Note 11 - Related Parties (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
Research and Development Expense [Member]
Related Party Transaction, Expenses from Transactions with Related Party	$ 0	$ 0
Reimbursement [Member]
Related Party Transaction, Amounts of Transaction	27,479	25,184
Advance from Related Parties [Member]
Related Party Transaction, Amounts of Transaction	$ 0	$ (555,000)