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Related Party Transactions - Additional Information (Detail) - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2015
Feb. 19, 2021
Related Party Transaction [Line Items]        
Research and development $ 49,643,000 $ 52,696,000    
M.D. Anderson Cancer Center        
Related Party Transaction [Line Items]        
Payment 100,000 0    
MD Anderson License and the Research and Development Agreement Member [Member]        
Related Party Transaction [Line Items]        
Cash resources on hand  0 8,100,000    
License Agreement | M.D. Anderson Cancer Center        
Related Party Transaction [Line Items]        
Issuance of common stock in licensing agreement (in shares)     11,722,163  
Research and development     $ 67,300,000  
Vineti Inc [Member] | Collaborative Arrangement        
Related Party Transaction [Line Items]        
Expenses From Transactions With Related Party 400,000 $ 29,000,000    
Watermill And Robert W Postma [Member]        
Related Party Transaction [Line Items]        
Amount due to related party, current       $ 400,000
Fees and Expenses, Related Party 650,000      
Eden BioCell [Member]        
Related Party Transaction [Line Items]        
Payments to Fund Long-term Loans to Related Parties 10,000,000.0      
Additional Loans Committed $ 25,000,000.0