Document Format Files
| Seq | Description | Document | Type | Size |
|---|---|---|---|---|
| 1 | FORM S-1 | ds1.htm | S-1 | 2669363 |
| 2 | THIRD AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF THE REGISTRANT | dex31.htm | EX-3.1 | 342283 |
| 3 | BYLAWS OF THE REGISTRANT | dex33.htm | EX-3.3 | 82177 |
| 4 | SECOND AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT | dex101.htm | EX-10.1 | 199337 |
| 5 | WARRANT TO PURCHASE SHARES OF COMMON STOCK - ECKHART KAMPGEN | dex102.htm | EX-10.2 | 49727 |
| 6 | WARRANT TO PURCHASE SHARES OF COMMON STOCK - JOHANNES W.G. VIEWEG, M.D. | dex103.htm | EX-10.3 | 42396 |
| 7 | 1999 STOCK OPTION PLAN | dex104.htm | EX-10.4 | 47557 |
| 8 | 2008 STOCK INCENTIVE PLAN | dex105.htm | EX-10.5 | 57649 |
| 9 | FORM OF INCENTIVE STOCK OPTION AGREEMENT UNDER 2008 STOCK INCENTIVE PLAN | dex106.htm | EX-10.6 | 45936 |
| 10 | FORM OF NONSTATUTORY STOCK OPTION AGREEMENT UNDER 2008 STOCK INCENTIVE PLAN | dex107.htm | EX-10.7 | 46504 |
| 11 | OFFER LETTER - CHARLES A. NICOLETTE, AS AMENDED | dex1011.htm | EX-10.11 | 77953 |
| 12 | OFFER LETTER - JEFFREY D. ABBEY, AS AMENDED | dex1012.htm | EX-10.12 | 63988 |
| 13 | OFFER LETTER - FREDERICK M. MIESOWICZ, AS AMENDED | dex1013.htm | EX-10.13 | 28432 |
| 14 | OFFER LETTER - LORI R. HARRELSON | dex1014.htm | EX-10.14 | 16399 |
| 15 | LEASE AGREEMENT, DATED AS OF JANUARY 16, 2001, AS AMENDED | dex1016.htm | EX-10.16 | 184659 |
| 16 | LICENSE AGREEMENT, DATED AS OF JANUARY 10, 2000 - AS AMENDED ON JULY 28, 2003 | dex1017.htm | EX-10.17 | 205592 |
| 17 | EXCLUSIVE LICENSE AGREEMENT, DATED AS OF JANUARY 15, 2002 | dex1018.htm | EX-10.18 | 85258 |
| 18 | EXCLUSIVE LICENSE AGREEMENT, DATED AS OF NOVEMBER 17, 2005 | dex1019.htm | EX-10.19 | 125528 |
| 19 | LIECNSE AGREEMENT, DATED AS OF MARCH 6, 2004 | dex1020.htm | EX-10.20 | 175753 |
| 20 | SUBSIDIARIES OF THE REGISTRANT | dex211.htm | EX-21.1 | 1792 |
| 21 | CONSENT OF PRICEWATERHOUSECOOPERS LLP | dex231.htm | EX-23.1 | 1447 |
| 23 | GRAPHIC | g214145argos_logo001.jpg | GRAPHIC | 18595 |
| 24 | GRAPHIC | g214145ex10_gpg007.jpg | GRAPHIC | 5445 |
| 25 | GRAPHIC | g214145ex10_jpg006.jpg | GRAPHIC | 10480 |
| 26 | GRAPHIC | g214145ex10_lpg017.jpg | GRAPHIC | 5402 |
| 27 | GRAPHIC | g214145ex10_lpg018.jpg | GRAPHIC | 2636 |
| 28 | GRAPHIC | g214145ex10_lpg019.jpg | GRAPHIC | 3787 |
| 29 | GRAPHIC | g214145ex10_lpg020.jpg | GRAPHIC | 5783 |
| 30 | GRAPHIC | g214145ex10_lpg021.jpg | GRAPHIC | 7650 |
| 31 | GRAPHIC | g214145ex10_lpg022.jpg | GRAPHIC | 10499 |
| 32 | GRAPHIC | g214145ex10_lpg023.jpg | GRAPHIC | 9234 |
| 33 | GRAPHIC | g214145ex10_lpg024.jpg | GRAPHIC | 3865 |
| 34 | GRAPHIC | g214145ex10_lpg025.jpg | GRAPHIC | 2829 |
| 35 | GRAPHIC | g214145ex10_lpg026.jpg | GRAPHIC | 2636 |
