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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Operating activities    
Net loss $ (14,298) $ (13,678)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 167 148
Stock based compensation expense 2,358 954
Gain on sale of asset, net   (2)
Amortization of debt discount and debt issuance costs 102 118
Accrual of the end of term charge on the debt 33 49
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (2,600) (797)
Accounts payable 3,889 1,124
Accrued expenses and deferred rent (770) 1,787
Accrued lease expenses (62) (64)
Accrued compensation (1,468) (848)
Net cash used in operating activities (12,649) (11,209)
Investing activities    
Purchase of fixed assets (331) (163)
Proceeds from sale of asset   2
Net cash used in investing activities (331) (161)
Financing activities    
Payments on capital lease obligations (16) (29)
Proceeds from exercise of stock options 353 51
Net cash provided by financing activities 337 22
Decrease in cash and cash equivalents (12,643) (11,348)
Cash and cash equivalents at beginning of period 113,894 90,782
Cash and cash equivalents at end of period 101,251 79,434
Supplemental disclosures of cash flow information:    
Cash paid for interest 463 476
Cash received for taxes $ 4,389 $ 1,221