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Stockholders' Equity (Details Textual) (USD $)
1 Months Ended 12 Months Ended 0 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended
Jul. 28, 2013
Dec. 29, 2013
Dec. 30, 2012
Jan. 01, 2012
Dec. 27, 2013
Dec. 30, 2007
Apr. 18, 2013
April 18, 2012 Discretionary Plan [Member]
Jan. 30, 2014
January 30 2014 Stock Repurchase Program [Member]
Aug. 31, 2011
August 2011 Discretionary Plan [Member]
Jan. 01, 2012
Discretionary Repurchase Concurrent with 2016 Note Issuance [Member]
Jul. 31, 2010
July 2010 Repurchase Program [Member]
Jan. 01, 2012
July 2010 Repurchase Program [Member]
Dec. 29, 2013
Stock Options [Member]
Minimum [Member]
Dec. 29, 2013
Stock Options [Member]
Maximum [Member]
Dec. 29, 2013
Restricted Stock Units [Member]
Dec. 29, 2013
Performance Stock Units [Member]
Dec. 29, 2013
Performance Stock Units [Member]
Minimum [Member]
Dec. 29, 2013
Performance Stock Units [Member]
Maximum [Member]
May 16, 2014
Warrant [Member]
Dec. 29, 2013
2005 Stock Plan [Member]
Dec. 29, 2013
2005 Illumina, 2005 Solexa, and 2008 Verinata Stock Plan [Member]
Dec. 29, 2013
Employee Stock Purchase Plan [Member]
Dec. 30, 2012
Employee Stock Purchase Plan [Member]
Jan. 01, 2012
Employee Stock Purchase Plan [Member]
Jan. 25, 2012
Stockholder Rights Plan [Member]
Jan. 25, 2012
Stockholder Rights Plan [Member]
Minimum [Member]
Jan. 25, 2012
Stockholder Rights Plan [Member]
Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                                                      
Increase in the maximum number of shares of common stock authorized for issuance (in shares)                                       5,000,000              
Shares available for issuance                                         6,800,000 15,000,000 15,400,000        
Vesting period                         4 years 5 years 4 years                        
Percentage of options vesting on the first anniversary of the grant date                         20.00% 25.00%                          
Maximum term of each grant of options                           10 years                          
Stock options exercisable (in shares)   4,700,000                                                  
Stock options exercisable outstanding weighted average exercise price per share (in dollars per share)   $ 31.83                                                  
Weighted average remaining life in years of options outstanding   4 years 11 months                                                  
Weighted average remaining life in years of options exercisable   4 years 6 months                                                  
Aggregate intrinsic value of options outstanding   $ 445,000,000                                                  
Aggregate intrinsic value of options exercisable   370,900,000                                                  
Share price (in dollars per share)         $ 110.38                                            
Total intrinsic value of options exercised   141,700,000 60,600,000 136,500,000                                              
Total fair value of options vested   24,000,000 31,900,000 49,500,000                                              
Vesting percentage, 1st anniversary                             15.00%                        
Vesting percentage, 2nd anniversary                             20.00%                        
Vesting percentage, 3rd anniversary                             30.00%                        
Vesting percentage, 4th anniversary                             35.00%                        
Performance stock award performance period                               3 years                      
Percentage of shares approved issuable at end of performance period                                 50.00% 150.00%                  
ESPP Number of shares authorized                                           15,500,000          
Specified percentage of the fair market value of the common stock on the first or last day of the offering period whichever is lower at which stock is purchased                                           85.00%          
Annual percent increases of shares available for issuance                                           3.00%          
ESPP Annual increases of shares available for issuance                                           3,000,000          
Total shares issued under the ESPP                                           400,000 328,000 328,000      
Exercise price of warrants held by hedging counter parties (in dollars per share)   $ 31.435                                                  
Number of common shares callable by warrants settled in period 3,000,000                                                    
Number of common shares called by warrants   15,400,000       18,300,000                                          
Warrant Expiration Period                                     40 days                
Number of shares purchased for warrants exercised       505,000                                              
(Payments for) proceeds from warrant settlements (125,000,000) (125,000,000)   5,512,000                                              
Repurchase of common shares (in shares)   900,000 1,900,000             4,900,000   2,400,000                              
Common stock repurchases (in dollars)   50,020,000 82,522,000 570,406,000           314,300,000   156,000,000                              
Stock repurchase program authorized amount             250,000,000 250,000,000.0 100,000,000   200,000,000                                
Dollar amount remaining in authorized stock repurchase program   117,500,000                                                  
Allocated to repurchasing company common stock under a 10b5-1 plan                     100,000,000                                
Period in force for repurchases under 10b5-1 plan                     12 months                                
Amount allocated to repurchasing Company common stock during open trading windows                     $ 100,000,000                                
Preferred stock, par value (in dollars per share)   $ 0.01 $ 0.01                                           $ 0.01    
Dividend price per share of Series A Junior Participating Preferred Stock (in dollars per Right)                                                 275.00    
Dividend portion of a share of Series A Junior Participating Preferred Stock                                                 0.001    
Minimum percent ownership of outstanding common stock required to exercise rights                                                 15.00%    
Price per right Board of Directors are entitled to redeem rights (in dollars per Right)                                                 0.001    
Number of shares per Right                                                 1    
Percent ownership of outstanding common stock required prior to exchange by board of directors                                                   15.00% 50.00%