As filed with the Securities and Exchange Commission on April 22, 2005

Registration No. 333-            

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

CURIS, INC.

(Exact Name of Registrant as Specified in Its Charter)

Delaware	04-3505116
(State or other jurisdiction of	(I.R.S. Employer
incorporation or organization)	Identification No.)

61 Moulton Street

Cambridge, Massachusetts 02138

(Address of principal executive offices) (zip code)

CURIS, INC. 2000 STOCK INCENTIVE PLAN

(Full title of the plan)

Daniel R. Passeri

President and Chief Executive Officer

61 Moulton Street

Cambridge, Massachusetts 02138

(Name and address of agent for service)

617-503-6500

(Telephone number, including area code, of agent for service)

CALCULATION OF REGISTRATION FEE

Title of Securities to be Registered	Amount to be Registered (1)	Proposed Maximum Offering Price Per Share (2)	Proposed Maximum Aggregate Offering Price (2)	Amount of Registration Fee
Common Stock, $0.01 par value per share	5,000,000	$3.48	$17,400,000	$2,047.98

(1) In accordance with Rule 416 under the Securities Act of 1933, as amended, this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.

(2) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as amended, and based upon the average of the high and low prices of the registrant’s common stock as reported on the NASDAQ National Market on April 20, 2005.

Statement of Incorporation by Reference

This registration statement on Form S-8 is filed to register the offer and sale of an additional 5,000,000 shares of the registrant’s common stock, $0.01 par value per share, to be issued under the Curis, Inc. 2000 Stock Incentive Plan. This registration statement incorporates by reference the registrant’s registration statement on Form S-8 (File No. 333-42598), as filed with the Securities and Exchange Commission (the “Commission”) on July 31, 2000.

Item 8. Exhibits.

The Exhibit Index immediately preceding the exhibits is incorporated herein by reference.

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SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on this 22nd day of April, 2005.

CURIS, INC.
By:	/s/ Daniel R. Passeri
	Daniel R. Passeri
	President and Chief Executive Officer

SIGNATURES AND POWER OF ATTORNEY

We, the undersigned officers and directors of Curis, Inc., hereby severally constitute and appoint Daniel R. Passeri, Michael P. Gray and Mary Elizabeth Potthoff, Esq., and each of them singly, our true and lawful attorneys with full power to any of them, and to each of them singly, to sign for us and in our names in the capacities indicated below the registration statement on Form S-8 filed herewith and any and all pre-effective and post-effective amendments to said registration statement and generally to do all such things in our name and behalf in our capacities as officers and directors to enable Curis, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

Signature	Title	Date
/s/ Daniel R. Passeri	President, Chief Executive Officer and Director (Principal Executive Officer)	April 22, 2005
Daniel R. Passeri
/s/ Michael P. Gray	Vice President of Finance, Chief Financial Officer (Principal Financial and Accounting Officer)	April 22, 2005
Michael P. Gray
/s/ James R. McNab, Jr.	Chairman of the Board of Directors	April 22, 2005
James R. McNab, Jr.
/s/ Susan B. Bayh	Director	April 22, 2005
Susan B. Bayh
/s/ Joseph M. Davie	Director	April 22, 2005
Joseph M. Davie

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Signature	Title	Date
/s/ Martyn D. Greenacre	Director	April 22, 2005
Martyn D. Greenacre
/s/ Kenneth I. Kaitin	Director	April 22, 2005
Kenneth I. Kaitin
	Director
Douglas A. Melton
/s/ James R. Tobin	Director	April 22, 2005
James R. Tobin

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EXHIBIT INDEX

Number	Description
4.1(1)	Restated Certificate of Incorporation of the registrant, as amended to date.
4.2(2)	Amended and Restated By-Laws of the registrant.
5.1	Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the registrant.
23.1	Consent of Wilmer Cutler Pickering Hale and Dorr LLP, included in Exhibit 5.1.
23.2	Consent of PricewaterhouseCoopers LLP.
23.3	Notice Regarding Consent of Arthur Andersen LLP.
24.1	Power of attorney, included on the signature page to this registration statement.

(1) Incorporated by reference to the registrant’s joint proxy statement-prospectus on Form S-4/A filed June 19, 2000 (File No. 333-32446).

(2) Incorporated by reference to the registrant’s registration statement on Form S-1 filed November 29, 2000 (File No. 333-50906).