10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

þ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the Quarterly Period Ended March 31, 2019

¨ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the transition period from             to            

Commission File Number 001-35406

Illumina, Inc.

(Exact name of registrant as specified in its charter)

Delaware	33-0804655
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)
5200 Illumina Way, San Diego, CA	92122
(Address of principal executive offices)	(Zip Code)

(858) 202-4500

(Registrant’s telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   þ    No   ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes   þ    No  ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	þ		Accelerated filer	¨
Non-accelerated filer	¨	(Do not check if a smaller reporting company)	Smaller reporting company	¨
			Emerging growth company	¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13a of the Exchange Act. o

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).     Yes  ¨    No   þ

As of April 18, 2019, there were 147 million shares of the registrant’s common stock outstanding.

ILLUMINA, INC.

INDEX

	Page
PART I. FINANCIAL INFORMATION
Item 1. Financial Statements	3
Condensed Consolidated Balance Sheets	3
Condensed Consolidated Statements of Income	4
Condensed Consolidated Statements of Comprehensive Income	5
Condensed Consolidated Statement of Stockholders’ Equity	6
Condensed Consolidated Statements of Cash Flows	8
Notes to Condensed Consolidated Financial Statements	9
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations	24
Item 3. Quantitative and Qualitative Disclosures About Market Risk	30
Item 4. Controls and Procedures	30
PART II. OTHER INFORMATION
Item 1. Legal Proceedings	31
Item 1A. Risk Factors	31
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds	31
Item 3. Defaults Upon Senior Securities	31
Item 4. Mine Safety Disclosures	32
Item 5. Other Information	32
Item 6. Exhibits	32
SIGNATURES	33

2

PART I. FINANCIAL INFORMATION

Item 1. Financial Statements.

ILLUMINA, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In millions)

	March 31, 2019			December 30, 2018
	(Unaudited)
ASSETS
Current assets:
Cash and cash equivalents	$	2,270		$	1,144
Short-term investments	1,345			2,368
Accounts receivable, net	457			514
Inventory	412			386
Prepaid expenses and other current assets	61			78
Total current assets	4,545			4,490
Property and equipment, net	852			1,075
Operating lease right-of-use assets	574			—
Goodwill	831			831
Intangible assets, net	175			185
Deferred tax assets, net	87			70
Other assets	326			308
Total assets	$	7,390		$	6,959
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	137		$	184
Accrued liabilities	473			513
Long-term debt, current portion	631			1,107
Total current liabilities	1,241			1,804
Operating lease liabilities	718			—
Long-term debt	1,112			890
Other long-term liabilities	212			359
Redeemable noncontrolling interests	37			61
Stockholders’ equity:
Common stock	2			2
Additional paid-in capital	3,385			3,290
Accumulated other comprehensive income (loss)	2			(1		)
Retained earnings	3,298			3,083
Treasury stock, at cost	(2,702		)	(2,616		)
Total Illumina stockholders’ equity	3,985			3,758
Noncontrolling interests	85			87
Total stockholders’ equity	4,070			3,845
Total liabilities and stockholders’ equity	$	7,390		$	6,959

See accompanying notes to condensed consolidated financial statements.

3

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF INCOME

(Unaudited)

(In millions, except per share amounts)

	Three Months Ended
	March 31, 2019			April 1, 2018
Revenue:
Product revenue	$	667		$	628
Service and other revenue	179			154
Total revenue	846			782
Cost of revenue:
Cost of product revenue	182			174
Cost of service and other revenue	71			62
Amortization of acquired intangible assets	9			8
Total cost of revenue	262			244
Gross profit	584			538
Operating expense:
Research and development	169			137
Selling, general and administrative	211			183
Total operating expense	380			320
Income from operations	204			218
Other income (expense):
Interest income	23			5
Interest expense	(15		)	(11		)
Other income, net	21			9
Total other income, net	29			3
Income before income taxes	233			221
Provision for income taxes	9			24
Consolidated net income	224			197
Add: Net loss attributable to noncontrolling interests	9			11
Net income attributable to Illumina stockholders	$	233		$	208
Earnings per share attributable to Illumina stockholders:
Basic	$	1.58		$	1.42
Diluted	$	1.57		$	1.41
Shares used in computing earnings per share:
Basic	147			147
Diluted	149			148

See accompanying notes to condensed consolidated financial statements.

4

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

(Unaudited)

(In millions)

	Three Months Ended
	March 31, 2019		April 1, 2018
Consolidated net income	$	224	$	197
Unrealized gain on available-for-sale debt securities, net of deferred tax	3		—
Total consolidated comprehensive income	227		197
Add: Comprehensive loss attributable to noncontrolling interests	9		11
Comprehensive income attributable to Illumina stockholders	$	236	$	208

See accompanying notes to condensed consolidated financial statements.

5

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(Unaudited)

(In millions)

	Illumina Stockholders
				Additional			Accumulated Other													Total
	Common Stock			Paid-In			Comprehensive			Retained		Treasury Stock					Noncontrolling			Stockholders’
	Shares	Amount		Capital			(Loss) Income			Earnings		Shares		Amount			Interests			Equity
Balance as of December 31, 2017	191	$	2	$	2,833		$	(1	)	$	2,256	(44	)	$	(2,341	)	$	—		$	2,749
Net income (loss)	—	—		—			—			208		—		—			(1		)	207
Issuance of common stock, net of repurchases	—	—		21			—			—		—		(13		)	—			8
Share-based compensation	—	—		48			—			—		—		—			—			48
Adjustment to the carrying value of redeemable noncontrolling interests	—	—		(5		)	—			—		—		—			—			(5		)
Contributions from noncontrolling interest owners	—	—		—			—			—		—		—			61			61
Issuance of subsidiary shares in business combination	—	—		—			—			—		—		—			5			5
Balance as of April 1, 2018	191	2		2,897			(1		)	2,464		(44	)	(2,354		)	65			3,073
Net income (loss)	—	—		—			—			209		—		—			(2		)	207
Issuance of common stock, net of repurchases	—	—		1			—			—		—		(2		)	—			(1		)
Share-based compensation	—	—		50			—			—		—		—			—			50
Vesting of redeemable equity awards	—	—		(1		)	—			—		—		—			—			(1		)
Adjustment to the carrying value of redeemable noncontrolling interests	—	—		(8		)	—			—		—		—			—			(8		)
Contributions from noncontrolling interest owners	—	—		—			—			—		—		—			31			31
Balance as of July 1, 2018	191	2		2,939			(1		)	2,673		(44	)	(2,356		)	94			3,351
Net income (loss)	—	—		—			—			199		—		—			(3		)	196
Unrealized loss on available-for-sale debt securities, net of deferred tax	—	—		—			(1		)	—		—		—			—			(1		)
Issuance of common stock, net of repurchases	—	—		23			—			—		—		(106		)	—			(83		)
Share-based compensation	—	—		47			—			—		—		—			—			47
Vesting of redeemable equity awards	—	—		(1		)	—			—		—		—			—			(1		)
Adjustment to the carrying value of redeemable noncontrolling interests	—	—		(8		)	—			—		—		—			—			(8		)
Issuance of convertible senior notes, net of tax impact	—	—		93			—			—		—		—			—			93
Balance as of September 30, 2018	191	2		3,093			(2		)	2,872		(44	)	(2,462		)	91			3,594
Net income (loss)	—	—		—			—			210		—		—			(4		)	206
Unrealized gain on available-for-sale debt securities, net of deferred tax	—	—		—			1			—		—		—			—			1
Issuance of common stock, net repurchases	1	—		1			—			—		(1	)	(154		)	—			(153		)
Share-based compensation	—	—		48			—			—		—		—			—			48
Adjustment to the carrying value of redeemable noncontrolling interests	—	—		148			—			—		—		—			—			148

6

Cumulative-effect adjustment from adoption of ASU 2016-01	—	—		—			—			1			—		—			—			1
Balance as of December 30, 2018	192	2		3,290			(1		)	3,083			(45	)	(2,616		)	87			3,845
Net income (loss)	—	—		—			—			233			—		—			(2		)	231
Unrealized gain on available-for-sale debt securities, net of deferred tax	—	—		—			3			—			—		—			—			3
Issuance of common stock, net of repurchases	—	—		27			—			—			—		(86		)	—			(59		)
Share-based compensation	—	—		51			—			—			—		—			—			51
Vesting of redeemable equity awards	—	—		(1		)	—			—			—		—			—			(1		)
Adjustment to the carrying value of redeemable noncontrolling interests	—	—		18			—			—			—		—			—			18
Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax	—	—		—			—			(18		)	—		—			—			(18		)
Balance as of March 31, 2019	192	$	2	$	3,385		$	2		$	3,298		(45	)	$	(2,702	)	$	85		$	4,070

See accompanying notes to condensed consolidated financial statements.

7

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(In millions)

	Three Months Ended
	March 31, 2019			April 1, 2018
Cash flows from operating activities:
Consolidated net income	$	224		$	197
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense	37			30
Amortization of intangible assets	10			9
Share-based compensation expense	51			48
Accretion of debt discount	14			8
Deferred income taxes	(11		)	(11		)
Gain on deconsolidation of GRAIL	(15		)	—
Other	(5		)	(6		)
Changes in operating assets and liabilities:
Accounts receivable	56			11
Inventory	(26		)	(17		)
Prepaid expenses and other current assets	6			(2		)
Operating lease right-of-use assets and liabilities, net	(1		)	—
Other assets	(8		)	(1		)
Accounts payable	(47		)	2
Accrued liabilities	(70		)	(18		)
Other long-term liabilities	(17		)	5
Net cash provided by operating activities	198			255
Cash flows from investing activities:
Purchases of available-for-sale securities	(117		)	(598		)
Sales of available-for-sale securities	118			288
Maturities of available-for-sale securities	1,031			415
Proceeds from deconsolidation of GRAIL	15			—
Net purchases of strategic investments	(3		)	(3		)
Purchases of property and equipment	(56		)	(90		)
Net cash provided by investing activities	988			12
Cash flows from financing activities:
Payments on financing obligations	(1		)	(2		)
Common stock repurchases	(63		)	—
Taxes paid related to net share settlement of equity awards	(23		)	(13		)
Proceeds from issuance of common stock	27			21
Contributions from noncontrolling interest owners	—			61
Net cash (used in) provided by financing activities	(60		)	67
Effect of exchange rate changes on cash and cash equivalents	—			1
Net increase in cash and cash equivalents	1,126			335
Cash and cash equivalents at beginning of period	1,144			1,225
Cash and cash equivalents at end of period	$	2,270		$	1,560
Supplemental cash flow information:
Cash paid for operating lease liabilities	$	21		$	—

See accompanying notes to condensed consolidated financial statements.

8

Illumina, Inc.

Notes to Condensed Consolidated Financial Statements

(Unaudited)

Unless the context requires otherwise, references in this report to “Illumina,” “we,” “us,” the “Company,” and “our” refer to Illumina, Inc. and its consolidated subsidiaries.

1. Basis of Presentation and Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Annual Report on Form 10-K for the fiscal year ended December 30, 2018, from which the prior year balance sheet information herein was derived. The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expense, and related disclosure of contingent assets and liabilities. Actual results could differ from those estimates.

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, majority-owned or controlled companies, and variable interest entities (VIEs) for which we are the primary beneficiary. All intercompany transactions and balances have been eliminated in consolidation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

We evaluate our ownership, contractual and other interests in entities that are not wholly-owned to determine if these entities are VIEs, and, if so, whether we are the primary beneficiary of the VIE. In determining whether we are the primary beneficiary of a VIE and therefore required to consolidate the VIE, we apply a qualitative approach that determines whether we have both (1) the power to direct the activities of the VIE that most significantly impact the VIE’s economic performance and (2) the obligation to absorb losses of, or the rights to receive benefits from, the VIE that could potentially be significant to that VIE. We continuously perform this assessment, as changes to existing relationships or future transactions may result in the consolidation or deconsolidation of a VIE. See note “10. Subsequent Event.”

We use the equity method to account for investments through which we have the ability to exercise significant influence, but not control, over the investee. Such investments are recorded in other assets, and our share of net income or loss is recognized on a one quarter lag in other income, net.

Redeemable Noncontrolling Interests

Noncontrolling interests represent the portion of equity (net assets) in Helix, our consolidated but not wholly-owned entity, that is neither directly nor indirectly attributable to us. Noncontrolling interests with embedded contingent redemption features, such as put rights, that are not solely within our control are considered redeemable noncontrolling interests, and are presented outside of stockholders’ equity on the condensed consolidated balance sheets.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. The three months ended March 31, 2019 and April 1, 2018 were both 13 weeks.

9

Reclassifications

Certain prior period amounts have been reclassified to conform to the current period presentation.

Significant Accounting Policies

During the three months ended March 31, 2019, there have been no changes to our significant accounting policies as described in our Annual Report on Form 10-K for the fiscal year ended December 30, 2018, except as described below.

Recently Adopted Accounting Pronouncements

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which requires lessees to recognize most leases on the balance sheet as lease liabilities with corresponding right-of-use assets and to disclose key information about leasing arrangements. We adopted Topic 842 on its effective date in the first quarter of 2019 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings as of December 31, 2018. We elected the available package of practical expedients upon adoption, which allowed us to carry forward our historical assessment of whether existing agreements contained a lease and the classification of our existing operating leases. We continue to report our financial position as of December 30, 2018 under the former lease accounting standard (Topic 840) in our condensed consolidated balance sheet.

The following table summarizes the impact of Topic 842 on our condensed consolidated balance sheet upon adoption on December 31, 2018 (in millions):

	December 31, 2018 (unaudited)
	Pre-adoption		Adoption Impact			Post-adoption
ASSETS
Prepaid expenses and other current assets	$	78	$	(8	)	$	70
Property and equipment, net	1,075		(241		)	834
Operating lease right-of-use assets	—		579			579
Deferred tax assets, net	70		6			76
Total assets	$	1,223	$	336		$	1,559
LIABILITIES AND STOCKHOLDERS’ EQUITY
Accrued liabilities	$	513	$	36		$	549
Operating lease liabilities	—		722			722
Long-term debt	1,107		(269		)	838
Other long-term liabilities	359		(135		)	224
Retained earnings	3,083		(18		)	3,065
Total liabilities and stockholders’ equity	$	5,062	$	336		$	5,398

The adoption impact summarized above was primarily due to the recognition of operating lease liabilities with corresponding right-of-use assets based on the present value of our remaining minimum lease payments, and the derecognition of existing fixed assets and financing obligations related to build-to-suit leasing arrangements that, under Topic 840, did not qualify for sale-leaseback accounting. The difference between these amounts, net of deferred tax, was recorded as a cumulative-effective adjustment to retained earnings.

Recently Issued Accounting Pronouncements

In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available-for-sale debt securities. The standard is effective for us beginning in the first quarter of 2020, with early adoption permitted.  We are currently evaluating the expected impact of ASU 2016-13 on our consolidated financial statements.

10

Revenue Recognition

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services and instrument service contracts.

We recognize revenue when control of our products and services is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products and services. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of a good or service to the customer, meaning the customer has the ability to use and obtain the benefit of the good or service.

Revenue from product sales is recognized generally upon delivery to the end customer, which is when control of the product is deemed to be transferred. Invoicing typically occurs upon shipment; and payment is typically due within 60 days from invoice. In instances where right of payment or transfer of title is contingent upon the customer’s acceptance of the product, revenue is deferred until all acceptance criteria have been met. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term. Revenue from genotyping and sequencing services is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer.

Revenue is recorded net of discounts, distributor commissions, and sales taxes collected on behalf of governmental authorities. Employee sales commissions are recorded as selling, general and administrative expenses when incurred as the amortization period for such costs, if capitalized, would have been one year or less.

We regularly enter into contracts with multiple performance obligations. Revenue recognition for contracts with multiple deliverables is based on the separate satisfaction of each distinct performance obligation within the contract. Most performance obligations are generally satisfied within a short time frame, approximately three to six months after the contract execution date. As of March 31, 2019, the aggregate amount of the transaction price allocated to remaining performance obligations was $1,083 million, of which approximately 85% is expected to be converted to revenue in the next twelve months, with the remainder thereafter.

The contract price is allocated to each performance obligation in proportion to its standalone selling price. We determine our best estimate of standalone selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, we rely upon prices set by management, adjusted for applicable discounts.

Contract liabilities, which consist of deferred revenue and customer deposits, as of March 31, 2019 and December 30, 2018 were $201 million and $206 million, respectively, of which the short-term portions of $169 million and $175 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded during the three months ended March 31, 2019 included $64 million of previously deferred revenue that was included in contract liabilities as of December 30, 2018. Contract assets as of March 31, 2019 and December 30, 2018 were not material.

In certain markets, products and services are sold to customers through distributors. In most sales through distributors, the product is delivered directly to customers by us. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers.

11

The following table represents revenue by source (in millions):

	Three Months Ended
	March 31, 2019						April 1, 2018
	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	481	$	75	$	556	$	422	$	88	$	510
Instruments	105		6		111		112		6		118
Total product revenue	586		81		667		534		94		628
Service and other revenue	113		66		179		96		58		154
Total revenue	$	699	$	147	$	846	$	630	$	152	$	782

Revenue related to our consolidated VIE, Helix, is included in sequencing service and other revenue.

The following table represents revenue by geographic area, based on region of destination (in millions):

	Three Months Ended
	March 31, 2019		April 1, 2018
Americas	$	473	$	440
Europe, Middle East, and Africa	210		194
Greater China (1)	88		78
Asia-Pacific	75		70
Total revenue	$	846	$	782

____________________________________

(1) Region includes revenue from China, Taiwan, and Hong Kong.

Earnings per Share

Basic earnings per share attributable to Illumina stockholders is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share attributable to Illumina stockholders is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Per-share earnings of our consolidated VIE, Helix, are included in the consolidated basic and diluted earnings per share computations based on our share of Helix’s securities.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. Convertible senior notes have a dilutive impact when the average market price of our common stock exceeds the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.

