanding litigation or claim will not have a material adverse effect on the Company’s consolidated financial position, liquidity, or results of operations.

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11. Subsequent Event

On October 25, 2011, the Company announced restructuring plans to reduce its global workforce by approximately 200 employees, or approximately 8%. As a result of the reductions, the Company expects to record a restructuring charge, comprised primarily of compensation and benefits afforded to terminated employees, of approximately $15—17 million, the majority of which will be recorded and paid in the fourth quarter of fiscal 2011.

Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.

Our Management’s Discussion and Analysis of Financial Condition and Results of Operations (MD&A) is provided in addition to the accompanying condensed consolidated financial statements and notes to assist readers in understanding our results of operations, financial condition, and cash flows. This MD&A is organized as follows:

• Business Overview and Outlook. High level discussion of our operating results and significant known trends that affect our business.

• Results of Operations. Detailed discussion of our revenues and expenses.

• Liquidity and Capital Resources. Discussion of key aspects of our statements of cash flows, changes in our financial position, and our financial commitments.

• Off-Balance Sheet Arrangements. We have no significant off-balance sheet arrangements.

• Critical Accounting Policies and Estimates. Discussion of significant changes since our most recent Annual Report on Form 10-K that we believe are important to understanding the assumptions and judgments underlying our financial statements.

• Recent Accounting Pronouncements. Description of recent accounting pronouncements and the potential impact of these pronouncements on our financial position, results of operations, and cash flows.

This MD&A discussion contains forward-looking statements that involve risks and uncertainties. Please see “Consideration Regarding Forward-Looking Statements” at the end of this MD&A section for important information to consider when evaluating such statements. This MD&A should be read in conjunction with our consolidated financial statements and accompanying notes included in this report and our Annual Report on Form 10-K for the fiscal year ended January 2, 2011. Operating results are not necessarily indicative of results that may occur in future periods.

Business Overview and Outlook

This overview and outlook provides a high level discussion of our operating results and significant known trends that affect our business. We believe that an understanding of these trends is important to understanding our financial results for the periods being reported herein as well as our future financial performance. This summary is not intended to be exhaustive, nor is it intended to be a substitute for the detailed discussion and analysis provided elsewhere in this Quarterly Report on Form 10-Q.

About Illumina

We are a leading developer, manufacturer, and marketer of life science tools and integrated systems for the analysis of genetic variation and function. Using our proprietary technologies, we provide a comprehensive line of genetic analysis solutions, with products and services that address a broad range of highly interconnected markets, including sequencing, genotyping, gene expression, and molecular diagnostics. Our customers include leading genomic research centers, academic institutions, government laboratories, and clinical research organizations, as well as pharmaceutical, biotechnology, agrigenomics, and consumer genomics companies.

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Our broad portfolio of instruments, consumables, and analysis tools are designed to simplify and accelerate genetic analysis. This portfolio addresses the full range of genomic complexity, price points, and throughputs, enabling researchers to select the best solution for their scientific challenge. In 2007, through our acquisition of Solexa, Inc., we acquired our proprietary sequencing by synthesis (SBS) technology that is at the heart of our leading-edge sequencing instruments. These systems can be used to efficiently perform a range of nucleic acid (DNA, RNA) analyses on large numbers of samples. For more focused studies, our array-based solutions provide ideal tools to perform genome-wide association studies (GWAS) involving single-nucleotide polymorphism (SNP) genotyping and copy number variation (CNV) analyses, as well as gene expression profiling and other DNA, RNA, and protein studies. To further enhance our genetic analysis workflows, in January 2011 we acquired Epicentre Technologies Corporation, a leading provider of nucleic acid sample preparation reagents and specialty enzymes for sequencing and microarray applications. In 2010, through our acquisition of Helixis, Inc., we expanded our instrument portfolio to include real-time polymerase chain reaction (PCR), one of the most widely used technologies in life sciences.

Our financial results have been, and will continue to be, impacted by several significant trends, which are described below. While these trends are important to understanding and evaluating our financial results, this discussion should be read in conjunction with our condensed consolidated financial statements and the notes thereto in Item 1, Part I of this report, and the other transactions, events, and trends discussed in “Risk Factors” in Item 1A, Part II of this report and Item 1A of our Annual Report on Form 10-K for the fiscal year ended January 2, 2011.

Funding Environment

Many of our customers receive funding from government agencies to purchase our instruments, products, and services. There remains significant uncertainty concerning government and academic research funding worldwide as governments in the United States and Europe, in particular, focus on reducing fiscal deficits while at the same time confronting slowing economic growth. We estimate that approximately one-third of our total revenue is derived, directly or indirectly, from funding provided by the U.S. National Institute of Health (NIH). After growing steadily through 2010, the NIH budget experienced an approximate 1% reduction in fiscal 2011, which ended on September 30, 2011, compared to fiscal 2010. Based on current Congressional proposals, we expect the fiscal 2012 NIH budget to be relatively flat to modestly lower compared to fiscal 2011 levels. In addition, we believe that the U.S. Department of Health and Human Services (HHS), of which the NIH is a part, has the ability to reallocate funds within its budget to spare the NIH from the full effect of HHS budget reductions. The significance and timing of any reductions to the NIH budget in fiscal 2012 and beyond will be significantly impacted by the actions of a bi-partisan Congressional committee established by the Budget Control Act of 2011, which was enacted on August 2, 2011. Nevertheless, we continue to believe that allocations within the NIH budget will continue to favor genetic analysis tools and, in particular, next-generation sequencing. Although we expect Q4 2011 revenue to be higher than Q3 2011, uncertainty surrounding the levels of research funding worldwide is expected to continue to negatively impact our business.

Next-Generation Sequencing

Over the next several years, expansion of the sequencing market, including an increase in the number of samples available, and enhancements in our product portfolio will continue to drive demand for our next-generation sequencing technologies. In Q2 2011, we launched new, higher-throughput sequencing consumable kits that enable our customers to sequence a greater number of samples in a single instrument run. We believe that this increased throughput created excess capacity that customers were unable to fully utilize due to a lack of available samples, which resulted in fewer sequencing runs per instrument. We believe that this excess capacity will diminish as customers scale and gain access to greater numbers of samples. We also believe that our new sequencing kits will enable customers to sequence whole human genomes for less than $5,000 in consumables costs.

With respect to sequencing instruments, during Q1 2011 we reduced our HiSeq 2000 backlog. In Q2 2011, HiSeq 2000 shipments decreased compared to Q1 2011 primarily due to the reduced backlog entering the quarter. Also, during Q2 2011, HiSeq 2000 average selling prices increased compared to Q1 2011 primarily due to the completion of promotional programs, including the Genome Analyzer trade-in program. In Q3 2011, we experienced a decrease in revenue from sequencing instrument sales, which we believe was a result of the continued uncertainty surrounding the levels of academic funding in the United States and Europe leading to purchasing delays and lower than expected upgrades of Genome Analyzers to HiSeq 2000 systems. In addition, we believe that the excess capacity created from the higher throughput of our new sequencing kits negatively affected sequencing instrument sales as a result of installed instruments being underutilized.

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With respect to sequencing consumables, we experienced a decrease in the consumable revenue per instrument in Q3 2011 despite an overall increase in sequencing consumable sales. We believe this decrease was driven, in part, by funding uncertainty and the excess capacity created from the higher throughput of our new sequencing kits. With respect to our new sequencing kits, we believe that the higher throughput resulted in fewer sequencing runs per instrument as certain customers awaited access to more available samples or adopted workflow changes, in each case to accommodate more samples per run in order to utilize this increased capacity. Also, we believe that certain customers finished sequencing projects earlier than expected because of the increased capacity. In addition, we experienced a significant decrease in consumable usage by our remaining Genome Analyzer installed base, which we believe resulted primarily from an underutilization of Genome Analyzer instruments as compared to HiSeq 2000 instruments in facilities where both instruments are installed. As we continue to make improvements that reduce the cost of sequencing, we believe that more customers will use the HiSeq 2000, which generates more revenue per instrument time than the Genome Analyzer, and that the increased capacity from our higher throughput sequencing kits will be more fully utilized as additional samples become increasingly available over the next few quarters. We believe that this will increase our consumable revenue per instrument over the long run.

Towards the end of Q3 2011, we began commercial shipments of our previously announced MiSeq, a low-cost personal sequencing system that we believe will provide individual researchers a platform with rapid turnaround time, high accuracy, and streamlined workflow. We believe the MiSeq will expand our presence in the lower throughput sequencing market. We expect to begin volume shipments of the MiSeq during Q4 2011.

MicroArrays

As a complement to next-generation sequencing, we believe microarrays offer a less expensive, faster, and more accurate technology for use when genetic content is already known. The information content of microarrays is fixed and reproducible. As such, microarrays provide repeatable, standardized assays for certain subsets of nucleotide bases within the overall genome. In late June 2011, we began shipments of the Omni5 BeadChip, a four-sample microarray featuring more than 4.3 million markers per sample with flexibility to include up to 500,000 custom markers. This product includes a majority of the rare variant content from the 1000 genomes project, an international research effort launched in 2008 to establish the most detailed catalog of human genetic variation.

Financial Overview

Financial highlights for the first three quarters of 2011 include the following:

• Net revenue grew by 26% during the first three quarters of 2011 compared to the same period in 2010. The increase in revenue was primarily driven by increased HiSeq 2000 shipments and an increase in consumables sales as our installed base expands.

• Gross profit as a percentage of revenue (gross margin) in the first three quarters of 2011 decreased from the same period in 2010 primarily due to a shift in sales mix from higher gross margin consumables to lower gross margin instruments. The change in mix was primarily due to the launch of the HiSeq 2000, which did not begin volume shipments until the second half of 2010. We believe several factors may contribute to improved gross margin over the long run, including increases in consumables sales, which may result in better overhead absorption, and measures to optimize our cost structure for manufacturing operations.

• Income from operations increased 20% in the first three quarters of 2011 compared to the same period in 2010 primarily due to higher revenue. Total operating expense increased by 25% in the same period, primarily due to increased personnel costs associated with increased headcount. On October 25, 2011, we announced restructuring plans to reduce our global workforce by approximately 200 employees, or approximately 8%. As a result of the reductions, we expect to record a restructuring charge, comprised primarily of compensation and benefits afforded to terminated employees, of approximately $15 -$17 million, the majority of which will be recorded and paid in the fourth quarter of fiscal 2011. We believe that our cost structure after the completion of the restructuring will be better aligned with our business to maintain profitability.

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• In December 2010, we entered into a lease agreement for new corporate headquarters. During the first three quarters of 2011, we incurred $11.6 million in headquarter relocation expense. We expect to incur additional headquarter relocation expense during the remainder of 2011, such as a cease-use loss upon vacating our current headquarters, accelerated depreciation of certain property and equipment, and double rent expense during the transition to the new facility.

• Our effective tax rate during the first three quarters of 2011 was 33.6%. The provision for income taxes is dependent on the mix of earnings in tax jurisdictions with different statutory tax rates and the other factors discussed in the risk factor “We are subject to risks related to taxation in multiple jurisdictions and the possible loss of the tax deduction on our outstanding convertible notes” in Item 1A of our Annual Report on Form 10-K for the fiscal year ended January 2, 2011. For 2011, we anticipate the provision for income taxes to increase in absolute dollars and the effective tax rate to approximate the U.S. federal statutory rate due to a significant portion of our earnings being subject to U.S. taxation. However, we anticipate the effective tax rate to decrease over time as the proportion of our earnings subject to lower statutory tax rates increases. We anticipate significant income tax payments in 2011 and beyond due to the expected utilization of the majority of our net operating loss carryforwards and U.S. federal research and development tax credit carryforwards.

• We ended the first three quarters of 2011 with cash, cash equivalents, and short-term investments totaling $1.1 billion. In the first three quarters of 2011, we generated $249.8 million in cash from operations, a $58.7 million, or 31%, increase from the same period in 2010. During the same period, we also generated $903.5 million in net proceeds from the issuance of our 0.25% Convertible Senior Notes due 2016, used $314.3 million to repurchase shares of our common stock concurrently with the issuance, and used $349.9 million to repay our existing 0.625% Convertible Senior Notes due 2014.

Results of Operations

To enhance comparability, the following table sets forth our unaudited condensed consolidated statements of operations for the specified reporting periods stated as a percentage of total revenue.

	Q3 2011			Q3 2010			YTD 2011			YTD 2010
Revenue:
Product revenue		94	%		95	%		94	%		93	%
Service and other revenue		6			5			6			7
Total revenue		100			100			100			100
Cost of revenue:
Cost of product revenue		29			31			30			29
Cost of service and other revenue		3			2			2			2
Amortization of acquired intangible assets		1			1			1			1
Total cost of revenue		33			34			33			32
Gross profit		67			66			67			68
Operating expense:
Research and development		21			19			19			21
Selling, general and administrative		28			23			25			25
Acquisition related (gain) expense, net		(1	)		—			—			—
Headquarter relocation expense		3			—			1			—
Total operating expense		51			42			45			46
Income from operations		16			24			21			22
Other income (expense):
Interest income		1			1			1			1
Interest expense		(4	)		(2	)		(3	)		(3	)
Other (expense) income, net		(1	)		—			(5	)		1
Total other expense, net		(4	)		—			(7	)		(1	)
Income before income taxes		12			23			14			21
Provision for income taxes		3			8			5			8
Net income		9	%		15	%		9	%		13	%

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Our fiscal year consists of 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. The three- and nine-month periods ended October 2, 2011 and October 3, 2010 were both 13 and 39 weeks, respectively.

Revenue

(Dollars in thousands)	Q3 2011		Q3 2010		Change			Percentage Change			YTD 2011		YTD 2010		Change		Percentage Change
Product revenue	$	220,296	$	224,668	$	(4,372	)		(2	)%	$	756,884	$	596,885	$	159,999		27	%
Service and other revenue		15,203		12,641		2,562			20			48,580		44,558		4,022		9
Total revenue	$	235,499	$	237,309	$	(1,820	)		(1	)%	$	805,464	$	641,443	$	164,021		26	%

Product revenue consists primarily of revenue from the sale of consumables and instruments. Our service and other revenue is primarily generated from instrument service contracts and genotyping and sequencing services.

Q3 2011 Compared to Q3 2010

Consumables revenue increased $11.9 million, or 9%, to $144.9 million in Q3 2011 compared to $133.0 million in Q3 2010. The increase was primarily attributable to increased sales of sequencing consumables driven by growth in the installed base of our sequencing systems, partially offset by decreased sales of microarray consumables. Additionally, although overall sequencing consumable sales increased, we experienced a decrease in the consumable revenue per instrument in our sequencing business. We believe this decrease was driven, in part, by the launch of new, higher-throughput sequencing kits in Q2 2011, which created excess capacity that customers were unable to fully utilize, resulting in fewer runs per instrument. In addition, we experienced a significant drop in consumable usage by our remaining Genome Analyzer installed base, which we believe resulted primarily from an underutilization of Genome Analyzer instruments as compared to HiSeq 2000 instruments in facilities where both instruments are installed.

Instrument revenue decreased $16.0 million, or 18%, to $71.8 million in Q3 2011 compared to $87.8 million in Q3 2010. The decrease was primarily attributable to decreased number of HiSeq 2000 units sold, despite an increase in the average selling price per sequencing instrument and the first commercial shipments of MiSeq in late September. We believe decreased HiSeq 2000 sales resulted from purchasing delays due to the continued uncertainty surrounding the levels of academic funding in the United States and Europe and overall economic conditions, as well as an excess of sequencing capacity in the market.

Revenue from HiSeq 2000 sales in 2011 and 2010 was impacted by discounts provided to customers under our Genome Analyzer trade-in program. While it is not possible to precisely quantify the net impact of the trade-in promotion due to the uncertainty surrounding orders that would have been received in the absence of the promotion, the estimated incremental sales incentive provided under this trade-in program was approximately $20.4 million in Q3 2010. The incremental sales incentive is calculated based on the total discount provided from list price in excess of our average discount on HiSeq 2000 sales during the period. The impact of the Genome Analyzer trade-in program was immaterial in Q3 2011. See “Revenue Recognition” in note “1. Summary of Significant Accounting Policies” in Part I, Item 1, of this Form 10-Q for additional information on the Genome Analyzer trade-in program.

Microarray instrument revenue also increased in Q3 2011 from Q3 2010 primarily due to the launch of our HiScan and HiScanSQ instruments in 2010.

The increase in service and other revenue in Q3 2011 compared to Q3 2010 was driven by the increase in our instrument service contract revenue as a result of our expanded installed base and an increase in sequencing services.

YTD Q3 2011 Compared to YTD Q3 2010

Year-to-date consumables revenue increased $79.3 million, or 21%, to $452.1 million in 2011 compared to $372.8 million in 2010. The increase was primarily attributable to increased sales of sequencing consumables driven by growth in the installed base of our sequencing systems, partially offset by a decrease in the consumable revenue per instrument in our sequencing business.

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Year-to-date instrument revenue increased $77.9 million, or 36%, to $292.9 million in 2011 compared to $215.0 million in 2010. The increase was primarily attributable to strong demand for the HiSeq 2000 since its launch in Q1 2010, and sales through three complete quarters in 2011 as compared to two complete quarters and a partial quarter in 2010. The average selling price per sequencing instrument increased during the period as well.

