Exhibit 22.1

List of Guarantor Subsidiaries

CHS/Community Health Systems, Inc. (“CHS”) is the sole issuer of the 6⅞% Senior Notes due 2022 and the 6¼% Senior Secured Notes due 2023 (collectively, “the Notes”). The following entities are direct and indirect subsidiaries of CHS which guarantee the Notes as of September 30, 2020.

1. Abilene Hospital, LLC

2. Abilene Merger, LLC

3. Affinity Health Systems, LLC

4. Affinity Hospital, LLC

5. Berwick Hospital Company, LLC

6. Biloxi H.M.A., LLC

7. Birmingham Holdings II, LLC

8. Birmingham Holdings, LLC

9. Bluffton Health System LLC

10. Brandon HMA, LLC

11. Brownwood Hospital, L.P.

12. Brownwood Medical Center, LLC

13. Bullhead City Hospital Corporation

14. Bullhead City Hospital Investment Corporation

15. Campbell County HMA, LLC

16. Carlsbad Medical Center, LLC

17. Carolinas Holdings, LLC

18. Carolinas JV Holdings General, LLC

19. Carolinas JV Holdings II, LLC

20. Carolinas JV Holdings, L.P.

21. Central Florida HMA Holdings, LLC

22. Central States HMA Holdings, LLC

23. CHS Receivables Funding, LLC

24. CHS Tennessee Holdings, LLC

25. CHS Virginia Holdings, LLC

26. CHSPSC, LLC

27. Citrus HMA, LLC

28. Clarksdale HMA, LLC

29. Clarksville Holdings II, LLC

30. Clarksville Holdings, LLC

31. Cleveland Hospital Company, LLC

32. Cleveland Tennessee Hospital Company, LLC

33. Clinton HMA, LLC

34. Cocke County HMA, LLC

35. Community Health Investment Company, LLC

36. CP Hospital GP, LLC

37. CPLP, LLC

38. Crestwood Healthcare, L.P.

39. Crestwood Hospital LP, LLC

40. Crestwood Hospital, LLC

41. CSMC, LLC

42. Desert Hospital Holdings, LLC

43. Detar Hospital, LLC

44. DHFW Holdings, LLC

45. Dukes Health System, LLC

46. Emporia Hospital Corporation

47. Florida HMA Holdings, LLC

48. Foley Hospital Corporation

49. Frankfort Health Partner, Inc.

50. Franklin Hospital Corporation

51. Gadsden Regional Medical Center, LLC

52. Granbury Hospital Corporation

53. Greenbrier VMC, LLC

54. GRMC Holdings, LLC

55. Hallmark Healthcare Company, LLC

56. Health Management Associates, LLC

57. Health Management Associates, LP

58. Health Management General Partner I, LLC

59. Health Management General Partner, LLC

60. Hernando HMA, LLC

61. HMA Hospitals Holdings, LP

62. HMA Santa Rosa Medical Center, LLC

63. HMA Services GP, LLC

64. HMA-TRI Holdings, LLC

65. Hobbs Medco, LLC

66. Hospital Management Associates, LLC

67. Hospital Management Services of Florida, LP

68. Jackson HMA, LLC

69. Jefferson County HMA, LLC

70. Kay County Hospital Corporation

71. Kay County Oklahoma Hospital Company, LLC

72. Key West HMA, LLC

73. Kirksville Hospital Company, LLC

74. Knox Hospital Company, LLC

75. Knoxville HMA Holdings, LLC

76. La Porte Health System, LLC

77. La Porte Hospital Company, LLC

78. Laredo Texas Hospital Company, L.P.

79. Las Cruces Medical Center, LLC

80. Lea Regional Hospital, LLC

81. Longview Clinic Operations Company, LLC

82. Longview Medical Center, L.P.

83. Longview Merger, LLC

84. LRH, LLC

85. Lutheran Health Network of Indiana, LLC

86. Marshall County HMA, LLC

87. MCSA, L.L.C.

88. Medical Center of Brownwood, LLC

89. Metro Knoxville HMA, LLC

90. Mississippi HMA Holdings I, LLC

91. Mississippi HMA Holdings II, LLC

92. Moberly Hospital Company,  LLC

93. Naples HMA, LLC

94. Natchez Hospital Company, LLC

95. Navarro Hospital, L.P.

96. Navarro Regional, LLC

97. NC-DSH, LLC

98. Northwest Arkansas Hospitals, LLC

99. Northwest Hospital, LLC

100. NOV Holdings, LLC

101. NRH, LLC

102. Oak Hill Hospital Corporation

103. Oro Valley Hospital, LLC

104. Palmer-Wasilla Health System, LLC

105. Poplar Bluff Regional Medical Center, LLC

106. Port Charlotte HMA, LLC

107. Punta Gorda HMA, LLC

108. QHG Georgia Holdings, Inc.

109. QHG of Bluffton Company, LLC

110. QHG of Clinton County, Inc.

111. QHG of Enterprise, Inc.

112. QHG of Forrest County, Inc.

113. QHG of Fort Wayne Company, LLC

114. QHG of Hattiesburg, Inc.

115. QHG of Springdale, Inc.

116. Regional Hospital of Longview, LLC

117. River Oaks Hospital, LLC

118. River Region Medical Corporation

119. ROH, LLC

120. Roswell Hospital Corporation

121. Ruston Hospital Corporation

122. Ruston Louisiana Hospital Company, LLC

123. SACMC, LLC

124. San Angelo Community Medical Center, LLC

125. San Angelo Hospital, L.P.

126. San Angelo Medical, LLC

127. Scranton Holdings, LLC

128. Scranton Hospital Company, LLC

129. Scranton Quincy Holdings, LLC

130. Scranton Quincy Hospital Company, LLC

131. Seminole HMA, LLC

132. Shelbyville Hospital Company, LLC

133. Siloam Springs Arkansas Hospital Company, LLC

134. Siloam Springs Holdings, LLC

135. Southeast HMA Holdings, LLC

136. Southern Texas Medical Center, LLC

137. Southwest Florida HMA Holdings, LLC

138. Statesville HMA, LLC

139. Tennessee HMA Holdings, LP

140. Tennyson Holdings, LLC

141. Triad Healthcare, LLC

142. Triad Holdings III, LLC

143. Triad Holdings IV, LLC

144. Triad Holdings V, LLC

145. Triad Nevada Holdings, LLC

146. Triad of Alabama, LLC

147. Triad-ARMC, LLC

148. Triad-El Dorado, Inc.

149. Triad-Navarro Regional Hospital Subsidiary, LLC

150. Tullahoma HMA, LLC

151. Tunkhannock Hospital Company, LLC

152. Venice HMA, LLC

153. VHC Medical, LLC

154. Vicksburg Healthcare, LLC

155. Victoria Hospital, LLC

156. Victoria of Texas, L.P.

157. Virginia Hospital Company, LLC

158. Warsaw Health System, LLC

159. Webb Hospital Corporation

160. Webb Hospital Holdings, LLC

161. Wesley Health System LLC

162. WHMC, LLC

163. Wilkes-Barre Behavioral Hospital Company, LLC

164. Wilkes-Barre Holdings, LLC

165. Wilkes-Barre Hospital Company, LLC

166. Woodland Heights Medical Center, LLC

167. Woodward Health System, LLC