The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in millions):

	Three Months Ended
	March 31, 2019	April 1, 2018
Weighted average shares outstanding	147	147
Effect of potentially dilutive common shares from:
Convertible senior notes	1	—
Equity awards	1	1
Weighted average shares used in calculating diluted earnings per share	149	148
Potentially dilutive shares excluded from calculation due to anti-dilutive effect	1	—

12

2. Balance Sheet Account Details

Investments

Debt Securities

Available-for-sale debt securities, included in short-term investments, consisted of the following (in millions):

	March 31, 2019									December 30, 2018
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
Debt securities in government sponsored entities	$	21	$	—	$	—		$	21	$	21	$	—	$	—		$	21
Corporate debt securities	716		2		(1		)	717		1,060		—		(2		)	1,058
U.S. Treasury securities	566		—		—			566		1,250		1		(1		)	1,250
Total	$	1,303	$	2	$	(1	)	$	1,304	$	2,331	$	1	$	(3	)	$	2,329

Realized gains and losses are determined based on the specific identification method and are reported in interest income.

Contractual maturities of available-for-sale debt securities, as of March 31, 2019, were as follows (in millions):

	Estimated Fair Value
Due within one year	$	711
After one but within five years	593
Total	$	1,304

We have the ability, if necessary, to liquidate any of our cash equivalents and short-term investments to meet our liquidity needs in the next 12 months. Accordingly, those investments with contractual maturities greater than one year from the date of purchase are classified as short-term on the accompanying condensed consolidated balance sheets.

Equity Securities

Our equity securities are strategic investments primarily in privately held companies.

The carrying values of our non-marketable equity securities without readily determinable market values are initially measured at cost and adjusted to fair value for observable transactions for identical or similar investments of the same issuer or impairment. Unrealized gains and losses on non-marketable equity securities are recognized in other income, net. As of March 31, 2019 and December 30, 2018, the aggregate carrying amounts of our non-marketable equity investments without readily determinable fair values were $230 million and $231 million, respectively, included in other assets.

One of our non-marketable equity investments is a VIE for which we have concluded that we are not the primary beneficiary, and therefore, we do not consolidate this VIE in our consolidated financial statements. We have determined our maximum exposure to loss, as a result of our involvement with the VIE, to be the carrying value of our investment, which was $189 million as of March 31, 2019 and December 30, 2018.

Our marketable equity security is measured at fair value. Unrealized gains and losses are recognized in other income, net. As of March 31, 2019 and December 30, 2018, the fair value of our marketable equity investment was $41 million and $39 million, respectively, included in short-term investments.

Revenue recognized from transactions with our strategic equity investees was $15 million and $36 million for the three months ended March 31, 2019 and April 1, 2018, respectively.

Venture Fund

We invest in a venture capital investment fund (the Fund) with a capital commitment of $100 million that is callable through April 2026, of which $66 million remained callable as of March 31, 2019. Our investment in the Fund is accounted for

13

as an equity-method investment. The carrying amounts of the Fund, included in other assets, were $38 million and $29 million as of March 31, 2019 and December 30, 2018, respectively.

Inventory

Inventory consisted of the following (in millions):

	March 31, 2019		December 30, 2018
Raw materials	$	115	$	117
Work in process	234		218
Finished goods	63		51
Total inventory	$	412	$	386

Property and Equipment

Property and equipment, net consisted of the following (in millions):

	March 31, 2019			December 30, 2018
Leasehold improvements	$	622		$	567
Machinery and equipment	390			382
Computer hardware and software	256			217
Furniture and fixtures	48			45
Buildings	44			285
Construction in progress	46			100
Total property and equipment, gross	1,406			1,596
Accumulated depreciation	(554		)	(521		)
Total property and equipment, net	$	852		$	1,075

Property and equipment, net included non-cash expenditures of $17 million and $33 million for the three months ended March 31, 2019 and April 1, 2018, respectively, which were excluded from the condensed consolidated statements of cash flows. Such non-cash expenditures included $6 million recorded under build-to-suit lease accounting for the three months ended April 1, 2018.

As of December 30, 2018, property and equipment, net included $241 million of project construction costs paid or reimbursed by our landlord related to our build-to-suit leases that did not qualify for sale-leaseback accounting under Topic 840. Upon adoption of Topic 842 on December 31, 2018, we derecognized the Buildings related to our build-to-suit leasing arrangements and began to account for these leases as operating leases. See note “1. Basis of Presentation and Summary of Significant Accounting Policies” for further details on the adoption impact of Topic 842.

Leases

We lease approximately 2.7 million square feet of office, lab, and manufacturing facilities under various non-cancellable operating lease agreements (real estate leases). Our real estate leases have remaining lease terms of 1 to 20 years, which represent the non-cancellable periods of the leases and include extension options that we determined are reasonably certain to be exercised. We exclude extension options that are not reasonably certain to be exercised from our lease terms, ranging from 6 months to 20 years. Our lease payments consist primarily of fixed rental payments for the right to use the underlying leased assets over the lease terms as well as payments for common-area-maintenance and administrative services. We often receive customary incentives from our landlords, such as reimbursements for tenant improvements and rent abatement periods, which effectively reduce the total lease payments owed for these leases.

Operating lease right-of-use assets and liabilities on our condensed consolidated balance sheets represent the present value of our remaining lease payments over the remaining lease terms. We do not allocate lease payments to non-lease components; therefore, fixed payments for common-area-maintenance and administrative services are included in our operating lease right-of-use assets and liabilities. We use our incremental borrowing rate to calculate the present value of our lease payments, as the implicit rates in our leases are not readily determinable.

14

As of March 31, 2019, the maturities of our operating lease liabilities were as follows (in millions):

	Remaining Lease Payments
2019	$	64
2020	85
2021	82
2022	85
2023	86
Thereafter	621
Total remaining lease payments	1,023
Less: imputed interest	(253		)
Total operating lease liabilities	770
Less: current portion	(52		)
Long-term operating lease liabilities	$	718
Weighted-average remaining lease term	12 years
Weighted-average discount rate	4.6		%

The components of our lease costs included in our condensed consolidated statements of income were as follows (in millions):

	Three months ended
	March 31, 2019
Operating lease costs	$	22
Sublease income	(3		)
Total lease costs	$	19

Operating lease costs consist of the fixed lease payments included in our operating lease liabilities and are recorded on a straight-line basis over the lease terms. We sublease certain real estate to third parties and this sublease income is also recorded on a straight-line basis.

Derivatives

We are exposed to foreign exchange rate risks in the normal course of business. We enter into foreign exchange contracts to manage foreign currency risks related to monetary assets and liabilities that are denominated in currencies other than the U.S. dollar. These foreign exchange contracts are carried at fair value in other current assets or accrued liabilities and are not designated as hedging instruments. Changes in the value of the derivatives are recognized in other income, net, along with the remeasurement gain or loss on the foreign currency denominated assets or liabilities.

As of March 31, 2019, we had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, and British pound. As of March 31, 2019 and December 30, 2018, the total notional amounts of outstanding forward contracts in place for foreign currency purchases were $272 million and $122 million, respectively.

15

Accrued Liabilities

Accrued liabilities consisted of the following (in millions):

	March 31, 2019		December 30, 2018
Contract liabilities, current portion	$	169	$	175
Accrued compensation expenses	105		193
Accrued taxes payable	83		82
Operating lease liabilities, current portion	52		—
Other, including warranties	64		63
Total accrued liabilities	$	473	$	513

Warranties

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

Changes in the reserve for product warranties during the three months ended March 31, 2019 and April 1, 2018 were as follows (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Balance at beginning of period	$	19		$	17
Additions charged to cost of product revenue	3			6
Repairs and replacements	(6		)	(7		)
Balance at end of period	$	16		$	16

Investment in Helix

In July 2015, we obtained a 50% voting equity ownership interest in Helix Holdings I, LLC (Helix), a limited liability company formed with unrelated third-party investors to pursue the development and commercialization of a marketplace for consumer genomics. We determined that Helix is a VIE as the holders of the at-risk equity investments as a group lack the power to direct the activities of Helix that most significantly impact Helix’s economic performance. Additionally, we determined that we have (a) unilateral power over one of the activities that most significantly impacts the economic performance of Helix through its contractual arrangements and no one individual party has unilateral power over the remaining significant activities of Helix and (b) the obligation to absorb losses of and the right to receive benefits from Helix that are potentially significant to Helix. As a result, we are deemed to be the primary beneficiary of Helix and are required to consolidate Helix.

As contractually committed, in July 2015, we contributed certain perpetual licenses, instruments, intangibles, initial laboratory setup, and discounted supply terms in exchange for voting equity interests in Helix. Such contributions were recorded at their historical basis as they remained within our control. Helix is financed through cash contributions made by us and third-party investors in exchange for voting equity interests in Helix. During the year endedDecember 30, 2018, we made additional investments of $100 million in exchange for voting equity interests in Helix. During the three months ended March 31, 2019, we did not provide any other financial or other support to Helix that we were not previously contractually required to provide. As of March 31, 2019, the noncontrolling shareholders and Illumina each held 50% of Helix’s outstanding voting equity interests.

16

Certain noncontrolling Helix investors may require us to redeem certain noncontrolling interests in cash at the then approximate redemption fair market value. Such redemption right is exercisable at the option of certain noncontrolling interest holders after January 1, 2021, provided that a bona fide pursuit of the sale of Helix has occurred and an initial public offering of Helix has not been completed. As the contingent redemption is outside of our control, the redeemable noncontrolling interests in Helix are classified outside of stockholders’ equity on the accompanying condensed consolidated balance sheets. The balance of the redeemable noncontrolling interests is reported at the greater of its carrying value after receiving its allocation of Helix’s profits and losses or its estimated redemption fair value at each reporting date. The fair value of the redeemable noncontrolling interests is considered a Level 3 instrument.

As of March 31, 2019, the accompanying condensed consolidated balance sheet included $106 million of cash, cash equivalents, and short-term investments attributable to Helix that will be used to settle its respective obligations and will not be available to settle obligations of Illumina. The remaining assets and liabilities of Helix were not significant to our financial position as of March 31, 2019. Helix had an immaterial impact on our condensed consolidated statements of income and cash flows for the three months ended March 31, 2019. Refer to note “10. Subsequent Event.”

Redeemable Noncontrolling Interests

The activity of the redeemable noncontrolling interests during the three months ended March 31, 2019 was as follows (in millions):

	Redeemable Noncontrolling Interests
Balance as of December 30, 2018	$	61
Vesting of redeemable equity awards	1
Net loss attributable to noncontrolling interests	(7		)
Adjustment down to the redemption value	(18		)
Balance as of March 31, 2019	$	37

3. Pending Acquisition

On November 1, 2018, we entered into an Agreement and Plan of Merger (the Merger Agreement) to acquire Pacific Biosciences of California, Inc. (PacBio) for an all-cash price of approximately $1.2 billion (or $8.00 per share). The transaction, which is expected to close mid-2019, is subject to certain customary closing conditions, including the receipt of certain required antitrust approvals. The Merger Agreement contains certain termination rights and provides that, upon termination of the Merger Agreement under specified circumstances, including but not limited to, a termination of the Merger Agreement in connection with PacBio accepting a superior offer or due to the withdrawal by PacBio’s board of directors of its recommendation of the merger, PacBio will pay us a cash termination fee of $43 million. In certain other circumstances related to antitrust approvals, we may be required to pay PacBio a termination fee of $98 million assuming the other closing conditions not related to antitrust or competition laws have been satisfied.

17

4. Fair Value Measurements

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis as of March 31, 2019 and December 30, 2018 (in millions):

	March 31, 2019								December 30, 2018
	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	1,805	$	—	$	—	$	1,805	$	832	$	—	$	—	$	832
Debt securities in government-sponsored entities	—		21		—		21		—		21		—		21
Corporate debt securities	—		717		—		717		—		1,058		—		1,058
U.S. Treasury securities	566		—		—		566		1,250		—		—		1,250
Marketable equity security	41		—		—		41		39		—		—		39
Deferred compensation plan assets	—		43		—		43		—		34		—		34
Total assets measured at fair value	$	2,412	$	781	$	—	$	3,193	$	2,121	$	1,113	$	—	$	3,234
Liabilities:
Deferred compensation plan liability	$	—	$	41	$	—	$	41	$	—	$	33	$	—	$	33

We hold available-for-sale securities that consist of highly-liquid, investment-grade debt securities. We consider information provided by our investment accounting and reporting service provider in the measurement of fair value of our debt securities. The investment service provider provides valuation information from an industry-recognized valuation service. Such valuations may be based on trade prices in active markets for identical assets or liabilities (Level 1 inputs) or valuation models using inputs that are observable either directly or indirectly (Level 2 inputs), such as quoted prices for similar assets or liabilities, yield curve, volatility factors, credit spreads, default rates, loss severity, current market and contractual prices for the underlying instruments or debt, broker and dealer quotes, as well as other relevant economic measures. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary.

18

5. Debt and Other Commitments

Summary of debt obligations

Debt obligations consisted of the following (dollars in millions):

	March 31, 2019			December 30, 2018
Principal amount of 2023 Notes outstanding	$	750		$	750
Principal amount of 2021 Notes outstanding	517			517
Principal amount of 2019 Notes outstanding	632			633
Unamortized discount of liability component of convertible senior notes	(160		)	(175		)
Net carrying amount of liability component of convertible senior notes	1,739			1,725
Obligations under financing leases	—			269
Other	4			3
Less: current portion	(631		)	(1,107		)
Long-term debt	$	1,112		$	890
Carrying value of equity component of convertible senior notes, net of debt issuance costs	$	287		$	287
Fair value of convertible senior notes outstanding (Level 2)	$	2,298		$	2,222
Weighted-average remaining amortization period of discount on the liability component of convertible senior notes	3.8 years			3.9 years

Convertible Senior Notes

0% Convertible Senior Notes due 2023 (2023 Notes)

On August 21, 2018, we issued $750 million aggregate principal amount of convertible senior notes due 2023 (2023 Notes). The 2023 Notes mature on August 15, 2023, and the implied estimated effective rate of the liability component of the Notes was 3.7%, assuming no conversion option.

The 2023 Notes will be convertible into cash, shares of our common stock or a combination of cash and shares of our common stock, at our election, based on an initial conversion rate, subject to adjustment, of 2.1845 shares of common stock per $1,000 principal amount of notes (which represents an initial conversion price of approximately $457.77 per share of common stock), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending on September 30, 2018 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price in effect on each applicable trading day; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of 2023 Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; (3) if we call any or all of the notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; or (4) upon the occurrence of specified corporate events described in the indenture. Regardless of the foregoing circumstances, the holders may convert their notes on or after May 15, 2023 until August 11, 2023.

We may redeem for cash all or any portion of the 2023 Notes, at our option, on or after August 20, 2021 if the last reported sale price of our common stock has been at least 130% of the conversion price then in effect (currently $595.10) for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending on, and including, the trading day immediately preceding the date on which we provide notice of redemption at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid special interest to, but excluding, the redemption date.

The 2023 Notes were not convertible as of March 31, 2019 and had no dilutive impact during the three months endedMarch 31, 2019. If the 2023 Notes were converted as of March 31, 2019, the if-converted value would not exceed the principal amount.

19

0% Convertible Senior Notes due 2019 (2019 Notes) and 0.5% Convertible Senior Notes due 2021 (2021 Notes)

In June 2014, we issued $633 million aggregate principal amount of 2019 Notes and $517 million aggregate principal amount of 2021 Notes. The 2019 and 2021 Notes mature on June 15, 2019 and June 15, 2021, respectively, and the implied estimated effective rates of the liability components of the Notes were 2.9% and 3.5%, respectively, assuming no conversion option.

Both the 2019 and 2021 Notes will be convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on an initial conversion rate, subject to adjustment, of 3.9318 shares per $1,000 principal amount of the notes (which represents an initial conversion price of approximately $254.34 per share), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending September 30, 2014 (and only during such calendar quarter), if the last reported sale price of our common stock for 20 or more trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per 2019 and 2021 Notes for each day of such measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; or (3) upon the occurrence of specified events described in the indenture for the 2019 and 2021 Notes. Regardless of the foregoing circumstances, the holders may convert their notes on or after March 15, 2019 until June 13, 2019 for the 2019 Notes and March 15, 2021 until June 11, 2021 for the 2021 Notes.

The potential dilutive impact of the 2019 and 2021 notes has been included in our calculation of diluted earnings per share for the three months endedMarch 31, 2019. If the 2019 and 2021 Notes were converted as of March 31, 2019, their if-converted values would exceed their principal amounts by $128 million and $105 million, respectively. The carrying values of the 2019 Notes were classified as current liabilities as they were convertible as of March 31, 2019 and mature within twelve months of the balance sheet date.

Obligations under financing leases

As of December 30, 2018, obligations under financing leases of $269 million represented project construction costs paid or reimbursed by our landlord related to our build-to-suit leases that did not qualify for sale-leaseback accounting under Topic 840. Upon adoption of Topic 842 on December 31, 2018, we derecognized the remaining financing obligations for our build-to-suit leasing arrangements and began to account for these leases as operating leases. See note “1. Basis of Presentation and Summary of Significant Accounting Policies” for further details on the adoption of Topic 842.

6. Stockholders’ Equity

As of March 31, 2019, approximately 4.8 million shares remained available for future grants under the 2015 Stock Plan.

20

Restricted Stock

Restricted stock activity for the three months ended March 31, 2019 was as follows (units in thousands):

	Restricted Stock Units (RSU)		Performance Stock Units (PSU)(1)		Weighted-Average Grant-Date Fair Value per Share
					RSU		PSU
Outstanding at December 30, 2018	1,840		660		$	227.00	$	196.99
Awarded	24		—		$	291.79	$	—
Vested	(28	)	—		$	176.83	—
Cancelled	(43	)	(39	)	$	204.64	$	163.53
Outstanding at March 31, 2019	1,793		621		$	229.18	$	199.48

______________________________________

(1) The number of units reflect the estimated number of shares to be issued at the end of the performance period.