Revenue from HiSeq 2000 sales in 2011 and 2010 was impacted by discounts provided to customers under our Genome Analyzer trade-in program. The estimated incremental sales incentive provided under this trade-in program was approximately $11.1 million and $24.1 million in the first three quarters of 2011 and 2010, respectively. See “Revenue Recognition” in note “1. Summary of Significant Accounting Policies” in Part I, Item 1, of this Form 10-Q for additional information on the Genome Analyzer trade-in program.

Microarray instrument revenue also increased year over year primarily due to the launch of our HiScan and HiScanSQ instruments in 2010.

The increase in service and other revenue in 2011 compared to 2010 was driven by the increase in our instrument service contract revenue as a result of our expanded installed base and an increase in sequencing services.

Gross Margin

(Dollars in thousands)	Q3 2011			Q3 2010			Change			Percentage Change		YTD 2011			YTD 2010			Change		Percentage Change
Gross profit	$	157,115		$	157,145		$	(30	)		—	$	538,512		$	435,414		$	103,098		24	%
Gross margin		66.7	%		66.2	%							66.9	%		67.9	%

Q3 2011 Compared to Q3 2010

The increase in gross margin in Q3 2011 compared to Q3 2010 was primarily attributable to a shift in sales mix from lower gross margin instruments to higher gross margin consumables, as a result of a decrease in instrument sales and an increase in consumable sales. The increase in gross margin is also partially attributable to an increase in instrument gross margins in Q3 2011 compared to Q3 2010, as Q3 2010 instrument sales were affected by promotional discounts provided to customers on HiSeq 2000 sales, including the Genome Analyzer trade-in program. Based on the estimated amount of incremental sales incentive provided, the Genome Analyzer trade-in program negatively impacted our gross margin by approximately 8.6% and in Q3 2010. The impact on our Q3 2011 gross margin was negligible.

YTD Q3 2011 Compared to YTD Q3 2010

Gross margin decreased in the first three quarters of 2011 compared to the same period in 2010. During the period, we experienced a shift in sales mix from higher gross margin consumables to lower gross margin instruments, primarily due to the launch of HiSeq 2000, which did not begin volume shipments until the second half of 2010. Lower margins on instrument sales reflect the effect of promotional discounts provided to customers on HiSeq 2000 sales, including the Genome Analyzer trade-in program. Based on the estimated amount of incremental sales incentive provided, the Genome Analyzer trade-in program negatively impacted our gross margin by approximately 1.4% and 3.8% in the first three quarters of 2011 and 2010, respectively.

Operating Expense

(Dollars in thousands)	Q3 2011			Q3 2010		Change			Percentage Change			YTD 2011		YTD 2010		Change		Percentage Change
Research and development	$	50,399		$	44,804	$	5,595			12	%	$	151,400	$	132,146	$	19,254		15	%
Selling, general and administrative		66,031			55,006		11,025			20			200,925		158,420		42,505		27
Acquisition related (gain) expense, net		(2,598	)		—		(2,598	)		(100	)		2,442		1,861		581		31
Headquarter relocation expense		6,519			—		6,519			100			11,583		—		11,583		100
Total operating expense	$	120,351		$	99,810	$	20,541			21	%	$	366,350	$	292,427	$	73,923		25	%

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Q3 2011 Compared to Q3 2010

The increase in research and development expense in Q3 2011 from Q3 2010 was primarily attributable to increase in personnel expenses of $4.2 million, associated with increased headcount in support of projects to develop and commercialize new products and to sustain and optimize our existing product portfolio. Personnel expenses included salaries, share-based compensation, and benefits.

The increase in selling, general and administrative expense in Q3 2011 from Q3 2010 was primarily attributable to an increase in personnel expenses of $9.0 million associated with increased headcount. Personnel expenses included salaries, share-based compensation, and benefits. The remaining increase of $2.0 million was primarily due to increases in bad debt expenses as a result of a customer bankruptcy and travel expenses.

Acquisition related (gain) expense, net, in Q3 2011 included gains related to changes in fair value of contingent consideration.

In anticipation of exiting our current headquarters facility, we recorded headquarter relocation expense of $6.5 million in Q3 2011, which primarily represents accelerated depreciation expense and rent expense on the new facility during the transition period of occupying both the current and new facility. Refer to note “1. Summary of Significant Accounting Policies” in Part I, Item 1 of this Form 10-Q for further information.

YTD Q3 2011 Compared to YTD Q3 2010

The increase in research and development expense in the first three quarters of 2011 from 2010 was primarily attributable to an increase in personnel expenses of $17.5 million associated with increased headcount in projects to develop and commercialize new products and to sustain and optimize our existing product portfolio. Personnel expenses included salaries, share-based compensation, and benefits.

The increase in selling, general and administrative expense in the first three quarters of 2011 from 2010 was primarily attributable to an increase in personnel expenses of $31.8 million associated with the growth of our business during the period. Personnel expenses included salaries, non-cash share-based compensation, and benefits. The remaining increase was primarily driven by a $2.6 million increase in bad debt expenses as a result of customer bankruptcies, a $2.1 million increase in travel expenses, a $1.9 million increase in outside service expenses comprised mostly of professional service expenses, and a $1.6 million increase in office and computer supplies.

Acquisition related (gain) expense, net, in the first three quarters of 2011 included gains related to changes in fair value of contingent consideration partially offset by acquired in-process research and development of $5.4 million related to a milestone payment for a prior acquisition. Acquisition related (gain) expense, net in the prior year periods was comprised primarily of acquired in-process research and development of $1.3 million.

In anticipation of exiting our current headquarters facility, we recorded headquarter relocation expense of $11.5 million in the first three quarters of 2011, which represented accelerated depreciation expense and rent expense on the new facility during the transition period of occupying both the current and new facility.

Other Expense, Net

(Dollars in thousands)	Q3 2011			Q3 2010			Change			Percentage Change			YTD 2011			YTD 2010			Change			Percentage Change
Interest income	$	1,388		$	2,791		$	(1,403	)		50	%	$	4,909		$	6,746		$	(1,837	)		(27	)%
Interest expense		(8,797	)		(6,190	)		(2,607	)		42			(25,605	)		(18,279	)		(7,326	)		40
Other (expense) income, net		(1,564	)		774			(2,338	)		(302	)		(38,643	)		3,142			(41,785	)		(1,330	)
Total other expense, net	$	(8,973	)	$	(2,625	)	$	(6,348	)		242	%	$	(59,339	)	$	(8,391	)	$	(50,948	)		607	%

Q3 2011 Compared to Q3 2010

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Interest income decreased in Q3 2011 as compared to Q3 2010 as a result of lower interest rates, partially offset by an increase in our average cash and investment balance. Interest expense increased primarily due to amortization of the discount on our 0.25% convertible senior notes due 2016 issued in the current year.

Other (expense) income, net, in Q3 2011 primarily consisted of a loss on the extinguishment of debt recorded on conversions of our 0.625% convertible senior notes due 2014 and foreign exchange transaction losses. The loss on extinguishment of debt was calculated as the difference between the carrying amount of the converted notes and their fair value as of the settlement dates. Refer to note “6. Convertible Senior Notes” in Part I, Item 1 of this Form 10-Q for further description. Other (expense) income, net in Q3 2010 consisted of foreign currency transaction losses.

YTD Q3 2011 Compared to YTD Q3 2010

The decrease in interest income in the first three quarters of 2011 compared to the first three quarters of 2010 was primarily driven by the lower interest rates. Interest expense increased primarily due to amortization of the discount on our 0.25% convertible senior notes due 2016.

Other (expense) income, net, in the first three quarters of 2011 primarily consisted of a loss on the extinguishment of debt recorded on conversions of our 0.625% convertible senior notes due 2014 of $37.6 million. Other (expense) income, net, in the prior year periods consisted of a $2.9 million gain on acquisition recorded in Q1 2010 for the difference between the carrying value of a cost method investment prior to the acquisition and the fair value of that investment at the time of acquisition, and foreign exchange gain or losses.

Provision for Income Taxes

(Dollars in thousands)	Q3 2011			Q3 2010			Change			Percentage Change			YTD 2011			YTD 2010			Change			Percentage Change
Income before income taxes	$	27,791		$	54,710		$	(26,919	)		(49	)%	$	112,823		$	134,596		$	(21,773	)		(16	)%
Provision for income taxes	$	7,640		$	19,263		$	(11,623	)		(60	)	$	37,915		$	48,145		$	(10,230	)		(21	)
Effective tax rate		27.5	%		35.2	%								33.6	%		35.8	%

Q3 2011 Compared to Q3 2010

The variance from the U.S statutory rate of 35% for Q3 2011 is primarily attributable to the tax benefit related to the loss on extinguishment of debt and adjustments related to tax returns for prior years in various jurisdictions. Our future effective tax rate may vary from the U.S. statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income.

The tax rate variance from the U.S. statutory rate in Q3 2010 was primarily related to the expiration of the federal research and development tax credit at the end of 2009 and the fact that retroactive legislative measure to extend the federal research and development tax credit was not passed until the end of 2010.

YTD Q3 2011 Compared to YTD Q3 2010

For the first three quarters of 2011, the variance from the U.S statutory rate of 35% is primarily attributable to the tax benefit related to the loss on extinguishment of debt and adjustments related to tax returns for prior years in various jurisdictions, partially offset by a tax detriment related to non-deductible additional IPR&D charges recorded to acquisition related (gain) expense, net.

The tax rate variance from the U.S. statutory rate in the first three quarters of 2010 was primarily related to the expiration of the federal research and development tax credit at the end of 2009 and the fact that retroactive legislative measure to extend the federal research and development tax credit was not passed until the end of 2010.

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Liquidity and Capital Resources

Cash flow summary

(In thousands)	YTD 2011			YTD 2010
Net cash provided by operating activities	$	249,840		$	191,092
Net cash used in investing activities		(358,039	)		(214,996	)
Net cash provided by financing activities		89,168			89,930
Effect of exchange rate changes on cash and cash equivalents		(70	)		(108	)
Net (decrease) increase in cash and cash equivalents	$	(19,101	)	$	66,134

Operating Activities

Cash provided by operating activities for the first three quarters of 2011 consisted of net income of $74.9 million plus net non-cash adjustments of $158.2 million and changes in net operating assets of $16.8 million. The primary non-cash expenses added back to net income included share-based compensation of $70.3 million, debt extinguishment loss of $37.6 million, depreciation and amortization expenses related to property and equipment and intangible assets of $49.8 million, and the accretion of the debt discount of $23.7 million. These non-cash add-backs were partially offset by the $40.4 million incremental tax benefit related to stock options exercised. The main drivers in the change in net operating assets included increases in accrued liabilities, and decreases in accounts payable and prepaid expenses and other current assets.

Cash provided by operating activities for the first three quarters of 2010 consisted of net income of $86.5 million plus net non-cash adjustments of $105.1 million and a $0.5 million increase in net operating assets. The primary non-cash expenses added back to net income included share based compensation of $51.8 million and depreciation and amortization expense related to property and equipment, intangibles and the debt discount on our convertible notes totaling $46.0 million.

Investing Activities

Cash used in investing activities totaled $358.0 million for the first three quarters of 2011. We purchased $1.1 billion of available-for-sale securities, and $840.1 million of our available-for-sale securities matured or were sold during Q3 2011. We used $58.3 million, net of cash acquired, in an acquisition and $11.4 million in the purchase of strategic investments. We also incurred $50.7 million in capital expenditures primarily associated with the purchase of R&D, manufacturing and servicing equipment, infrastructure in our facilities, and information technology equipment and systems.

Cash used in investing activities totaled $215.0 million for the first three quarters of 2010. We purchased available-for-sale securities totaling $663.4 million, sold available-for-sale securities totaling $558.1 million, and sold trading securities totaling $54.9 million. We paid $98.2 million for acquisitions and $22.5 million for strategic investments. We also incurred $37.4 million in capital expenditures primarily associated with the purchase of manufacturing equipment for our San Diego facility, infrastructure for additional production capacity, and addition of instruments deployed for internal use.

Financing Activities

Cash provided by financing activities totaled $89.2 million for the first three quarters of 2011. We received $903.5 million in proceeds from the issuance of $920.0 million of our 0.25% Convertible Senior Notes due 2016, net of issuance discounts. $349.9 million was used to repay the principal amount of our 0.625% Convertible Senior Notes due 2014 upon conversions during the first three quarters of 2011. Total cash of $570.4 million was used in repurchases of our common stock. We also received $60.1 million in proceeds from the issuance of our common stock through the exercise of stock options and warrants and the sale of shares under our Employee Stock Purchase Plan. In addition, we received $40.4 million in incremental tax benefit related to stock options exercised.

Cash provided by financing activities totaled $89.9 million for the first three quarters of 2010. We received $91.4 million in proceeds from the exercise of stock options and warrants and the sale of shares under our Employee Stock Purchase Plan and $14.6 million in incremental tax benefit related to stock options exercised. These increases were partially offset by common stock repurchases of $16.0 million.

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Liquidity

We manage our business to maximize operating cash flows as the primary source of our liquidity. Our ability to generate cash from operations provides us with the financial flexibility we need to meet operating, investing, and financing needs. Historically, we have also issued debt and equity securities to fund our needs and business plans when necessary.

At October 2, 2011, we had approximately $1.1 billion in cash and short-term investments. Our short-term investments consist of marketable securities, including debt securities in government sponsored entities, corporate debt securities, and U.S. Treasury notes.

Earlier in 2011, we issued $920.0 million in principal amount of convertible senior notes that mature March 15, 2016. We pay 0.25% interest per annum on the principal amount of the notes, payable semi-annually in arrears in cash on March 15 and September 15 of each year. In 2007, we issued $400.0 million in principal of convertible senior notes that mature February 15, 2014. We pay 0.625% interest per annum on the principal amount of the notes, payable semi-annually in arrears in cash on February 15 and August 15 of each year. The notes are convertible into cash and, if applicable and so elect, shares of our common stock under certain circumstances as described in note “6. Convertible Senior Notes” in Part I, Item 1, of this Form 10-Q. As of July 3, 2011, the principal amounts of our 0.25% Convertible Senior Notes due 2016 and our 0.625% Convertible Senior Notes due 2014 were $920.0 million and $40.1 million, respectively.

During the first three quarters of 2011, we used a total of $349.9 million from the net proceeds from the issuance of our 0.25% Convertible Senior Notes due 2016 in extinguishment of our 0.625% Convertible Senior Notes due 2014 upon conversion. We will continue to use the net proceeds from the issuance of our 0.25% Convertible Senior Notes due 2016 for future debt extinguishment. In addition, we used an additional $314.3 million of the net proceeds to purchase 4.9 million shares of our common stock in privately negotiated transactions concurrently with the issuance. We intend to use the remaining net proceeds for other general corporate purposes, which may include acquisitions and additional purchases of our common stock.

Our primary short-term needs for capital, which are subject to change, include expenditures related to:

• potential strategic acquisitions and investments;

• support of our commercialization efforts related to our current and future products, including expansion of our direct sales force and field support resources both in the United States and abroad;

• the repurchase of our outstanding common stock;

• the continued advancement of research and development efforts;

• the acquisition of equipment and other fixed assets for use in our current and future manufacturing and research and development facilities; and

• the expansion needs of our facilities, including costs of leasing additional facilities.

We expect that our product revenue and the resulting operating income, as well as the status of each of our new product development programs, will significantly impact our cash management decisions.

We anticipate that our current cash and cash equivalents and income from operations will be sufficient to fund our operating needs for at least the next 12 months, barring unforeseen circumstances. Operating needs include the planned costs to operate our business, including amounts required to fund working capital and capital expenditures. At the present time, we have no material commitments for capital expenditures. Our future capital requirements and the adequacy of our available funds will depend on many factors, including:

• our ability to successfully commercialize and further develop our technologies and create innovative products in our markets;

• progress in our research and development programs and the magnitude of those programs;

28

• competing technological and market developments; and

• the need to enter into collaborations with other companies or acquire other companies or technologies to enhance or complement our product and service offerings.

Off-Balance Sheet Arrangements

We do not participate in any transactions that generate relationships with unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or special purpose entities, which would have been established for the purpose of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes. During the first three quarters of 2011, we were not involved in any “off-balance sheet arrangements” within the meaning of the rules of the SEC.

Critical Accounting Policies and Estimates

In preparing our financial statements, we make estimates, assumptions and judgments that can have a significant impact on our net revenue, operating income and net income, as well as on the value of certain assets and liabilities on our balance sheet. We believe that the estimates, assumptions and judgments involved in the accounting policies described in Management’s Discussion and Analysis of Financial Condition and Results of Operations in Item 7 of our Annual Report on Form 10-K for the fiscal year ended January 2, 2011 have the greatest potential impact on our financial statements, so we consider them to be our critical accounting policies and estimates. There were no material changes to our critical accounting policies and estimates during the first three quarters 2011.

