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Segment Information (Details)
$ in Millions
3 Months Ended
Mar. 29, 2020
USD ($)
segment
Mar. 31, 2019
USD ($)
Segment Reporting [Abstract]    
Number of reportable segments | segment 1  
Segment Reporting Information [Line Items]    
Revenue $ 859 $ 846
Income (loss) from operations 189 204
Operating Segments | Core Illumina    
Segment Reporting Information [Line Items]    
Revenue 859 846
Income (loss) from operations 189 221
Operating Segments | Helix    
Segment Reporting Information [Line Items]    
Revenue 0 1
Income (loss) from operations 0 (18)
Elimination of intersegment    
Segment Reporting Information [Line Items]    
Revenue 0 (1)
Income (loss) from operations $ 0 $ 1