| 36 | GRAPHIC | g214145ex10_lpg027.jpg | GRAPHIC | 4808 |
| 37 | GRAPHIC | g214145ex10_lpg028.jpg | GRAPHIC | 3598 |
| 38 | GRAPHIC | g214145ex10_lpg029.jpg | GRAPHIC | 5346 |
| 39 | GRAPHIC | g214145ex10_lpg030.jpg | GRAPHIC | 7130 |
| 40 | GRAPHIC | g214145ex10_lpg031.jpg | GRAPHIC | 6863 |
| 41 | GRAPHIC | g214145ex10_lpg032.jpg | GRAPHIC | 7004 |
| 42 | GRAPHIC | g214145ex10_lpg033.jpg | GRAPHIC | 10208 |
| 43 | GRAPHIC | g214145ex10_lpg034.jpg | GRAPHIC | 9953 |
| 44 | GRAPHIC | g214145ex10_lpg035.jpg | GRAPHIC | 9373 |
| 45 | GRAPHIC | g214145ex10_lpg036.jpg | GRAPHIC | 6369 |
| 46 | GRAPHIC | g214145ex10_lpg037.jpg | GRAPHIC | 4367 |
| 47 | GRAPHIC | g214145ex10_lpg038.jpg | GRAPHIC | 3422 |
| 48 | GRAPHIC | g214145ex10_lpg038a.jpg | GRAPHIC | 10733 |
| 49 | GRAPHIC | g214145ex10_lpg039.jpg | GRAPHIC | 11412 |
| 50 | GRAPHIC | g214145ex10_lpg40.jpg | GRAPHIC | 18172 |
| 51 | GRAPHIC | g214145ex10_lpg41a.jpg | GRAPHIC | 3163 |
| 52 | GRAPHIC | g214145ex10_lpg41b.jpg | GRAPHIC | 3955 |
| 53 | GRAPHIC | g214145ex10_lpg42.jpg | GRAPHIC | 5679 |
| 54 | GRAPHIC | g214145ex10_lpg43.jpg | GRAPHIC | 5662 |
| 55 | GRAPHIC | g214145ex10_lpg44.jpg | GRAPHIC | 8589 |
| 56 | GRAPHIC | g214145ex10_lpg45.jpg | GRAPHIC | 6451 |
| 57 | GRAPHIC | g214145ex10_lpg46.jpg | GRAPHIC | 5992 |
| 58 | GRAPHIC | g214145ex10_lpg47.jpg | GRAPHIC | 8004 |
| 59 | GRAPHIC | g214145ex10_lpg48.jpg | GRAPHIC | 8472 |
| 60 | GRAPHIC | g214145ex10_mpg001a.jpg | GRAPHIC | 11929 |
| 61 | GRAPHIC | g214145ex10_mpg001b.jpg | GRAPHIC | 2906 |
| 62 | GRAPHIC | g214145ex10_mpg003.jpg | GRAPHIC | 10164 |
| 63 | GRAPHIC | g214145ex10_mpg004.jpg | GRAPHIC | 6530 |
| 64 | GRAPHIC | g214145ex10_mpg005a.jpg | GRAPHIC | 4720 |
| 65 | GRAPHIC | g214145ex10_mpg005b.jpg | GRAPHIC | 7069 |
| 66 | GRAPHIC | g214145ex10_mpg005l.jpg | GRAPHIC | 26632 |
| 67 | GRAPHIC | g214145ex10_npg001a.jpg | GRAPHIC | 11467 |
| 68 | GRAPHIC | g214145ex10_npg001b.jpg | GRAPHIC | 7427 |
| 69 | GRAPHIC | g214145ex10_npg003.jpg | GRAPHIC | 5959 |
| 70 | GRAPHIC | g214145ex10_npg004.jpg | GRAPHIC | 5313 |
| 71 | GRAPHIC | g214145ex10_npg005a.jpg | GRAPHIC | 8846 |
| 72 | GRAPHIC | g214145ex10_npg005b.jpg | GRAPHIC | 1811 |
| 73 | GRAPHIC | g214145ex10_npg005c.jpg | GRAPHIC | 4151 |
| 74 | GRAPHIC | g214145ex10_npg007a.jpg | GRAPHIC | 3741 |
| 75 | GRAPHIC | g214145ex10_npg007b.jpg | GRAPHIC | 6233 |
| 76 | GRAPHIC | g214145ex10_npg007c.jpg | GRAPHIC | 64590 |
| 77 | GRAPHIC | g214145ex10_npg008.jpg | GRAPHIC | 19592 |
| 78 | GRAPHIC | g214145ex10_npg009a.jpg | GRAPHIC | 7933 |
| 79 | GRAPHIC | g214145ex10_npg009b.jpg | GRAPHIC | 5745 |
| 80 | GRAPHIC | g214145ex10_npg021x.jpg | GRAPHIC | 3917 |
| 81 | GRAPHIC | g214145ex10_opg001a.jpg | GRAPHIC | 12505 |