Recent Accounting Pronouncements

For a description of recent accounting pronouncements and the potential impact of these pronouncements on our financial position, results of operations and cash flows, see note “1. Summary of Significant Accounting Principles” to the financial statements in Part I, Item 1 of this Quarterly Report on Form 10-Q.

Consideration Regarding Forward-Looking Statements

This Quarterly Report on Form 10-Q contains forward-looking statements that involve risks and uncertainties, such as statements of our plans, strategies, objectives, expectations, intentions, and adequacy of resources. Words such as “anticipate,” “believe,” “continue,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” or similar words or phrases, or the negatives of these words, may identify forward-looking statements, but the absence of these words does not necessarily mean that a statement is not forward looking. Examples of forward-looking statements include, among others, statements regarding the integration of our acquired technologies with our existing technology, the commercial launch of new products, the entry into new business segments or markets, and the duration which our existing cash and other resources is expected to fund our operating activities.

Forward-looking statements are subject to known and unknown risks and uncertainties and are based on potentially inaccurate assumptions that could cause actual results to differ materially from those expected or implied by the forward-looking statements. Among the important factors that could cause actual results to differ materially from those in any forward-looking statements include the following:

• reductions in the funding levels to our primary customers, including as a result of significant uncertainty concerning government and academic research funding worldwide;

• our ability to develop and commercialize further our sequencing, array, PCR, and consumables technologies and to deploy new sequencing, genotyping, gene expression, and diagnostics products and applications for our technology platforms;

• our ability to manufacture robust instrumentation and consumables;

• our expectations and beliefs regarding future conduct and growth of the business;

• our ability to maintain our revenue and profitability during periods of research funding reduction or uncertainty, adverse economic and business conditions, including as a result of slowing economic growth in the United States or worldwide;

29

• the assumptions underlying our Critical Accounting Policies and Estimates, including our estimates regarding stock volatility and other assumptions used to estimate the fair value of share-based compensation; the fair value of goodwill; and expected future amortization of acquired intangible assets;

• our belief that the investments we hold are not other-than-temporarily impaired;

• our assessments and estimates that determine our effective tax rate;

• our belief that our cash and cash equivalents, investments and cash generated from operations will be sufficient to meet our working capital, capital expenditures and other liquidity requirements for at least the next 12 months’; and

• our assessments and beliefs regarding the future outcome of pending legal proceedings and the liability, if any, that Illumina may incur as a result of those proceeding.

The foregoing factors should be considered together with other factors detailed in our filings with the Securities and Exchange Commission, including our most recent filings on Forms 10-K and 10-Q, or in information disclosed in public conference calls, the date and time of which are released beforehand. We undertake no obligation, and do not intend, to update these forward-looking statements, to review or confirm analysts’ expectations, or to provide interim reports or updates on the progress of the current financial quarter. Accordingly, you should not unduly rely on these forward-looking statements, which speak only as of the date of this Quarterly Report on Form 10-Q.

Additionally, our business is subject to various risks, including those described in Item 1A of our Annual Report on Form 10-K for the fiscal year ended January 2, 2011, which we strongly encourage you to review.

Item 3. Quantitative and Qualitative Disclosures About Market Risk.

There were no substantial changes to our market risks in the nine months ended October 2, 2011, when compared to the disclosures in Item 7A of our Annual Report on Form 10-K for the fiscal year ended January 2, 2011, except as noted below:

Interest Rate Sensitivity

Changes in interest rates may impact gains or losses from the conversion of our outstanding convertible senior notes. During the first three quarters of 2011, we issued $920 million in aggregate principal amount of our 0.25% convertible senior notes due 2016. At our election, the notes are convertible into cash, shares of our common stock, or a combination of cash and shares of our common stock in each case under certain circumstances, including trading price conditions related to our common stock. If the trading price of our common stock reaches a price at 130% above the conversion price, the notes will become convertible. Upon conversion, we are required to record a gain or loss for the difference between the fair value of the debt to be extinguished and its corresponding net carrying value. The fair value of the debt to be extinguished depends on our then-current incremental borrowing rate. If our incremental borrowing rate at the time of conversion is higher or lower than the implied interest rate of the notes, we will record a gain or loss in our consolidated statement of income during the period in which the notes are converted. The implicit interest rate for the notes is 4.5%. An incremental borrowing rate that is a hypothetical 100 basis points lower than the implicit interest rate upon conversion of $100 million aggregate principal amount of the notes would result in a loss of approximately $5.0 million.

Item 4. Controls and Procedures.

We design our internal controls to provide reasonable assurance that (1) our transactions are properly authorized; (2) our assets are safeguarded against unauthorized or improper use; and (3) our transactions are properly recorded and reported in conformity with U.S. generally accepted accounting principles. We also maintain internal controls and procedures to ensure that we comply with applicable laws and our established financial policies.

Based on management’s evaluation (under the supervision and with the participation of our chief executive officer (CEO) and chief financial officer (CFO)), as of the end of the period covered by this report, our CEO and CFO concluded that our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the

30

Exchange Act)), are effective to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in SEC rules and forms, and is accumulated and communicated to management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.

During the third quarter of 2011, there were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act) that materially affected or are reasonably likely to materially affect internal control over financial reporting.

An evaluation was also performed under the supervision and with the participation of our management, including our chief executive officer and chief financial officer, of any change in our internal control over financial reporting that occurred during the third quarter of 2011 and that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting. The evaluation did not identify any such change.

PART II — OTHER INFORMATION

Item 1. Legal Proceedings.

The Company is involved in various lawsuits and claims arising in the ordinary course of business. Because of the uncertainties related to the occurrence, amount, and range of loss on any pending litigation or claim, management is currently unable to predict their ultimate outcome, to determine whether a liability has been incurred, or to make a meaningful estimate of the reasonably possible loss or range of loss that could result from an unfavorable outcome. The Company believes, however, that the liability, if any, resulting from the aggregate amount of losses for any outstanding litigation or claim will not have a material adverse effect on the Company’s consolidated financial position, liquidity, or results of operations.

Item 1A. Risk Factors.

Our business is subject to various risks, including those described in Item 1A of our Annual Report on Form 10-K for the fiscal year ended January 2, 2011, which we strongly encourage you to review. There have been no material changes from the risk factors disclosed in Item 1A of our Form 10-K.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

Unregistered Sales of Equity Securities

None during the quarterly period ended October 2, 2011.

Issuer Purchases of Equity Securities

In July 2010, our board of directors authorized a $200 million stock repurchase program, with $100 million allocated to repurchasing Company common stock under a 10b5-1 plan and $100 million allocated to repurchasing Company common stock at management’s discretion during open trading windows. In August 2011, our board of directors authorized the Company to repurchase up to an additional $100 million of Company common stock at management’s discretion during open trading windows. The following table summarizes shares repurchased pursuant to these programs during the quarter ended October 2, 2011:

Period	Total Number  of Shares Purchased (1)		Average Price Paid per  Share		Total Number of Shares  Purchased as Part of Publicly Announced Programs		Approximate Dollar Value of Shares that May Yet Be Purchased Under the Programs
July 4, 2011 — July 31, 2011		1,055,895	$	61.32		1,055,895	$	39,275,121
August 1, 2011 — August 28, 2011		2,529,751		55.08		2,529,751		—
August 29, 2011 — October 2, 2011		—		—		—		—
Total		3,585,646	$	56.92		3,585,646	$	—

(1) All shares purchased during the nine month ended October 2, 2011 were in connection with our stock repurchase program authorized by our board of directors in July 2010 and August 2011. All stock repurchases were made under a 10b5-1 trading program or in open-market transactions.

31

Item 3. Defaults Upon Senior Securities.

None.

Item 4. (Removed and Reserved).

Item 5. Other Information.

None.

Item 6. Exhibits.

Exhibit Number	Description of Document
31.1	Certification of Jay T. Flatley pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
31.2	Certification of Christian O. Henry pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
32.1	Certification of Jay T. Flatley pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
32.2	Certification of Christian O. Henry pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101.INS	XBRL Instance Document
101.SCH	XBRL Taxonomy Extension Schema
101.CAL	XBRL Taxonomy Extension Calculation Linkbase
101.LAB	XBRL Taxonomy Extension Label Linkbase
101.PRE	XBRL Taxonomy Extension Presentation Linkbase
101.DEF	XBRL Taxonomy Extension Definition Linkbase

32

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	Illumina, Inc. (registrant)
Date: November 4, 2011		/s/ CHRISTIAN O. HENRY
		Christian O. Henry Senior Vice President and Chief Financial Officer

33

EX-31.1

Exhibit 31.1

CERTIFICATION OF JAY T. FLATLEY PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Jay T. Flatley, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: November 4, 2011	/S/ JAY T. FLATLEY
	Jay T. Flatley
	President and Chief Executive Officer

34

EX-31.2

Exhibit 31.2

CERTIFICATION OF CHRISTIAN O. HENRY PURSUANT TO SECTION 302 OF THE

SARBANES-OXLEY ACT OF 2002

I, Christian O. Henry, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: November 4, 2011	/s/ CHRISTIAN O. HENRY
	Christian O. Henry
	Senior Vice President and Chief Financial Officer

35

EX-32.1

Exhibit 32.1

CERTIFICATION OF JAY T. FLATLEY PURSUANT TO 18 U.S.C. SECTION

1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-

OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the three months ended October 2, 2011, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Jay T. Flatley, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: November 4, 2011	By:	/s/ JAY T. FLATLEY
		Jay T. Flatley
		President and Chief Executive Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

36

EX-32.2

Exhibit 32.2

CERTIFICATION OF CHRISTIAN O. HENRY PURSUANT TO 18 U.S.C.

SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the three months ended October 2, 2011, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Christian O. Henry, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: November 4, 2011	By:	/s/ CHRISTIAN O. HENRY
		Christian O. Henry
		Senior Vice President and Chief Financial Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

37

XML

Condensed Consolidated Statements of Income (Unaudited) (USD $) In Thousands, except Per Share data	3 Months Ended		9 Months Ended
	Oct. 02, 2011	Oct. 03, 2010	Oct. 02, 2011	Oct. 03, 2010
Revenue:
Product revenue	$ 220,296	$ 224,668	$ 756,884	$ 596,885
Service and other revenue	15,203	12,641	48,580	44,558
Total revenue	235,499	237,309	805,464	641,443
Cost of revenue:
Cost of product revenue	68,764	72,248	238,719	184,814
Cost of service and other revenue	6,585	5,621	19,178	15,705
Amortization of acquired intangible assets	3,035	2,295	9,055	5,510
Total cost of revenue	78,384	80,164	266,952	206,029
Gross profit	157,115	157,145	538,512	435,414
Operating expense:
Research and development	50,399	44,804	151,400	132,146
Selling, general and administrative	66,031	55,006	200,925	158,420
Acquisition related (gain) expense, net	(2,598)		2,442	1,861
Headquarter relocation expense	6,519		11,583
Total operating expense	120,351	99,810	366,350	292,427
Income from operations	36,764	57,335	172,162	142,987
Other income (expense):
Interest income	1,388	2,791	4,909	6,746
Interest expense	(8,797)	(6,190)	(25,605)	(18,279)
Other (expense) income, net	(1,564)	774	(38,643)	3,142
Total other expense, net	(8,973)	(2,625)	(59,339)	(8,391)
Income before income taxes	27,791	54,710	112,823	134,596
Provision for income taxes	7,640	19,263	37,915	48,145
Net income	$ 20,151	$ 35,447	$ 74,908	$ 86,451
Net income per basic share	$ 0.17	$ 0.28	$ 0.60	$ 0.70
Net income per diluted share	$ 0.15	$ 0.24	$ 0.52	$ 0.61
Shares used in calculating basic net income per share	122,079	124,684	124,017	122,816
Shares used in calculating diluted net income per share	135,966	145,205	143,620	140,854

XML

Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $) In Thousands	9 Months Ended
	Oct. 02, 2011	Oct. 03, 2010
Cash flows from operating activities:
Net income	$ 74,908	$ 86,451
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense	40,303	24,611
Amortization of acquired intangible assets	9,501	5,510
Share-based compensation expense	70,276	51,804
Accretion of debt discount	23,673	15,904
Loss on extinguishment of debt	37,611
Contingent compensation expense	2,897	1,325
Gain on acquisition		(2,914)
Incremental tax benefit related to stock options exercised	(40,387)	(14,551)
Deferred income taxes	6,209	18,844
Other non-cash adjustments	8,070	4,567
Changes in operating assets and liabilities:
Accounts receivable	(2,544)	(12,752)
Inventory	9,315	(36,463)
Prepaid expenses and other current assets	(15,474)	2,571
Other assets	(3,110)	(2,467)
Accounts payable	(14,897)	17,499
Accrued liabilities	41,376	31,288
Other long-term liabilities	4,002	(564)
Unrealized gain on foreign exchange	(1,889)	429
Net cash provided by operating activities	249,840	191,092
Cash flows from investing activities:
Purchases of available-for-sale securities	(1,076,674)	(663,430)
Sales and maturities of available-for-sale securities	840,107	558,128
Sales and maturities of trading securities		54,900
Net cash paid for acquisitions	(58,302)	(98,210)
Purchases of investments	(11,384)	(22,450)
Purchases of property and equipment	(50,686)	(37,434)
Cash paid for intangible assets	(1,100)	(6,500)
Net cash used in investing activities	(358,039)	(214,996)
Cash flows from financing activities:
Payments on current portion of long-term debt	(349,874)
Proceeds from issuance of convertible notes	903,492
Incremental tax benefit related to stock options exercised	40,387	14,551
Common stock repurchases	(570,406)	(16,006)
Proceeds from exercises of warrants	5,512	9,587
Proceeds from issuance of common stock	60,057	81,798
Net cash provided by financing activities	89,168	89,930
Effect of exchange rate changes on cash and cash equivalents	(70)	(108)
Net (decrease) increase in cash and cash equivalents	(19,101)	66,134
Cash and cash equivalents at beginning of period	248,947	144,633
Cash and cash equivalents at end of period	$ 229,846	$ 210,767

XML

Share-based Compensation Expense [Tables]

9 Months Ended

Oct. 02, 2011

Share-based Compensation Expense [Abstract]

Share-based compensation expense for all stock awards

	Three Months Ended						Nine Months Ended
	October 2, 2011			October 3, 2010			October 2, 2011			October 3, 2010
Cost of product revenue	$	1,955		$	1,359		$	5,267		$	3,869
Cost of service and other revenue		194			137			536			394
Research and development		8,621			6,521			24,810			18,451
Selling, general and administrative		13,801			9,943			39,663			29,090
Share-based compensation expense before taxes		24,571			17,960			70,276			51,804
Related income tax benefits		(8,464	)		(6,107	)		(24,424	)		(17,639	)
Share-based compensation expense, net of taxes	$	16,107		$	11,853		$	45,852		$	34,165

Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted

	Employee  Stock Options			Employee Stock Purchase  Rights
Interest rate		2.22 — 2.23	%		0.16 — 0.28	%
Volatility		41 — 43	%		43 — 46	%
Expected life		5.5 years			0.5 — 1.0 year
Expected dividend yield		0	%		0	%
Weighted average fair value per share	$	29.53		$	19.93

XML

Document and Entity Information (USD $)	9 Months Ended
	Oct. 02, 2011	Oct. 15, 2011	Jul. 03, 2011
Document and Entity Information [Abstract]
Entity Registrant Name	ILLUMINA INC
Entity Central Index Key	0001110803
Document Type	10-Q
Document Period End Date	Oct. 02, 2011
Amendment Flag	false
Document Fiscal Year Focus	2011
Document Fiscal Period Focus	Q3
Current Fiscal Year End Date	--01-01
Entity Well Known Seasoned Issuer	Yes
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Filer Category	Large Accelerated Filer
Entity Public Float			$ 7,885,265,238
Entity Common Stock Shares Outstanding		121,439,286

XML

Summary of Significant Accounting Principles (Details 1) (USD $) In Thousands	3 Months Ended		9 Months Ended
	Oct. 02, 2011	Oct. 03, 2010	Oct. 02, 2011	Oct. 03, 2010
Comprehensive income
Net income	$ 20,151	$ 35,447	$ 74,908	$ 86,451
Unrealized gain (loss) on available-for-sale securities, net of deferred tax	(261)	(48)	321	(265)
Total comprehensive income	$ 19,890	$ 35,399	$ 75,229	$ 86,186

XML

Subsequent Event (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Jan. 01, 2012	Oct. 25, 2011 Employee
Subsequent Event [Abstract]
Employee reduction number		200
Employee reduction percentage		8.00%
Expected restructuring charge at lower range	$ 15
Expected restructuring charge at higher range	$ 17

XML

Stockholders' Equity

9 Months Ended

Oct. 02, 2011

Stockholders' Equity [Abstract]

Stockholders' Equity

8. Stockholders’ Equity

Stock Options

The Company’s stock option activity under all stock option plans during the nine months ended October 2, 2011 is as follows:

	Options			Weighted Average Exercise Price per Share		Weighted Average Grant-Date Fair Value per Share
	(in thousands)
Outstanding at January 2, 2011		11,882		$	22.83	$	12.82
Granted		1,226			70.06		29.53
Exercised		(2,647	)		18.20		10.66
Cancelled		(41	)		21.07		13.17
Outstanding at October 2, 2011		10,420		$	29.57	$	15.33

At October 2, 2011, outstanding options to purchase approximately 6,631,000 shares were exercisable with a weighted average per share exercise price of $22.45.

