Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities
Net loss	$ (321,411)	$ (321,676)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	3,095	7,011
Amortization of intangible assets	3,789	3,790
Stock-based compensation expense	42,736	34,501
Loss on extinguishment of debt	0	17,689
Amortization of debt issuance costs and accretion of debt discount	2,465	22,055
Finance lease amortization expense	1,846	809
Noncash operating lease expense	11,440	11,218
Change in fair value of deferred and contingent consideration liabilities	(19,002)	8,300
Changes in operating assets and liabilities:
Accounts receivable	(5,440)	(2,875)
Inventory	624	(18,588)
Prepaid expenses and other current assets	1,806	(2,097)
Other assets	(13,023)	(20,994)
Accounts payable and accrued liabilities	15,137	(4,057)
Other liabilities	(21,352)	(14,256)
Net cash used in operating activities	(297,290)	(279,170)
Investing activities
Purchase of fixed assets	(5,187)	(6,147)
Purchase of marketable securities	(99,706)	0
Cash used for Business Acquisition, net	0	(6,920)
Maturities of marketable securities	50,000	0
Net cash used in investing activities	(54,893)	(13,067)
Financing activities
Proceeds from exercise of stock options, ESPP, and RSU vestings	17,333	16,021
Proceeds from issuance of common stock, net	33,383	269,886
Payment on extinguishment of 1.75% convertible senior notes due 2025	0	(12,578)
Payment of principal on 1.75% convertible senior notes due 2025	0	(225,000)
Proceeds from issuance of 0.75% convertible senior notes due 2028	0	575,000
Payment of debt issuance costs	0	(15,702)
Payments of finance lease principal	(830)	(791)
Net cash provided by financing activities	49,886	606,836
Effect of exchange rates on cash and cash equivalents	148	(799)
Net (decrease) increase in cash and cash equivalents	(302,149)	313,800
Cash and cash equivalents at beginning of period	716,782	532,756
Cash and cash equivalents at end of period	414,633	846,556
Supplemental disclosures of cash flow information:
Cash paid for interest	7,442	8,202
Cash paid for income taxes	$ 1,626	$ 1,451