| 82 | GRAPHIC | g214145ex10_opg001b.jpg | GRAPHIC | 7304 |
| 83 | GRAPHIC | g214145ex10_opg003a.jpg | GRAPHIC | 11301 |
| 84 | GRAPHIC | g214145ex10_opg003b.jpg | GRAPHIC | 8632 |
| 85 | GRAPHIC | g214145ex10_opg004a.jpg | GRAPHIC | 10654 |
| 86 | GRAPHIC | g214145ex10_opg004b.jpg | GRAPHIC | 1884 |
| 87 | GRAPHIC | g214145ex10_opg004c.jpg | GRAPHIC | 4718 |
| 88 | GRAPHIC | g214145ex10_opg006.jpg | GRAPHIC | 20750 |
| 89 | GRAPHIC | g214145ex10_opg007a.jpg | GRAPHIC | 6945 |
| 90 | GRAPHIC | g214145ex10_opg007b.jpg | GRAPHIC | 10734 |
| 91 | GRAPHIC | g214145ex10_qpg009.jpg | GRAPHIC | 3126 |
| 92 | GRAPHIC | g214145ex10_rpg007a.jpg | GRAPHIC | 4421 |
| 93 | GRAPHIC | g214145ex10_rpg007b.jpg | GRAPHIC | 5167 |
| 94 | GRAPHIC | g214145ex10_rpg007c.jpg | GRAPHIC | 5529 |
| 95 | GRAPHIC | g214145ex10_rpg007d.jpg | GRAPHIC | 5885 |
| 96 | GRAPHIC | g214145ex10_rpg007e.jpg | GRAPHIC | 3465 |
| 97 | GRAPHIC | g214145ex10_rpg008a.jpg | GRAPHIC | 5444 |
| 98 | GRAPHIC | g214145ex10_rpg008b.jpg | GRAPHIC | 5601 |
| 99 | GRAPHIC | g214145ex10_rpg018a.jpg | GRAPHIC | 2342 |
| 100 | GRAPHIC | g214145ex10_rpg018b.jpg | GRAPHIC | 5665 |
| 101 | GRAPHIC | g214145ex10_rpg018c.jpg | GRAPHIC | 4532 |
| 102 | GRAPHIC | g214145ex10_rpg018d.jpg | GRAPHIC | 3984 |
| 103 | GRAPHIC | g214145ex10_rpg021a.jpg | GRAPHIC | 7055 |
| 104 | GRAPHIC | g214145ex10_rpg021b.jpg | GRAPHIC | 7485 |
| 105 | GRAPHIC | g214145ex10_rpg022a.jpg | GRAPHIC | 6143 |
| 106 | GRAPHIC | g214145ex10_rpg022b.jpg | GRAPHIC | 3046 |
| 107 | GRAPHIC | g214145ex10_rpg022c.jpg | GRAPHIC | 6612 |
| 108 | GRAPHIC | g214145ex10_spg001.jpg | GRAPHIC | 9024 |
| 109 | GRAPHIC | g214145ex10_spg003.jpg | GRAPHIC | 5772 |
| 110 | GRAPHIC | g214145ex10_spg003b.jpg | GRAPHIC | 2996 |
| 111 | GRAPHIC | g214145ex3_1pg01.jpg | GRAPHIC | 14077 |
| 112 | GRAPHIC | g214145ex3_1pg54.jpg | GRAPHIC | 13417 |
| 113 | GRAPHIC | g214145ex3_1pg57.jpg | GRAPHIC | 12229 |
| 114 | GRAPHIC | g214145ex3_1pg60.jpg | GRAPHIC | 12580 |
| 115 | GRAPHIC | g214145ex3_1pg63.jpg | GRAPHIC | 11515 |
| 116 | GRAPHIC | g214145g34e30.jpg | GRAPHIC | 110110 |
| 117 | GRAPHIC | g214145g52c56.jpg | GRAPHIC | 15832 |
| 118 | GRAPHIC | g214145g56p44.jpg | GRAPHIC | 385826 |
| 119 | GRAPHIC | g214145g74j32.jpg | GRAPHIC | 46174 |
| 120 | GRAPHIC | g214145g74q46.jpg | GRAPHIC | 13601 |
| 121 | GRAPHIC | g214145g89g99.jpg | GRAPHIC | 261344 |
| 122 | GRAPHIC | g214145g91z02.jpg | GRAPHIC | 62891 |
| 123 | GRAPHIC | g214145g95d35.jpg | GRAPHIC | 14289 |
| 124 | GRAPHIC | g214145g96w37.jpg | GRAPHIC | 405967 |
| Complete submission text file | 0001193125-11-202087.txt | 7417361 |
IRS No.: 562110007 | State of Incorp.: DE | Fiscal Year End: 1231
Type: S-1 | Act: 33 | File No.: 333-175880 | Film No.: 11995937