Employee Stock Purchase Plan

The price at which common stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first or last day of the offering period, whichever is lower. During the nine months ended October 2, 2011, approximately 328,000 shares were issued under the ESPP. As of October 2, 2011, there were approximately 15,734,000 shares available for issuance under the ESPP.

Restricted Stock Units

A summary of the Company’s restricted stock unit activity and related information for the nine months ended October 2, 2011 is as follows:

	Restricted Stock  Units(1)			Weighted Average Grant-Date Fair Value per Share
	(in thousands)
Outstanding at January 2, 2011		3,109		$	40.39
Awarded		528			68.07
Vested		(355	)		36.97
Cancelled		(158	)		41.30
Outstanding at October 2, 2011		3,124		$	45.41

(1) The fair value of each restricted stock unit represents the fair market value of one share of the Company’s common stock.

Warrants

In conjunction with an acquisition in January 2007, the Company assumed a certain number of warrants, the majority of which were exercised in periods prior to 2011. During the first quarter of 2011, the remaining assumed warrants to purchase approximately 505,000 shares of the Company’s common stock were exercised, resulting in cash proceeds to the Company of approximately $5.5 million. As of October 2, 2011, warrants to purchase approximately 18,322,000 shares of common stock were outstanding with an exercise price of $31.44, which were all sold in connection with the offering of the Company’s 2014 Notes as discussed in note “6. Convertible Senior Notes.” All outstanding warrants expire on February 15, 2014.

Share Repurchases

In August 2011, the Company’s board of directors authorized a $100 million discretionary repurchase program. During the three months ended October 2, 2011, the Company utilized the authorized amount in its entirety and repurchased approximately 1,894,000 shares under this program.

In July 2010, the Company’s board of directors authorized a $200 million stock repurchase program, with $100 million allocated to repurchasing Company common stock under a 10b5-1 plan over a 12 month period and $100 million allocated to repurchasing Company common stock at management’s discretion during open trading windows. During the three and nine months ended October 2, 2011, the Company repurchased approximately 1,692,000 shares for $104.0 million and 2,438,000 shares for $156.0 million, respectively. The authorized repurchase amount had been utilized completely as of October 2, 2011.

Concurrently with the issuance of the Company’s 2016 Notes on March 18, 2011, 4,890,500 shares were repurchased for $314.3 million.

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Summary of Significant Accounting Principles (Details Textual) (USD $)	3 Months Ended	9 Months Ended
	Oct. 02, 2011	Oct. 02, 2011
Summary of Significant Accounting Principles (Textual) [Abstract]
Total notional amount of outstanding forward contract in place for foreign currency purchase	$ 26,400,000	$ 26,400,000
Headquarter relocation expenses represent accelerated depreciation expense, double-rent expense and cease-use loss	$ 6,519,000	$ 11,583,000

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Stockholders' Equity (Details) (USD $) In Thousands, except Per Share data	9 Months Ended
	Oct. 02, 2011
Stock option activity
Options, Outstanding at January 2, 2011	11,882
Options, Granted	1,226
Options, Exercised	(2,647)
Options, Cancelled	(41)
Options, Outstanding at October 2, 2011	10,420
Weighted-Average Exercise Price, Outstanding at January 2, 2011	$ 22.83
Weighted Average Exercise Price, Granted	$ 70.06
Weighted Average Exercise Price, Exercised	$ 18.20
Weighted Average Exercise Price, Cancelled	$ 21.07
Weighted-Average Exercise Price, Outstanding at October 2, 2011	$ 29.57
Weighted Average Grant Date Fair Value per Share, Outstanding at January 2, 2011	$ 12.82
Weighted Average Grant Date Fair Value per Share, Granted	$ 29.53
Weighted Average Grant Date Fair Value per Share, Exercised	$ 10.66
Weighted Average Grant Date Fair Value per Share, Cancelled	$ 13.17
Weighted Average Grant Date Fair Value per Share, Outstanding at October 2, 2011	$ 15.33

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Convertible Senior Notes (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended	9 Months Ended
	Oct. 02, 2011	Oct. 02, 2011
Summarized Information about the conversions of Notes
Cash paid for principal of notes converted		349,874
Loss on extinguishment of debt		(37,611)
Maximum [Member] | 0.625% Convertible senior notes due 2014 [Member]
Summarized Information about the conversions of Notes
Effective interest rates used to measure fair value of converted notes	4.30%	4.30%
Minimum [Member] | 0.625% Convertible senior notes due 2014 [Member]
Summarized Information about the conversions of Notes
Effective interest rates used to measure fair value of converted notes	3.50%	3.50%
0.625% Convertible senior notes due 2014 [Member]
Summarized Information about the conversions of Notes
Cash paid for principal of notes converted	8,965	349,874
Conversion value over principal amount paid in shares of common stock	11,185	727,618
Number of shares of common stock issued upon conversion	244	10,733
Loss on extinguishment of debt	754	37,611

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Summary of Significant Accounting Principles (Details) In Thousands	3 Months Ended		9 Months Ended
	Oct. 02, 2011	Oct. 03, 2010	Oct. 02, 2011	Oct. 03, 2010
Weighted-average shares used to calculate basic and diluted net income per share
Weighted average shares outstanding	122,079	124,684	124,017	122,816
Effect of dilutive potential common shares:
Dilutive convertible senior notes	1,292	9,292	4,885	8,381
Dilutive equity awards	4,549	4,734	5,315	4,407
Dilutive warrants sold in connection with the Convertible Senior Notes	8,046	5,662	9,403	4,316
Dilutive warrants assumed in an acquisition		833		934
Weighted average shares used in calculation of diluted net income per share	135,966	145,205	143,620	140,854
Potentially dilutive shares excluded from calculation due to anti-dilutive effect	1,543	2,518	1,189	2,350

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Summary of Significant Accounting Principles (Tables)

9 Months Ended

Oct. 02, 2011

Summary of Significant Accounting Principles [Abstract]

Weighted-average shares used to calculate basic and diluted net income per share

	Three Months Ended				Nine Months Ended
	October 2, 2011		October 3, 2010		October 2, 2011		October 3, 2010
Weighted average shares outstanding		122,079		124,684		124,017		122,816
Effect of dilutive potential common shares:
Dilutive convertible senior notes		1,292		9,292		4,885		8,381
Dilutive equity awards		4,549		4,734		5,315		4,407
Dilutive warrants sold in connection with convertible senior notes		8,046		5,662		9,403		4,316
Dilutive warrants assumed in an acquisition		—		833		—		934
Weighted average shares used in calculation of diluted net income per share		135,966		145,205		143,620		140,854
Potentially dilutive shares excluded from calculation due to anti-dilutive effect		1,543		2,518		1,189		2,350

Comprehensive income

	Three Months Ended						Nine Months Ended
	October 2, 2011			October 3, 2010			October 2, 2011		October 3, 2010
Net income	$	20,151		$	35,447		$	74,908	$	86,451
Unrealized gain (loss) on available-for-sale securities, net of deferred tax		(261	)		(48	)		321		(265	)
Total comprehensive income	$	19,890		$	35,399		$	75,229	$	86,186

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Fair Value Measurements

9 Months Ended

Oct. 02, 2011

Fair Value Measurements [Abstract]

Fair Value Measurements

4. Fair Value Measurements

The following table presents the Company’s hierarchy for assets and liabilities measured at fair value on a recurring basis as of October 2, 2011 and January 2, 2011 (in thousands):

	October 2, 2011
	Quoted Prices in Active  Markets for Identical Assets (Level 1)		Significant Other Observable  Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Total
Assets:
Money market funds (cash equivalent)	$	120,569	$	—	$	—	$	120,569
Debt securities in government sponsored entities		—		401,319		—		401,319
Corporate debt securities		—		454,460		—		454,460
U.S. Treasury securities		46,565		—		—		46,565
Total assets measured at fair value	$	167,134	$	855,779	$	—	$	1,022,913
Liability:
Contingent consideration	$	—	$	—	$	8,162	$	8,162

	January 2, 2011
	Quoted Prices in Active  Markets for Identical Assets (Level 1)		Significant Other Observable  Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Total
Assets:
Money market funds (cash equivalent)	$	148,822	$	—	$	—	$	148,822
Debt securities in government sponsored entities		—		261,697		—		261,697
Corporate debt securities		—		330,758		—		330,758
U.S. Treasury securities		52,887		—		—		52,887
Total assets measured at fair value	$	201,709	$	592,455	$	—	$	794,164
Liability:
Contingent consideration	$	—	$	—	$	3,738	$	3,738

The Company measures the fair value of debt securities in government sponsored entities and corporate debt securities on a recurring basis primarily using quoted prices for similar assets in active markets.

At October 2, 2011, the Company reassessed the fair value of the contingent consideration settled in cash related to acquisitions using the income approach. These fair value measurements are Level 3 measurements. Significant assumptions used in the measurement include probabilities of achieving the remaining milestones and the discount rates, which depends on the milestone risk profiles. Due to changes in the estimated probabilities to achieve the relevant milestones and a shorter discounting period, the fair value of the contingent consideration liabilities changed, resulting in a gain of $2.6 million and $3.0 million recorded in acquisition related (gain) expense, net, in the consolidated statements of income during the three and nine months ended October 2, 2011, respectively.

Changes in estimated fair value of contingent consideration liabilities from January 2, 2011 through October 2, 2011 are as follows (in thousands):

	Contingent Consideration Liability (Level 3 Measurement)
Balance at January 2, 2011	$	3,738
Acquisition of Epicentre		7,400
Gain recorded in acquisition related (gain) expense, net		(2,976	)
Balance at October 2, 2011	$	8,162

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Fair Value Measurements (Details) (USD $) In Thousands	3 Months Ended	9 Months Ended																		3 Months Ended	9 Months Ended
	Oct. 02, 2011	Oct. 02, 2011	Oct. 03, 2010	Oct. 02, 2011 Debt securities in government sponsored entities [Member] Fair Value, Inputs, Level 2 [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Debt securities in government sponsored entities [Member] Fair Value, Inputs, Level 2 [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 Debt securities in government sponsored entities [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Debt securities in government sponsored entities [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 Corporate debt securities [Member] Fair Value, Inputs, Level 2 [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Corporate debt securities [Member] Fair Value, Inputs, Level 2 [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 Corporate debt securities [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Corporate debt securities [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 U.S. Treasury securities [Member] Fair Value, Inputs, Level 1 [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 U.S. Treasury securities [Member] Fair Value, Inputs, Level 1 [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 U.S. Treasury securities [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 U.S. Treasury securities [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 Fair Value, Inputs, Level 1 [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Fair Value, Inputs, Level 1 [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 Fair Value, Inputs, Level 2 [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Fair Value, Inputs, Level 2 [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 Fair Value, Inputs, Level 3 [Member]	Oct. 02, 2011 Fair Value, Inputs, Level 3 [Member]	Oct. 02, 2011 Fair Value, Inputs, Level 3 [Member] Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Fair Value, Inputs, Level 3 [Member] Fair Value, Measurements, Recurring [Member]	Oct. 02, 2011 Fair Value, Measurements, Recurring [Member]	Jan. 02, 2011 Fair Value, Measurements, Recurring [Member]
Assets:
Money market funds (cash equivalent)																$ 120,569	$ 148,822							$ 120,569	$ 148,822
Investments, fair value disclosure				401,319	261,697	401,319	261,697	454,460	330,758	454,460	330,758	46,565	52,887	46,565	52,887
Total assets measured at fair value																167,134	201,709	855,779	592,455					1,022,913	794,164
Liability:
Contingent consideration																				8,162	8,162	8,162	3,738	8,162	3,738
Change in estimated fair value of the contingent consideration liability
Balance as of January 2, 2011																					3,738	8,162	3,738	8,162	3,738
Acquisition of Epicentre																					7,400
Gain recorded in acquisition related (gain) expense, net	(2,598)	2,442	1,861																	(2,598)	(2,976)
Balance as of October 2, 2011																				$ 8,162	$ 8,162	$ 8,162	$ 3,738	$ 8,162	$ 3,738

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Legal Proceedings

9 Months Ended

Oct. 02, 2011

Legal Proceedings [Abstract]

Legal Proceedings

10. Legal Proceedings

The Company is involved in various lawsuits and claims arising in the ordinary course of business. Because of the uncertainties related to the occurrence, amount, and range of loss on any pending litigation or claim, management is currently unable to predict their ultimate outcome, to determine whether a liability has been incurred, or to make a meaningful estimate of the reasonably possible loss or range of loss that could result from an unfavorable outcome. The Company believes, however, that the liability, if any, resulting from the aggregate amount of losses for any outstanding litigation or claim will not have a material adverse effect on the Company’s consolidated financial position, liquidity, or results of operations.

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Acquisitions (Tables)

9 Months Ended

Oct. 02, 2011

Acquisitions [Abstract]

Contingent compensation expense and IPR&D

	Three Months Ended					Nine Months Ended
	October 2, 2011			October 3, 2010		October 2, 2011		October 3, 2010
Contingent compensation expense, included in research and development expense	$	775		$	919	$	4,067	$	2,757
Contingent compensation expense, included in selling, general and administrative expense		(279	)		—		1,259		—
Total contingent compensation expense	$	496		$	919	$	5,326	$	2,757
IPR&D, included in acquisition related (gain) expense, net	$	—		$	—	$	5,425	$	1,325

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Subsequent Event

9 Months Ended

Oct. 02, 2011

Subsequent Event [Abstract]

Subsequent Event

11. Subsequent Event

On October 25, 2011, the Company announced restructuring plans to reduce its global workforce by approximately 200 employees, or approximately 8%. As a result of the reductions, the Company expects to record a restructuring charge, comprised primarily of compensation and benefits afforded to terminated employees, of approximately $15—17 million, the majority of which will be recorded and paid in the fourth quarter of fiscal 2011.

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Balance Sheet Account Details (Details Textual) (USD $)	3 Months Ended		9 Months Ended
	Oct. 02, 2011 Position	Oct. 03, 2010	Oct. 02, 2011 Year Position	Oct. 03, 2010	Jan. 02, 2011
Balance Sheet Account Details (Textual) [Abstract]
Number of available-for-sale securities in a gross unrealized loss position	118		118
Impairment considered other-than-temporary	$ 0		$ 0
Gross realized gains			1,000,000
Company's cost-method investments in non-publicly traded company	43,500,000		43,500,000		32,000,000
Impairment loss during the period	$ 0	$ 0	$ 0	$ 0

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Income Taxes

9 Months Ended

Oct. 02, 2011

Income Taxes [Abstract]

Income Taxes

9. Income Taxes

The Company’s effective tax rate may vary from the U.S statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income. The effective tax rates for the three and nine months ended October 2, 2011 were 27.5% and 33.6 %, respectively. For the three months ended October 2, 2011, the variance from the U.S statutory rate of 35% was primarily attributable to adjustments related to tax returns for prior years in various jurisdictions and the tax benefit related to the loss on the extinguishment of debt. For the nine months ended October 2, 2011, the variance from the U.S statutory rate of 35% was primarily attributable to the same factors as in the three month period, partially offset by non-deductible additional IPR&D recorded in acquisition related (gain) expense, net.

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Balance Sheet Account Details

9 Months Ended

Oct. 02, 2011

Balance Sheet Account Details [Abstract]

Balance Sheet Account Details

2. Balance Sheet Account Details

Short-Term Investments

The following is a summary of short-term investments (in thousands):

	October 2, 2011									January 2, 2011
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
Available-for-sale securities:
Debt securities in government sponsored entities	$	401,007	$	501	$	(189	)	$	401,319	$	261,890	$	106	$	(299	)	$	261,697
Corporate debt securities		453,771		1,290		(601	)		454,460		329,823		1,170		(235	)		330,758
U.S. Treasury securities		46,355		217		(7	)		46,565		52,938		70		(121	)		52,887
Total available-for-sale securities	$	901,133	$	2,008	$	(797	)	$	902,344	$	644,651	$	1,346	$	(655	)	$	645,342

As of October 2, 2011, the Company had 118 available-for-sale securities in a gross unrealized loss position, all of which had been in such position for less than twelve months. There was no impairment considered other-than-temporary as it is more likely than not the Company will hold the securities until maturity or a recovery of the cost basis. The following table shows the fair values and the gross unrealized losses of the Company’s available-for-sale securities that were in unrealized loss positions as of October 2, 2011 and January 2, 2011 aggregated by investment category (in thousands):

	October 2, 2011					January 2, 2011
	Fair Value		Gross Unrealized Losses			Fair Value		Gross Unrealized Losses
Debt securities in government sponsored entities	$	157,455	$	(189	)	$	127,756	$	(299	)
Corporate debt securities		168,979		(601	)		92,199		(235	)
U.S. Treasury securities		6,093		(7	)		13,490		(121	)
Total	$	332,527	$	(797	)	$	233,445	$	(655	)

Realized gains and losses are determined based on the specific identification method and are reported in interest income in the consolidated statements of income. Gross realized gains and losses on sales of available-for-sale securities for the three months ended October 2, 2011 and October 3, 2010 and gross realized losses for the nine months ended October 2, 2010 were immaterial. Gross realized gains for the nine months ended October 2, 2011 were $1.0 million.