Stock Options

Stock option activity during the three months ended March 31, 2019 was as follows:

	Options (in thousands)		Weighted-Average Exercise Price
Outstanding at December 30, 2018	192		$	54.52
Exercised	(34	)	$	47.86
Outstanding and exercisable at March 31, 2019	158		$	55.95

ESPP

The price at which common stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. During the three months ended March 31, 2019, approximately 0.1 million shares were issued under the ESPP. As of March 31, 2019, there were approximately 13.6 million shares available for issuance under the ESPP.

Share Repurchases

On February 6, 2019, our Board of Directors authorized a new share repurchase program, which supersedes all prior and available repurchase authorizations, to repurchase $550 million of outstanding common stock. The repurchases may be completed under a 10b5-1 plan or at management’s discretion. During the three months ended March 31, 2019, we repurchased 0.2 million shares for approximately $63 million.  Authorizations to repurchase approximately $488 million of our common stock remained available as of March 31, 2019.

21

Share-based Compensation

Share-based compensation expense reported in our condensed consolidated statements of income was as follows (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Cost of product revenue	$	5		$	4
Cost of service and other revenue	1			1
Research and development	18			15
Selling, general and administrative	27			28
Share-based compensation expense before taxes	51			48
Related income tax benefits	(10		)	(10		)
Share-based compensation expense, net of taxes	$	41		$	38

The assumptions used for the specified reporting periods and the resulting estimates of weighted-average fair value per share for stock purchased under the Employee Stock Purchase Plan (ESPP) during the three months ended March 31, 2019 were as follows:

	Employee Stock Purchase Rights
Risk-free interest rate	1.89% - 2.56%
Expected volatility	30% - 38%
Expected term	0.5 - 1.0 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	71.48

As of March 31, 2019, approximately $433 million of total unrecognized compensation cost related to restricted stock and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.3 years.

7. Legal Proceedings

We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.

8. Income Taxes

Our effective tax rate may vary from the U.S. federal statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income. The effective tax rate for the three months ended March 31, 2019 was 3.9%. For the three months ended March 31, 2019, the decrease from the U.S. federal statutory tax rate of 21% was primarily attributable to a discrete tax benefit related to uncertain tax positions, the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom, and excess tax benefits related to share-based compensation.

22

9. Segment Information

We report segment information based on the management approach. This approach designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. Based on the information used by the CODM, we have determined our reportable segments as follows:

Core Illumina:

Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of our consolidated VIE, Helix.

Helix:

Helix, our consolidated VIE, was established to enable individuals to explore their genetic information by providing affordable sequencing and database services for consumers through third-party partners, driving the creation of an ecosystem of consumer applications.

Management evaluates the performance of our reportable segments based upon income (loss) from operations. We do not allocate expenses between segments. Core Illumina sells products and provides services to Helix in accordance with contractual agreements between the entities.

The following table presents the operating performance of each reportable segment (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Revenue:
Core Illumina	$	846		$	783
Helix	1			3
Elimination of intersegment revenue	(1		)	(4		)
Consolidated revenue	$	846		$	782
Income (loss) from operations:
Core Illumina	$	221		$	238
Helix	(18		)	(21		)
Elimination of intersegment earnings	1			1
Consolidated income from operations	$	204		$	218

The following table presents the total assets of each reportable segment (in millions):

	March 31, 2019			December 30, 2018
Core Illumina	$	7,362		$	6,912
Helix	134			154
Elimination of intersegment assets	(106		)	(107		)
Consolidated total assets	$	7,390		$	6,959

10. Subsequent Event

On April 25, 2019, we entered into an agreement to sell our interest in, and relinquish control over, our consolidated VIE, Helix. In connection with the transaction, the redeemable noncontrolling interest of $37 million as of March 31, 2019 was eliminated, and we will no longer consolidate Helix effective April 25, 2019.

23

Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.

Our Management’s Discussion and Analysis of Financial Condition and Results of Operations (MD&A) will help readers understand our results of operations, financial condition, and cash flow. It is provided in addition to the accompanying condensed consolidated financial statements and notes. This MD&A is organized as follows:

• Business Overview and Outlook. High level discussion of our operating results and significant known trends that affect our business.

• Results of Operations. Detailed discussion of our revenues and expenses.

• Liquidity and Capital Resources. Discussion of key aspects of our condensed consolidated statements of cash flows, changes in our financial position, and our financial commitments.

• Off-Balance Sheet Arrangements. We have no off-balance sheet arrangements.

• Critical Accounting Policies and Estimates. Discussion of significant changes since our most recent Annual Report on Form 10-K that we believe are important to understanding the assumptions and judgments underlying our condensed consolidated financial statements.

• Recent Accounting Pronouncements. Summary of recent accounting pronouncements applicable to our condensed consolidated financial statements.

This MD&A discussion contains forward-looking statements that involve risks and uncertainties. Please see “Consideration Regarding Forward-Looking Statements” preceding Item 3 of this report for additional factors relating to such statements. This MD&A should be read in conjunction with our condensed consolidated financial statements and accompanying notes included in this report and our Annual Report on Form 10-K for the fiscal year ended December 30, 2018. Operating results are not necessarily indicative of results that may occur in future periods.

Business Overview and Outlook

This overview and outlook provides a high-level discussion of our operating results and significant known trends that affect our business. We believe that an understanding of these trends is important to understanding our financial results for the periods being reported herein as well as our future financial performance. This summary is not intended to be exhaustive, nor is it intended to be a substitute for the detailed discussion and analysis provided elsewhere in this report.

About Illumina

We have two reportable segments: Illumina’s core operations (Core Illumina) and one segment related to the activities of our consolidated VIE, Helix. For information on Helix, refer to notes 2, 9, and 10 of the Notes to the Condensed Consolidated Financial Statements provided in this report.

Our focus on innovation has established us as the global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments.

Our customers include a broad range of academic, government, pharmaceutical, biotechnology, and other leading institutions around the globe.

Our comprehensive line of products addresses the scale of experimentation and breadth of functional analysis to advance disease research, drug development, and the development of molecular tests. This portfolio of leading-edge sequencing and array-based solutions addresses a range of genomic complexity and throughput, enabling researchers and clinical practitioners to select the best solution for their scientific challenge.

On November 1, 2018, we entered into an Agreement and Plan of Merger to acquire Pacific Biosciences of California, Inc. (PacBio) for an all-cash price of approximately $1.2 billion (or $8.00 per share), subject to applicable regulatory approvals. We believe PacBio’s highly accurate long reads combined with our highly accurate and scalable short reads will provide researchers and clinicians with a more perfect view of the genome, enhancing their ability to make novel discoveries and broaden clinical utility across a range of applications. The transaction is expected to close mid-2019. See note “3. Pending Acquisition” in Part I, Item 1 of this report for further details regarding this acquisition.

Our financial results have been, and will continue to be, impacted by several significant trends, which are described below. While these trends are important to understanding and evaluating our financial results, this discussion should be read in conjunction with our condensed consolidated financial statements and the notes thereto in Item 1, Part I of this report, and the other transactions, events, and trends discussed in “Risk Factors” in Item 1A, Part II of this report and Item 1A of our Annual Report on Form 10-K for the fiscal year ended December 30, 2018.

Financial Overview

Consolidated financial highlights for Q1 2019 included the following:

• Revenue increased8% during Q1 2019 to $846 million compared to $782 million in Q1 2018 due to the growth in sales of our consumables and services,primarily driven by increases in sequencing. We expect our revenue, as compared to the prior year, to continue to increase in 2019.

• Gross profit as a percentage of revenue (gross margin) was 69.1% in Q1 2019 compared to 68.8% in Q1 2018. The gross margin increase was primarily driven by an increase in sequencing consumables as a percentage of total revenue, which generate higher gross margins, and an increase in revenue generated from a non-recurring licensing agreement. Our gross margin in future periods will depend on several factors, including: market conditions that may impact our pricing; sales mix changes among consumables, instruments, and services; product mix changes between established products and new products; excess and obsolete inventories; royalties; our cost structure for manufacturing operations relative to volume; and product support obligations.

• Income from operations as a percentage of revenue decreased to 24.2% in Q1 2019 compared to 27.8% in Q1 2018 primarily due to increased operating expenses as a percentage of revenue. We expect our operating expenses to continue to grow on an absolute basis.

• Our effective tax rate was 3.9% in Q1 2019 compared to 10.6% in Q1 2018. In Q1 2019, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to a discrete tax benefit related to uncertain tax positions, the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom, and excess tax benefits related to share-based compensation.

• We ended Q1 2019 with cash, cash equivalents, and short-term investments totaling $3.6 billion as of March 31, 2019, of which approximately $610 million was held by our foreign subsidiaries.

Results of Operations

To enhance comparability, the following table sets forth unaudited condensed consolidated statement of operations data for the specified reporting periods, stated as a percentage of total revenue.

	Q1 2019		Q1 2018
Revenue:
Product revenue	78.8	%	80.3	%
Service and other revenue	21.2		19.7
Total revenue	100.0		100.0
Cost of revenue:
Cost of product revenue	21.5		22.3
Cost of service and other revenue	8.3		7.9
Amortization of acquired intangible assets	1.1		1.0
Total cost of revenue	30.9		31.2
Gross profit	69.1		68.8
Operating expense:
Research and development	20.0		17.5

24

Selling, general and administrative	24.9		23.5
Total operating expense	44.9		41.0
Income from operations	24.2		27.8
Other income (expense):
Interest income	2.7		0.6
Interest expense	(1.8	)	(1.4	)
Other income, net	2.5		1.2
Total other income, net	3.4		0.4
Income before income taxes	27.6		28.2
Provision for income taxes	1.1		3.0
Consolidated net income	26.5		25.2
Add: Net loss attributable to noncontrolling interests	1.0		1.4
Net income attributable to Illumina stockholders	27.5	%	26.6	%

Percentages may not recalculate due to rounding

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. The three-month periods ended March 31, 2019 and April 1, 2018 were both 13 weeks.

Revenue

(Dollars in millions)	Q1 2019		Q1 2018		Change			% Change
Consumables	$	556	$	510	$	46		9	%
Instruments	111		118		(7		)	(6	)
Total product revenue	667		628		39			6
Service and other revenue	179		154		25			16
Total revenue	$	846	$	782	$	64		8	%

Service and other revenue consists primarily of sequencing and genotyping service revenue as well as instrument service contract revenue. Total revenue primarily relates to Core Illumina for all periods presented.

The increase in consumables revenue in Q1 2019 compared to Q1 2018 was primarily due to a $59 million increase in sequencing consumables revenue, driven primarily by growth in theinstrument installed base. Instruments revenue decreased in Q1 2019 primarily due to a $7 million decrease in sequencing instruments revenue driven by timing of NovaSeq shipments, partially offset by increased shipments of our NextSeq instruments. Service and other revenue increased in Q1 2019 as a result of a non-recurring licensing agreement and increased revenue from co-development agreements.

Gross Margin

(Dollars in millions)	Q1 2019			Q1 2018			Change		% Change
Gross profit	$	584		$	538		$	46	9%
Gross margin	69.1		%	68.8		%

The gross margin increase in Q1 2019 was driven primarily by an increase in sequencing consumables as a percentage of total revenue, which generate higher gross margins, and an increase in revenue generated from a non-recurring licensing agreement.

25

Operating Expense

(Dollars in millions)	Q1 2019		Q1 2018		Change		% Change
Research and development	$	169	$	137	$	32	23	%
Selling, general and administrative	211		183		28		15
Total operating expense	$	380	$	320	$	60	19	%

Core Illumina R&D expense increased by $31 million, or 24%, in Q1 2019, primarily due to increased headcount, as we continue to invest in the research and development of new products and enhancements to existing products. Helix R&D expense increased by $1 million in Q1 2019.

Core Illumina SG&A expense increased by $31 million, or 18%, in Q1 2019, primarily due to expenses related to the pending Pacific Biosciences acquisition, increased headcount, and investments in facilities to support the continued growth and scale of our operations. Helix SG&A expense decreased by $3 million in Q1 2019.

Other Income, Net

(Dollars in millions)	Q1 2019			Q1 2018			Change			% Change
Interest income	$	23		$	5		$	18		360	%
Interest expense	(15		)	(11		)	(4		)	36
Other income, net	21			9			12			133
Total other income, net	$	29		$	3		$	26		867	%

Other income, net relates primarily to Core Illumina for all periods presented.

Interest income increased in Q1 2019 as a result of higher yields on our short-term debt securities and higher cash and cash-equivalent balances. Interest expense consisted primarily of accretion of discount on our convertible senior notes and increased in Q1 2019 primarily due to the 2023 Notes issued in August 2018. Other income, net, increased in Q1 2019 primarily due to a $15 million gain resulting from the settlement of a contingency related to the deconsolidation of GRAIL in 2017.

Provision for Income Taxes

(Dollars in millions)	Q1 2019			Q1 2018			Change			% Change
Income before income taxes	$	233		$	221		$	12		5	%
Provision for income taxes	9			24			(15		)	(63	)
Consolidated net income	$	224		$	197		$	27		14	%
Effective tax rate	3.9		%	10.6		%

Our effective tax rate was 3.9% for Q1 2019 compared to 10.6% in Q1 2018. The variance from the U.S. federal statutory tax rate of 21% in Q1 2019 was primarily attributable to a discrete tax benefit related to uncertain tax positions, the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom, and excess tax benefits related to share-based compensation. The variance from the U.S. federal statutory tax rate of 21% in Q1 2018 was primarily attributable to the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom, and the discrete tax benefit associated with the recognition of prior year losses from our investment in Helix.

Our future effective tax rate may vary from the U.S. federal statutory tax rate due to the mix of earnings in tax

jurisdictions with different statutory tax rates and the other factors discussed in the risk factor “We are subject to risks related to taxation in multiple jurisdictions” in Part I Item 1A of our Annual Report on Form 10-K for the fiscal year ended December 30, 2018.

26

Liquidity and Capital Resources

At March 31, 2019, we had approximately $2.3 billion in cash and cash equivalents, of which approximately $610 million was held by our foreign subsidiaries. Cash and cash equivalents held by Helix as of March 31, 2019 were $28 million. Cash and cash equivalents increased by $1.1 billion from December 30, 2018, due to the factors described in the “Cash Flow Summary” below. Our primary source of liquidity, other than our holdings of cash, cash equivalents and investments, has been cash flows from operations and, from time to time, issuances of debt. Our ability to generate cash from operations provides us with the financial flexibility we need to meet operating, investing, and financing needs.

Historically, we have liquidated our short-term investments and/or issued debt and equity securities to finance our business needs as a supplement to cash provided by operating activities. As of March 31, 2019, we had $1.3 billion in short-term investments,including $78 million held by Helix. Our short-term investments are predominantly comprised of marketable securities consisting of U.S. government-sponsored entities, corporate debt securities, and U.S. Treasury securities.

Our convertible senior notes due on June 15, 2019 have an aggregate principal balance of $632 million. The notes became convertible on March 15, 2019 and remain convertible through June 13, 2019. It is our intent and policy to settle conversions of the notes through combination settlement; this involves repayment of an amount of cash equal to the principal amount and delivery of the excess of conversion value over the principal amount in shares of common stock. Our convertible senior notes due in 2021 and 2023 were not convertible as of March 31, 2019.

We anticipate that our current cash, cash equivalents, and short-term investments, together with cash provided by operating activities are sufficient to fund our near-term capital and operating needs for at least the next 12 months including the repayment of $632 million in convertible senior notes and the pending acquisition of PacBio for a cash price of approximately $1.2 billion. Operating needs include the planned costs to operate our business, including amounts required to fund working capital and capital expenditures. Our primary short-term needs for capital, which are subject to change, include:

• support of commercialization efforts related to our current and future products, including expansion of our direct sales force and field support resources both in the United States and abroad;

• acquisitions of equipment and other fixed assets for use in our current and future manufacturing and research and development facilities;

• the continued advancement of research and development efforts;

• potential strategic acquisitions and investments;

• repayment of debt obligations;

• the expansion needs of our facilities, including costs of leasing and building out additional facilities; and

• repurchases of our outstanding common stock.

On February 6, 2019, our Board of Directors authorized a new share repurchase program, which supersedes all prior and available repurchase authorizations, to repurchase $550 million of outstanding common stock. The repurchases may be completed under a 10b5-1 plan or at management’s discretion. Authorizations to repurchase $488 million of our common stock remained available as of March 31, 2019.

Certain noncontrolling Helix investors may require Illumina to redeem certain noncontrolling interests in cash at the then approximate redemption fair market value. Such redemption right is exercisable at the option of certain noncontrolling interest holders after January 1, 2021, provided that a bona fide pursuit of the sale of Helix has occurred and an initial public offering of Helix has not been completed. The fair value of the redeemable noncontrolling interests related to Helix as of March 31, 2019 was $37 million.

We had $66 million remaining in our capital commitment to a venture capital investment fund as of March 31, 2019 that is callable through April 2026.

We expect that our revenue and the resulting operating income, as well as the status of each of our new product development programs, will significantly impact our cash management decisions.

Our future capital requirements and the adequacy of our available funds will depend on many factors, including:

27

• our ability to successfully commercialize and further develop our technologies and create innovative products in our markets;

• scientific progress in our research and development programs and the magnitude of those programs;

• competing technological and market developments; and

• the need to enter into collaborations with other companies or acquire other companies or technologies to enhance or complement our product and service offerings.

Cash Flow Summary

(In millions)	Q1 2019			Q1 2018
Net cash provided by operating activities	$	198		$	255
Net cash provided by investing activities	988			12
Net cash (used in) provided by financing activities	(60		)	67
Effect of exchange rate changes on cash and cash equivalents	—			1
Net increase in cash and cash equivalents	$	1,126		$	335

Operating Activities

Net cash provided by operating activities in Q1 2019 primarily consisted of net income of $224 million plus net adjustments of $81 million, partially offset by net changes in operating assets and liabilities of $107 million. The primary non-cash adjustments to net income included share-based compensation of $51 million,depreciation and amortization expenses of $47 million, accretion of debt discount of $14 million, partially offset by deferred income taxes of $11 million. Cash flow impact from changes in net operating assets and liabilities were primarily driven by increases in inventory and other assets and decreases in accrued liabilities, accounts payable, and other long-term liabilities, partially offset by decreases in accounts receivable and prepaid expenses and other current assets.

