Leases and Commitments - Lease Cost (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Lessee, Lease, Description [Line Items]
Operating lease cost	$ 1,353,000	$ 1,336	$ 1,002
Research and development expenses
Lessee, Lease, Description [Line Items]
Operating lease cost	1,042,000	1,061	651
General and administrative expenses
Lessee, Lease, Description [Line Items]
Operating lease cost	$ 311,000	$ 275	$ 351