Contractual maturities of available-for-sale securities as of October 2, 2011 were as follows (in thousands):

	Estimated Fair Value
Due within one year	$	278,464
After one but within five years		623,880
Total	$	902,344

Inventory

Inventory, net, consists of the following (in thousands):

	October 2, 2011		January 2, 2011
Raw materials	$	62,916	$	54,762
Work in process		57,146		64,862
Finished goods		19,203		22,587
Total inventory, net	$	139,265	$	142,211

Cost-Method Investments

As of October 2, 2011 and January 2, 2011, the aggregate carrying amounts of the Company’s cost-method investments in non-publicly traded companies were $43.5 million and $32.0 million, respectively, which were included in other long-term assets in the consolidated balance sheets. The Company assesses all cost-method investments for impairment quarterly. No impairment loss was recorded during the three and nine months ended October 2, 2011 or October 3, 2010. The Company does not reassess the fair value of cost-method investments if there are no identified events or changes in circumstances that may have a significant adverse effect on the fair value of the investments.

Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

	October 2, 2011		January 2, 2011
Deferred revenue, current portion	$	51,655	$	45,863
Accrued compensation expenses		46,031		49,368
Unsettled short-term investment purchases		26,373		—
Accrued taxes payable		25,995		13,277
Customer deposits		16,948		14,900
Reserve for product warranties		15,868		16,761
Deferred rent, current portion		11,542		—
Accrued royalties		4,855		2,781
Acquisition related contingent consideration liability, current portion		2,215		3,738
Other accrued expenses		9,689		9,476
Total accrued liabilities	$	211,171	$	156,164

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Warranties

9 Months Ended

Oct. 02, 2011

Warranties [Abstract]

Warranties

5. Warranties

The Company generally provides a one-year warranty on instruments. Additionally, the Company provides a warranty on its consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. The Company establishes an accrual for estimated warranty expenses based on historical experience as well as anticipated product performance. The Company periodically reviews the adequacy of its warranty reserve and adjusts, if necessary, the warranty percentage and accrual based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue. Expenses associated with instrument service contracts are recorded as a cost of service and other revenue as incurred.

Changes in the Company’s reserve for product warranties from January 2, 2011 through October 2, 2011 are as follows (in thousands):

Balance as of January 2, 2011	$	16,761
Additions charged to cost of revenue		18,477
Repairs and replacements		(19,370	)
Balance as of October 2, 2011	$	15,868

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Convertible Senior Notes (Details Textual) (USD $)	9 Months Ended		3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended			3 Months Ended	9 Months Ended
	Oct. 02, 2011	Oct. 03, 2010	Oct. 02, 2011 Maximum [Member] 0.625% Convertible senior notes due 2014 [Member]	Oct. 02, 2011 Maximum [Member] 0.625% Convertible senior notes due 2014 [Member]	Oct. 02, 2011 Minimum [Member] 0.625% Convertible senior notes due 2014 [Member]	Oct. 02, 2011 Minimum [Member] 0.625% Convertible senior notes due 2014 [Member]	Oct. 02, 2011 0.25% Convertible Senior Notes due 2016 [Member] Year	Oct. 02, 2011 0.25% Convertible Senior Notes due 2016 [Member] Year	Apr. 18, 2011 0.25% Convertible Senior Notes due 2016 [Member]	Mar. 18, 2011 0.25% Convertible Senior Notes due 2016 [Member]	Oct. 02, 2011 0.625% Convertible senior notes due 2014 [Member] Financial_Instruments Year	Oct. 02, 2011 0.625% Convertible senior notes due 2014 [Member] Financial_Instruments Year	Jan. 02, 2011 0.625% Convertible senior notes due 2014 [Member] Year	Feb. 16, 2007 0.625% Convertible senior notes due 2014 [Member]
Convertible Senior Notes (Textual) [Abstract]
Interest rate on convertible senior notes							0.25%	0.25%						0.625%
Debt issuance price as a percentage of principal								98.25%
Interest payments												$ 1,200,000
Maximum shares entitles to purchase shares under hedge transaction upon issuance of the convertible senior notes												18,322,320
Maximum shares exercisable by counterparties warrants sold												18,322,320
Strike price of common shares under hedge transaction upon issuance of the convertible senior notes											$ 21.83	$ 21.83
Conversion Price							$ 83.55	$ 83.55
Strike price of warrants sold to hedge counterparties upon issuance of convertible notes											$ 31.435	$ 31.435
Debt issuance costs								400,000
Amount of Notes Offered to Initial Purchasers at their Option									120,000,000
Net initial issuance								785,600,000
Net Subsequent Issuance								117,900,000
Conversion rate per 1,000 principal amount of notes								11.9687
Circumstances of converting notes at referred conversion ratio								during the five business-day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per 2016 Note for each day of such measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such day; (2) during any calendar quarter (and only during that quarter) after the calendar quarter ending March 31, 2011, if the last reported sale price of the Company's common stock for 20 or more trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; (3) upon the occurrence of specified events described in the indenture for the 2016 Notes; and (4) at any time on or after December 15, 2015 through the second scheduled trading day immediately preceding the maturity date
Number of business days 2016 Notes are convertible after measurement period								5 days
Number of consecutive trading days in the measurement period								10 days
Conversion triggering common stock trading price as a percentage of price last reported in Measurement period converted at conversion rate								Less than 98%
Number of days in which common stock prices needed to exceed triggering price in order to trigger conversion								20 or more
Number of consecutive trading days on which trading price is examined for triggering of conversion								30 days
Conversion triggering common stock price as a percentage of applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter								Exceeds 130%
Date after which notes will become convertible								Dec. 15, 2015
Maximum payment on principal portion to be cash settled upon conversion								1,000
Principal amount used in calculating incremental share settlement amount								1,000
Estimated interest rate of convertible senior notes			4.30%	4.30%	3.50%	3.50%		4.50%
Fair value of liability component at issuance									748,500,000
Principal amount of convertible notes outstanding							920,000,000	920,000,000			40,125,000	40,125,000	389,999,000
Carrying Amount of Equity Component							155,366,000	155,366,000			113,429,000	113,429,000	71,199,000
Cash proceeds								903,900,000
Coupon Interest expense							700,000	1,300,000
Accretion of discount on liability component	23,673,000	15,904,000					7,800,000	16,600,000
Proceeds from Debt Issuance Used in Stock Repurchases								314,300,000
Number of shares repurchased concurrent with convertible debt issuance								4,890,500
Cash paid for principal of notes converted	349,874,000										8,965,000	349,874,000
Repurchase Price as a Percentage of Principal Amount upon designated events								100.00%
Issuance of convertible senior notes										800,000,000				400,000,000
Unamortized discount							$ 154,923,000	$ 154,923,000			$ 6,332,000	$ 6,332,000	$ 78,390,000
Remaining discount amortization period							4.5	4.5			2.4	2.4	3.1
Amortization period for debt issuance cost										5 years

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Balance Sheet Account Details (Details 3) (USD $) In Thousands	Oct. 02, 2011	Jan. 02, 2011
Accrued liabilities
Deferred revenue, current portion	$ 51,655	$ 45,863
Accrued compensation expenses	46,031	49,368
Unsettled short-term investment purchases	26,373	0
Accrued taxes payable	25,995	13,277
Customer deposits	16,948	14,900
Reserve for product warranties	15,868	16,761
Deferred rent, current portion	11,542	0
Accrued royalties	4,855	2,781
Acquisition related contingent consideration liability, current portion	2,215	3,738
Other accrued expenses	9,689	9,476
Total accrued liabilities	$ 211,171	$ 156,164

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Convertible Senior Notes

9 Months Ended

Oct. 02, 2011

Convertible Senior Notes [Abstract]

Convertible Senior Notes

6. Convertible Senior Notes

0.25% Convertible Senior Notes due 2016

In March 2011, the Company issued $800 million aggregate principal amount of 0.25% convertible senior notes due 2016 (the 2016 Notes) in an offering conducted in accordance with Rule 144A under the Securities Act of 1933, as amended. The 2016 Notes were issued at 98.25% of par value. Debt issuance costs of approximately $0.4 million primarily comprised legal, accounting, and other professional fees, the majority of which were recorded in other noncurrent assets and are being amortized to interest expense over the five-year term of the 2016 Notes. The Company issued an additional $120 million aggregate principal amount of 2016 Notes in April 2011. The net proceeds from the initial issuance and subsequent issuance, after deducting the initial purchasers’ discount and the estimated offering expenses payable by the Company, were $785.6 million and $117.9 million, respectively.

The 2016 Notes will be convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at the Company’s election, based on an initial conversion rate, subject to adjustment, of 11.9687 shares per $1,000 principal amount of the 2016 Notes (which represents an initial conversion price of approximately $83.55 per share), only in the following circumstances and to the following extent: (1) during the five business-day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per 2016 Note for each day of such measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such day; (2) during any calendar quarter (and only during that quarter) after the calendar quarter ending March 31, 2011, if the last reported sale price of the Company’s common stock for 20 or more trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; (3) upon the occurrence of specified events described in the indenture for the 2016 Notes; and (4) at any time on or after December 15, 2015 through the second scheduled trading day immediately preceding the maturity date.

As noted in the indenture for the 2016 Notes, it is the Company’s intent and policy to settle conversions through combination settlement, which essentially involves repayment of an amount of cash equal to the “principal portion” and delivery of the “share amount” in excess of the conversion value over the principal portion in shares of common stock. In general, for each $1,000 in principal, the “principal portion” of cash upon settlement is defined as the lesser of $1,000, and the conversion value during the 20-day observation period as described in the indenture for the 2016 Notes. The conversion value is the sum of the daily conversion value which is the product of the effective conversion rate divided by 20 days and the daily volume weighted average price (“VWAP”) of the Company’s common stock. The “share amount” is the cumulative “daily share amount” during the observation period, which is calculated by dividing the daily VWAP into the difference between the daily conversion value (i.e., conversion rate x daily VWAP) and $1,000.

The Company will pay 0.25% interest per annum on the principal amount of the 2016 Notes, payable semiannually in arrears in cash on March 15 and September 15 of each year, beginning September 15, 2011. The 2016 Notes mature on March 15, 2016. If a designated event, as defined in the indenture for the 2016 Notes, occurs prior to the maturity date, subject to certain limitations, holders of the 2016 Notes may require the Company to repurchase all or a portion of their 2016 Notes for cash at a repurchase price equal to 100% of the principal amount of the 2016 Notes to be repurchased, plus any accrued and unpaid interest to, but excluding, the repurchase date.

The Company accounts separately for the liability and equity components of the 2016 Notes in accordance with authoritative guidance for convertible debt instruments that may be settled in cash upon conversion. The guidance requires the carrying amount of the liability component to be estimated by measuring the fair value of a similar liability that does not have an associated conversion feature. Because the Company has no outstanding non-convertible public debt, the Company determined that senior, unsecured corporate bonds traded on the market represent a similar liability to the convertible senior notes without the conversion option. Based on market data available for publicly traded, senior, unsecured corporate bonds issued by companies in the same industry and with similar maturity, the Company estimated the implied interest rate of its 2016 Notes to be 4.5%, assuming no conversion option. Assumptions used in the estimate represent what market participants would use in pricing the liability component, including market interest rates, credit standing, and yield curves, all of which are defined as Level 2 observable inputs. The estimated implied interest rate was applied to the 2016 Notes, which resulted in a fair value of the liability component of $748.5 million upon issuance, calculated as the present value of implied future payments based on the $920.0 million aggregate principal amount. The $155.4 million difference between the cash proceeds of $903.9 million and the estimated fair value of the liability component was recorded in additional paid-in capital as the 2016 Notes are not considered currently redeemable at the balance sheet date.

The interest expense recognized during the three and nine months ended October 2, 2011 includes $0.7 million and $1.3 million, respectively, for the contractual coupon interest, and $7.8 million and $16.6 million, respectively, for the accretion of discount on the liability component. If the 2016 Notes were converted as of October 2, 2011, the if-converted value would not exceed the principal amount. As a policy election under applicable guidance related to the calculation of diluted net income per share, the Company elected the combination settlement method as its stated settlement policy and applied the treasury stock method in the calculation of dilutive impact of the 2016 Notes, which was anti-dilutive for the three and nine months ended October 2, 2011.

The Company used $314.3 million of the net proceeds to purchase 4,890,500 shares of its common stock in privately negotiated transactions concurrently with the issuance. The Company also used part of the net proceeds for the extinguishment of $9.0 million and $349.9 million principal amount of its outstanding 0.625% convertible senior notes due 2014 upon conversions during the three and nine months ended October 3, 2011, respectively.

0.625% Convertible Senior Notes due 2014

In February 2007, the Company issued $400.0 million principal amount of 0.625% convertible senior notes due 2014 (the 2014 Notes). The Company pays 0.625% interest per annum on the principal amount of the 2014 Notes, payable semi-annually in arrears in cash on February 15 and August 15 of each year. The Company made an interest payment of $1.2 million in February 2011. Interest payment in August 2011 was immaterial due to conversions prior to the payment date. The 2014 Notes mature on February 15, 2014.

The Company entered into a hedge transaction concurrently with the issuance of the 2014 Notes under which the Company is entitled to purchase up to 18,322,320 shares of the Company’s common stock at a strike price of approximately $21.83 per share, subject to adjustment. In addition, the Company sold to the hedge counterparties warrants exercisable, on a cashless basis, for up to 18,322,320 shares of the Company’s common stock at a strike price of $31.435 per share, subject to adjustment.

The 2014 Notes became convertible into cash and shares of the Company’s common stock in various prior periods and continue to be convertible through, and including, December 31, 2011. During the three and nine months ended October 2, 2011, the principal amount of any 2014 Notes converted were repaid with cash and the excess of the conversion value over the principal amount was paid in shares of common stock. The equity dilution resulting from the issuance of common stock related to the conversion of the 2014 Notes was offset by repurchase of the same amount of shares under the convertible note hedge transactions.

As a result of the conversions during the three and nine months ended October 2, 2011, the Company recorded losses on extinguishment of debt calculated as the difference between the estimated fair value of the debt and the carrying value of the notes as of the settlement dates. To measure the fair value of the converted notes as of the settlement dates, the applicable interest rates were estimated using Level 2 observable inputs and applied to the converted notes using the same methodology as in the issuance date valuation.

The following table summarizes information about the conversions of the 2014 Notes during the three and nine months ended October 2, 2011 (in thousands):

	Three Months Ended		Nine Months Ended
Cash paid for principal of notes converted	$	8,965	$	349,874
Conversion value over principal amount paid in shares of common stock	$	11,185	$	727,618
Number of shares of common stock issued upon conversion		244		10,733
Loss on extinguishment of debt	$	754	$	37,611
Effective interest rates used to measure fair value of converted notes		3.5% - 4.3%		3.5% - 4.3%

The following table summarizes information about the equity and liability components of the 2014 and 2016 Notes (in thousands). The fair values of the respective notes outstanding were measured based on quoted market prices.

