Note 9 - Related Parties (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Research and Development Expense [Member]
Related Party Transaction, Expenses from Transactions with Related Party	$ 47,490	$ 240,370
Reimbursement [Member]
Related Party Transaction, Amounts of Transaction	31,622	25,770
Advance from Related Parties [Member]
Related Party Transaction, Amounts of Transaction	$ 262,000	$ 150,000