Net cash provided by operating activities in Q1 2018 consisted of net income of $197 million plus net adjustments of $78 million partially offset by net changes in operating assets and liabilities of $20 million. The primary non-cash adjustments to net income included depreciation and amortization expenses of $39 million, share-based compensation of $48 million, and accretion of debt discount of $8 million, partially offset by deferred income taxes of $11 million. Cash flow impact from changes in net operating assets and liabilities were primarily driven by a decrease in accrued liabilities and an increase in inventory, partially offset by a decrease in accounts receivable and increases in accounts payable and other long-term liabilities.

Investing Activities

Net cash provided by investing activities totaled $988 million in Q1 2019. We purchased $117 million of available-for-sale securities and $1,149 million of our available-for-sale securities matured or were sold during the period. We received $15 million in proceeds from the settlement of a contingency related to the deconsolidation of GRAIL in 2017. We invested $56 million in capital expenditures, primarily associated with our investment in facilities, and paid net cash of $3 million for strategic investments.

Net cash provided by investing activities in Q1 2018 totaled $12 million. We purchased $598 million of available-for-sale securities and $703 million of our available-for-sale securities matured or were sold during the period. We invested $90 million in capital expenditures, primarily associated with our investment in facilities.

Financing Activities

Net cash used in financing activities in Q1 2019 totaled $60 million. We received $27 million in proceeds from the issuance of common stock through the exercise of stock options and the sale of shares under our employee stock purchase plan. We used $63 million to repurchase our common stock and $23 million to pay taxes related to net share settlement of equity awards. Additionally, $1 million was used by Helix to repay financing obligations.

Net cash provided by financing activities in Q1 2018 totaled $67 million. We received $21 million in proceeds from issuance of common stock through the exercise of stock options and the sale of shares under our employee stock purchase plan, and contributions from noncontrolling interest owners were $61 million. We used $13 million to pay taxes related to net share settlement of equity awards.

28

Off-Balance Sheet Arrangements

We do not participate in any transactions that generate relationships with unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or special purpose entities, which would have been established for the purpose of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes. During Q1 2019, we were not involved in any “off-balance sheet arrangements” within the meaning of the rules of the Securities and Exchange Commission.

Critical Accounting Policies and Estimates

In preparing our condensed consolidated financial statements, we make estimates, assumptions and judgments that can have a significant impact on our net revenue, operating income and net income, as well as on the value of certain assets and liabilities on our balance sheet. We believe that the estimates, assumptions and judgments involved in the accounting policies described in Management’s Discussion and Analysis of Financial Condition and Results of Operations in Item 7 of our Annual Report on Form 10-K for the fiscal year ended December 30, 2018 have the greatest potential impact on our financial statements, so we consider them to be our critical accounting policies and estimates. There were no material changes to our critical accounting policies and estimates during Q1 2019.

Recent Accounting Pronouncements

For summary of recent accounting pronouncements applicable to our condensed consolidated financial statements, see note “1. Summary of Significant Accounting Policies” in Part I, Item 1, Notes to Condensed Consolidated Financial Statements, which is incorporated herein by reference.

Consideration Regarding Forward-Looking Statements

This Quarterly Report on Form 10-Q contains, and our officers and representatives may from time to time make, “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995.  Forward-looking statements can be identified by words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “continue,” “project,” “estimate,” “expect,” “strategy,” “future,” “likely,” “may,” “potential,” “predict,” should,” “will,” or similar words or phrases, or the negatives of these words, may identify forward-looking statements, but the absence of these words does not necessarily mean that a statement is not forward looking.  Examples of forward-looking statements include, among others, statements we make regarding:

• our expectations as to our future financial performance, results of operations, cash flows or other operational results or metrics;

• our expectations regarding the launch of new products or services;

• the benefits that we expect will result from our business activities and certain transactions we have completed, such as product introductions, increased revenue, decreased expenses, and avoided expenses and expenditures;

• our expectations of the effect on our financial condition of claims, litigation, contingent liabilities, and governmental investigations, proceedings, and regulations;

• our strategies or expectations for product development, market position, financial results, and reserves;

• our expectations regarding the integration of any acquired technologies with our existing technology; and

• other expectations, beliefs, plans, strategies, anticipated developments, and other matters that are not historical facts.

Forward-looking statements are neither historical facts nor assurances of future performance.  Instead, they are based only on our current beliefs, expectations, and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy, and other future conditions.  Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that are difficult to predict and many of which are outside of our control.  Our actual results and financial condition may differ materially from those indicated in the forward-looking statements.  Therefore, you should not rely on any of these forward-looking statements.  Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:

• challenges inherent in developing, manufacturing, and launching new products and services, including expanding manufacturing operations and reliance on third-party suppliers for critical components;

29

• the timing and mix of customer orders among our products and services;

• the impact of recently launched or pre-announced products and services on existing products and services;

• our ability to develop and commercialize our instruments and consumables, to deploy new products, services, and applications, and to expand the markets for our technology platforms;

• our ability to manufacture robust instrumentation and consumables;

• our ability to identify and integrate acquired technologies, products, or businesses successfully;

• our expectations and beliefs regarding prospects and growth for the business and its markets;

• our expectations regarding the pending acquisition of Pacific Biosciences of California, Inc.;

• the assumptions underlying our critical accounting policies and estimates;

• our assessments and estimates that determine our effective tax rate;

• our assessments and beliefs regarding the outcome of pending legal proceedings and any liability, that we may incur as a result of those proceedings;

• uncertainty, or adverse economic and business conditions, including as a result of slowing or uncertain economic growth in the United States or worldwide; and

• other factors detailed in our filings with the SEC, including the risks, uncertainties, and assumptions described in Item 1A of our Annual Report on Form 10-K for the fiscal year ended December 30, 2018, or in information disclosed in public conference calls, the date and time of which are released beforehand.

The foregoing factors should be considered together with other factors detailed in our filings with the Securities and Exchange Commission, including our most recent filings on Forms 10-K and 10-Q, or in information disclosed in public conference calls, the date and time of which are released beforehand.  We undertake no obligation, and do not intend, to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, or to review or confirm analysts’ expectations, or to provide interim reports or updates on the progress of any current financial quarter, in each case whether as a result of new information, future developments, or otherwise.

Item 3. Quantitative and Qualitative Disclosures About Market Risk.

There were no substantial changes to our market risks in the three months ended March 31, 2019, when compared to the disclosures in Item 7A of our Annual Report on Form 10-K for the fiscal year ended December 30, 2018.

Item 4. Controls and Procedures.

We design our internal controls to provide reasonable assurance that (1) our transactions are properly authorized; (2) our assets are safeguarded against unauthorized or improper use; and (3) our transactions are properly recorded and reported in conformity with U.S. generally accepted accounting principles. We also maintain internal controls and procedures to ensure that we comply with applicable laws and our established financial policies.

Based on management’s evaluation (under the supervision and with the participation of our chief executive officer (CEO) and chief financial officer (CFO)), as of the end of the period covered by this report, our CEO and CFO concluded that our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)), are effective to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in SEC rules and forms, and is accumulated and communicated to management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.

During Q1 2019, we continued to monitor and evaluate the design and operating effectiveness of key controls including those related to the adoption of Topic 842 discussed in Item 9A of our Annual Report on Form 10-K for the fiscal year ended December 30, 2018.  There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act) that materially affected or are reasonably likely to materially affect internal control over financial reporting.

30

PART II — OTHER INFORMATION

Item 1. Legal Proceedings.

See discussion of legal proceedings in note “7. Legal Proceedings” in Part I, Item 1, Notes to Condensed Consolidated Financial Statements, which is incorporated herein by reference.

Item 1A. Risk Factors.

Our business is subject to various risks, including those described in Item 1A of our Annual Report on Form 10-K for the fiscal year ended December 30, 2018, which we strongly encourage you to review. There have been no material changes from the risk factors disclosed in Item 1A of our Form 10-K.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

Unregistered Sales of Equity Securities

None during the quarterly period ended March 31, 2019.

Purchases of Equity Securities by the Issuer

The following table summarizes shares repurchased pursuant to our share repurchase program during the three months ended March 31, 2019 (in thousands except for price per share):

Period	Total Number of Shares Purchased (1)	Average Price Paid per Share		Total Number of Shares Purchased as Part of Publicly Announced Programs	Approximate Dollar Value of Shares that May Yet Be Purchased Under the Programs
December 31, 2018 - January 27, 2019	—	—		—	$	550,000
January 28, 2019 - February 24, 2019	158	$	297.24	158	$	503,070
February 25, 2019 - March 31, 2019	52	$	297.82	52	$	487,500
Total	210	$	297.38	210	$	487,500

_________

(1) All shares repurchased were made in open-market transactions.

Item 3. Defaults Upon Senior Securities.

None.

31

Item 4. Mine Safety Disclosures.

Not applicable.

Item 5. Other Information.

None.

Item 6. Exhibits.

Exhibit Number	Description of Document
31.1	Certification of Francis A. deSouza pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
31.2	Certification of Sam A. Samad pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
32.1	Certification of Francis A. deSouza pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
32.2	Certification of Sam A. Samad pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101.INS	XBRL Instance Document
101.SCH	XBRL Taxonomy Extension Schema
101.CAL	XBRL Taxonomy Extension Calculation Linkbase
101.LAB	XBRL Taxonomy Extension Label Linkbase
101.PRE	XBRL Taxonomy Extension Presentation Linkbase
101.DEF	XBRL Taxonomy Extension Definition Linkbase

32

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

		ILLUMINA, INC. (registrant)
Date:	April 25, 2019		/s/ SAM A. SAMAD
			Sam A. Samad Senior Vice President and Chief Financial Officer

33

EX-31.1

Exhibit 31.1

CERTIFICATION OF FRANCIS A. DESOUZA PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Francis A. deSouza, certify that:

1	I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;
2	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
	a)	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
	b)	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
	c)	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
	d)	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5	The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
	a)	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
	b)	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: April 25, 2019

By:	/s/ FRANCIS A. DESOUZA
	Francis A. deSouza
	President and Chief Executive Officer

EX-31.2

Exhibit 31.2

CERTIFICATION OF SAM A. SAMAD PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Sam A. Samad, certify that:

1	I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;
2	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
	a)	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
	b)	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
	c)	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
	d)	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5	The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
	a)	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
	b)	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: April 25, 2019

By:	/s/ SAM A. SAMAD
	Sam A. Samad
	Senior Vice President and Chief Financial Officer

EX-32.1

Exhibit 32.1

CERTIFICATION OF FRANCIS A. DESOUZA PURSUANT TO 18 U.S.C. SECTION

1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-

OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the quarter ended March 31, 2019, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Francis A. deSouza, President and Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: April 25, 2019

By:	/s/ FRANCIS A. DESOUZA
	Francis A. deSouza
	President and Chief Executive Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

EX-32.2

Exhibit 32.2

CERTIFICATION OF SAM A. SAMAD PURSUANT TO 18 U.S.C.

SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the quarter ended March 31, 2019, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Sam A. Samad, Senior Vice President and Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: April 25, 2019

By:	/s/ SAM A. SAMAD
	Sam A. Samad
	Senior Vice President and Chief Financial Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

XML

Document and Entity Information - shares shares in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 18, 2019
Document and Entity Information [Abstract]
Entity Registrant Name	Illumina Inc
Entity Central Index Key	0001110803
Current Fiscal Year End Date	--12-29
Entity Filer Category	Large Accelerated Filer
Document Type	10-Q
Document Period End Date	Mar. 31, 2019
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q1
Amendment Flag	false
Entity Common Stock, Shares Outstanding		147
Entity Emerging Growth Company	false
Entity Small Business	false

XML

Condensed Consolidated Balance Sheets - USD ($) $ in Millions	Mar. 31, 2019	Dec. 30, 2018
Current assets:
Cash and cash equivalents	$ 2,270	$ 1,144
Short-term investments	1,345	2,368
Accounts receivable, net	457	514
Inventory	412	386
Prepaid expenses and other current assets	61	78
Total current assets	4,545	4,490
Property and equipment, net	852	1,075
Operating lease right-of-use assets	574
Goodwill	831	831
Intangible assets, net	175	185
Deferred tax assets, net	87	70
Other assets	326	308
Total assets	7,390	6,959
Current liabilities:
Accounts payable	137	184
Accrued liabilities	473	513
Long-term debt, current portion	631	1,107
Total current liabilities	1,241	1,804
Operating lease liabilities	718
Long-term debt	1,112	890
Other long-term liabilities	212	359
Redeemable noncontrolling interests	37	61
Stockholders’ equity:
Common stock	2	2
Additional paid-in capital	3,385	3,290
Accumulated other comprehensive income (loss)	2	(1)
Retained earnings	3,298	3,083
Treasury stock, at cost	(2,702)	(2,616)
Total Illumina stockholders’ equity	3,985	3,758
Noncontrolling interests	85	87
Total stockholders’ equity	4,070	3,845
Total liabilities and stockholders’ equity	$ 7,390	$ 6,959

XML

Condensed Consolidated Statements of Income - USD ($) shares in Millions, $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018
Revenue:
Total revenue	$ 846	$ 782
Cost of revenue:
Amortization of acquired intangible assets	9	8
Total cost of revenue	262	244
Gross profit	584	538
Operating expense:
Research and development	169	137
Selling, general and administrative	211	183
Total operating expense	380	320
Income from operations	204	218
Other income (expense):
Interest income	23	5
Interest expense	(15)	(11)
Other income, net	21	9
Total other income, net	29	3
Income before income taxes	233	221
Provision for income taxes	9	24
Consolidated net income	224	197
Add: Net loss attributable to noncontrolling interests	9	11
Net Income (Loss) Attributable to Parent	$ 233	$ 208
Earnings per share attributable to Illumina stockholders:
Basic (in dollars per share)	$ 1.58	$ 1.42
Diluted (in dollars per share)	$ 1.57	$ 1.41
Shares used in computing earnings per share:
Basic (in shares)	147	147
Diluted (in shares)	149	148
Product revenue
Revenue:
Total revenue	$ 667	$ 628
Cost of revenue:
Cost of revenue	182	174
Service and other revenue
Revenue:
Total revenue	179	154
Cost of revenue:
Cost of revenue	$ 71	$ 62

XML

Condensed Consolidated Statements of Comprehensive Income - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018
Statement of Comprehensive Income [Abstract]
Consolidated net income	$ 224	$ 197
Unrealized gain on available-for-sale debt securities, net of deferred tax	3
Total consolidated comprehensive income	227	197
Add: Comprehensive loss attributable to noncontrolling interests	9	11
Comprehensive income attributable to Illumina stockholders	$ 236	$ 208

XML

Condensed Consolidated Statements of Stockholders' Equity Statement - USD ($) shares in Millions, $ in Millions	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive (Loss) Income	Retained Earnings	Treasury Stock	Noncontrolling Interests
Beginning balance (in shares) at Dec. 31, 2017		191				44
Beginning balance at Dec. 31, 2017	$ 2,749	$ 2	$ 2,833	$ (1)	$ 2,256	$ (2,341)	$ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	207				208		(1)
Issuance of common stock, net of repurchases	8		21			$ (13)
Share-based compensation	48		48
Adjustment to the carrying value of redeemable noncontrolling interests	(5)		(5)
Contributions from noncontrolling interest owners	61						61
Issuance of subsidiary shares in business combination	5						5
Ending balance (in shares) at Apr. 01, 2018		191				44
Ending balance at Apr. 01, 2018	3,073	$ 2	2,897	(1)	2,464	$ (2,354)	65
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	207				209		(2)
Issuance of common stock, net of repurchases	(1)		1			$ (2)
Share-based compensation	50		50
Vesting of redeemable equity awards	(1)		(1)
Adjustment to the carrying value of redeemable noncontrolling interests	(8)		(8)
Contributions from noncontrolling interest owners	31						31
Ending balance (in shares) at Jul. 01, 2018		191				44
Ending balance at Jul. 01, 2018	3,351	$ 2	2,939	(1)	2,673	$ (2,356)	94
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	196				199		(3)
Unrealized gain (loss) on available-for-sale debt securities, net of deferred tax	(1)			(1)
Issuance of common stock, net of repurchases	(83)		23			$ (106)
Share-based compensation	47		47
Vesting of redeemable equity awards	(1)		(1)
Adjustment to the carrying value of redeemable noncontrolling interests	(8)		(8)
Issuance of convertible senior notes, net of tax impact	93		93
Ending balance (in shares) at Sep. 30, 2018		191				44
Ending balance at Sep. 30, 2018	3,594	$ 2	3,093	(2)	2,872	$ (2,462)	91
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	206				210		(4)
Unrealized gain (loss) on available-for-sale debt securities, net of deferred tax	1			1
Issuance of common stock, net repurchases (in shares)		1				(1)
Issuance of common stock, net of repurchases	(153)		1			$ (154)
Share-based compensation	48		48
Adjustment to the carrying value of redeemable noncontrolling interests	148		148
Cumulative-effect adjustment from adoption of ASU	1				1
Ending balance (in shares) at Dec. 30, 2018		192				45
Ending balance at Dec. 30, 2018	3,845	$ 2	3,290	(1)	3,083	$ (2,616)	87
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	231				233		(2)
Unrealized gain (loss) on available-for-sale debt securities, net of deferred tax	3			3
Issuance of common stock, net of repurchases	(59)		27			$ (86)
Share-based compensation	51		51
Vesting of redeemable equity awards	(1)		(1)
Adjustment to the carrying value of redeemable noncontrolling interests	18		18
Cumulative-effect adjustment from adoption of ASU	(18)				(18)
Ending balance (in shares) at Mar. 31, 2019		192				45
Ending balance at Mar. 31, 2019	$ 4,070	$ 2	$ 3,385	$ 2	$ 3,298	$ (2,702)	$ 85

XML

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018
Cash flows from operating activities:
Consolidated net income	$ 224	$ 197
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense	37	30
Amortization of intangible assets	10	9
Share-based compensation expense	51	48
Accretion of debt discount	14	8
Deferred income taxes	(11)	(11)
Gain on deconsolidation of GRAIL	(15)
Other	(5)	(6)
Changes in operating assets and liabilities:
Accounts receivable	56	11
Inventory	(26)	(17)
Prepaid expenses and other current assets	6	(2)
Operating lease right-of-use assets and liabilities, net	(1)
Other assets	(8)	(1)
Accounts payable	(47)	2
Accrued liabilities	(70)	(18)
Other long-term liabilities	(17)	5
Net cash provided by operating activities	198	255
Cash flows from investing activities:
Purchases of available-for-sale securities	(117)	(598)
Sales of available-for-sale securities	118	288
Maturities of available-for-sale securities	1,031	415
Proceeds from deconsolidation of GRAIL	15
Net purchases of strategic investments	(3)	(3)
Purchases of property and equipment	(56)	(90)
Net cash provided by investing activities	988	12
Cash flows from financing activities:
Payments on financing obligations	(1)	(2)
Common stock repurchases	(63)
Taxes paid related to net share settlement of equity awards	(23)	(13)
Proceeds from issuance of common stock	27	21
Contributions from noncontrolling interest owners		61
Net cash (used in) provided by financing activities	(60)	67
Effect of exchange rate changes on cash and cash equivalents		1
Net increase in cash and cash equivalents	1,126	335
Cash and cash equivalents at beginning of period	1,144	1,225
Cash and cash equivalents at end of period	2,270	$ 1,560
Supplemental Cash Flow Information [Abstract]
Cash paid for operating lease liabilities	$ 21

XML

Basis of Presentation and Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2019

Accounting Policies [Abstract]

Basis of Presentation and Summary of Significant Accounting Policies

Basis of Presentation and Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Annual Report on Form 10-K for the fiscal year ended December 30, 2018, from which the prior year balance sheet information herein was derived. The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expense, and related disclosure of contingent assets and liabilities. Actual results could differ from those estimates.