	October 2, 2011						January 2, 2011
	0.25% Convertible Senior  Notes due 2016			0.625% Convertible Senior  Notes due 2014			0.625% Convertible Senior  Notes due 2014
Principal amount of convertible notes outstanding	$	920,000		$	40,125		$	389,999
Unamortized discount of liability component		(154,923	)		(6,332	)		(78,390	)
Net carrying amount of liability component		765,077			33,793			311,609
Less: current portion		—			(33,793	)		(311,609	)
Long-term debt	$	765,077		$	—		$	—
Conversion option subject to cash settlement		—		$	6,332		$	78,390
Carrying value of equity component, net of debt issuance cost	$	155,366		$	113,429		$	71,199
Fair value of outstanding notes	$	806,017		$	72,513		$	1,157,450
Remaining amortization period of discount on the liability component		4.5 years			2.4 years			3.1 years

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Share-based Compensation Expense (Details Textual) (USD $) In Millions, unless otherwise specified	9 Months Ended
	Oct. 02, 2011 Year Position
Share-based Compensation Expense [Abstract]
Unrecognized compensation cost related to stock options, restricted stock units and ESPP shares issued to date	$ 154.1
Weighted-average period of unrecognized compensation cost related to stock options, restricted stock units and ESPP shares issued to date	2.2

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Balance Sheet Account Details (Details) (USD $) In Thousands	Oct. 02, 2011	Jan. 02, 2011
Available-for-sale securities:
Available for sale securities, Amortized Cost	$ 901,133	$ 644,651
Available for sale securities, Gross Unrealized Gains	2,008	1,346
Available for sale securities, Gross Unrealized Losses	(797)	(655)
Available for sale securities, Estimated Fair Value	902,344	645,342
Debt securities in government sponsored entities [Member]
Available-for-sale securities:
Available for sale securities, Amortized Cost	401,007	261,890
Available for sale securities, Gross Unrealized Gains	501	106
Available for sale securities, Gross Unrealized Losses	(189)	(299)
Available for sale securities, Estimated Fair Value	401,319	261,697
Corporate debt securities [Member]
Available-for-sale securities:
Available for sale securities, Amortized Cost	453,771	329,823
Available for sale securities, Gross Unrealized Gains	1,290	1,170
Available for sale securities, Gross Unrealized Losses	(601)	(235)
Available for sale securities, Estimated Fair Value	454,460	330,758
U.S. Treasury securities [Member]
Available-for-sale securities:
Available for sale securities, Amortized Cost	46,355	52,938
Available for sale securities, Gross Unrealized Gains	217	70
Available for sale securities, Gross Unrealized Losses	(7)	(121)
Available for sale securities, Estimated Fair Value	$ 46,565	$ 52,887

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Acquisitions (Details 1) (USD $) In Thousands	3 Months Ended		9 Months Ended
	Oct. 02, 2011	Oct. 03, 2010	Oct. 02, 2011	Oct. 03, 2010
Contingent compensation expense and IPR&D
Total contingent compensation expense	$ 496	$ 919	$ 5,326	$ 2,757
IPR&D [Member]
Contingent compensation expense and IPR&D
IPR&D, included in acquisition related (gain) expense, net			5,425	1,325
Research and development [Member]
Contingent compensation expense and IPR&D
Total contingent compensation expense	775	919	4,067	2,757
Selling General and Administrative Expense [Member]
Contingent compensation expense and IPR&D
Total contingent compensation expense	$ (279)		$ 1,259

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Share-based Compensation Expense (Details) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Oct. 02, 2011	Oct. 03, 2010	Oct. 02, 2011	Oct. 03, 2010
Share-based Compensation
Share-based compensation expense before taxes	$ 24,571	$ 17,960	$ 70,276	$ 51,804
Related income tax benefits	(8,464)	(6,107)	(24,424)	(17,639)
Share-based compensation expense, net of taxes	16,107	11,853	45,852	34,165
Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted
Weighted average fair value per share			$ 29.53
Cost of product revenue [Member]
Share-based Compensation
Share-based compensation expense before taxes	1,955	1,359	5,267	3,869
Cost of Service and other Revenue [Member]
Share-based Compensation
Share-based compensation expense before taxes	194	137	536	394
Research and development [Member]
Share-based Compensation
Share-based compensation expense before taxes	8,621	6,521	24,810	18,451
Selling, General and Administrative [Member]
Share-based Compensation
Share-based compensation expense before taxes	$ 13,801	$ 9,943	$ 39,663	$ 29,090
Maximum [Member] | Employee Stock Purchase Rights [Member]
Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate			0.28%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate			46.00%
Expected Life			1.0
Minimum [Member] | Employee Stock Purchase Rights [Member]
Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate			0.16%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate			43.00%
Expected Life			0.5
Employee Stock Purchase Rights [Member]
Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted
Expected dividend yield			0.00%
Weighted average fair value per share			$ 19.93
Maximum [Member] | Employee Stock Option [Member]
Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate			2.23%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate			43.00%
Minimum [Member] | Employee Stock Option [Member]
Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate			2.22%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate			41.00%
Employee Stock Option [Member]
Assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted
Expected Life			5.5
Expected dividend yield			0.00%
Weighted average fair value per share			$ 29.53

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Balance Sheet Account Details (Details 2) (USD $) In Thousands	Oct. 02, 2011	Jan. 02, 2011
Contractual maturities of available-for-sale securities
Due within one year	$ 278,464
After one but within five years	623,880
Total	902,344	645,342
Inventory, net
Raw materials	62,916	54,762
Work in process	57,146	64,862
Finished goods	19,203	22,587
Total inventory, net	$ 139,265	$ 142,211

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Balance Sheet Account Details (Tables)

9 Months Ended

Oct. 02, 2011

Balance Sheet Account Details [Abstract]

Short-term Investments

	October 2, 2011									January 2, 2011
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
Available-for-sale securities:
Debt securities in government sponsored entities	$	401,007	$	501	$	(189	)	$	401,319	$	261,890	$	106	$	(299	)	$	261,697
Corporate debt securities		453,771		1,290		(601	)		454,460		329,823		1,170		(235	)		330,758
U.S. Treasury securities		46,355		217		(7	)		46,565		52,938		70		(121	)		52,887
Total available-for-sale securities	$	901,133	$	2,008	$	(797	)	$	902,344	$	644,651	$	1,346	$	(655	)	$	645,342

Available-for-sale securities in unrealized loss positions

	October 2, 2011					January 2, 2011
	Fair Value		Gross Unrealized Losses			Fair Value		Gross Unrealized Losses
Debt securities in government sponsored entities	$	157,455	$	(189	)	$	127,756	$	(299	)
Corporate debt securities		168,979		(601	)		92,199		(235	)
U.S. Treasury securities		6,093		(7	)		13,490		(121	)
Total	$	332,527	$	(797	)	$	233,445	$	(655	)

Contractual maturities of available-for-sale securities

	Estimated Fair Value
Due within one year	$	278,464
After one but within five years		623,880
Total	$	902,344

Inventory, net

	October 2, 2011		January 2, 2011
Raw materials	$	62,916	$	54,762
Work in process		57,146		64,862
Finished goods		19,203		22,587
Total inventory, net	$	139,265	$	142,211

Accrued liabilities

	October 2, 2011		January 2, 2011
Deferred revenue, current portion	$	51,655	$	45,863
Accrued compensation expenses		46,031		49,368
Unsettled short-term investment purchases		26,373		—
Accrued taxes payable		25,995		13,277
Customer deposits		16,948		14,900
Reserve for product warranties		15,868		16,761
Deferred rent, current portion		11,542		—
Accrued royalties		4,855		2,781
Acquisition related contingent consideration liability, current portion		2,215		3,738
Other accrued expenses		9,689		9,476
Total accrued liabilities	$	211,171	$	156,164

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Share-based Compensation Expense

9 Months Ended

Oct. 02, 2011

Share-based Compensation Expense [Abstract]

Share-based Compensation Expense

7. Share-based Compensation Expense

Share-based compensation expense for employee stock options, restricted stock units, and stock purchases under the ESPP consists of the following (in thousands):

	Three Months Ended						Nine Months Ended
	October 2, 2011			October 3, 2010			October 2, 2011			October 3, 2010
Cost of product revenue	$	1,955		$	1,359		$	5,267		$	3,869
Cost of service and other revenue		194			137			536			394
Research and development		8,621			6,521			24,810			18,451
Selling, general and administrative		13,801			9,943			39,663			29,090
Share-based compensation expense before taxes		24,571			17,960			70,276			51,804
Related income tax benefits		(8,464	)		(6,107	)		(24,424	)		(17,639	)
Share-based compensation expense, net of taxes	$	16,107		$	11,853		$	45,852		$	34,165

The assumptions used to estimate the fair value per share of options granted and employee stock purchase rights granted in connection with the ESPP during the nine months ended October 2, 2011 are as follows:

	Employee  Stock Options			Employee Stock Purchase  Rights
Interest rate		2.22 — 2.23	%		0.16 — 0.28	%
Volatility		41 — 43	%		43 — 46	%
Expected life		5.5 years			0.5 — 1.0 year
Expected dividend yield		0	%		0	%
Weighted average fair value per share	$	29.53		$	19.93

As of October 2, 2011, approximately $154.1 million of unrecognized compensation cost related to stock options, restricted stock units, and ESPP shares is expected to be recognized over a weighted average period of approximately 2.2 years.

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Warranties (Tables)

9 Months Ended

Oct. 02, 2011

Warranties [Abstract]

Reserve for product warranties

Balance as of January 2, 2011	$	16,761
Additions charged to cost of revenue		18,477
Repairs and replacements		(19,370	)
Balance as of October 2, 2011	$	15,868

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Convertible Senior Notes (Details 1) (USD $) In Thousands, unless otherwise specified	Oct. 02, 2011	Jan. 02, 2011
Summarized information about equity and liability components of convertible senior notes
Current portion of long-term debt	$ (33,793)	$ (311,609)
Long-term debt	765,077
Conversion option subject to cash settlement	6,332	78,390
0.625% Convertible senior notes due 2014 [Member]
Summarized information about equity and liability components of convertible senior notes
Principal amount of convertible notes outstanding	40,125	389,999
Unamortized discount of liability component	(6,332)	(78,390)
Net carrying amount of liability component	33,793	311,609
Current portion of long-term debt	(33,793)	311,609
Long-term debt	0	0
Conversion option subject to cash settlement	6,332	78,390
Carrying value of equity component, net of debt issuance cost	113,429	71,199
Fair value of outstanding notes	72,513	1,157,450
Remaining amortization period of discount on the liability component	2.4	3.1
0.25% Convertible Senior Notes due 2016 [Member]
Summarized information about equity and liability components of convertible senior notes
Principal amount of convertible notes outstanding	920,000
Unamortized discount of liability component	(154,923)
Net carrying amount of liability component	765,077
Current portion of long-term debt	0
Long-term debt	765,077
Conversion option subject to cash settlement	0
Carrying value of equity component, net of debt issuance cost	155,366
Fair value of outstanding notes	$ 806,017
Remaining amortization period of discount on the liability component	4.5

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Balance Sheet Account Details (Details 1) (USD $) In Thousands	Oct. 02, 2011	Jan. 02, 2011
Available-for-sale securities gross unrealized loss position
Fair Value	$ 332,527	$ 233,445
Gross Unrealized Losses	(797)	(655)
Debt securities in government sponsored entities [Member]
Available-for-sale securities gross unrealized loss position
Fair Value	157,455	127,756
Gross Unrealized Losses	(189)	(299)
Corporate debt securities [Member]
Available-for-sale securities gross unrealized loss position
Fair Value	168,979	92,199
Gross Unrealized Losses	(601)	(235)
U.S. Treasury securities [Member]
Available-for-sale securities gross unrealized loss position
Fair Value	6,093	13,490
Gross Unrealized Losses	$ (7)	$ (121)

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Summary of Significant Accounting Principles

9 Months Ended

Oct. 02, 2011

Summary of Significant Accounting Principles [Abstract]

Summary of Significant Accounting Principles

1. Summary of Significant Accounting Principles

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation. In management’s opinion, the accompanying financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited financial statements should be read in conjunction with the Company’s audited financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the fiscal year ended January 2, 2011, from which the balance sheet information herein was derived.

The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expenses, and related disclosure of contingent assets and liabilities. Actual results could differ from those estimates.

Fiscal Year

The Company’s fiscal year consists of 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. The three and nine months ended October 2, 2011 and October 3, 2010 were both 13 and 39 weeks, respectively.

Reclassifications

Certain prior period amounts have been reclassified to conform to the current period presentation.

Revenue Recognition

The Company’s revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instrumentation and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from instrument service contracts, genotyping and sequencing services, and research agreements with government grants.

The Company recognizes revenue when persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the price is fixed or determinable, and collectibility is reasonably assured. In instances where final acceptance of the product is required, revenue is deferred until all the acceptance criteria have been met. All revenue is recorded net of discounts.

Revenue for product sales is recognized generally upon transfer of title to the customer, provided that no significant obligations remain and collection of the receivable is reasonably assured. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term, and revenue from genotyping and sequencing services is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer or agreed upon milestones are reached. Revenue from research agreements with government grants is recognized in the period during which the related costs are incurred.

In order to assess whether the price is fixed or determinable, the Company evaluates whether refund rights exist. If there are refund rights or payment terms based on future performance, the Company defers revenue recognition until the price becomes fixed or determinable. The Company assesses collectibility based on a number of factors, including past transaction history with the customer and the creditworthiness of the customer. If the Company determines that collection of a payment is not reasonably assured, revenue recognition is deferred until receipt of payment.

The Company regularly enters into contracts where revenue is derived from multiple deliverables including any mix of products or services. These products or services are generally delivered within a short time frame, approximately three to six months, after the contract execution date. Revenue recognition for contracts with multiple deliverables is based on the individual units of accounting determined to exist in the contract. A delivered item is considered a separate unit of accounting when the delivered item has value to the customer on a stand-alone basis. Items are considered to have stand-alone value when they are sold separately by any vendor or when the customer could resell the item on a stand-alone basis. Consideration is allocated at the inception of the contract to all deliverables based on their relative selling price. The relative selling price for each deliverable is determined using vendor specific objective evidence (VSOE) of selling price or third-party evidence of selling price if VSOE does not exist. If neither VSOE nor third-party evidence exists, the Company uses its best estimate of the selling price for the deliverable.

In order to establish VSOE of selling price, the Company must regularly sell the product or service on a stand-alone basis with a substantial majority priced within a relatively narrow range. VSOE of selling price is usually the midpoint of that range. If there are not a sufficient number of standalone sales and VSOE of selling price cannot be determined, then the Company considers whether third party evidence can be used to establish selling price. Due to the lack of similar products and services sold by other companies within the industry, the Company has rarely established selling price using third-party evidence. If neither VSOE nor third party evidence of selling price exists, the Company determines its best estimate of selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, the Company relies upon prices set by the Company’s pricing committee adjusted for applicable discounts. The Company recognizes revenue for delivered elements only when it determines there are no uncertainties regarding customer acceptance.

In the first quarter of 2010, the Company offered an incentive with the HiSeq 2000 launch that enabled existing Genome Analyzer customers to trade in their Genome Analyzer and receive a discount on the purchase of a HiSeq 2000. The incentive was limited to customers who had purchased a Genome Analyzer as of the date of the announcement and was the first significant trade-in program offered by the Company. The Company accounts for HiSeq 2000 discounts related to the Genome Analyzer trade-in program as reductions to revenue upon recognition of the HiSeq 2000 sales revenue, which is later than the date the trade-in program was launched.

In certain markets within Europe, the Asia-Pacific region, Latin America, the Middle East, and South Africa, the Company sells products and provides services to customers through distributors that specialize in life science products. In most sales through distributors, the product is delivered directly to customers. In cases where the product is delivered to a distributor, revenue recognition is deferred until acceptance is received from the distributor, and/or the end-user, if required by the applicable sales contract. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers. These transactions are accounted for in accordance with the Company’s revenue recognition policy described herein.

Goodwill, Intangible Assets, and Other Long-Lived Assets

Goodwill represents the excess of cost over fair value of net assets acquired. The change in the carrying value of goodwill during the nine months ended October 2, 2011 was due to goodwill recorded in connection with the Company’s acquisition of Epicentre Technologies Corporation (Epicentre) in January 2011.

The Company’s identifiable intangible assets are comprised primarily of in-process research and development (IPR&D), licensed technology, acquired core technologies, customer relationships, trade names, and license agreements. Except IPR&D, the cost of all identifiable intangible assets is amortized on a straight-line basis over their respective useful lives. The Company regularly performs reviews to determine if the carrying values of its long-lived assets are impaired. A review of intangible assets that have finite useful lives and other long-lived assets is performed when an event occurs indicating the potential for impairment. If indicators of impairment exist, the Company assesses the recoverability of the affected long-lived assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows associated with such assets. If impairment is indicated, the Company compares the carrying amount to the estimated fair value of the affected assets and adjusts the value of such assets accordingly. Factors that would necessitate an impairment assessment include a significant decline in the Company’s stock price and market capitalization compared to its net book value, significant changes in the ability of a particular asset to generate positive cash flows, and significant changes in the Company’s strategic business objectives and utilization of a particular asset. The Company performed quarterly reviews of its long-lived assets and noted no indications of impairment for the three and nine months ended October 2, 2011.

Goodwill and IPR&D, which have indefinite useful lives, are reviewed for impairment at least annually during the second fiscal quarter, or more frequently if an event occurs indicating the potential for impairment. The performance of the goodwill impairment test is a two-step process. The first step of the impairment test involves comparing the estimated fair value of the reporting unit with its carrying value, including goodwill. If the carrying amount of the reporting unit exceeds its fair value, the Company performs the second step of the goodwill impairment test to determine the amount of loss, which involves comparing the implied fair value of the goodwill with the carrying value of the goodwill. The Company performed its annual impairment test of goodwill in the second fiscal quarter of 2011, noting no impairment. In its impairment test, the Company concluded that it has a single reporting unit and that its fair value exceeded its book value, using market capitalization as a reference for the Company’s fair value. Therefore, the first step recoverability test was passed and the second step analysis was not required.

The IPR&D impairment test requires the Company to assess the fair value of the asset as compared to its carrying value, and if the carrying value exceeds the fair value, record an impairment charge. The Company performed its annual impairment test of its IPR&D in the second fiscal quarter of 2011, noting no impairment. In its impairment test, the Company assessed the fair value of IPR&D using an income approach, taking into consideration various factors such as future revenue contributions, additional research and development costs to be incurred, and contributory asset charges. The rate used to discount net future cash flows to their present values was based on a risk-adjusted rate of return.

Fair Value Measurements

The Company determines the fair value of its assets and liabilities based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value maximize the use of observable inputs and minimize the use of unobservable inputs. The Company uses a fair value hierarchy with three levels of inputs, of which the first two are considered observable and the last unobservable, to measure fair value:

• Level 1 — Quoted prices in active markets for identical assets or liabilities.

