EXHIBIT 32.2

                                 ILLUMINA, INC.
      CERTIFICATION OF CHRISTIAN HENRY PURSUANT TO 18 U.S.C. SECTION 1350,
      AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the "Company") on
Form 10-Q for the period ended July 3, 2005, as filed with the Securities and
Exchange Commission on the date hereof (the "Report"), I, Christian Henry, Chief
Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350,
as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

      (1) The Report fully complies with the requirements of Section 13(a) or
      15(d) of the Securities Exchange Act of 1934; and

      (2) The information contained in the Report fairly presents, in all
      material respects, the financial condition and results of operations of
      the Company.

Dated: August 8, 2005

                           By: /s/ CHRISTIAN O. HENRY
                               ---------------------------------------------
                               Christian O. Henry
                               Vice President and Chief Financial Officer

This certification accompanies the Form 10-Q to which it relates, is not deemed
filed with the Securities and Exchange Commission for purposes of Section 18 of
the Securities Exchange Act of 1934, as amended, or otherwise subject to the
liabilities such Section, and is not to be incorporated by reference into any
filing of the Company under the Securities Act of 1933, as amended, or the
Securities Exchange Act of 1934, as amended (whether made before or after the
date of the Form 10-Q), irrespective of any general incorporation language
contained in such filing.