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, majority-owned or controlled companies, and variable interest entities (VIEs) for which we are the primary beneficiary. All intercompany transactions and balances have been eliminated in consolidation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

We evaluate our ownership, contractual and other interests in entities that are not wholly-owned to determine if these entities are VIEs, and, if so, whether we are the primary beneficiary of the VIE. In determining whether we are the primary beneficiary of a VIE and therefore required to consolidate the VIE, we apply a qualitative approach that determines whether we have both (1) the power to direct the activities of the VIE that most significantly impact the VIE’s economic performance and (2) the obligation to absorb losses of, or the rights to receive benefits from, the VIE that could potentially be significant to that VIE. We continuously perform this assessment, as changes to existing relationships or future transactions may result in the consolidation or deconsolidation of a VIE. See note “10. Subsequent Event.”

We use the equity method to account for investments through which we have the ability to exercise significant influence, but not control, over the investee. Such investments are recorded in other assets, and our share of net income or loss is recognized on a one quarter lag in other income, net.

Redeemable Noncontrolling Interests

Noncontrolling interests represent the portion of equity (net assets) in Helix, our consolidated but not wholly-owned entity, that is neither directly nor indirectly attributable to us. Noncontrolling interests with embedded contingent redemption features, such as put rights, that are not solely within our control are considered redeemable noncontrolling interests, and are presented outside of stockholders’ equity on the condensed consolidated balance sheets.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. The three months ended March 31, 2019 and April 1, 2018 were both 13 weeks.

Reclassifications

Certain prior period amounts have been reclassified to conform to the current period presentation.

Significant Accounting Policies

During the three months ended March 31, 2019, there have been no changes to our significant accounting policies as described in our Annual Report on Form 10-K for the fiscal year ended December 30, 2018, except as described below.

Recently Adopted Accounting Pronouncements

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which requires lessees to recognize most leases on the balance sheet as lease liabilities with corresponding right-of-use assets and to disclose key information about leasing arrangements. We adopted Topic 842 on its effective date in the first quarter of 2019 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings as of December 31, 2018. We elected the available package of practical expedients upon adoption, which allowed us to carry forward our historical assessment of whether existing agreements contained a lease and the classification of our existing operating leases. We continue to report our financial position as of December 30, 2018 under the former lease accounting standard (Topic 840) in our condensed consolidated balance sheet.

The following table summarizes the impact of Topic 842 on our condensed consolidated balance sheet upon adoption on December 31, 2018 (in millions):

	December 31, 2018 (unaudited)
	Pre-adoption		Adoption Impact			Post-adoption
ASSETS
Prepaid expenses and other current assets	$	78	$	(8	)	$	70
Property and equipment, net	1,075		(241		)	834
Operating lease right-of-use assets	—		579			579
Deferred tax assets, net	70		6			76
Total assets	$	1,223	$	336		$	1,559
LIABILITIES AND STOCKHOLDERS’ EQUITY
Accrued liabilities	$	513	$	36		$	549
Operating lease liabilities	—		722			722
Long-term debt	1,107		(269		)	838
Other long-term liabilities	359		(135		)	224
Retained earnings	3,083		(18		)	3,065
Total liabilities and stockholders’ equity	$	5,062	$	336		$	5,398

The adoption impact summarized above was primarily due to the recognition of operating lease liabilities with corresponding right-of-use assets based on the present value of our remaining minimum lease payments, and the derecognition of existing fixed assets and financing obligations related to build-to-suit leasing arrangements that, under Topic 840, did not qualify for sale-leaseback accounting. The difference between these amounts, net of deferred tax, was recorded as a cumulative-effective adjustment to retained earnings.

Recently Issued Accounting Pronouncements

In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available-for-sale debt securities. The standard is effective for us beginning in the first quarter of 2020, with early adoption permitted.  We are currently evaluating the expected impact of ASU 2016-13 on our consolidated financial statements.

Revenue Recognition

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services and instrument service contracts.

We recognize revenue when control of our products and services is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products and services. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of a good or service to the customer, meaning the customer has the ability to use and obtain the benefit of the good or service.

Revenue from product sales is recognized generally upon delivery to the end customer, which is when control of the product is deemed to be transferred. Invoicing typically occurs upon shipment; and payment is typically due within 60 days from invoice. In instances where right of payment or transfer of title is contingent upon the customer’s acceptance of the product, revenue is deferred until all acceptance criteria have been met. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term. Revenue from genotyping and sequencing services is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer.

Revenue is recorded net of discounts, distributor commissions, and sales taxes collected on behalf of governmental authorities. Employee sales commissions are recorded as selling, general and administrative expenses when incurred as the amortization period for such costs, if capitalized, would have been one year or less.

We regularly enter into contracts with multiple performance obligations. Revenue recognition for contracts with multiple deliverables is based on the separate satisfaction of each distinct performance obligation within the contract. Most performance obligations are generally satisfied within a short time frame, approximately three to six months after the contract execution date. As of March 31, 2019, the aggregate amount of the transaction price allocated to remaining performance obligations was $1,083 million, of which approximately 85% is expected to be converted to revenue in the next twelve months, with the remainder thereafter.

The contract price is allocated to each performance obligation in proportion to its standalone selling price. We determine our best estimate of standalone selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, we rely upon prices set by management, adjusted for applicable discounts.

Contract liabilities, which consist of deferred revenue and customer deposits, as of March 31, 2019 and December 30, 2018 were $201 million and $206 million, respectively, of which the short-term portions of $169 million and $175 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded during the three months ended March 31, 2019 included $64 million of previously deferred revenue that was included in contract liabilities as of December 30, 2018. Contract assets as of March 31, 2019 and December 30, 2018 were not material.

In certain markets, products and services are sold to customers through distributors. In most sales through distributors, the product is delivered directly to customers by us. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers.

The following table represents revenue by source (in millions):

	Three Months Ended
	March 31, 2019						April 1, 2018
	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	481	$	75	$	556	$	422	$	88	$	510
Instruments	105		6		111		112		6		118
Total product revenue	586		81		667		534		94		628
Service and other revenue	113		66		179		96		58		154
Total revenue	$	699	$	147	$	846	$	630	$	152	$	782

Revenue related to our consolidated VIE, Helix, is included in sequencing service and other revenue.

The following table represents revenue by geographic area, based on region of destination (in millions):

	Three Months Ended
	March 31, 2019		April 1, 2018
Americas	$	473	$	440
Europe, Middle East, and Africa	210		194
Greater China (1)	88		78
Asia-Pacific	75		70
Total revenue	$	846	$	782

____________________________________

(1) Region includes revenue from China, Taiwan, and Hong Kong.

Earnings per Share

Basic earnings per share attributable to Illumina stockholders is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share attributable to Illumina stockholders is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Per-share earnings of our consolidated VIE, Helix, are included in the consolidated basic and diluted earnings per share computations based on our share of Helix’s securities.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. Convertible senior notes have a dilutive impact when the average market price of our common stock exceeds the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.

The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in millions):

	Three Months Ended
	March 31, 2019	April 1, 2018
Weighted average shares outstanding	147	147
Effect of potentially dilutive common shares from:
Convertible senior notes	1	—
Equity awards	1	1
Weighted average shares used in calculating diluted earnings per share	149	148
Potentially dilutive shares excluded from calculation due to anti-dilutive effect	1	—

XML

Balance Sheet Account Details

3 Months Ended

Mar. 31, 2019

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Balance Sheet Account Details

Balance Sheet Account Details

Investments

Debt Securities

Available-for-sale debt securities, included in short-term investments, consisted of the following (in millions):

	March 31, 2019									December 30, 2018
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
Debt securities in government sponsored entities	$	21	$	—	$	—		$	21	$	21	$	—	$	—		$	21
Corporate debt securities	716		2		(1		)	717		1,060		—		(2		)	1,058
U.S. Treasury securities	566		—		—			566		1,250		1		(1		)	1,250
Total	$	1,303	$	2	$	(1	)	$	1,304	$	2,331	$	1	$	(3	)	$	2,329

Realized gains and losses are determined based on the specific identification method and are reported in interest income.

Contractual maturities of available-for-sale debt securities, as of March 31, 2019, were as follows (in millions):

	Estimated Fair Value
Due within one year	$	711
After one but within five years	593
Total	$	1,304

We have the ability, if necessary, to liquidate any of our cash equivalents and short-term investments to meet our liquidity needs in the next 12 months. Accordingly, those investments with contractual maturities greater than one year from the date of purchase are classified as short-term on the accompanying condensed consolidated balance sheets.

Equity Securities

Our equity securities are strategic investments primarily in privately held companies.

The carrying values of our non-marketable equity securities without readily determinable market values are initially measured at cost and adjusted to fair value for observable transactions for identical or similar investments of the same issuer or impairment. Unrealized gains and losses on non-marketable equity securities are recognized in other income, net. As of March 31, 2019 and December 30, 2018, the aggregate carrying amounts of our non-marketable equity investments without readily determinable fair values were $230 million and $231 million, respectively, included in other assets.

One of our non-marketable equity investments is a VIE for which we have concluded that we are not the primary beneficiary, and therefore, we do not consolidate this VIE in our consolidated financial statements. We have determined our maximum exposure to loss, as a result of our involvement with the VIE, to be the carrying value of our investment, which was $189 million as of March 31, 2019 and December 30, 2018.

Our marketable equity security is measured at fair value. Unrealized gains and losses are recognized in other income, net. As of March 31, 2019 and December 30, 2018, the fair value of our marketable equity investment was $41 million and $39 million, respectively, included in short-term investments.

Revenue recognized from transactions with our strategic equity investees was $15 million and $36 million for the three months ended March 31, 2019 and April 1, 2018, respectively.

Venture Fund

We invest in a venture capital investment fund (the Fund) with a capital commitment of $100 million that is callable through April 2026, of which $66 million remained callable as of March 31, 2019. Our investment in the Fund is accounted for as an equity-method investment. The carrying amounts of the Fund, included in other assets, were $38 million and $29 million as of March 31, 2019 and December 30, 2018, respectively.

Inventory

Inventory consisted of the following (in millions):

	March 31, 2019		December 30, 2018
Raw materials	$	115	$	117
Work in process	234		218
Finished goods	63		51
Total inventory	$	412	$	386

Property and Equipment

Property and equipment, net consisted of the following (in millions):

	March 31, 2019			December 30, 2018
Leasehold improvements	$	622		$	567
Machinery and equipment	390			382
Computer hardware and software	256			217
Furniture and fixtures	48			45
Buildings	44			285
Construction in progress	46			100
Total property and equipment, gross	1,406			1,596
Accumulated depreciation	(554		)	(521		)
Total property and equipment, net	$	852		$	1,075

Property and equipment, net included non-cash expenditures of $17 million and $33 million for the three months ended March 31, 2019 and April 1, 2018, respectively, which were excluded from the condensed consolidated statements of cash flows. Such non-cash expenditures included $6 million recorded under build-to-suit lease accounting for the three months ended April 1, 2018.

As of December 30, 2018, property and equipment, net included $241 million of project construction costs paid or reimbursed by our landlord related to our build-to-suit leases that did not qualify for sale-leaseback accounting under Topic 840. Upon adoption of Topic 842 on December 31, 2018, we derecognized the Buildings related to our build-to-suit leasing arrangements and began to account for these leases as operating leases. See note “1. Basis of Presentation and Summary of Significant Accounting Policies” for further details on the adoption impact of Topic 842.

Leases

We lease approximately 2.7 million square feet of office, lab, and manufacturing facilities under various non-cancellable operating lease agreements (real estate leases). Our real estate leases have remaining lease terms of 1 to 20 years, which represent the non-cancellable periods of the leases and include extension options that we determined are reasonably certain to be exercised. We exclude extension options that are not reasonably certain to be exercised from our lease terms, ranging from 6 months to 20 years. Our lease payments consist primarily of fixed rental payments for the right to use the underlying leased assets over the lease terms as well as payments for common-area-maintenance and administrative services. We often receive customary incentives from our landlords, such as reimbursements for tenant improvements and rent abatement periods, which effectively reduce the total lease payments owed for these leases.

Operating lease right-of-use assets and liabilities on our condensed consolidated balance sheets represent the present value of our remaining lease payments over the remaining lease terms. We do not allocate lease payments to non-lease components; therefore, fixed payments for common-area-maintenance and administrative services are included in our operating lease right-of-use assets and liabilities. We use our incremental borrowing rate to calculate the present value of our lease payments, as the implicit rates in our leases are not readily determinable.

As of March 31, 2019, the maturities of our operating lease liabilities were as follows (in millions):

	Remaining Lease Payments
2019	$	64
2020	85
2021	82
2022	85
2023	86
Thereafter	621
Total remaining lease payments	1,023
Less: imputed interest	(253		)
Total operating lease liabilities	770
Less: current portion	(52		)
Long-term operating lease liabilities	$	718
Weighted-average remaining lease term	12 years
Weighted-average discount rate	4.6		%

The components of our lease costs included in our condensed consolidated statements of income were as follows (in millions):

	Three months ended
	March 31, 2019
Operating lease costs	$	22
Sublease income	(3		)
Total lease costs	$	19

Operating lease costs consist of the fixed lease payments included in our operating lease liabilities and are recorded on a straight-line basis over the lease terms. We sublease certain real estate to third parties and this sublease income is also recorded on a straight-line basis.

Derivatives

We are exposed to foreign exchange rate risks in the normal course of business. We enter into foreign exchange contracts to manage foreign currency risks related to monetary assets and liabilities that are denominated in currencies other than the U.S. dollar. These foreign exchange contracts are carried at fair value in other current assets or accrued liabilities and are not designated as hedging instruments. Changes in the value of the derivatives are recognized in other income, net, along with the remeasurement gain or loss on the foreign currency denominated assets or liabilities.

As of March 31, 2019, we had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, and British pound. As of March 31, 2019 and December 30, 2018, the total notional amounts of outstanding forward contracts in place for foreign currency purchases were $272 million and $122 million, respectively.

Accrued Liabilities

Accrued liabilities consisted of the following (in millions):

	March 31, 2019		December 30, 2018
Contract liabilities, current portion	$	169	$	175
Accrued compensation expenses	105		193
Accrued taxes payable	83		82
Operating lease liabilities, current portion	52		—
Other, including warranties	64		63
Total accrued liabilities	$	473	$	513

Warranties

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

Changes in the reserve for product warranties during the three months ended March 31, 2019 and April 1, 2018 were as follows (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Balance at beginning of period	$	19		$	17
Additions charged to cost of product revenue	3			6
Repairs and replacements	(6		)	(7		)
Balance at end of period	$	16		$	16

Investment in Helix

In July 2015, we obtained a 50% voting equity ownership interest in Helix Holdings I, LLC (Helix), a limited liability company formed with unrelated third-party investors to pursue the development and commercialization of a marketplace for consumer genomics. We determined that Helix is a VIE as the holders of the at-risk equity investments as a group lack the power to direct the activities of Helix that most significantly impact Helix’s economic performance. Additionally, we determined that we have (a) unilateral power over one of the activities that most significantly impacts the economic performance of Helix through its contractual arrangements and no one individual party has unilateral power over the remaining significant activities of Helix and (b) the obligation to absorb losses of and the right to receive benefits from Helix that are potentially significant to Helix. As a result, we are deemed to be the primary beneficiary of Helix and are required to consolidate Helix.

As contractually committed, in July 2015, we contributed certain perpetual licenses, instruments, intangibles, initial laboratory setup, and discounted supply terms in exchange for voting equity interests in Helix. Such contributions were recorded at their historical basis as they remained within our control. Helix is financed through cash contributions made by us and third-party investors in exchange for voting equity interests in Helix. During the year endedDecember 30, 2018, we made additional investments of $100 million in exchange for voting equity interests in Helix. During the three months ended March 31, 2019, we did not provide any other financial or other support to Helix that we were not previously contractually required to provide. As of March 31, 2019, the noncontrolling shareholders and Illumina each held 50% of Helix’s outstanding voting equity interests.

Certain noncontrolling Helix investors may require us to redeem certain noncontrolling interests in cash at the then approximate redemption fair market value. Such redemption right is exercisable at the option of certain noncontrolling interest holders after January 1, 2021, provided that a bona fide pursuit of the sale of Helix has occurred and an initial public offering of Helix has not been completed. As the contingent redemption is outside of our control, the redeemable noncontrolling interests in Helix are classified outside of stockholders’ equity on the accompanying condensed consolidated balance sheets. The balance of the redeemable noncontrolling interests is reported at the greater of its carrying value after receiving its allocation of Helix’s profits and losses or its estimated redemption fair value at each reporting date. The fair value of the redeemable noncontrolling interests is considered a Level 3 instrument.