• Level 2 — Inputs, other than Level 1, that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

• Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The carrying amounts of financial instruments such as cash and cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable, and accrued liabilities, excluding acquisition related contingent consideration liabilities, approximate the related fair values due to the short-term maturities of these instruments.

Derivatives

The Company is exposed to foreign exchange rate risks in the normal course of business. To manage a portion of the accounting exposure resulting from changes in foreign currency exchange rates, the Company enters into foreign exchange contracts to hedge monetary assets and liabilities that are denominated in currencies other than the United States dollar. These foreign exchange contracts are carried at fair value and are not designated as hedging instruments. Changes in the value of the foreign exchange contracts are recognized in other (expense) income, net, in the consolidated statements of income for the current period, along with an offsetting gain or loss on the underlying monetary assets or liabilities.

As of October 2, 2011, the Company had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, and Australian dollar. As of October 2, 2011, the total notional amount of outstanding forward contracts in place for foreign currency purchases was approximately $26.4 million. Gains and losses related to the non-designated foreign exchange forward contracts for the three and nine months ended October 2, 2011 were immaterial.

Leases

Leases are reviewed and classified as capital or operating at their inception. For leases that contain rent escalations, the Company records rent expense on a straight-line basis over the term of the lease, which includes the construction build-out period and lease extension periods, if appropriate. The difference between rent payments and straight-line rent expense is recorded as deferred rent in accrued liabilities and other long-term liabilities. Landlord allowances are amortized on a straight-line basis over the lease term as a reduction to rent expense. The Company capitalizes leasehold improvements and amortizes them over the shorter of the lease term or their expected useful lives.

In December 2010, the Company agreed to lease a facility in San Diego, California that will serve as its new corporate headquarters. The Company started recording rent expense upon obtaining control of the new facility in July 2011. The Company incurs additional rent expense on the new facility during the transition period of occupying both the current and new facility, until vacating the current facility, which is expected to be substantially completed near the end of 2011. In addition, the Company records accelerated depreciation expense for leasehold improvements at its current headquarter facility based on the reassessed useful lives of less than a year. During the three and nine months ended October 2, 2011, the Company recorded headquarter relocation expense of $6.5 million and $11.6 million, respectively, which primarily consisted of accelerated depreciation expense and additional rent expense during the transition period. In addition, the Company will also record a cease-use loss in headquarter relocation expense upon vacating its current headquarter facility. The cease-use loss will be calculated as the present value of the expected difference between the remaining lease payments obligation and estimated sublease rental during the remaining lease period, adjusted for deferred items and leasehold improvements.

Net Income per Share

Basic net income per share is computed by dividing net income by the weighted average number of common shares outstanding during the reporting period. Diluted net income per share is computed by dividing net income by the weighted average number of common shares outstanding during the reporting period increased to include dilutive potential common shares calculated using the treasury stock method. Diluted net income per share reflects the potential dilution from outstanding stock options, restricted stock units, employee stock purchase plan (ESPP), warrants, shares subject to forfeiture, and convertible senior notes. Under the treasury stock method, convertible senior notes will have a dilutive impact when the average market price of the Company’s common stock is above the applicable conversion price of the respective notes. In addition, the following amounts are assumed to be used to repurchase shares: the amount that must be paid to exercise stock options and warrants and purchase shares under the ESPP; the amount of compensation expense for future services that the Company has not yet recognized for stock options, restricted stock units, ESPP, and shares subject to forfeiture; and the amount of tax benefits that will be recorded in additional paid-in capital when the expenses related to respective awards become deductible.

The following table presents the calculation of weighted average shares used to calculate basic and diluted net income per share (in thousands):

	Three Months Ended				Nine Months Ended
	October 2, 2011		October 3, 2010		October 2, 2011		October 3, 2010
Weighted average shares outstanding		122,079		124,684		124,017		122,816
Effect of dilutive potential common shares:
Dilutive convertible senior notes		1,292		9,292		4,885		8,381
Dilutive equity awards		4,549		4,734		5,315		4,407
Dilutive warrants sold in connection with convertible senior notes		8,046		5,662		9,403		4,316
Dilutive warrants assumed in an acquisition		—		833		—		934
Weighted average shares used in calculation of diluted net income per share		135,966		145,205		143,620		140,854
Potentially dilutive shares excluded from calculation due to anti-dilutive effect		1,543		2,518		1,189		2,350

Comprehensive Income

Total comprehensive income consisted of the following (in thousands):

	Three Months Ended						Nine Months Ended
	October 2, 2011			October 3, 2010			October 2, 2011		October 3, 2010
Net income	$	20,151		$	35,447		$	74,908	$	86,451
Unrealized gain (loss) on available-for-sale securities, net of deferred tax		(261	)		(48	)		321		(265	)
Total comprehensive income	$	19,890		$	35,399		$	75,229	$	86,186

Recent Accounting Pronouncements

In September 2011, the Financial Accounting Standards Board (FASB) issued an update to the Intangibles – Goodwill and Other topic of the Accounting Standards Codification (ASC). The updated guidance will allow companies to assess qualitative factors to determine if it is more likely than not that goodwill might be impaired and whether it is necessary to perform the two-step goodwill impairment test required under current accounting standards. This new guidance is effective for the Company beginning January 2, 2012, with early adoption permitted. The Company is currently evaluating this guidance, but does not expect the adoption will have a material effect on its consolidated financial statements.

In June 2011, the FASB issued an update to the Comprehensive Income topic of the ASC. This update requires an entity to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. This update eliminates the option to present the components of other comprehensive income as part of the statement of equity. It is effective for the Company beginning January 2, 2012 and should be applied retrospectively. The update is to be adopted prospectively and early adoption is permitted. The Company does not believe that adoption of this update will have an impact on its consolidated financial statements.

In May 2011, the FASB issued an amendment to the Fair value Measurements and Disclosures topic of the ASC. The amendment clarifies the application of certain existing fair value measurement guidance and expands the disclosure requirements for fair value measurements that are estimated using significant unobservable (Level 3) inputs. This amendment is effective for the Company in first quarter of fiscal 2012. The amendment is to be adopted prospectively and early adoption is not permitted. The Company does not believe that adoption of the amendment will have a significant impact on its consolidated financial statements.

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Convertible Senior Notes (Tables)

9 Months Ended

Oct. 02, 2011

Convertible Senior Notes [Abstract]

Summarized information about the conversion of convertible senior notes

	Three Months Ended		Nine Months Ended
Cash paid for principal of notes converted	$	8,965	$	349,874
Conversion value over principal amount paid in shares of common stock	$	11,185	$	727,618
Number of shares of common stock issued upon conversion		244		10,733
Loss on extinguishment of debt	$	754	$	37,611
Effective interest rates used to measure fair value of converted notes		3.5% - 4.3%		3.5% - 4.3%

Summarized information about equity and liability components of convertible senior notes

	October 2, 2011						January 2, 2011
	0.25% Convertible Senior  Notes due 2016			0.625% Convertible Senior  Notes due 2014			0.625% Convertible Senior  Notes due 2014
Principal amount of convertible notes outstanding	$	920,000		$	40,125		$	389,999
Unamortized discount of liability component		(154,923	)		(6,332	)		(78,390	)
Net carrying amount of liability component		765,077			33,793			311,609
Less: current portion		—			(33,793	)		(311,609	)
Long-term debt	$	765,077		$	—		$	—
Conversion option subject to cash settlement		—		$	6,332		$	78,390
Carrying value of equity component, net of debt issuance cost	$	155,366		$	113,429		$	71,199
Fair value of outstanding notes	$	806,017		$	72,513		$	1,157,450
Remaining amortization period of discount on the liability component		4.5 years			2.4 years			3.1 years

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Stockholders' Equity (Details 1) (Restricted Stock [Member], USD $) In Thousands, except Per Share data	9 Months Ended
	Oct. 02, 2011
Restricted Stock [Member]
Restricted stock unit activity
Restricted Stock Units, Outstanding at January 2, 2011	3,109
Restricted Stock Units, Awarded	528
Restricted Stock Units, Vested	(355)
Restricted Stock Units, Cancelled	(158)
Restricted Stock Units, Outstanding at October 2, 2011	3,124
Weighted Average Grant Date Fair Value per Share, Outstanding at January 2, 2011	$ 40.39
Weighted Average Grant Date Fair Value per Share, Awarded	$ 68.07
Weighted Average Grant Date Fair Value per Share, Vested	$ 36.97
Weighted Average Grant Date Fair Value per Share, Cancelled	$ 41.30
Weighted Average Grant Date Fair Value per Share, Outstanding at October 2, 2011	$ 45.41

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Stockholders' Equity (Tables)

9 Months Ended

Oct. 02, 2011

Stockholders' Equity [Abstract]

Stock option activity

	Options			Weighted Average Exercise Price per Share		Weighted Average Grant-Date Fair Value per Share
	(in thousands)
Outstanding at January 2, 2011		11,882		$	22.83	$	12.82
Granted		1,226			70.06		29.53
Exercised		(2,647	)		18.20		10.66
Cancelled		(41	)		21.07		13.17
Outstanding at October 2, 2011		10,420		$	29.57	$	15.33

Restricted stock unit activity

	Restricted Stock  Units(1)			Weighted Average Grant-Date Fair Value per Share
	(in thousands)
Outstanding at January 2, 2011		3,109		$	40.39
Awarded		528			68.07
Vested		(355	)		36.97
Cancelled		(158	)		41.30
Outstanding at October 2, 2011		3,124		$	45.41

(1) The fair value of each restricted stock unit represents the fair market value of one share of the Company’s common stock.

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Acquisitions

9 Months Ended

Oct. 02, 2011

Acquisitions [Abstract]

Acquisitions

3. Acquisitions

Epicentre

On January 10, 2011, the Company acquired Epicentre, a provider of nucleic acid sample preparation reagents and specialty enzymes used in sequencing and microarray applications. Total consideration for the acquisition was $71.4 million, which included $59.4 million in net cash payments made at closing, $4.6 million in the fair value of contingent consideration settled in stock that is subject to forfeiture if certain non-revenue based milestones are not met, and $7.4 million in the fair value of contingent cash consideration of up to $15 million based on the achievement of certain revenue based milestones by January 10, 2013.

The Company estimated the fair value of contingent stock consideration based on the closing price of its common stock as of the acquisition date. Approximately 229,000 shares of common stock were issued to Epicentre shareholders in connection with the acquisition, which are subject to forfeiture if certain non-revenue-based milestones are not met. One third of these shares issued with an assessed fair value of $4.6 million were determined to be part of the purchase price. The remaining shares with an assessed fair value of $10.5 million were determined to be compensation for post-acquisition service, the cost of which will be recognized as contingent compensation expense over a period of two years in research and development expense or selling, general and administrative expense.

The Company estimated the fair value of contingent cash consideration using a probability weighted discounted cash flow approach, a Level 3 measurement based on unobservable inputs that are supported by little or no market activity and reflect the Company’s own assumptions in measuring fair value. The Company used a discount rate of 21% in the assessment of the acquisition date fair value for the contingent cash consideration. Future changes in significant inputs such as the discount rate and estimated probabilities of milestone achievements could have a significant effect on the fair value of the contingent consideration.

The Company allocated approximately $0.9 million of the total consideration to tangible assets, net of liabilities, and $26.9 million to identified intangible assets, including additional developed technologies of $23.3 million, customer relationships of $1.1 million, and a trade name of $2.5 million, with weighted average useful lives of approximately nine, three, and ten years, respectively. The Company recorded the excess consideration of approximately $43.6 million as goodwill.

Other Acquisitions

During 2010, the Company completed several acquisitions that were not individually or collectively material to its overall consolidated financial statements. These acquisitions were included in the 2010 consolidated financial statements from the respective dates of the acquisitions. As a result of one of the acquisitions, the fair value of cash contingent consideration that could range from $0 to $35 million, based on the achievement of certain revenue-based milestones by December 31, 2011, was recorded as a liability. In addition, the Company completed the acquisition of a development-stage company in 2008. In accordance with the applicable accounting guidance effective at that time, the Company recorded a charge of $24.7 million for purchased IPR&D. As part of the acquisition agreement, the Company agreed to pay the former shareholders of the entity up to an additional $35.0 million in contingent cash consideration based on the achievement of certain product-related and employment-related milestones.

As of October 2, 2011, the Company’s remaining gross milestone obligations related to these prior year acquisitions consisted of potential employment-related milestone payments of $1.4 million. Employment-related contingent compensation expense is recorded in operating expense.

Contingent compensation expenses and IPR&D charges as a result of acquisitions consist of the following (in thousands):

	Three Months Ended					Nine Months Ended
	October 2, 2011			October 3, 2010		October 2, 2011		October 3, 2010
Contingent compensation expense, included in research and development expense	$	775		$	919	$	4,067	$	2,757
Contingent compensation expense, included in selling, general and administrative expense		(279	)		—		1,259		—
Total contingent compensation expense	$	496		$	919	$	5,326	$	2,757
IPR&D, included in acquisition related (gain) expense, net	$	—		$	—	$	5,425	$	1,325

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Summary of Significant Accounting Principles (Policies)

9 Months Ended

Oct. 02, 2011

Summary of Significant Accounting Principles [Abstract]

Basis of Presentation

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation. In management’s opinion, the accompanying financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited financial statements should be read in conjunction with the Company’s audited financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the fiscal year ended January 2, 2011, from which the balance sheet information herein was derived.

The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expenses, and related disclosure of contingent assets and liabilities. Actual results could differ from those estimates.

Fiscal Year

Fiscal Year

The Company’s fiscal year consists of 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. The three and nine months ended October 2, 2011 and October 3, 2010 were both 13 and 39 weeks, respectively.

Reclassifications

Reclassifications

Certain prior period amounts have been reclassified to conform to the current period presentation.

Revenue Recognition

Revenue Recognition

The Company’s revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instrumentation and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from instrument service contracts, genotyping and sequencing services, and research agreements with government grants.

The Company recognizes revenue when persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the price is fixed or determinable, and collectibility is reasonably assured. In instances where final acceptance of the product is required, revenue is deferred until all the acceptance criteria have been met. All revenue is recorded net of discounts.

Revenue for product sales is recognized generally upon transfer of title to the customer, provided that no significant obligations remain and collection of the receivable is reasonably assured. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term, and revenue from genotyping and sequencing services is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer or agreed upon milestones are reached. Revenue from research agreements with government grants is recognized in the period during which the related costs are incurred.

In order to assess whether the price is fixed or determinable, the Company evaluates whether refund rights exist. If there are refund rights or payment terms based on future performance, the Company defers revenue recognition until the price becomes fixed or determinable. The Company assesses collectibility based on a number of factors, including past transaction history with the customer and the creditworthiness of the customer. If the Company determines that collection of a payment is not reasonably assured, revenue recognition is deferred until receipt of payment.

The Company regularly enters into contracts where revenue is derived from multiple deliverables including any mix of products or services. These products or services are generally delivered within a short time frame, approximately three to six months, after the contract execution date. Revenue recognition for contracts with multiple deliverables is based on the individual units of accounting determined to exist in the contract. A delivered item is considered a separate unit of accounting when the delivered item has value to the customer on a stand-alone basis. Items are considered to have stand-alone value when they are sold separately by any vendor or when the customer could resell the item on a stand-alone basis. Consideration is allocated at the inception of the contract to all deliverables based on their relative selling price. The relative selling price for each deliverable is determined using vendor specific objective evidence (VSOE) of selling price or third-party evidence of selling price if VSOE does not exist. If neither VSOE nor third-party evidence exists, the Company uses its best estimate of the selling price for the deliverable.

In order to establish VSOE of selling price, the Company must regularly sell the product or service on a stand-alone basis with a substantial majority priced within a relatively narrow range. VSOE of selling price is usually the midpoint of that range. If there are not a sufficient number of standalone sales and VSOE of selling price cannot be determined, then the Company considers whether third party evidence can be used to establish selling price. Due to the lack of similar products and services sold by other companies within the industry, the Company has rarely established selling price using third-party evidence. If neither VSOE nor third party evidence of selling price exists, the Company determines its best estimate of selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, the Company relies upon prices set by the Company’s pricing committee adjusted for applicable discounts. The Company recognizes revenue for delivered elements only when it determines there are no uncertainties regarding customer acceptance.

In the first quarter of 2010, the Company offered an incentive with the HiSeq 2000 launch that enabled existing Genome Analyzer customers to trade in their Genome Analyzer and receive a discount on the purchase of a HiSeq 2000. The incentive was limited to customers who had purchased a Genome Analyzer as of the date of the announcement and was the first significant trade-in program offered by the Company. The Company accounts for HiSeq 2000 discounts related to the Genome Analyzer trade-in program as reductions to revenue upon recognition of the HiSeq 2000 sales revenue, which is later than the date the trade-in program was launched.

In certain markets within Europe, the Asia-Pacific region, Latin America, the Middle East, and South Africa, the Company sells products and provides services to customers through distributors that specialize in life science products. In most sales through distributors, the product is delivered directly to customers. In cases where the product is delivered to a distributor, revenue recognition is deferred until acceptance is received from the distributor, and/or the end-user, if required by the applicable sales contract. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers. These transactions are accounted for in accordance with the Company’s revenue recognition policy described herein.

