Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating activities
Net loss	$ (94,621)	$ (91,641)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	1,286	2,388
Amortization of intangible assets	1,263	1,263
Stock-based compensation expense	12,823	10,535
Amortization of debt issuance costs and accretion of debt discount	822	5,257
Finance lease amortization expense	729	270
Noncash operating lease expense	2,369	5,208
Change in fair value of deferred and contingent consideration liabilities	(11,618)	0
Changes in operating assets and liabilities:
Accounts receivable	(1,798)	(1,066)
Inventory	2,240	(2,754)
Prepaid expenses and other current assets	(2,752)	2,056
Other assets	(6,289)	(19,731)
Accounts payable	13,363	(20,273)
Accrued liabilities, accrued compensation and other	(22,978)	(19,793)
Net cash used in operating activities	(105,161)	(128,281)
Investing activities
Purchase of fixed assets	(1,701)	(1,181)
Purchase of marketable securities	(99,706)	0
Net cash used in investing activities	(101,407)	(1,181)
Financing activities
Proceeds from exercise of stock options, ESPP, and RSU vestings	6,818	6,961
Payments of finance lease principal	(359)	(258)
Net cash provided by financing activities	6,459	6,703
Effect of exchange rates on cash and cash equivalents	(969)	(246)
Net decrease in cash and cash equivalents	(201,078)	(123,005)
Cash and cash equivalents at beginning of period	716,782	532,756
Cash and cash equivalents at end of period	515,704	409,751
Supplemental disclosures of cash flow information:
Cash paid for interest	2,375	4,271
Cash paid for income taxes	$ 635	$ 672