As of March 31, 2019, the accompanying condensed consolidated balance sheet included $106 million of cash, cash equivalents, and short-term investments attributable to Helix that will be used to settle its respective obligations and will not be available to settle obligations of Illumina. The remaining assets and liabilities of Helix were not significant to our financial position as of March 31, 2019. Helix had an immaterial impact on our condensed consolidated statements of income and cash flows for the three months ended March 31, 2019. Refer to note “10. Subsequent Event.”

Redeemable Noncontrolling Interests

The activity of the redeemable noncontrolling interests during the three months ended March 31, 2019 was as follows (in millions):

	Redeemable Noncontrolling Interests
Balance as of December 30, 2018	$	61
Vesting of redeemable equity awards	1
Net loss attributable to noncontrolling interests	(7		)
Adjustment down to the redemption value	(18		)
Balance as of March 31, 2019	$	37

XML

Pending Acquisition

3 Months Ended

Mar. 31, 2019

Goodwill and Intangible Assets Disclosure [Abstract]

Pending Acquisition

Pending Acquisition

On November 1, 2018, we entered into an Agreement and Plan of Merger (the Merger Agreement) to acquire Pacific Biosciences of California, Inc. (PacBio) for an all-cash price of approximately $1.2 billion (or $8.00 per share). The transaction, which is expected to close mid-2019, is subject to certain customary closing conditions, including the receipt of certain required antitrust approvals. The Merger Agreement contains certain termination rights and provides that, upon termination of the Merger Agreement under specified circumstances, including but not limited to, a termination of the Merger Agreement in connection with PacBio accepting a superior offer or due to the withdrawal by PacBio’s board of directors of its recommendation of the merger, PacBio will pay us a cash termination fee of $43 million. In certain other circumstances related to antitrust approvals, we may be required to pay PacBio a termination fee of $98 million assuming the other closing conditions not related to antitrust or competition laws have been satisfied.

XML

Fair Value Measurements

3 Months Ended

Mar. 31, 2019

Fair Value Disclosures [Abstract]

Fair Value Measurements

Fair Value Measurements

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis as of March 31, 2019 and December 30, 2018 (in millions):

	March 31, 2019								December 30, 2018
	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	1,805	$	—	$	—	$	1,805	$	832	$	—	$	—	$	832
Debt securities in government-sponsored entities	—		21		—		21		—		21		—		21
Corporate debt securities	—		717		—		717		—		1,058		—		1,058
U.S. Treasury securities	566		—		—		566		1,250		—		—		1,250
Marketable equity security	41		—		—		41		39		—		—		39
Deferred compensation plan assets	—		43		—		43		—		34		—		34
Total assets measured at fair value	$	2,412	$	781	$	—	$	3,193	$	2,121	$	1,113	$	—	$	3,234
Liabilities:
Deferred compensation plan liability	$	—	$	41	$	—	$	41	$	—	$	33	$	—	$	33

We hold available-for-sale securities that consist of highly-liquid, investment-grade debt securities. We consider information provided by our investment accounting and reporting service provider in the measurement of fair value of our debt securities. The investment service provider provides valuation information from an industry-recognized valuation service. Such valuations may be based on trade prices in active markets for identical assets or liabilities (Level 1 inputs) or valuation models using inputs that are observable either directly or indirectly (Level 2 inputs), such as quoted prices for similar assets or liabilities, yield curve, volatility factors, credit spreads, default rates, loss severity, current market and contractual prices for the underlying instruments or debt, broker and dealer quotes, as well as other relevant economic measures. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary.

XML

Debt and Other Commitments

3 Months Ended

Mar. 31, 2019

Debt Disclosure [Abstract]

Debt and Other Commitments

Debt and Other Commitments

Summary of debt obligations

Debt obligations consisted of the following (dollars in millions):

	March 31, 2019			December 30, 2018
Principal amount of 2023 Notes outstanding	$	750		$	750
Principal amount of 2021 Notes outstanding	517			517
Principal amount of 2019 Notes outstanding	632			633
Unamortized discount of liability component of convertible senior notes	(160		)	(175		)
Net carrying amount of liability component of convertible senior notes	1,739			1,725
Obligations under financing leases	—			269
Other	4			3
Less: current portion	(631		)	(1,107		)
Long-term debt	$	1,112		$	890
Carrying value of equity component of convertible senior notes, net of debt issuance costs	$	287		$	287
Fair value of convertible senior notes outstanding (Level 2)	$	2,298		$	2,222
Weighted-average remaining amortization period of discount on the liability component of convertible senior notes	3.8 years			3.9 years

Convertible Senior Notes

0% Convertible Senior Notes due 2023 (2023 Notes)

On August 21, 2018, we issued $750 million aggregate principal amount of convertible senior notes due 2023 (2023 Notes). The 2023 Notes mature on August 15, 2023, and the implied estimated effective rate of the liability component of the Notes was 3.7%, assuming no conversion option.

The 2023 Notes will be convertible into cash, shares of our common stock or a combination of cash and shares of our common stock, at our election, based on an initial conversion rate, subject to adjustment, of 2.1845 shares of common stock per $1,000 principal amount of notes (which represents an initial conversion price of approximately $457.77 per share of common stock), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending on September 30, 2018 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price in effect on each applicable trading day; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of 2023 Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; (3) if we call any or all of the notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; or (4) upon the occurrence of specified corporate events described in the indenture. Regardless of the foregoing circumstances, the holders may convert their notes on or after May 15, 2023 until August 11, 2023.

We may redeem for cash all or any portion of the 2023 Notes, at our option, on or after August 20, 2021 if the last reported sale price of our common stock has been at least 130% of the conversion price then in effect (currently $595.10) for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending on, and including, the trading day immediately preceding the date on which we provide notice of redemption at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid special interest to, but excluding, the redemption date.

The 2023 Notes were not convertible as of March 31, 2019 and had no dilutive impact during the three months endedMarch 31, 2019. If the 2023 Notes were converted as of March 31, 2019, the if-converted value would not exceed the principal amount.

0% Convertible Senior Notes due 2019 (2019 Notes) and 0.5% Convertible Senior Notes due 2021 (2021 Notes)

In June 2014, we issued $633 million aggregate principal amount of 2019 Notes and $517 million aggregate principal amount of 2021 Notes. The 2019 and 2021 Notes mature on June 15, 2019 and June 15, 2021, respectively, and the implied estimated effective rates of the liability components of the Notes were 2.9% and 3.5%, respectively, assuming no conversion option.

Both the 2019 and 2021 Notes will be convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on an initial conversion rate, subject to adjustment, of 3.9318 shares per $1,000 principal amount of the notes (which represents an initial conversion price of approximately $254.34 per share), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending September 30, 2014 (and only during such calendar quarter), if the last reported sale price of our common stock for 20 or more trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per 2019 and 2021 Notes for each day of such measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; or (3) upon the occurrence of specified events described in the indenture for the 2019 and 2021 Notes. Regardless of the foregoing circumstances, the holders may convert their notes on or after March 15, 2019 until June 13, 2019 for the 2019 Notes and March 15, 2021 until June 11, 2021 for the 2021 Notes.

The potential dilutive impact of the 2019 and 2021 notes has been included in our calculation of diluted earnings per share for the three months endedMarch 31, 2019. If the 2019 and 2021 Notes were converted as of March 31, 2019, their if-converted values would exceed their principal amounts by $128 million and $105 million, respectively. The carrying values of the 2019 Notes were classified as current liabilities as they were convertible as of March 31, 2019 and mature within twelve months of the balance sheet date.

Obligations under financing leases

As of December 30, 2018, obligations under financing leases of $269 million represented project construction costs paid or reimbursed by our landlord related to our build-to-suit leases that did not qualify for sale-leaseback accounting under Topic 840. Upon adoption of Topic 842 on December 31, 2018, we derecognized the remaining financing obligations for our build-to-suit leasing arrangements and began to account for these leases as operating leases. See note “1. Basis of Presentation and Summary of Significant Accounting Policies” for further details on the adoption of Topic 842.

XML

Stockholders' Equity

3 Months Ended

Mar. 31, 2019

Equity [Abstract]

Stockholders' Equity

Stockholders’ Equity

As of March 31, 2019, approximately 4.8 million shares remained available for future grants under the 2015 Stock Plan.

Restricted Stock

Restricted stock activity for the three months ended March 31, 2019 was as follows (units in thousands):

	Restricted Stock Units (RSU)		Performance Stock Units (PSU)(1)		Weighted-Average Grant-Date Fair Value per Share
					RSU		PSU
Outstanding at December 30, 2018	1,840		660		$	227.00	$	196.99
Awarded	24		—		$	291.79	$	—
Vested	(28	)	—		$	176.83	—
Cancelled	(43	)	(39	)	$	204.64	$	163.53
Outstanding at March 31, 2019	1,793		621		$	229.18	$	199.48

______________________________________

(1) The number of units reflect the estimated number of shares to be issued at the end of the performance period.

Stock Options

Stock option activity during the three months ended March 31, 2019 was as follows:

	Options (in thousands)		Weighted-Average Exercise Price
Outstanding at December 30, 2018	192		$	54.52
Exercised	(34	)	$	47.86
Outstanding and exercisable at March 31, 2019	158		$	55.95

ESPP

The price at which common stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. During the three months ended March 31, 2019, approximately 0.1 million shares were issued under the ESPP. As of March 31, 2019, there were approximately 13.6 million shares available for issuance under the ESPP.

Share Repurchases

On February 6, 2019, our Board of Directors authorized a new share repurchase program, which supersedes all prior and available repurchase authorizations, to repurchase $550 million of outstanding common stock. The repurchases may be completed under a 10b5-1 plan or at management’s discretion. During the three months ended March 31, 2019, we repurchased 0.2 million shares for approximately $63 million.  Authorizations to repurchase approximately $488 million of our common stock remained available as of March 31, 2019.

Share-based Compensation

Share-based compensation expense reported in our condensed consolidated statements of income was as follows (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Cost of product revenue	$	5		$	4
Cost of service and other revenue	1			1
Research and development	18			15
Selling, general and administrative	27			28
Share-based compensation expense before taxes	51			48
Related income tax benefits	(10		)	(10		)
Share-based compensation expense, net of taxes	$	41		$	38

The assumptions used for the specified reporting periods and the resulting estimates of weighted-average fair value per share for stock purchased under the Employee Stock Purchase Plan (ESPP) during the three months ended March 31, 2019 were as follows:

	Employee Stock Purchase Rights
Risk-free interest rate	1.89% - 2.56%
Expected volatility	30% - 38%
Expected term	0.5 - 1.0 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	71.48

As of March 31, 2019, approximately $433 million of total unrecognized compensation cost related to restricted stock and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.3 years.

XML

Legal Proceedings

3 Months Ended

Mar. 31, 2019

Commitments and Contingencies Disclosure [Abstract]

Legal Proceedings

Legal Proceedings

We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.

XML

Income Taxes

3 Months Ended

Mar. 31, 2019

Income Tax Disclosure [Abstract]

Income Taxes

Income Taxes

Our effective tax rate may vary from the U.S. federal statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income. The effective tax rate for the three months ended March 31, 2019 was 3.9%. For the three months ended March 31, 2019, the decrease from the U.S. federal statutory tax rate of 21% was primarily attributable to a discrete tax benefit related to uncertain tax positions, the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom, and excess tax benefits related to share-based compensation.

XML

Segment Information

3 Months Ended

Mar. 31, 2019

Segment Reporting [Abstract]

Segment Information

Segment Information

We report segment information based on the management approach. This approach designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. Based on the information used by the CODM, we have determined our reportable segments as follows:

Core Illumina:

Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of our consolidated VIE, Helix.

Helix:

Helix, our consolidated VIE, was established to enable individuals to explore their genetic information by providing affordable sequencing and database services for consumers through third-party partners, driving the creation of an ecosystem of consumer applications.

Management evaluates the performance of our reportable segments based upon income (loss) from operations. We do not allocate expenses between segments. Core Illumina sells products and provides services to Helix in accordance with contractual agreements between the entities.

The following table presents the operating performance of each reportable segment (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Revenue:
Core Illumina	$	846		$	783
Helix	1			3
Elimination of intersegment revenue	(1		)	(4		)
Consolidated revenue	$	846		$	782
Income (loss) from operations:
Core Illumina	$	221		$	238
Helix	(18		)	(21		)
Elimination of intersegment earnings	1			1
Consolidated income from operations	$	204		$	218

The following table presents the total assets of each reportable segment (in millions):

	March 31, 2019			December 30, 2018
Core Illumina	$	7,362		$	6,912
Helix	134			154
Elimination of intersegment assets	(106		)	(107		)
Consolidated total assets	$	7,390		$	6,959

XML

Subsequent Event

3 Months Ended

Mar. 31, 2019

Subsequent Events [Abstract]

Subsequent Event

Subsequent Event

On April 25, 2019, we entered into an agreement to sell our interest in, and relinquish control over, our consolidated VIE, Helix. In connection with the transaction, the redeemable noncontrolling interest of $37 million as of March 31, 2019 was eliminated, and we will no longer consolidate Helix effective April 25, 2019.

XML

Basis of Presentation and Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2019

Accounting Policies [Abstract]

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements.

Consolidation

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, majority-owned or controlled companies, and variable interest entities (VIEs) for which we are the primary beneficiary. All intercompany transactions and balances have been eliminated in consolidation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Variable Interest Entities

We evaluate our ownership, contractual and other interests in entities that are not wholly-owned to determine if these entities are VIEs, and, if so, whether we are the primary beneficiary of the VIE. In determining whether we are the primary beneficiary of a VIE and therefore required to consolidate the VIE, we apply a qualitative approach that determines whether we have both (1) the power to direct the activities of the VIE that most significantly impact the VIE’s economic performance and (2) the obligation to absorb losses of, or the rights to receive benefits from, the VIE that could potentially be significant to that VIE. We continuously perform this assessment, as changes to existing relationships or future transactions may result in the consolidation or deconsolidation of a VIE.

Equity Method Investments

We use the equity method to account for investments through which we have the ability to exercise significant influence, but not control, over the investee. Such investments are recorded in other assets, and our share of net income or loss is recognized on a one quarter lag in other income, net.

Redeemable Noncontrolling Interests

Noncontrolling interests represent the portion of equity (net assets) in Helix, our consolidated but not wholly-owned entity, that is neither directly nor indirectly attributable to us. Noncontrolling interests with embedded contingent redemption features, such as put rights, that are not solely within our control are considered redeemable noncontrolling interests, and are presented outside of stockholders’ equity on the condensed consolidated balance sheets.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31.

Reclassifications

Certain prior period amounts have been reclassified to conform to the current period presentation.

Recently Adopted and Issued Accounting Pronouncements

Recently Adopted Accounting Pronouncements

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which requires lessees to recognize most leases on the balance sheet as lease liabilities with corresponding right-of-use assets and to disclose key information about leasing arrangements. We adopted Topic 842 on its effective date in the first quarter of 2019 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings as of December 31, 2018. We elected the available package of practical expedients upon adoption, which allowed us to carry forward our historical assessment of whether existing agreements contained a lease and the classification of our existing operating leases. We continue to report our financial position as of December 30, 2018 under the former lease accounting standard (Topic 840) in our condensed consolidated balance sheet.

The following table summarizes the impact of Topic 842 on our condensed consolidated balance sheet upon adoption on December 31, 2018 (in millions):

	December 31, 2018 (unaudited)
	Pre-adoption		Adoption Impact			Post-adoption
ASSETS
Prepaid expenses and other current assets	$	78	$	(8	)	$	70
Property and equipment, net	1,075		(241		)	834
Operating lease right-of-use assets	—		579			579
Deferred tax assets, net	70		6			76
Total assets	$	1,223	$	336		$	1,559
LIABILITIES AND STOCKHOLDERS’ EQUITY
Accrued liabilities	$	513	$	36		$	549
Operating lease liabilities	—		722			722
Long-term debt	1,107		(269		)	838
Other long-term liabilities	359		(135		)	224
Retained earnings	3,083		(18		)	3,065
Total liabilities and stockholders’ equity	$	5,062	$	336		$	5,398

The adoption impact summarized above was primarily due to the recognition of operating lease liabilities with corresponding right-of-use assets based on the present value of our remaining minimum lease payments, and the derecognition of existing fixed assets and financing obligations related to build-to-suit leasing arrangements that, under Topic 840, did not qualify for sale-leaseback accounting. The difference between these amounts, net of deferred tax, was recorded as a cumulative-effective adjustment to retained earnings.

Recently Issued Accounting Pronouncements

In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available-for-sale debt securities. The standard is effective for us beginning in the first quarter of 2020, with early adoption permitted.  We are currently evaluating the expected impact of ASU 2016-13 on our consolidated financial statements.

Revenue Recognition

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services and instrument service contracts.

We recognize revenue when control of our products and services is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products and services. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of a good or service to the customer, meaning the customer has the ability to use and obtain the benefit of the good or service.

Revenue from product sales is recognized generally upon delivery to the end customer, which is when control of the product is deemed to be transferred. Invoicing typically occurs upon shipment; and payment is typically due within 60 days from invoice. In instances where right of payment or transfer of title is contingent upon the customer’s acceptance of the product, revenue is deferred until all acceptance criteria have been met. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term. Revenue from genotyping and sequencing services is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer.

Revenue is recorded net of discounts, distributor commissions, and sales taxes collected on behalf of governmental authorities. Employee sales commissions are recorded as selling, general and administrative expenses when incurred as the amortization period for such costs, if capitalized, would have been one year or less.

We regularly enter into contracts with multiple performance obligations. Revenue recognition for contracts with multiple deliverables is based on the separate satisfaction of each distinct performance obligation within the contract. Most performance obligations are generally satisfied within a short time frame, approximately three to six months after the contract execution date. As of March 31, 2019, the aggregate amount of the transaction price allocated to remaining performance obligations was $1,083 million, of which approximately 85% is expected to be converted to revenue in the next twelve months, with the remainder thereafter.