Goodwill, Intangible Assets and Other Long-Lived Assets

Goodwill, Intangible Assets, and Other Long-Lived Assets

Goodwill represents the excess of cost over fair value of net assets acquired. The change in the carrying value of goodwill during the nine months ended October 2, 2011 was due to goodwill recorded in connection with the Company’s acquisition of Epicentre Technologies Corporation (Epicentre) in January 2011.

The Company’s identifiable intangible assets are comprised primarily of in-process research and development (IPR&D), licensed technology, acquired core technologies, customer relationships, trade names, and license agreements. Except IPR&D, the cost of all identifiable intangible assets is amortized on a straight-line basis over their respective useful lives. The Company regularly performs reviews to determine if the carrying values of its long-lived assets are impaired. A review of intangible assets that have finite useful lives and other long-lived assets is performed when an event occurs indicating the potential for impairment. If indicators of impairment exist, the Company assesses the recoverability of the affected long-lived assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows associated with such assets. If impairment is indicated, the Company compares the carrying amount to the estimated fair value of the affected assets and adjusts the value of such assets accordingly. Factors that would necessitate an impairment assessment include a significant decline in the Company’s stock price and market capitalization compared to its net book value, significant changes in the ability of a particular asset to generate positive cash flows, and significant changes in the Company’s strategic business objectives and utilization of a particular asset. The Company performed quarterly reviews of its long-lived assets and noted no indications of impairment for the three and nine months ended October 2, 2011.

Goodwill and IPR&D, which have indefinite useful lives, are reviewed for impairment at least annually during the second fiscal quarter, or more frequently if an event occurs indicating the potential for impairment. The performance of the goodwill impairment test is a two-step process. The first step of the impairment test involves comparing the estimated fair value of the reporting unit with its carrying value, including goodwill. If the carrying amount of the reporting unit exceeds its fair value, the Company performs the second step of the goodwill impairment test to determine the amount of loss, which involves comparing the implied fair value of the goodwill with the carrying value of the goodwill. The Company performed its annual impairment test of goodwill in the second fiscal quarter of 2011, noting no impairment. In its impairment test, the Company concluded that it has a single reporting unit and that its fair value exceeded its book value, using market capitalization as a reference for the Company’s fair value. Therefore, the first step recoverability test was passed and the second step analysis was not required.

The IPR&D impairment test requires the Company to assess the fair value of the asset as compared to its carrying value, and if the carrying value exceeds the fair value, record an impairment charge. The Company performed its annual impairment test of its IPR&D in the second fiscal quarter of 2011, noting no impairment. In its impairment test, the Company assessed the fair value of IPR&D using an income approach, taking into consideration various factors such as future revenue contributions, additional research and development costs to be incurred, and contributory asset charges. The rate used to discount net future cash flows to their present values was based on a risk-adjusted rate of return.

Fair Value Measurements

Fair Value Measurements

The Company determines the fair value of its assets and liabilities based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value maximize the use of observable inputs and minimize the use of unobservable inputs. The Company uses a fair value hierarchy with three levels of inputs, of which the first two are considered observable and the last unobservable, to measure fair value:

• Level 1 — Quoted prices in active markets for identical assets or liabilities.

• Level 2 — Inputs, other than Level 1, that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

• Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The carrying amounts of financial instruments such as cash and cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable, and accrued liabilities, excluding acquisition related contingent consideration liabilities, approximate the related fair values due to the short-term maturities of these instruments.

Derivatives

Derivatives

The Company is exposed to foreign exchange rate risks in the normal course of business. To manage a portion of the accounting exposure resulting from changes in foreign currency exchange rates, the Company enters into foreign exchange contracts to hedge monetary assets and liabilities that are denominated in currencies other than the United States dollar. These foreign exchange contracts are carried at fair value and are not designated as hedging instruments. Changes in the value of the foreign exchange contracts are recognized in other (expense) income, net, in the consolidated statements of income for the current period, along with an offsetting gain or loss on the underlying monetary assets or liabilities.

As of October 2, 2011, the Company had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, and Australian dollar. As of October 2, 2011, the total notional amount of outstanding forward contracts in place for foreign currency purchases was approximately $26.4 million. Gains and losses related to the non-designated foreign exchange forward contracts for the three and nine months ended October 2, 2011 were immaterial.

Leases

Leases

Leases are reviewed and classified as capital or operating at their inception. For leases that contain rent escalations, the Company records rent expense on a straight-line basis over the term of the lease, which includes the construction build-out period and lease extension periods, if appropriate. The difference between rent payments and straight-line rent expense is recorded as deferred rent in accrued liabilities and other long-term liabilities. Landlord allowances are amortized on a straight-line basis over the lease term as a reduction to rent expense. The Company capitalizes leasehold improvements and amortizes them over the shorter of the lease term or their expected useful lives.

In December 2010, the Company agreed to lease a facility in San Diego, California that will serve as its new corporate headquarters. The Company started recording rent expense upon obtaining control of the new facility in July 2011. The Company incurs additional rent expense on the new facility during the transition period of occupying both the current and new facility, until vacating the current facility, which is expected to be substantially completed near the end of 2011. In addition, the Company records accelerated depreciation expense for leasehold improvements at its current headquarter facility based on the reassessed useful lives of less than a year. During the three and nine months ended October 2, 2011, the Company recorded headquarter relocation expense of $6.5 million and $11.6 million, respectively, which primarily consisted of accelerated depreciation expense and additional rent expense during the transition period. In addition, the Company will also record a cease-use loss in headquarter relocation expense upon vacating its current headquarter facility. The cease-use loss will be calculated as the present value of the expected difference between the remaining lease payments obligation and estimated sublease rental during the remaining lease period, adjusted for deferred items and leasehold improvements.

Net Income per Share

Net Income per Share

Basic net income per share is computed by dividing net income by the weighted average number of common shares outstanding during the reporting period. Diluted net income per share is computed by dividing net income by the weighted average number of common shares outstanding during the reporting period increased to include dilutive potential common shares calculated using the treasury stock method. Diluted net income per share reflects the potential dilution from outstanding stock options, restricted stock units, employee stock purchase plan (ESPP), warrants, shares subject to forfeiture, and convertible senior notes. Under the treasury stock method, convertible senior notes will have a dilutive impact when the average market price of the Company’s common stock is above the applicable conversion price of the respective notes. In addition, the following amounts are assumed to be used to repurchase shares: the amount that must be paid to exercise stock options and warrants and purchase shares under the ESPP; the amount of compensation expense for future services that the Company has not yet recognized for stock options, restricted stock units, ESPP, and shares subject to forfeiture; and the amount of tax benefits that will be recorded in additional paid-in capital when the expenses related to respective awards become deductible.

The following table presents the calculation of weighted average shares used to calculate basic and diluted net income per share (in thousands):

	Three Months Ended				Nine Months Ended
	October 2, 2011		October 3, 2010		October 2, 2011		October 3, 2010
Weighted average shares outstanding		122,079		124,684		124,017		122,816
Effect of dilutive potential common shares:
Dilutive convertible senior notes		1,292		9,292		4,885		8,381
Dilutive equity awards		4,549		4,734		5,315		4,407
Dilutive warrants sold in connection with convertible senior notes		8,046		5,662		9,403		4,316
Dilutive warrants assumed in an acquisition		—		833		—		934
Weighted average shares used in calculation of diluted net income per share		135,966		145,205		143,620		140,854
Potentially dilutive shares excluded from calculation due to anti-dilutive effect		1,543		2,518		1,189		2,350

Recent Accounting Pronouncements

Recent Accounting Pronouncements

In September 2011, the Financial Accounting Standards Board (FASB) issued an update to the Intangibles – Goodwill and Other topic of the Accounting Standards Codification (ASC). The updated guidance will allow companies to assess qualitative factors to determine if it is more likely than not that goodwill might be impaired and whether it is necessary to perform the two-step goodwill impairment test required under current accounting standards. This new guidance is effective for the Company beginning January 2, 2012, with early adoption permitted. The Company is currently evaluating this guidance, but does not expect the adoption will have a material effect on its consolidated financial statements.

In June 2011, the FASB issued an update to the Comprehensive Income topic of the ASC. This update requires an entity to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. This update eliminates the option to present the components of other comprehensive income as part of the statement of equity. It is effective for the Company beginning January 2, 2012 and should be applied retrospectively. The update is to be adopted prospectively and early adoption is permitted. The Company does not believe that adoption of this update will have an impact on its consolidated financial statements.

In May 2011, the FASB issued an amendment to the Fair value Measurements and Disclosures topic of the ASC. The amendment clarifies the application of certain existing fair value measurement guidance and expands the disclosure requirements for fair value measurements that are estimated using significant unobservable (Level 3) inputs. This amendment is effective for the Company in first quarter of fiscal 2012. The amendment is to be adopted prospectively and early adoption is not permitted. The Company does not believe that adoption of the amendment will have a significant impact on its consolidated financial statements.

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Acquisitions (Details Textual) (USD $)		12 Months Ended			1 Months Ended					1 Months Ended
	Jul. 04, 2010 Helixis Inc [Member]	Dec. 28, 2008 Avantome Inc [Member]	Oct. 02, 2011 Avantome Inc [Member]	Aug. 01, 2008 Avantome Inc [Member]	Jan. 31, 2011 Epicentre [Member]	Jan. 10, 2011 Epicentre [Member]	Jan. 10, 2011 Epicentre [Member] Customer Relationships [Member]	Jan. 10, 2011 Epicentre [Member] Trade Names [Member]	Jan. 10, 2011 Epicentre [Member] Developed Technology Rights [Member]	Jan. 31, 2011 Customer Relationships [Member] Year	Jan. 31, 2011 Trade Names [Member] Year	Jan. 31, 2011 Developed Technology Rights [Member] Year
Acquisition Details (Textual) [Abstract]
Business acquisition total consideration						$ 71,400,000
Business acquisition net cash consideration						59,400,000
Fair value of contingent consideration to be settled in stock						4,600,000
Fair value of contingent consideration to be settled in cash						7,400,000
Revenue based milestone						15,000,000
Share issued to epicentre shareholders in connection with business acquisition					229,000
Fair value of shares contingently issued as part of purchase price for acquisition						4,600,000
Fair value of shares as contingent compensation for post acquisition service						10,500,000
Discount rate for assessment of the acquisition date fair value of the contingent consideration settled in cash						21.00%
Total consideration to tangible assets, net of liabilities						900,000
Excess Consideration goodwill						43,600,000
Contingent consideration payments, minimum	0
Contingent consideration payments, maximum	35,000,000			35,000,000
Acquired in-process research and development		24,700,000
Remaining potential payment of contingent consideration			1,400,000
Consideration to identified intangible assets						$ 26,900,000	$ 1,100,000	$ 2,500,000	$ 23,300,000
Weighted average useful life of identified intangible assets										3	10	9

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Fair Value Measurements (Tables)

9 Months Ended

Oct. 02, 2011

Fair Value Measurements [Abstract]

Fair value measurements

	October 2, 2011
	Quoted Prices in Active  Markets for Identical Assets (Level 1)		Significant Other Observable  Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Total
Assets:
Money market funds (cash equivalent)	$	120,569	$	—	$	—	$	120,569
Debt securities in government sponsored entities		—		401,319		—		401,319
Corporate debt securities		—		454,460		—		454,460
U.S. Treasury securities		46,565		—		—		46,565
Total assets measured at fair value	$	167,134	$	855,779	$	—	$	1,022,913
Liability:
Contingent consideration	$	—	$	—	$	8,162	$	8,162

	January 2, 2011
	Quoted Prices in Active  Markets for Identical Assets (Level 1)		Significant Other Observable  Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Total
Assets:
Money market funds (cash equivalent)	$	148,822	$	—	$	—	$	148,822
Debt securities in government sponsored entities		—		261,697		—		261,697
Corporate debt securities		—		330,758		—		330,758
U.S. Treasury securities		52,887		—		—		52,887
Total assets measured at fair value	$	201,709	$	592,455	$	—	$	794,164
Liability:
Contingent consideration	$	—	$	—	$	3,738	$	3,738

Changes in fair value of contingent consideration liabilities

	Contingent Consideration Liability (Level 3 Measurement)
Balance at January 2, 2011	$	3,738
Acquisition of Epicentre		7,400
Gain recorded in acquisition related (gain) expense, net		(2,976	)
Balance at October 2, 2011	$	8,162

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Condensed Consolidated Balance Sheets (Unaudited) (USD $) In Thousands	Oct. 02, 2011	Jan. 02, 2011
Current assets:
Cash and cash equivalents	$ 229,846	$ 248,947
Short-term investments	902,344	645,342
Accounts receivable, net	169,052	165,598
Inventory, net	139,265	142,211
Deferred tax assets, current portion	25,122	19,378
Prepaid expenses and other current assets	38,585	36,922
Total current assets	1,504,214	1,258,398
Property and equipment, net	135,393	129,874
Goodwill	321,853	278,206
Intangible assets, net	109,767	91,462
Deferred tax assets, long-term portion	19,356	39,497
Other assets	56,476	41,676
Total assets	2,147,059	1,839,113
Current liabilities:
Accounts payable	52,249	66,744
Accrued liabilities	211,171	156,164
Long-term debt, current portion	33,793	311,609
Total current liabilities	297,213	534,517
Long-term debt	765,077
Other long-term liabilities	42,897	28,531
Conversion option subject to cash settlement	6,332	78,390
Stockholders' equity:
Preferred stock
Common stock	1,661	1,516
Additional paid-in capital	2,221,980	1,891,288
Accumulated other comprehensive income	2,086	1,765
Accumulated deficit	(80,432)	(155,335)
Treasury stock, at cost	(1,109,755)	(541,559)
Total stockholders' equity	1,035,540	1,197,675
Total liabilities and stockholders' equity	$ 2,147,059	$ 1,839,113

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Fair Value Measurements (Details Textual) (USD $) In Thousands	3 Months Ended	9 Months Ended
	Oct. 02, 2011	Oct. 02, 2011	Oct. 03, 2010
Fair Value Measurements (Textual) [Abstract]
Gain recorded in acquisition related (gain) expense, net	$ (2,598)	$ 2,442	$ 1,861
Fair Value, Inputs, Level 3 [Member]
Fair Value Measurements (Textual) [Abstract]
Gain recorded in acquisition related (gain) expense, net	$ (2,598)	$ (2,976)

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Stockholders' Equity (Details Textual) (USD $)	1 Months Ended		3 Months Ended		9 Months Ended
	Aug. 31, 2011	Jul. 31, 2010	Oct. 02, 2011	Apr. 03, 2011	Oct. 02, 2011	Oct. 03, 2010
Additional Stockholders' Equity (Textual) [Abstract]
Common stock repurchases					$ 570,406,000	$ 16,006,000
Repurchase of common shares			1,692,000		2,438,000
Stockholders' Equity (Textual) [Abstract]
Stock option Exercisable			6,631,000		6,631,000
Stock option Exercisable outstanding weighted average exercise price per share			$ 22.45		$ 22.45
Stock repurchase program authorized amount	100,000,000	200,000,000
Common stock repurchasing period under 10b5-1 plan		12 months
Allocated to repurchasing Company common stock under a 10b5-1 plan		100,000,000
Amount allocated to repurchasing Company common stock during open trading windows	100,000,000	100,000,000
Cash proceeds from warrants exercised to the Company				5,500,000
Payments for Repurchase of Common Stock under 10b5-1 Plan			104,000,000		156,000,000
Employee Stock Purchase Plan [Member]
Additional Stockholders' Equity (Textual) [Abstract]
Specified percentage of the fair market value of the common stock on the first or last day of the offering period whichever is lower at which stock is purchased			85.00%		85.00%
Total shares were issued under the ESPP					328,000
Shares available for issuance under the ESPP			15,734,000		15,734,000
Warrants [Member]
Additional Stockholders' Equity (Textual) [Abstract]
Number of Shares			18,322,000		18,322,000
Number of shares purchased for warrants exercised				505,000
Exercise Price			31.44		31.44
August 2011 authorized [Member]
Additional Stockholders' Equity (Textual) [Abstract]
Repurchase of common shares			1,894,000
0.25% Convertible Senior Notes due 2016 [Member]
Additional Stockholders' Equity (Textual) [Abstract]
Proceeds from Debt Issuance Used in Stock Repurchases					$ 314,300,000
Purchase of number of shares					4,890,500

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Income Taxes (Details Textual)	3 Months Ended	9 Months Ended
	Oct. 02, 2011	Oct. 02, 2011
Income Taxes (Textual) [Abstract]
Effective tax rate	27.50%	33.60%
U.S statutory rate	35.00%	35.00%

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Warranties (Details) (USD $) In Thousands	9 Months Ended
	Oct. 02, 2011
Reserve for product warranties
Balance as of January 2, 2011	$ 16,761
Additions charged to cost of revenue	18,477
Repairs and replacements	(19,370)
Balance as of October 2, 2011	$ 15,868
Warranties (Textual) [Abstract]
Warranty on instruments	1 year
Warranty on its consumable sales through the expiry date	Six to Twelve months after manufacturing Date