Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Statement of Comprehensive Income [Abstract]
Product revenues, net	$ 305,208	$ 245,358	$ 188,461
Revenue from Contract with Customer, Product and Service [Extensible Enumeration]	Product [Member]	Product [Member]	Product [Member]
Operating expenses:
Cost of product revenues (excluding amortization of intangible assets)	$ 65,573	$ 55,126	$ 44,152
Cost, Product and Service [Extensible Enumeration]	Product [Member]	Product [Member]	Product [Member]
Research and development	$ 571,011	$ 397,518	$ 272,744
Selling, general and administrative	344,501	265,784	234,273
Amortization of intangible assets	5,052	5,053	5,052
Change in fair value of deferred and contingent consideration liabilities	28,697	(20,802)	7,334
Total operating expenses	1,014,834	702,679	563,555
Operating loss	(709,626)	(457,321)	(375,094)
Investment income	42,132	11,081	174
Interest expense	(81,694)	(26,446)	(40,473)
Change in fair value of interest rate swap	320	(1,526)	0
Loss on extinguishment of debt	0	0	(17,689)
Other income (expense), net	1,856	(5,939)	(3,330)
Loss before income taxes	(747,012)	(480,151)	(436,412)
Provision (benefit) for income taxes	2,555	1,383	(1,758)
Net loss	$ (749,567)	$ (481,534)	$ (434,654)
Net loss per share, Basic (in dollars per share)	$ (5.34)	$ (3.91)	$ (3.88)
Net loss per share, Diluted (in dollars per share)	$ (5.34)	$ (3.91)	$ (3.88)
Weighted average basic common shares outstanding (in shares)	140,433	123,035	112,111
Weighted average diluted common shares outstanding (in shares)	140,433	123,035	112,111
Net loss	$ (749,567)	$ (481,534)	$ (434,654)
Other comprehensive income (loss):
Foreign currency translation and other (losses) gains	(2,214)	303	775
Unrealized gain (loss) on marketable securities	713	(515)	0
Total comprehensive loss	$ (751,068)	$ (481,746)	$ (433,879)