The contract price is allocated to each performance obligation in proportion to its standalone selling price. We determine our best estimate of standalone selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, we rely upon prices set by management, adjusted for applicable discounts.

Contract liabilities, which consist of deferred revenue and customer deposits, as of March 31, 2019 and December 30, 2018 were $201 million and $206 million, respectively, of which the short-term portions of $169 million and $175 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded during the three months ended March 31, 2019 included $64 million of previously deferred revenue that was included in contract liabilities as of December 30, 2018. Contract assets as of March 31, 2019 and December 30, 2018 were not material.

In certain markets, products and services are sold to customers through distributors. In most sales through distributors, the product is delivered directly to customers by us. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers.

Earnings per Share

Basic earnings per share attributable to Illumina stockholders is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share attributable to Illumina stockholders is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Per-share earnings of our consolidated VIE, Helix, are included in the consolidated basic and diluted earnings per share computations based on our share of Helix’s securities.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. Convertible senior notes have a dilutive impact when the average market price of our common stock exceeds the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.

Equity Securities

Our equity securities are strategic investments primarily in privately held companies.

The carrying values of our non-marketable equity securities without readily determinable market values are initially measured at cost and adjusted to fair value for observable transactions for identical or similar investments of the same issuer or impairment. Unrealized gains and losses on non-marketable equity securities are recognized in other income, net. As of March 31, 2019 and December 30, 2018, the aggregate carrying amounts of our non-marketable equity investments without readily determinable fair values were $230 million and $231 million, respectively, included in other assets.

One of our non-marketable equity investments is a VIE for which we have concluded that we are not the primary beneficiary, and therefore, we do not consolidate this VIE in our consolidated financial statements. We have determined our maximum exposure to loss, as a result of our involvement with the VIE, to be the carrying value of our investment, which was $189 million as of March 31, 2019 and December 30, 2018.

Our marketable equity security is measured at fair value. Unrealized gains and losses are recognized in other income, net. As of March 31, 2019 and December 30, 2018, the fair value of our marketable equity investment was $41 million and $39 million, respectively, included in short-term investments.

Derivatives

We are exposed to foreign exchange rate risks in the normal course of business. We enter into foreign exchange contracts to manage foreign currency risks related to monetary assets and liabilities that are denominated in currencies other than the U.S. dollar. These foreign exchange contracts are carried at fair value in other current assets or accrued liabilities and are not designated as hedging instruments. Changes in the value of the derivatives are recognized in other income, net, along with the remeasurement gain or loss on the foreign currency denominated assets or liabilities.

Warranties

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

XML

Basis of Presentation and Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2019

Accounting Policies [Abstract]

Summary of Impact of Topic 842

The following table summarizes the impact of Topic 842 on our condensed consolidated balance sheet upon adoption on December 31, 2018 (in millions):

	December 31, 2018 (unaudited)
	Pre-adoption		Adoption Impact			Post-adoption
ASSETS
Prepaid expenses and other current assets	$	78	$	(8	)	$	70
Property and equipment, net	1,075		(241		)	834
Operating lease right-of-use assets	—		579			579
Deferred tax assets, net	70		6			76
Total assets	$	1,223	$	336		$	1,559
LIABILITIES AND STOCKHOLDERS’ EQUITY
Accrued liabilities	$	513	$	36		$	549
Operating lease liabilities	—		722			722
Long-term debt	1,107		(269		)	838
Other long-term liabilities	359		(135		)	224
Retained earnings	3,083		(18		)	3,065
Total liabilities and stockholders’ equity	$	5,062	$	336		$	5,398

Disaggregation of Revenue from External Customers

The following table represents revenue by source (in millions):

	Three Months Ended
	March 31, 2019						April 1, 2018
	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	481	$	75	$	556	$	422	$	88	$	510
Instruments	105		6		111		112		6		118
Total product revenue	586		81		667		534		94		628
Service and other revenue	113		66		179		96		58		154
Total revenue	$	699	$	147	$	846	$	630	$	152	$	782

Revenue related to our consolidated VIE, Helix, is included in sequencing service and other revenue.

The following table represents revenue by geographic area, based on region of destination (in millions):

	Three Months Ended
	March 31, 2019		April 1, 2018
Americas	$	473	$	440
Europe, Middle East, and Africa	210		194
Greater China (1)	88		78
Asia-Pacific	75		70
Total revenue	$	846	$	782

____________________________________

(1) Region includes revenue from China, Taiwan, and Hong Kong.

Summary of Calculation of Weighted Average Shares used to Calculate Basic and Diluted Earnings Per Share, Earnings Per Share

The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in millions):

	Three Months Ended
	March 31, 2019	April 1, 2018
Weighted average shares outstanding	147	147
Effect of potentially dilutive common shares from:
Convertible senior notes	1	—
Equity awards	1	1
Weighted average shares used in calculating diluted earnings per share	149	148
Potentially dilutive shares excluded from calculation due to anti-dilutive effect	1	—

XML

Balance Sheet Account Details (Tables)

3 Months Ended

Mar. 31, 2019

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Summary of Short-term Investments

Available-for-sale debt securities, included in short-term investments, consisted of the following (in millions):

	March 31, 2019									December 30, 2018
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
Debt securities in government sponsored entities	$	21	$	—	$	—		$	21	$	21	$	—	$	—		$	21
Corporate debt securities	716		2		(1		)	717		1,060		—		(2		)	1,058
U.S. Treasury securities	566		—		—			566		1,250		1		(1		)	1,250
Total	$	1,303	$	2	$	(1	)	$	1,304	$	2,331	$	1	$	(3	)	$	2,329

Summary of Contractual Maturities of Available-for-sale Debt Securities

Contractual maturities of available-for-sale debt securities, as of March 31, 2019, were as follows (in millions):

	Estimated Fair Value
Due within one year	$	711
After one but within five years	593
Total	$	1,304

Summary of Inventory

Inventory consisted of the following (in millions):

	March 31, 2019		December 30, 2018
Raw materials	$	115	$	117
Work in process	234		218
Finished goods	63		51
Total inventory	$	412	$	386

Summary of Property and Equipment

Property and equipment, net consisted of the following (in millions):

	March 31, 2019			December 30, 2018
Leasehold improvements	$	622		$	567
Machinery and equipment	390			382
Computer hardware and software	256			217
Furniture and fixtures	48			45
Buildings	44			285
Construction in progress	46			100
Total property and equipment, gross	1,406			1,596
Accumulated depreciation	(554		)	(521		)
Total property and equipment, net	$	852		$	1,075

Summary of Leases

As of March 31, 2019, the maturities of our operating lease liabilities were as follows (in millions):

	Remaining Lease Payments
2019	$	64
2020	85
2021	82
2022	85
2023	86
Thereafter	621
Total remaining lease payments	1,023
Less: imputed interest	(253		)
Total operating lease liabilities	770
Less: current portion	(52		)
Long-term operating lease liabilities	$	718
Weighted-average remaining lease term	12 years
Weighted-average discount rate	4.6		%

Components of Lease Costs

The components of our lease costs included in our condensed consolidated statements of income were as follows (in millions):

	Three months ended
	March 31, 2019
Operating lease costs	$	22
Sublease income	(3		)
Total lease costs	$	19

Summary of Accrued Liabilities

Accrued liabilities consisted of the following (in millions):

	March 31, 2019		December 30, 2018
Contract liabilities, current portion	$	169	$	175
Accrued compensation expenses	105		193
Accrued taxes payable	83		82
Operating lease liabilities, current portion	52		—
Other, including warranties	64		63
Total accrued liabilities	$	473	$	513

Summary of Changes in Reserve for Product Warranties

Changes in the reserve for product warranties during the three months ended March 31, 2019 and April 1, 2018 were as follows (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Balance at beginning of period	$	19		$	17
Additions charged to cost of product revenue	3			6
Repairs and replacements	(6		)	(7		)
Balance at end of period	$	16		$	16

Summary of Activity of Redeemable Noncontrolling Interests

The activity of the redeemable noncontrolling interests during the three months ended March 31, 2019 was as follows (in millions):

	Redeemable Noncontrolling Interests
Balance as of December 30, 2018	$	61
Vesting of redeemable equity awards	1
Net loss attributable to noncontrolling interests	(7		)
Adjustment down to the redemption value	(18		)
Balance as of March 31, 2019	$	37

XML

Fair Value Measurements (Tables)

3 Months Ended

Mar. 31, 2019

Fair Value Disclosures [Abstract]

Summary of Hierarchy for Assets and Liabilities Measured at Fair Value on a Recurring Basis

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis as of March 31, 2019 and December 30, 2018 (in millions):

	March 31, 2019								December 30, 2018
	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	1,805	$	—	$	—	$	1,805	$	832	$	—	$	—	$	832
Debt securities in government-sponsored entities	—		21		—		21		—		21		—		21
Corporate debt securities	—		717		—		717		—		1,058		—		1,058
U.S. Treasury securities	566		—		—		566		1,250		—		—		1,250
Marketable equity security	41		—		—		41		39		—		—		39
Deferred compensation plan assets	—		43		—		43		—		34		—		34
Total assets measured at fair value	$	2,412	$	781	$	—	$	3,193	$	2,121	$	1,113	$	—	$	3,234
Liabilities:
Deferred compensation plan liability	$	—	$	41	$	—	$	41	$	—	$	33	$	—	$	33

XML

Debt and Other Commitments (Tables)

3 Months Ended

Mar. 31, 2019

Debt Disclosure [Abstract]

Summary of Debt Obligations

Debt obligations consisted of the following (dollars in millions):

	March 31, 2019			December 30, 2018
Principal amount of 2023 Notes outstanding	$	750		$	750
Principal amount of 2021 Notes outstanding	517			517
Principal amount of 2019 Notes outstanding	632			633
Unamortized discount of liability component of convertible senior notes	(160		)	(175		)
Net carrying amount of liability component of convertible senior notes	1,739			1,725
Obligations under financing leases	—			269
Other	4			3
Less: current portion	(631		)	(1,107		)
Long-term debt	$	1,112		$	890
Carrying value of equity component of convertible senior notes, net of debt issuance costs	$	287		$	287
Fair value of convertible senior notes outstanding (Level 2)	$	2,298		$	2,222
Weighted-average remaining amortization period of discount on the liability component of convertible senior notes	3.8 years			3.9 years

XML

Stockholders' Equity (Tables)

3 Months Ended

Mar. 31, 2019

Equity [Abstract]

Summary of Restricted Stock Activity and Related Information, Restricted Stock

Restricted stock activity for the three months ended March 31, 2019 was as follows (units in thousands):

	Restricted Stock Units (RSU)		Performance Stock Units (PSU)(1)		Weighted-Average Grant-Date Fair Value per Share
					RSU		PSU
Outstanding at December 30, 2018	1,840		660		$	227.00	$	196.99
Awarded	24		—		$	291.79	$	—
Vested	(28	)	—		$	176.83	—
Cancelled	(43	)	(39	)	$	204.64	$	163.53
Outstanding at March 31, 2019	1,793		621		$	229.18	$	199.48

______________________________________

(1) The number of units reflect the estimated number of shares to be issued at the end of the performance period.

Summary of Restricted Stock Activity and Related Information, Performance Units

Restricted stock activity for the three months ended March 31, 2019 was as follows (units in thousands):

	Restricted Stock Units (RSU)		Performance Stock Units (PSU)(1)		Weighted-Average Grant-Date Fair Value per Share
					RSU		PSU
Outstanding at December 30, 2018	1,840		660		$	227.00	$	196.99
Awarded	24		—		$	291.79	$	—
Vested	(28	)	—		$	176.83	—
Cancelled	(43	)	(39	)	$	204.64	$	163.53
Outstanding at March 31, 2019	1,793		621		$	229.18	$	199.48

______________________________________

(1) The number of units reflect the estimated number of shares to be issued at the end of the performance period.

Summary of Stock Option Activity Under all Stock Option Plans

Stock option activity during the three months ended March 31, 2019 was as follows:

	Options (in thousands)		Weighted-Average Exercise Price
Outstanding at December 30, 2018	192		$	54.52
Exercised	(34	)	$	47.86
Outstanding and exercisable at March 31, 2019	158		$	55.95

Summary of Share-based Compensation Expense for all Stock Awards

Share-based compensation expense reported in our condensed consolidated statements of income was as follows (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Cost of product revenue	$	5		$	4
Cost of service and other revenue	1			1
Research and development	18			15
Selling, general and administrative	27			28
Share-based compensation expense before taxes	51			48
Related income tax benefits	(10		)	(10		)
Share-based compensation expense, net of taxes	$	41		$	38

Summary of Assumptions used to Estimate the Weighted-Average Fair Value Per Share for Stock Purchase under the Employee Stock Purchase Plan

The assumptions used for the specified reporting periods and the resulting estimates of weighted-average fair value per share for stock purchased under the Employee Stock Purchase Plan (ESPP) during the three months ended March 31, 2019 were as follows:

	Employee Stock Purchase Rights
Risk-free interest rate	1.89% - 2.56%
Expected volatility	30% - 38%
Expected term	0.5 - 1.0 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	71.48

XML

Segment Information (Tables)

3 Months Ended

Mar. 31, 2019

Segment Reporting [Abstract]

Summary of Operating Performance and Assets by Segment

The following table presents the operating performance of each reportable segment (in millions):

	Three Months Ended
	March 31, 2019			April 1, 2018
Revenue:
Core Illumina	$	846		$	783
Helix	1			3
Elimination of intersegment revenue	(1		)	(4		)
Consolidated revenue	$	846		$	782
Income (loss) from operations:
Core Illumina	$	221		$	238
Helix	(18		)	(21		)
Elimination of intersegment earnings	1			1
Consolidated income from operations	$	204		$	218

The following table presents the total assets of each reportable segment (in millions):

	March 31, 2019			December 30, 2018
Core Illumina	$	7,362		$	6,912
Helix	134			154
Elimination of intersegment assets	(106		)	(107		)
Consolidated total assets	$	7,390		$	6,959

XML

Basis of Presentation and Summary of Significant Accounting Policies - Summary of Impact of Topic 842 (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 31, 2018	Dec. 30, 2018
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Prepaid expenses and other current assets	$ 61	$ 70	$ 78
Property and equipment, net	852	834	1,075
Operating lease right-of-use assets	574	579
Deferred tax assets, net	87	76	70
Total assets		1,559
Accrued liabilities	473	549	513
Total operating lease liabilities	770	722
Long-term debt		838
Other long-term liabilities	212	224	359
Retained earnings	$ 3,298	3,065	$ 3,083
Total liabilities and stockholders’ equity		5,398
ASU 2016-02
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Prepaid expenses and other current assets		(8)
Property and equipment, net		(241)
Operating lease right-of-use assets		579
Deferred tax assets, net		6
Total assets		336
Accrued liabilities		36
Total operating lease liabilities		722
Long-term debt		(269)
Other long-term liabilities		(135)
Retained earnings		(18)
Total liabilities and stockholders’ equity		336
Pre Adoption of ASU [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Prepaid expenses and other current assets		78
Property and equipment, net		1,075
Deferred tax assets, net		70
Total assets		1,223
Accrued liabilities		513
Long-term debt		1,107
Other long-term liabilities		359
Retained earnings		3,083
Total liabilities and stockholders’ equity		$ 5,062

XML

Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Dec. 30, 2018
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Period of time average selling prices are observed	12 months
Contract liability	$ 201	$ 206
Contract liabilities, current portion	169	$ 175
Revenue recognized, previously deferred	$ 64
Minimum
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Product or service delivery period	3 months
Maximum
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Product or service delivery period	6 months

XML

Basis of Presentation and Summary of Significant Accounting Policies - Narrative - Revenue, Remaining Performance Obligation (Details) $ in Millions	Mar. 31, 2019 USD ($)
Accounting Policies [Abstract]
Remaining performance obligation	$ 1,083
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2019-04-01
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Percent of remaining performance obligation	85.00%
Expected timing of remaining performance obligation	12 months

XML

Basis of Presentation and Summary of Significant Accounting Policies - Recently Adopted Accounting Principles (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018
Disaggregation of Revenue [Line Items]
Revenue	$ 846	$ 782
Americas
Disaggregation of Revenue [Line Items]
Revenue	473	440
Europe, Middle East, and Africa
Disaggregation of Revenue [Line Items]
Revenue	210	194
Greater China
Disaggregation of Revenue [Line Items]
Revenue	88	78
Asia-Pacific
Disaggregation of Revenue [Line Items]
Revenue	75	70
Sequencing
Disaggregation of Revenue [Line Items]
Revenue	699	630
Microarray
Disaggregation of Revenue [Line Items]
Revenue	147	152
Total product revenue
Disaggregation of Revenue [Line Items]
Revenue	667	628
Total product revenue | Sequencing
Disaggregation of Revenue [Line Items]
Revenue	586	534
Total product revenue | Microarray
Disaggregation of Revenue [Line Items]
Revenue	81	94
Consumables
Disaggregation of Revenue [Line Items]
Revenue	556	510
Consumables | Sequencing
Disaggregation of Revenue [Line Items]
Revenue	481	422
Consumables | Microarray
Disaggregation of Revenue [Line Items]
Revenue	75	88
Instruments
Disaggregation of Revenue [Line Items]
Revenue	111	118
Instruments | Sequencing
Disaggregation of Revenue [Line Items]
Revenue	105	112
Instruments | Microarray
Disaggregation of Revenue [Line Items]
Revenue	6	6
Service and other revenue
Disaggregation of Revenue [Line Items]
Revenue	179	154
Service and other revenue | Sequencing
Disaggregation of Revenue [Line Items]
Revenue	113	96
Service and other revenue | Microarray
Disaggregation of Revenue [Line Items]
Revenue	$ 66	$ 58

XML

Basis of Presentation and Summary of Significant Accounting Policies - Summary of Calculation of Weighted Average Shares used to Calculate Basic and Diluted Earnings Per Share (Details) - shares shares in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018
Weighted average shares used to calculate basic and diluted earnings per share
Weighted average shares outstanding	147	147
Effect of potentially dilutive common shares from:
Convertible senior notes	1
Equity awards	1	1
Weighted average shares used in calculating diluted earnings per share	149	148
Potentially dilutive shares excluded from calculation due to anti-dilutive effect	1

XML

Balance Sheet Account Details - Summary of Short-term Investments (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 30, 2018
Available-for-sale debt securities:
Amortized Cost	$ 1,303	$ 2,331
Gross Unrealized Gains	2	1
Gross Unrealized Losses	(1)	(3)
Estimated Fair Value	1,304	2,329
Debt securities in government sponsored entities
Available-for-sale debt securities:
Amortized Cost	21	21
Gross Unrealized Losses
Estimated Fair Value	21	21
Corporate debt securities
Available-for-sale debt securities:
Amortized Cost	716	1,060
Gross Unrealized Gains	2
Gross Unrealized Losses	(1)	(2)
Estimated Fair Value	717	1,058
U.S. Treasury securities
Available-for-sale debt securities:
Amortized Cost	566	1,250
Gross Unrealized Gains		1
Gross Unrealized Losses		(1)
Estimated Fair Value	$ 566	$ 1,250

XML

Balance Sheet Account Details - Summary of Contractual Maturities of Available-for-sale Debt Securities (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 30, 2018
Estimated Fair Value
Due within one year	$ 711
After one but within five years	593
Total	$ 1,304	$ 2,329

XML

Balance Sheet Account Details - Narrative - Strategic Investments (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018	Dec. 30, 2018
Schedule of Investments [Line Items]
Carrying Value	$ 189		$ 189
Marketable equity security	41		39
Commitment in new venture capital investment fund	100
Remaining capital commitment	66
Other Assets
Schedule of Investments [Line Items]
Strategic equity investments, without readily determinable fair values	230		231
Equity method investments	38		$ 29
Investee
Schedule of Investments [Line Items]
Revenue from transactions with Company's strategic equity investees	$ 15	$ 36

XML

Balance Sheet Account Details - Summary of Inventory (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 30, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Raw materials	$ 115	$ 117
Work in process	234	218
Finished goods	63	51
Total inventory	$ 412	$ 386

XML

Balance Sheet Account Details - Summary of Property and Equipment (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 31, 2018	Dec. 30, 2018
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 1,406		$ 1,596
Accumulated depreciation	(554)		(521)
Total property and equipment, net	852	$ 834	1,075
Leasehold improvements
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	622		567
Machinery and equipment
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	390		382
Computer hardware and software
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	256		217
Furniture and fixtures
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	48		45
Buildings
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	44		285
Construction in progress
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 46		$ 100

XML

Balance Sheet Account Details - Narrative - Property and Equipment (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018	Dec. 31, 2018	Dec. 30, 2018
Property, Plant and Equipment [Line Items]
Non-cash expenditures included in capital expenditures	$ 17	$ 33
Property and equipment, net	$ 852		$ 834	$ 1,075
Construction In Progress And Build to Suit Lease Liability
Property, Plant and Equipment [Line Items]
Non-cash expenditures included in capital expenditures		$ 6
ASU 2016-02
Property, Plant and Equipment [Line Items]
Property and equipment, net			$ (241)

XML

Balance Sheet Account Details - Narrative - Leases (Details) ft² in Millions	3 Months Ended
	Mar. 31, 2019 ft²
Lessee, Lease, Description [Line Items]
Leased office space (in square feet)	2.7
Minimum
Lessee, Lease, Description [Line Items]
Remaining lease terms	1 year
Terms of extension options	6 months
Maximum
Lessee, Lease, Description [Line Items]
Remaining lease terms	20 years
Terms of extension options	20 years

XML

Balance Sheet Account Details - Summary of Leases (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 31, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]
2019	$ 64
2020	85
2021	82
2022	85
2023	86
Thereafter	621
Total remaining lease payments	1,023
Less: imputed interest	(253)
Total operating lease liabilities	770	$ 722
Less: current portion	(52)
Long-term operating lease liabilities	$ 718
Weighted-average remaining lease term	12 years
Weighted-average discount rate	4.60%

XML

Balance Sheet Account Details - Summary of Lease Costs (Details) $ in Millions	3 Months Ended
	Mar. 31, 2019 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Operating lease costs	$ 22
Sublease income	(3)
Total lease costs	$ 19

XML

Balance Sheet Account Details - Narrative - Derivatives (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 30, 2018
Not Designated as Hedging Instrument | Foreign Exchange Forward
Derivative [Line Items]
Derivative, notional amount	$ 272	$ 122

XML

Balance Sheet Account Details - Summary of Accrued Liabilities (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 31, 2018	Dec. 30, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Contract liabilities, current portion	$ 169		$ 175
Accrued compensation expenses	105		193
Accrued taxes payable	83		82
Operating lease liabilities, current portion	52
Other, including warranties	64		63
Total accrued liabilities	$ 473	$ 549	$ 513

XML

Balance Sheet Account Details - Narrative - Warranties (Details)	3 Months Ended
	Mar. 31, 2019
Instruments
Product Warranty Liability [Line Items]
Warranty period	1 year
Consumables | Minimum
Product Warranty Liability [Line Items]
Warranty period	6 months
Consumables | Maximum
Product Warranty Liability [Line Items]
Warranty period	12 months

XML

Balance Sheet Account Details - Summary of Changes in Reserve for Product Warranties (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018
Reserve for product warranties [Roll Forward]
Balance at beginning of period	$ 19	$ 17
Additions charged to cost of product revenue	3	6
Repairs and replacements	6	7
Balance at end of period	$ 16	$ 16

XML

Balance Sheet Account Details - Narrative - Investment in Helix (Details) - Helix Holdings I, LLC - Variable Interest Entity, Primary Beneficiary - USD ($) $ in Millions	12 Months Ended
	Dec. 30, 2018	Mar. 31, 2019	Jul. 31, 2015
Variable Interest Entity [Line Items]
Equity ownership interest percentage		50.00%	50.00%
Additional investment in exchange for voting equity interests	$ 100
Cash and cash equivalents		$ 106

XML

Balance Sheet Account Details - Summary of Activity of Redeemable Noncontrolling Interests (Details) $ in Millions	3 Months Ended
	Mar. 31, 2019 USD ($)
Increase (Decrease) in Redeemable Noncontrolling Interests [Roll Forward]
Balance as of December 30, 2018	$ 61
Vesting of redeemable equity awards	1
Net loss attributable to noncontrolling interests	(7)
Adjustment down to the redemption value	(18)
Balance as of March 31, 2019	$ 37

XML

Pending Acquisition (Details) - Pacific Biosciences of California, Inc (PacBio) $ / shares in Units, $ in Millions	Nov. 01, 2018 USD ($) $ / shares
Business Acquisition [Line Items]
Expected business acquisition total consideration	$ 1,200
Expected share price (in dollars per share) | $ / shares	$ 8.00
Potential fee paid to Illumina if contract terminates	$ 43
Potential fee paid by Illumina if contract terminates	$ 98

XML

Fair Value Measurements - Summary of Hierarchy for Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 30, 2018
Assets:
Available-for-sale securities	$ 1,304	$ 2,329
Marketable equity security	41	39
Debt securities in government sponsored entities
Assets:
Available-for-sale securities	21	21
Corporate debt securities
Assets:
Available-for-sale securities	717	1,058
U.S. Treasury securities
Assets:
Available-for-sale securities	566	1,250
Fair Value, Measurements, Recurring
Assets:
Marketable equity security	41	39
Deferred compensation plan assets	43	34
Total assets measured at fair value	3,193	3,234
Liabilities:
Deferred compensation plan liability	41	33
Fair Value, Measurements, Recurring | Debt securities in government sponsored entities
Assets:
Available-for-sale securities	21	21
Fair Value, Measurements, Recurring | Corporate debt securities
Assets:
Available-for-sale securities	717	1,058
Fair Value, Measurements, Recurring | U.S. Treasury securities
Assets:
Available-for-sale securities	566	1,250
Fair Value, Measurements, Recurring | Money market funds (cash equivalents)
Assets:
Money market funds (cash equivalents)	1,805	832
Fair Value, Measurements, Recurring | Level 1
Assets:
Marketable equity security	41	39
Total assets measured at fair value	2,412	2,121
Fair Value, Measurements, Recurring | Level 1 | U.S. Treasury securities
Assets:
Available-for-sale securities	566	1,250
Fair Value, Measurements, Recurring | Level 1 | Money market funds (cash equivalents)
Assets:
Money market funds (cash equivalents)	1,805	832
Fair Value, Measurements, Recurring | Level 2
Assets:
Deferred compensation plan assets	43	34
Total assets measured at fair value	781	1,113
Liabilities:
Deferred compensation plan liability	41	33
Fair Value, Measurements, Recurring | Level 2 | Debt securities in government sponsored entities
Assets:
Available-for-sale securities	21	21
Fair Value, Measurements, Recurring | Level 2 | Corporate debt securities
Assets:
Available-for-sale securities	$ 717	$ 1,058

XML

Debt and Other Commitments - Summary of Debt Obligations (Details) - USD ($) $ in Millions	3 Months Ended	12 Months Ended
	Mar. 31, 2019	Dec. 30, 2018	Aug. 21, 2018	Jun. 29, 2014
Debt Instrument [Line Items]
Obligations under financing leases		$ 269
Other	$ 4	3
Less: current portion	(631)	(1,107)
Long-term debt	1,112	890
Convertible Senior Notes
Debt Instrument [Line Items]
Unamortized discount of liability component of convertible senior notes	(160)	(175)
Net carrying amount of liability component of convertible senior notes	1,739	1,725
Carrying value of equity component, net of debt issuance cost	$ 287	$ 287
Weighted-average remaining amortization period of discount on the liability component of convertible senior notes	3 years 9 months	3 years 11 months
Level 2 | Convertible Senior Notes
Debt Instrument [Line Items]
Fair value of convertible senior notes outstanding (Level 2)	$ 2,298	$ 2,222
2023 | Convertible Senior Notes
Debt Instrument [Line Items]
Principal amount of notes outstanding	750	750	$ 750
2021 | Convertible Senior Notes
Debt Instrument [Line Items]
Principal amount of notes outstanding	517	517		$ 517
2019 | Convertible Senior Notes
Debt Instrument [Line Items]
Principal amount of notes outstanding	$ 632	$ 633		$ 633

XML

Debt and Other Commitments - Narrative (Details) - Convertible Senior Notes $ / shares in Units, $ in Millions		1 Months Ended	3 Months Ended
	Aug. 21, 2018 USD ($) day $ / shares	Jun. 29, 2014 USD ($) day $ / shares	Mar. 31, 2019 USD ($)	Dec. 30, 2018 USD ($)
2023
Debt Instrument [Line Items]
Stated rate			0.00%
Principal amount of notes outstanding | $	$ 750		$ 750	$ 750
Effective interest rate used to measure fair value of convertible senior note	3.70%
Conversion rate	0.0021845
Conversion price (in dollars per share) | $ / shares	$ 457.77
Threshold common stock trading days	20
Threshold consecutive common stock trading days	30
Threshold percentage of common stock price trigger	130.00%
Threshold note trading days	5
Threshold consecutive note trading days	10
Threshold percentage of note price trigger	98.00%
Convertible stock price trigger | $ / shares	$ 595.10
2019
Debt Instrument [Line Items]
Stated rate			0.00%
Principal amount of notes outstanding | $		$ 633	$ 632	633
Effective interest rate used to measure fair value of convertible senior note		2.90%
If-converted value in excess of principal | $			$ 128
2021
Debt Instrument [Line Items]
Stated rate			0.50%
Principal amount of notes outstanding | $		$ 517	$ 517	$ 517
Effective interest rate used to measure fair value of convertible senior note		3.50%
If-converted value in excess of principal | $			$ 105
2019 and 2021
Debt Instrument [Line Items]
Conversion rate		0.0039318
Conversion price (in dollars per share) | $ / shares		$ 254.34
Threshold common stock trading days		20
Threshold consecutive common stock trading days		30
Threshold percentage of common stock price trigger		130.00%
Threshold note trading days		5
Threshold consecutive note trading days		10
Threshold percentage of note price trigger		98.00%

XML

Debt and Other Commitments - Narrative - Obligations Under Financing Leases (Details) $ in Millions	Dec. 30, 2018 USD ($)
Debt Disclosure [Abstract]
Obligations under financing leases	$ 269

XML

Stockholders' Equity - Narrative (Details) shares in Millions	Mar. 31, 2019 shares
2015 Stock Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for issuance (in shares)	4.8

XML

Stockholders' Equity - Summary of Restricted Stock Activity and Related Information (Details) shares in Thousands	3 Months Ended
	Mar. 31, 2019 $ / shares shares
Restricted Stock Units (RSU)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Outstanding at period start (in shares) | shares	1,840
Awarded (in shares) | shares	24
Vested (in shares) | shares	(28)
Cancelled (in shares) | shares	(43)
Outstanding at period end (in shares) | shares	1,793
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted-Average Grant Date Fair Value per Share, Outstanding at period start (in dollars per share) | $ / shares	$ 227.00
Weighted-Average Fair Value Per Share, Awarded (in dollars per share) | $ / shares	291.79
Weighted-Average Grant Date Fair Value per Share, Vested (in dollars per share) | $ / shares	176.83
Weighted-Average Grant Date Fair Value per Share, Cancelled (in dollars per share) | $ / shares	204.64
Weighted-Average Grant Date Fair Value per Share, Outstanding at period end (in dollars per share) | $ / shares	$ 229.18
Performance Stock Units (PSU)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Outstanding at period start (in shares) | shares	660
Cancelled (in shares) | shares	(39)
Outstanding at period end (in shares) | shares	621
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted-Average Grant Date Fair Value per Share, Outstanding at period start (in dollars per share) | $ / shares	$ 196.99
Weighted-Average Grant Date Fair Value per Share, Cancelled (in dollars per share) | $ / shares	163.53
Weighted-Average Grant Date Fair Value per Share, Outstanding at period end (in dollars per share) | $ / shares	$ 199.48

XML

Stockholders' Equity - Summary of Stock Option Activity Under all Stock Option Plans (Details) shares in Thousands	3 Months Ended
	Mar. 31, 2019 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Options, Outstanding at period start (in shares) | shares	192
Options, Exercised (in shares) | shares	(34)
Options, Outstanding at period end (in shares) | shares	158
Options, Exercisable (in shares) | shares	158
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted-Average Exercise Price, Options, Outstanding at period start (in dollars per share) | $ / shares	$ 54.52
Weighted-Average Exercise Price, Options, Exercised (in dollars per share) | $ / shares	47.86
Weighted-Average Exercise Price, Options, Outstanding at period end (in dollars per share) | $ / shares	55.95
Weighted-Average Exercise Price, Options, Exercisable (in dollars per share) | $ / shares	$ 55.95

XML

Stockholders' Equity - Narrative - Employee Stock Purchase Plan (Details) - ESPP - Employee Stock shares in Millions	3 Months Ended
	Mar. 31, 2019 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Specified percentage of the fair market value of the common stock on the first or last day of the offering period whichever is lower at which stock is purchased	85.00%
Total shares issued under the ESPP (in shares)	0.1
Shares available for issuance (in shares)	13.6

XML

Stockholders' Equity - Narrative - Share Repurchases (Details) - USD ($) shares in Millions, $ in Millions	3 Months Ended
	Mar. 31, 2019	Feb. 06, 2019
Class of Stock [Line Items]
Common stock repurchases	$ 63
Common Stock
Class of Stock [Line Items]
Repurchased common stock (in shares)	0.2
Common stock repurchases	$ 63
Dollar amount remaining in authorized stock repurchase program	$ 488
Common Stock | February 2019 Share Repurchase Plan
Class of Stock [Line Items]
Stock repurchase program, authorized amount		$ 550

XML

Stockholders' Equity - Summary of Share-based Compensation Expense for all Stock Awards (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	$ 51	$ 48
Related income tax benefits	(10)	(10)
Share-based compensation expense, net of taxes	41	38
Cost of product revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	5	4
Cost of service and other revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	1	1
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	18	15
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	$ 27	$ 28

XML

Stockholders' Equity - Summary of Assumptions Used to Estimate the Weighted Average Fair Value Per Share (Details) $ / shares in Units, $ in Millions	3 Months Ended
	Mar. 31, 2019 USD ($) $ / shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost related to stock options, restricted stock, and ESPP shares granted to date | $	$ 433
Weighted-average period of unrecognized compensation cost related to stock options, restricted stock, and ESPP shares granted to date	2 years 3 months
Employee Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected volatility, minimum	30.00%
Expected volatility, maximum	38.00%
Expected dividends	0.00%
Weighted-average fair value per share (in dollars per share) | $ / shares	$ 71.48
Minimum | Employee Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-free interest rate	1.89%
Expected term	6 months
Maximum | Employee Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-free interest rate	2.56%
Expected term	1 year

XML

Income Taxes - Narrative (Details)	3 Months Ended
	Mar. 31, 2019
Income Tax Disclosure [Abstract]
Effective tax rate	3.90%

XML

Segment Information (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2019	Apr. 01, 2018	Dec. 30, 2018
Segment Reporting Information [Line Items]
Consolidated revenue	$ 846	$ 782
Consolidated income from operations	204	218
Consolidated total assets	7,390		$ 6,959
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated revenue	846	783
Consolidated income from operations	221	238
Consolidated total assets	7,362		6,912
Operating Segments | Helix
Segment Reporting Information [Line Items]
Consolidated revenue	1	3
Consolidated income from operations	(18)	(21)
Consolidated total assets	134		154
Elimination of intersegment
Segment Reporting Information [Line Items]
Consolidated revenue	(1)	(4)
Consolidated income from operations	1	$ 1
Consolidated total assets	$ (106)		$ (107)

XML

Subsequent Event Narrative (Details) - USD ($) $ in Millions	Mar. 31, 2019	Dec. 30, 2018
Subsequent Event [Line Items]
Redeemable noncontrolling interest in VIE	$ 37	$ 61
Helix Holdings I, LLC
Subsequent Event [Line Items]
Redeemable noncontrolling interest in VIE	$ 37